PH26199A - Poly-kringle plasmogen activator - Google Patents
Poly-kringle plasmogen activator Download PDFInfo
- Publication number
- PH26199A PH26199A PH34127A PH34127A PH26199A PH 26199 A PH26199 A PH 26199A PH 34127 A PH34127 A PH 34127A PH 34127 A PH34127 A PH 34127A PH 26199 A PH26199 A PH 26199A
- Authority
- PH
- Philippines
- Prior art keywords
- dna
- kringle
- ser
- plasminogen activator
- hybrid
- Prior art date
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- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
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- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 238000013492 plasmid preparation Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 210000004896 polypeptide structure Anatomy 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 238000011536 re-plating Methods 0.000 description 1
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- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 229910001868 water Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76616385A | 1985-08-14 | 1985-08-14 | |
US06/884,835 US4916071A (en) | 1985-08-14 | 1986-07-11 | Poly-kringle plasminogen activator |
Publications (1)
Publication Number | Publication Date |
---|---|
PH26199A true PH26199A (en) | 1992-03-18 |
Family
ID=27117699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH34127A PH26199A (en) | 1985-08-14 | 1986-08-12 | Poly-kringle plasmogen activator |
Country Status (15)
Country | Link |
---|---|
US (1) | US4916071A (ja) |
EP (1) | EP0213794B1 (ja) |
JP (2) | JPH0829086B2 (ja) |
KR (1) | KR900007649B1 (ja) |
AU (1) | AU596369B2 (ja) |
CA (1) | CA1341449C (ja) |
DE (1) | DE3676760D1 (ja) |
DK (1) | DK175420B1 (ja) |
GB (1) | GB2179948B (ja) |
GR (1) | GR862076B (ja) |
HU (1) | HU200795B (ja) |
IE (1) | IE59380B1 (ja) |
IL (1) | IL79644A (ja) |
PH (1) | PH26199A (ja) |
PT (1) | PT83170B (ja) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5112755A (en) * | 1982-04-15 | 1992-05-12 | Genentech, Inc. | Preparation of functional human urokinase proteins |
GB8334498D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
US4880776A (en) * | 1983-12-24 | 1989-11-14 | Beecham Group P.L.C. | Plasmin A-chain urokinase B-chain hybrid protein |
JP2581668B2 (ja) * | 1985-11-27 | 1997-02-12 | 三井東圧化学株式会社 | ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいdna配列とそれを含むベクタ−及び細胞 |
ES2053449T3 (es) * | 1985-12-20 | 1994-08-01 | Upjohn Co | Analogos (tpa) de activadores de plasminogeno de tejido. |
US5204255A (en) * | 1986-01-31 | 1993-04-20 | Sagami Chemical Research Center | Hybrid tissue plasminogen activator/urokinase polypeptides |
ATE70301T1 (de) * | 1986-02-17 | 1991-12-15 | Stichting Centraal Lab | Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen. |
US5047241A (en) * | 1986-07-11 | 1991-09-10 | American Home Products Corporation | Tris-Kringle plasminogen activator with novel K2 insert |
US5580559A (en) * | 1986-12-05 | 1996-12-03 | Ciba-Geigy Corporation | Hybrid plasminogen activator |
US5242819A (en) * | 1986-12-05 | 1993-09-07 | Ciba-Geigy Corporation | DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase |
FI100106B (fi) * | 1986-12-05 | 1997-09-30 | Novartis Ag | Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi |
AU1295088A (en) * | 1987-01-30 | 1988-08-24 | American Home Products Corporation | Des-epidermal growth factor plasminogen activators |
GB8705377D0 (en) * | 1987-03-07 | 1987-04-08 | Beecham Group Plc | Compounds |
GB8711957D0 (en) * | 1987-05-20 | 1987-06-24 | Beecham Group Plc | Compounds |
DK275788A (da) * | 1987-05-22 | 1989-02-03 | Zymogenetics Inc | Fibrinolytiske proteiner |
ZA884012B (en) * | 1987-06-04 | 1989-02-22 | Zymogenetics Inc | Tissue plasminogen activator analogs having modified growth factor domains |
ATE118815T1 (de) * | 1987-06-04 | 1995-03-15 | Zymogenetics Inc | Gewebs-plasminogen-aktivator-analoge mit modifizierten wachstumsfaktordomänen. |
US5149533A (en) * | 1987-06-04 | 1992-09-22 | Zymogenetics, Inc. | Modified t-PA with kringle-/replaced by another kringle |
HUT47151A (en) * | 1987-07-01 | 1989-01-30 | Beecham Group Plc | Process for producing new hybrid plasminogen activator compounds |
US5302390A (en) * | 1987-07-01 | 1994-04-12 | Beecham Group Plc | Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment |
JPH03500002A (ja) * | 1987-07-06 | 1991-01-10 | ジェネティックス・インスチチュート・インコーポレーテッド | 新規な血栓崩壊蛋白 |
JP2708749B2 (ja) * | 1987-08-10 | 1998-02-04 | エーザイ株式会社 | 修飾型tPA含有注射用組成物 |
US5100666A (en) * | 1987-10-09 | 1992-03-31 | Monsanto Company | Modified tissue plasminogen activator K2K2SP |
US5244676A (en) * | 1987-10-09 | 1993-09-14 | Monsanto Company | Modified tissue plasminogen activator with modified glycosylation site |
AU3410289A (en) * | 1988-04-22 | 1989-11-24 | Collaborative Research Inc. | Plasminogen activators with increased fibrin selectivity |
GB8826975D0 (en) * | 1988-11-18 | 1988-12-21 | Beecham Group Plc | Novel compounds |
US5326700A (en) * | 1990-11-06 | 1994-07-05 | Eli Lilly And Company | DNA sequences encoding t-PA derivatives with cleavable sites |
WO2003087393A2 (en) * | 2002-04-09 | 2003-10-23 | Global Biotech Inc. | Human tissue urokinase type plasminogen activator production |
US8333973B2 (en) * | 2008-01-02 | 2012-12-18 | The Trustees Of The University Of Pennsylvania | Targeting recombinant therapeutics to circulating red blood cells |
WO2019113224A1 (en) | 2017-12-05 | 2019-06-13 | The Trustees Of The University Of Pennsylvania | Fusion proteins and antibodies targeting human red blood cell antigens |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI88932C (fi) * | 1982-04-15 | 1993-07-26 | Genentech Inc | Framstaellning av funktionellt maenskligt urokinasprotein |
SU1662352A3 (ru) * | 1982-05-05 | 1991-07-07 | Генентек, Инк (Фирма) | Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа |
US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
IL68561A (en) | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
GB8334498D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
DE3781420T2 (de) * | 1986-01-31 | 1993-02-25 | Sagami Chem Res | Hybrides plasminogenaktivatoraehnliches polypeptid. |
-
1986
- 1986-07-11 US US06/884,835 patent/US4916071A/en not_active Expired - Lifetime
- 1986-08-06 GB GB8619154A patent/GB2179948B/en not_active Expired
- 1986-08-06 EP EP86306058A patent/EP0213794B1/en not_active Expired - Lifetime
- 1986-08-06 DE DE8686306058T patent/DE3676760D1/de not_active Expired - Lifetime
- 1986-08-06 GR GR862076A patent/GR862076B/el unknown
- 1986-08-06 IL IL79644A patent/IL79644A/xx not_active IP Right Cessation
- 1986-08-08 PT PT83170A patent/PT83170B/pt unknown
- 1986-08-08 HU HU863509A patent/HU200795B/hu unknown
- 1986-08-12 PH PH34127A patent/PH26199A/en unknown
- 1986-08-13 AU AU61102/86A patent/AU596369B2/en not_active Expired
- 1986-08-13 CA CA000515883A patent/CA1341449C/en not_active Expired - Fee Related
- 1986-08-13 DK DK198603856A patent/DK175420B1/da not_active IP Right Cessation
- 1986-08-13 IE IE217886A patent/IE59380B1/en not_active IP Right Cessation
- 1986-08-13 JP JP61191173A patent/JPH0829086B2/ja not_active Expired - Lifetime
- 1986-08-13 KR KR1019860006663A patent/KR900007649B1/ko not_active IP Right Cessation
-
1994
- 1994-08-10 JP JP6188238A patent/JP2610783B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH07147984A (ja) | 1995-06-13 |
PT83170A (en) | 1986-09-01 |
CA1341449C (en) | 2003-12-09 |
JP2610783B2 (ja) | 1997-05-14 |
US4916071A (en) | 1990-04-10 |
GR862076B (en) | 1986-12-24 |
HU200795B (en) | 1990-08-28 |
HUT41443A (en) | 1987-04-28 |
JPH0829086B2 (ja) | 1996-03-27 |
KR900007649B1 (ko) | 1990-10-17 |
PT83170B (pt) | 1988-07-29 |
DK385686A (da) | 1987-02-15 |
EP0213794A1 (en) | 1987-03-11 |
JPS62104577A (ja) | 1987-05-15 |
IE59380B1 (en) | 1994-02-23 |
GB8619154D0 (en) | 1986-09-17 |
AU596369B2 (en) | 1990-05-03 |
GB2179948A (en) | 1987-03-18 |
IE862178L (en) | 1987-02-14 |
GB2179948B (en) | 1989-08-16 |
IL79644A (en) | 1991-06-10 |
EP0213794B1 (en) | 1991-01-09 |
DE3676760D1 (de) | 1991-02-14 |
DK175420B1 (da) | 2004-10-04 |
DK385686D0 (da) | 1986-08-13 |
AU6110286A (en) | 1987-02-19 |
KR870002264A (ko) | 1987-03-30 |
IL79644A0 (en) | 1986-11-30 |
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