DK175393B1 - Bifunktionelle chelateringsmidler, komplekser deraf, antistof-konjugater omfattende komplekserne samt fremgangsmåde til fremstilling af chelateringsmidlerne - Google Patents

Bifunktionelle chelateringsmidler, komplekser deraf, antistof-konjugater omfattende komplekserne samt fremgangsmåde til fremstilling af chelateringsmidlerne Download PDF

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Publication number
DK175393B1
DK175393B1 DK199000493A DK49390A DK175393B1 DK 175393 B1 DK175393 B1 DK 175393B1 DK 199000493 A DK199000493 A DK 199000493A DK 49390 A DK49390 A DK 49390A DK 175393 B1 DK175393 B1 DK 175393B1
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DK
Denmark
Prior art keywords
complex
compound
acid
hydrogen
metal
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Application number
DK199000493A
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Danish (da)
English (en)
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DK49390D0 (da
DK49390A (da
Inventor
William A Fordyce
David A Wilson
Joseph R Garlich
Jaime Simon
Garry E Kiefer
Kenneth Mcmillan
Roberta C Cheng
William F Goeckeler
Sharon Baughman
Richard Keith Frank
J Kruper William Jr
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Dow Global Technologies Inc
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Publication of DK49390D0 publication Critical patent/DK49390D0/da
Publication of DK49390A publication Critical patent/DK49390A/da
Application granted granted Critical
Publication of DK175393B1 publication Critical patent/DK175393B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DK199000493A 1988-06-24 1990-02-23 Bifunktionelle chelateringsmidler, komplekser deraf, antistof-konjugater omfattende komplekserne samt fremgangsmåde til fremstilling af chelateringsmidlerne DK175393B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US21149688A 1988-06-24 1988-06-24
US21149688 1988-06-24
US37095689A 1989-06-21 1989-06-21
US37095689 1989-06-21
US8902788 1989-06-23
PCT/US1989/002788 WO1989012631A1 (en) 1988-06-24 1989-06-23 Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates

Publications (3)

Publication Number Publication Date
DK49390D0 DK49390D0 (da) 1990-02-23
DK49390A DK49390A (da) 1990-02-23
DK175393B1 true DK175393B1 (da) 2004-09-20

Family

ID=26906194

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199000493A DK175393B1 (da) 1988-06-24 1990-02-23 Bifunktionelle chelateringsmidler, komplekser deraf, antistof-konjugater omfattende komplekserne samt fremgangsmåde til fremstilling af chelateringsmidlerne

Country Status (20)

Country Link
US (1) US5435990A (el)
EP (2) EP0353450B1 (el)
JP (1) JP2831073B2 (el)
KR (1) KR0137930B1 (el)
AT (1) ATE120457T1 (el)
AU (1) AU634167B2 (el)
BR (1) BR8907507A (el)
CA (1) CA1341373C (el)
DE (2) DE68921941T2 (el)
DK (1) DK175393B1 (el)
ES (1) ES2013978A4 (el)
FI (2) FI103792B (el)
GR (1) GR900300034T1 (el)
HK (1) HK60696A (el)
HU (1) HU219485B (el)
IE (1) IE67273B1 (el)
IL (1) IL90730A0 (el)
NO (1) NO179008C (el)
NZ (1) NZ229700A (el)
WO (1) WO1989012631A1 (el)

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HK60696A (en) 1996-04-19
HU894432D0 (en) 1992-02-28
NO900869L (no) 1990-04-11
IE892045L (en) 1989-12-24
AU3979489A (en) 1990-01-12
IL90730A0 (en) 1990-01-18
JPH04504247A (ja) 1992-07-30
ES2013978A4 (es) 1990-06-16
FI982303A0 (fi) 1998-10-23
NO179008B (no) 1996-04-09
DK49390D0 (da) 1990-02-23
NO179008C (no) 1996-07-17
ATE120457T1 (de) 1995-04-15
FI982303A (fi) 1998-10-23
EP0353450B1 (en) 1995-03-29
AU634167B2 (en) 1993-02-18
EP0353450A1 (en) 1990-02-07
IE67273B1 (en) 1996-03-20
WO1989012631A1 (en) 1989-12-28
FI103792B1 (fi) 1999-09-30
KR900701765A (ko) 1990-12-04
DK49390A (da) 1990-02-23
EP0420942A1 (en) 1991-04-10
DE68921941T2 (de) 1995-07-27
BR8907507A (pt) 1991-06-11
NO900869D0 (no) 1990-02-23
GR900300034T1 (en) 1991-07-31
FI103792B (fi) 1999-09-30
NZ229700A (en) 1993-01-27
DE68921941D1 (de) 1995-05-04
CA1341373C (en) 2002-07-02
DE353450T1 (de) 1990-09-06
HU219485B (hu) 2001-04-28
HUT70200A (en) 1995-09-28
FI906368A0 (fi) 1990-12-21
JP2831073B2 (ja) 1998-12-02
KR0137930B1 (en) 1998-05-15
US5435990A (en) 1995-07-25
FI117889B (fi) 2007-04-13

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