DK175393B1 - Bifunktionelle chelateringsmidler, komplekser deraf, antistof-konjugater omfattende komplekserne samt fremgangsmåde til fremstilling af chelateringsmidlerne - Google Patents
Bifunktionelle chelateringsmidler, komplekser deraf, antistof-konjugater omfattende komplekserne samt fremgangsmåde til fremstilling af chelateringsmidlerne Download PDFInfo
- Publication number
- DK175393B1 DK175393B1 DK199000493A DK49390A DK175393B1 DK 175393 B1 DK175393 B1 DK 175393B1 DK 199000493 A DK199000493 A DK 199000493A DK 49390 A DK49390 A DK 49390A DK 175393 B1 DK175393 B1 DK 175393B1
- Authority
- DK
- Denmark
- Prior art keywords
- complex
- compound
- acid
- hydrogen
- metal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
- A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21149688A | 1988-06-24 | 1988-06-24 | |
US21149688 | 1988-06-24 | ||
US37095689A | 1989-06-21 | 1989-06-21 | |
US37095689 | 1989-06-21 | ||
US8902788 | 1989-06-23 | ||
PCT/US1989/002788 WO1989012631A1 (en) | 1988-06-24 | 1989-06-23 | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates |
Publications (3)
Publication Number | Publication Date |
---|---|
DK49390D0 DK49390D0 (da) | 1990-02-23 |
DK49390A DK49390A (da) | 1990-02-23 |
DK175393B1 true DK175393B1 (da) | 2004-09-20 |
Family
ID=26906194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK199000493A DK175393B1 (da) | 1988-06-24 | 1990-02-23 | Bifunktionelle chelateringsmidler, komplekser deraf, antistof-konjugater omfattende komplekserne samt fremgangsmåde til fremstilling af chelateringsmidlerne |
Country Status (20)
Country | Link |
---|---|
US (1) | US5435990A (el) |
EP (2) | EP0353450B1 (el) |
JP (1) | JP2831073B2 (el) |
KR (1) | KR0137930B1 (el) |
AT (1) | ATE120457T1 (el) |
AU (1) | AU634167B2 (el) |
BR (1) | BR8907507A (el) |
CA (1) | CA1341373C (el) |
DE (2) | DE68921941T2 (el) |
DK (1) | DK175393B1 (el) |
ES (1) | ES2013978A4 (el) |
FI (2) | FI103792B (el) |
GR (1) | GR900300034T1 (el) |
HK (1) | HK60696A (el) |
HU (1) | HU219485B (el) |
IE (1) | IE67273B1 (el) |
IL (1) | IL90730A0 (el) |
NO (1) | NO179008C (el) |
NZ (1) | NZ229700A (el) |
WO (1) | WO1989012631A1 (el) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5422096A (en) * | 1985-05-08 | 1995-06-06 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
US5250285A (en) * | 1985-05-08 | 1993-10-05 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
DE68927479T2 (de) * | 1988-05-02 | 1997-04-03 | Phanos Tech Inc | Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen |
US5756065A (en) * | 1988-06-24 | 1998-05-26 | The Dow Chemical Company | Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents |
JP2930708B2 (ja) * | 1988-12-23 | 1999-08-03 | ザ ダウ ケミカル カンパニー | イソチオシアナト官能化金属錯体の製造方法 |
US5914095A (en) * | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
DE69032761T2 (de) * | 1989-08-28 | 1999-04-22 | The General Hospital Corp., Charlestown, Mass. | Hydroxy-aryl metallchelate für bildformung zur nmr diagnose |
DE3938992A1 (de) | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5410043A (en) * | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
CA2092596A1 (en) * | 1992-03-27 | 1993-09-28 | Kan Kubomura | Tetraazacyclododecane derivative and its use |
WO1993020852A2 (en) * | 1992-04-13 | 1993-10-28 | The Dow Chemical Company | Macrocyclic chelating agents, chelates and conjugates thereof |
US5310535A (en) * | 1992-04-24 | 1994-05-10 | The Dow Chemical Company | Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies |
DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
US5505931A (en) * | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
US5462725A (en) * | 1993-05-06 | 1995-10-31 | The Dow Chemical Company | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
EP0661279B1 (fr) * | 1993-12-30 | 2001-03-07 | Guerbet | Ligands polyaminés, complexes métalliques, procédé de préparation, applications diagnostiques et thérapeutiques |
CA2180662A1 (en) * | 1994-01-07 | 1995-07-13 | Ramaswamy Subramanian | New polyaminocarboxylate chelators |
AU2194695A (en) * | 1994-03-28 | 1995-10-17 | Regents Of The University Of California, The | Method for preparing radionuclide-labeled chelating agent-ligand complexes |
US5582814A (en) * | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
US6693190B1 (en) | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
AU698763B2 (en) * | 1994-09-07 | 1998-11-05 | Dow Chemical Company, The | Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof |
US7820798B2 (en) * | 1994-11-07 | 2010-10-26 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
US7597886B2 (en) * | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
TW319763B (el) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
DE19505960A1 (de) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Konjugat zur individuellen Dosierung von Arzneimitteln |
TR28540A (tr) * | 1995-03-16 | 1996-09-30 | Guerbet Sa | Poliamine edilmis baglayicilar ve bunlarin metal kompleksleri. |
JP3356289B2 (ja) * | 1995-06-26 | 2002-12-16 | コンキャット リミティド | 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用 |
US6348581B1 (en) | 1996-10-31 | 2002-02-19 | The Dow Chemical Company | High affinity humanized anti-TAG-72 monoclonalantibodies |
WO1999043287A2 (en) * | 1998-02-25 | 1999-09-02 | Biotraces, Inc. | Phosphate-based dendrimers for bioassays |
US6231832B1 (en) | 1998-03-23 | 2001-05-15 | Brookhaven Science Associates | Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use |
US6040124A (en) * | 1998-11-20 | 2000-03-21 | Eastman Kodak Company | Imaging element with biaxially oriented sheet with fluoropolymer |
JP2002537769A (ja) | 1999-02-26 | 2002-11-12 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | ヒトエンドカインαおよび使用方法 |
US6696551B1 (en) | 1999-03-23 | 2004-02-24 | The United States Of America As Represented By The Department Of Health And Human Services | 225Ac-HEHA and related compounds, methods of synthesis and methods of use |
LU90544B1 (en) * | 2000-03-14 | 2001-09-17 | Europ Economic Community | Bifunctional chelating agent |
EP1276756A4 (en) | 2000-04-12 | 2004-06-09 | Human Genome Sciences Inc | ALBUMIN FUSION PROTEINS |
WO2001096528A2 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
PT2281843T (pt) | 2000-06-16 | 2017-01-02 | Human Genome Sciences Inc | Anticorpos que se ligam imunoespecificamente a blys |
IL157142A0 (en) * | 2001-01-29 | 2004-02-08 | Idec Pharma Corp | Modified antibodies and methods of use |
AU2002327164A1 (en) * | 2001-01-29 | 2002-12-09 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
AU2002309647C1 (en) | 2001-05-25 | 2008-09-11 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
DE10135356C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
ES2545090T3 (es) | 2001-12-21 | 2015-09-08 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina y GCSF |
AU2003218456A1 (en) * | 2002-04-01 | 2003-10-20 | Human Genome Sciences, Inc. | Antibodies that specifically bind to gmad |
JP2005535572A (ja) | 2002-04-12 | 2005-11-24 | メディミューン,インコーポレーテッド | 組換え抗インターロイキン−9抗体 |
JP4643255B2 (ja) | 2002-06-10 | 2011-03-02 | バクシネックス インコーポレーティッド | 乳癌および膀胱癌において差次的に発現される遺伝子ならびにコードされるポリペプチド |
US20030086868A1 (en) * | 2002-08-12 | 2003-05-08 | Dangshe Ma | Actinium-225 complexes and conjugates for radioimmunotherapy |
US7214545B2 (en) * | 2003-04-28 | 2007-05-08 | The Regents Of The University Of California | Element-coded affinity tags |
US8038983B2 (en) * | 2003-07-29 | 2011-10-18 | Immunomedics, Inc. | Fluorinated carbohydrate conjugates |
WO2005014051A1 (en) * | 2003-08-08 | 2005-02-17 | Barnes-Jewish Hospital | Emulsion particles for imaging and therapy and methods of use thereof |
US7259249B2 (en) | 2003-12-01 | 2007-08-21 | Immunomedics, Inc. | Method for preparing conjugates of proteins and chelating agents |
AU2004296184B2 (en) * | 2003-12-04 | 2010-12-16 | Vaccinex, Inc. | Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells |
WO2005075647A1 (en) * | 2004-02-06 | 2005-08-18 | Nymox Corporation | Humanized antibody |
HUE027902T2 (en) | 2004-02-09 | 2016-11-28 | Human Genome Sciences Inc Corp Service Company | Albumin fusion proteins |
US7973139B2 (en) * | 2004-03-26 | 2011-07-05 | Human Genome Sciences, Inc. | Antibodies against nogo receptor |
CA2569461A1 (en) | 2004-06-09 | 2005-12-29 | Kereos, Inc. | Lipophilic derivatives of chelate monoamides |
US20060210479A1 (en) * | 2004-08-10 | 2006-09-21 | Dow Global Technologies Inc. | Targeting chelants and chelates |
EP1891111A1 (en) | 2005-05-06 | 2008-02-27 | ZymoGenetics, Inc. | Il-31 monoclonal antibodies and methods of use |
US20080279768A1 (en) * | 2005-11-29 | 2008-11-13 | Moore Dennis A | Bifunctional Metal Chelating Conjugates |
EP1988925A2 (en) * | 2006-02-24 | 2008-11-12 | Mallinckrodt, Inc. | Bifunctional resorcinol, thioresorcinol, and dithioresorcinol derivative metal chelating conjugates |
CN101400661A (zh) * | 2006-03-14 | 2009-04-01 | 马林克罗特公司 | 四氮杂大环衍生物的金属络合物 |
US20090053137A1 (en) * | 2006-03-15 | 2009-02-26 | Moore Dennis A | Chelating Conjugates Having a Substituted Aromatic Moiety and Derivatives Thereof |
BRPI0709338A2 (pt) | 2006-03-21 | 2011-07-12 | Genentech Inc | anticorpo, molécula de ácido nucleico isolada, célula, composições, método de detecção da proteìna alfa5beta1, uso de anticorpo, métodos de tratamento, kit, uso de uma composição, uso de uma antagonista de alfa5beta e uso de uma antagonista de vegf |
AU2007261247A1 (en) * | 2006-06-22 | 2007-12-27 | Vaccinex, Inc. | Anti-C35 antibodies for treating cancer |
WO2008008797A2 (en) | 2006-07-10 | 2008-01-17 | The Regents Of The University Of California | Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides |
ES2548714T3 (es) | 2006-09-01 | 2015-10-20 | Zymogenetics, Inc. | Anticuerpos monoclonales IL-31 y procedimientos de uso |
AU2007329592A1 (en) * | 2006-11-21 | 2008-06-12 | Barnes-Jewish Hospital | Methods of imaging employing chelating agents |
GB0624587D0 (en) * | 2006-12-08 | 2007-01-17 | Univ Muenchen Tech | Chelating agent |
US8507199B2 (en) * | 2007-01-25 | 2013-08-13 | Lumiphore, Inc. | Multi-color time resolved fluorophores based on macrocyclic lanthanide complexes |
WO2008105473A1 (ja) * | 2007-02-28 | 2008-09-04 | National University Corporation Chiba University | 抗悪性腫瘍薬 |
JP2010531666A (ja) | 2007-06-26 | 2010-09-30 | ユニバーシティ オブ マイアミ | 抗体−エンドスタチン融合タンパク質及びそのバリアント |
AU2008333131B2 (en) | 2007-12-07 | 2013-10-24 | Merck Serono S/A | Humanized antibody molecules specific for IL-31 |
AU2008341050B2 (en) | 2007-12-26 | 2013-10-24 | Vaccinex, Inc. | Anti-C35 antibody combination therapies and methods |
JP2009215238A (ja) * | 2008-03-11 | 2009-09-24 | Osaka Univ | 希土類発光プローブ |
EA022201B1 (ru) | 2008-04-11 | 2015-11-30 | Мерримак Фармасьютикалз, Инк. | Агент, способный связываться с опухолевой клеткой, содержащий линкер на основе hsa, и его применение |
WO2010000714A2 (en) * | 2008-07-04 | 2010-01-07 | Oslo Universitetssykehus Hf | Radioimmunoconjugate kit |
WO2010051544A2 (en) * | 2008-10-31 | 2010-05-06 | Lumiphore, Inc. | Rapid homogeneous diagnostic testing platform based on lanthanide fluorescent resonance energy transfer |
PE20120770A1 (es) | 2009-03-25 | 2012-07-10 | Genentech Inc | ANTICUERPOS ANTI alfa5ß1 CON ACTIVIDAD SOBRE GLIOBLASTOMAS |
EP2470513B1 (en) | 2009-08-24 | 2014-10-08 | Lumiphore, Inc. | Macrocyclic hopo chelators |
WO2011079291A1 (en) * | 2009-12-24 | 2011-06-30 | Lumiphore, Inc. | Radiopharmaceutical complexes |
KR101253100B1 (ko) | 2010-02-16 | 2013-04-10 | 경북대학교 산학협력단 | 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용 |
US20110293629A1 (en) | 2010-05-14 | 2011-12-01 | Bastid Jeremy | Methods of Treating and/or Preventing Cell Proliferation Disorders with IL-17 Antagonists |
US11453652B2 (en) | 2013-03-15 | 2022-09-27 | Lumiphore, Inc. | Di-macrocycles |
PT3148581T (pt) | 2014-05-30 | 2020-01-06 | Henlix Biotech Co Ltd | Anticorpos antirrecetor do fator de crescimento epidérmico (egfr) |
WO2015196070A1 (en) | 2014-06-20 | 2015-12-23 | Genentech, Inc. | Chagasin-based scaffold compositions, methods, and uses |
CA2956161A1 (en) | 2014-07-23 | 2016-01-28 | Ohio State Innovation Foundation | Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72) |
GB201421162D0 (en) * | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Lanthanide complex formulations |
RU2754041C2 (ru) | 2015-04-03 | 2021-08-25 | Еурека Терапьютикс, Инк. | Конструкции, направленные на комплексы пептида afp/мнс, и виды их использования |
CN107787332B (zh) | 2015-04-24 | 2022-09-09 | 豪夫迈·罗氏有限公司 | 多特异性抗原结合蛋白 |
WO2018052818A1 (en) | 2016-09-16 | 2018-03-22 | Henlix, Inc. | Anti-pd-1 antibodies |
US11274157B2 (en) | 2017-01-12 | 2022-03-15 | Eureka Therapeutics, Inc. | Constructs targeting histone H3 peptide/MHC complexes and uses thereof |
US11447564B2 (en) | 2017-04-26 | 2022-09-20 | Eureka Therapeutics, Inc. | Constructs specifically recognizing glypican 3 and uses thereof |
FR3069245B1 (fr) * | 2017-07-21 | 2019-07-26 | Guerbet | Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales |
RU2020128013A (ru) | 2018-03-14 | 2022-04-15 | Бейцзин Сюаньи Фармасайенсиз Ко., Лтд. | Антитела против клаудина 18.2 |
CA3098492A1 (en) * | 2018-04-27 | 2019-12-19 | University Of Iowa Research Foundation | Compositions for chelating metals at low temperatures |
WO2019245991A1 (en) | 2018-06-18 | 2019-12-26 | Eureka Therapeutics, Inc. | Constructs targeting prostate-specific membrane antigen (psma) and uses thereof |
WO2020229974A1 (en) * | 2019-05-10 | 2020-11-19 | Janssen Biotech, Inc. | Macrocyclic chelators and methods of use thereof |
CN112300279A (zh) | 2019-07-26 | 2021-02-02 | 上海复宏汉霖生物技术股份有限公司 | 针对抗cd73抗体和变体的方法和组合物 |
CN110818795B (zh) | 2020-01-10 | 2020-04-24 | 上海复宏汉霖生物技术股份有限公司 | 抗tigit抗体和使用方法 |
US20220143231A1 (en) * | 2020-11-10 | 2022-05-12 | Janssen Biotech, Inc. | Macrocyclic compounds and methods of use thereof |
CA3240565A1 (en) | 2021-12-17 | 2023-06-22 | Wenfeng Xu | Anti-ox40 antibodies and methods of use |
WO2023109900A1 (en) | 2021-12-17 | 2023-06-22 | Shanghai Henlius Biotech, Inc. | Anti-ox40 antibodies, multispecific antibodies and methods of use |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
SE8301395L (sv) * | 1983-03-15 | 1984-09-16 | Wallac Oy | Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler |
US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
DE3772785D1 (de) * | 1986-01-23 | 1991-10-17 | Squibb & Sons Inc | 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga. |
US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
GB8603537D0 (en) * | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
DE3713842A1 (de) * | 1987-04-22 | 1988-11-17 | Schering Ag | Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US5006643A (en) * | 1987-06-24 | 1991-04-09 | The Dow Chemical Company | Process for preparing isothiocyanato functionalized metal complexes |
US4994560A (en) * | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
GB8719041D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
GB8719042D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
DE68925904T2 (de) * | 1988-05-25 | 1996-10-31 | The United States Of America, Represented By The Secretary, U.S. Department Of Commerce, Springfield, Va. | Makrocyclische chelate und verwendungsverfahren |
ZA894792B (en) * | 1988-06-24 | 1991-04-24 | Dow Chemical Co | Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates |
-
1989
- 1989-06-23 IL IL90730A patent/IL90730A0/xx unknown
- 1989-06-23 EP EP89111497A patent/EP0353450B1/en not_active Expired - Lifetime
- 1989-06-23 AT AT89111497T patent/ATE120457T1/de not_active IP Right Cessation
- 1989-06-23 NZ NZ229700A patent/NZ229700A/xx unknown
- 1989-06-23 DE DE68921941T patent/DE68921941T2/de not_active Expired - Lifetime
- 1989-06-23 IE IE204589A patent/IE67273B1/en not_active IP Right Cessation
- 1989-06-23 DE DE198989111497T patent/DE353450T1/de active Pending
- 1989-06-23 BR BR898907507A patent/BR8907507A/pt not_active Application Discontinuation
- 1989-06-23 ES ES89111497T patent/ES2013978A4/es active Pending
- 1989-06-23 WO PCT/US1989/002788 patent/WO1989012631A1/en active IP Right Grant
- 1989-06-23 JP JP1508008A patent/JP2831073B2/ja not_active Expired - Lifetime
- 1989-06-23 CA CA000603894A patent/CA1341373C/en not_active Expired - Fee Related
- 1989-06-23 HU HU432/89A patent/HU219485B/hu unknown
- 1989-06-23 AU AU39794/89A patent/AU634167B2/en not_active Expired
- 1989-06-23 EP EP89908599A patent/EP0420942A1/en not_active Withdrawn
-
1990
- 1990-02-23 KR KR90700403A patent/KR0137930B1/ko not_active IP Right Cessation
- 1990-02-23 NO NO900869A patent/NO179008C/no not_active IP Right Cessation
- 1990-02-23 DK DK199000493A patent/DK175393B1/da not_active IP Right Cessation
- 1990-12-21 FI FI906368A patent/FI103792B/fi active IP Right Grant
-
1991
- 1991-07-31 GR GR90300034T patent/GR900300034T1/el unknown
-
1992
- 1992-10-15 US US07/962,168 patent/US5435990A/en not_active Expired - Lifetime
-
1996
- 1996-04-11 HK HK60696A patent/HK60696A/xx not_active IP Right Cessation
-
1998
- 1998-10-23 FI FI982303A patent/FI117889B/fi active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK175393B1 (da) | Bifunktionelle chelateringsmidler, komplekser deraf, antistof-konjugater omfattende komplekserne samt fremgangsmåde til fremstilling af chelateringsmidlerne | |
US5756065A (en) | Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents | |
US5652361A (en) | Macrocyclic ligands and complexes | |
KR100245941B1 (ko) | 카복스아미드 변성된 폴리아민 킬레이트제 및 방사성 착화합물 및 결합체 | |
US5696239A (en) | Conjugates possessing ortho ligating functionality and complexes thereof | |
US5342604A (en) | Complexes possessing ortho ligating functionality | |
BR112019023246B1 (pt) | Compostos compreendendo uma fração quelante, métodos para produção dos mesmos e usos dos mesmos | |
KR0153468B1 (ko) | 오르토 결합 작용기를 갖는 킬란트 및 그의 착물 | |
WO1998043678A2 (en) | Tetraaza- or n2s2- complexants, and their use in radiodiagnostics or radiotherapy | |
CA2048899A1 (en) | Reducing chelating agents, their technetium and rhenium complexes, process for their production as well as their use in diagnosis and treatment | |
KR0153501B1 (ko) | 오르토 결합 작용기를 갖는 킬란트 및 그의 착물 | |
KR20110095143A (ko) | 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용 | |
NO179871B (no) | Diagnostisk anvendelig makrocyklisk kompleksforbindelse | |
NO179585B (no) | Fremgangsmåte ved fremstilling av antistoffkonjugater med makrocykliske bifunksjonelle chelaterte komplekser | |
TW202419460A (zh) | 一種rgd二聚體化合物及其製備方法和應用 | |
JPH04500376A (ja) | 蛋白質の放射性標識用の放射性核種金属キレート | |
FI104898B (fi) | Menetelmä terapeuttisesti aktiivisen metallikompleksiyhdisteen valmistamiseksi | |
KR100306331B1 (ko) | 비사이클로폴리아자매크로사이클로카복실산착체,그의결합체,그의제조방법및조영제로서의그의용도 | |
NZ245370A (en) | Chelants containing amino groups;complexes,conjugates and pharmaceutical formulations thereof | |
Kasina et al. | S 3 N chelating compounds | |
HU221187B1 (en) | Process for the production of 1,4,7,10-tetraazacyclododecane derivatives, complexes and conjugates with antibody thereof and medicaments containing the same and diagnostics compraising these conjugates and complexes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |