DK1753512T3 - Tetrahydropyridothiophener - Google Patents

Tetrahydropyridothiophener

Info

Publication number
DK1753512T3
DK1753512T3 DK05749649T DK05749649T DK1753512T3 DK 1753512 T3 DK1753512 T3 DK 1753512T3 DK 05749649 T DK05749649 T DK 05749649T DK 05749649 T DK05749649 T DK 05749649T DK 1753512 T3 DK1753512 T3 DK 1753512T3
Authority
DK
Denmark
Prior art keywords
tetrahydropyridothiophenes
compounds
proliferative
description
meanings indicated
Prior art date
Application number
DK05749649T
Other languages
Danish (da)
English (en)
Inventor
Klaus Pekari
Thomas Baer
Bjoern Bartels
Mathias Schmidt
Thomas Beckers
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Application granted granted Critical
Publication of DK1753512T3 publication Critical patent/DK1753512T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK05749649T 2004-05-28 2005-05-25 Tetrahydropyridothiophener DK1753512T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04102413 2004-05-28
EP04104193 2004-09-01
PCT/EP2005/052384 WO2005118071A2 (en) 2004-05-28 2005-05-25 Tetrahydropyridothiophenes

Publications (1)

Publication Number Publication Date
DK1753512T3 true DK1753512T3 (da) 2008-11-17

Family

ID=35045196

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05749649T DK1753512T3 (da) 2004-05-28 2005-05-25 Tetrahydropyridothiophener

Country Status (25)

Country Link
US (2) US7723523B2 (pt)
EP (1) EP1753512B1 (pt)
JP (1) JP4881297B2 (pt)
KR (1) KR20070037578A (pt)
CN (1) CN1988934B (pt)
AT (1) ATE400319T1 (pt)
AU (1) AU2005249718B2 (pt)
BR (1) BRPI0511461A (pt)
CA (1) CA2567648A1 (pt)
CY (1) CY1108399T1 (pt)
DE (1) DE602005008050D1 (pt)
DK (1) DK1753512T3 (pt)
EA (1) EA012280B1 (pt)
ES (1) ES2309765T3 (pt)
HK (1) HK1106171A1 (pt)
HR (1) HRP20080499T3 (pt)
IL (1) IL178727A (pt)
MX (1) MXPA06013383A (pt)
NO (1) NO20065907L (pt)
NZ (1) NZ550513A (pt)
PL (1) PL1753512T3 (pt)
PT (1) PT1753512E (pt)
RS (1) RS50613B (pt)
SI (1) SI1753512T1 (pt)
WO (1) WO2005118071A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE400319T1 (de) 2004-05-28 2008-07-15 Nycomed Gmbh Tetrahydropyridothiophene
ATE397000T1 (de) 2004-06-04 2008-06-15 Nycomed Gmbh Tetrahydropyridothiophenen zur verwendung in der behandlung von krebs
AU2005251485A1 (en) 2004-06-11 2005-12-22 4Sc Ag Tetrahydropyridothiophenes for treating hyperproliferative disorders
JP2008529989A (ja) 2005-02-09 2008-08-07 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン
EP1893618A2 (en) 2005-05-25 2008-03-05 Nycomed GmbH Tetrahydropyridothiophenes for use in the treatment of cancer
AU2006251167A1 (en) 2005-05-25 2006-11-30 4Sc Ag Tetrahydropyridothiophenes for use in the treatment of cancer
JP2010500396A (ja) * 2006-08-16 2010-01-07 4エスツェー アクチェンゲゼルシャフト テトラヒドロベンゾチオフェン誘導体
AU2007285714A1 (en) * 2006-08-16 2008-02-21 4Sc Ag Ntetrahydropyridothiophene derivatives for the treatment of cancer
TWI492759B (zh) * 2008-03-05 2015-07-21 Otsuka Pharma Co Ltd 膽甾烷醇衍生物之併用用途
TW201005466A (en) * 2008-07-24 2010-02-01 Advanced Analog Technology Inc Low dropout regulator
BRPI0919898A2 (pt) * 2008-10-24 2016-02-16 Gruenenthal Gmbh 4,5,6,7-tetra-hidrotienopiridinas substituídas como moduladores de kcnq2/3
CA2754075A1 (en) * 2009-03-04 2010-09-10 Otsuka Pharmaceutical Co., Ltd. Cholestanol derivative for combined use
CN104478850A (zh) * 2014-12-08 2015-04-01 上海应用技术学院 一种2-氨基噻吩-3甲酰胺的衍生物的制备方法

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DE272078C (pt)
DE1225167B (de) * 1965-04-07 1966-09-22 Huels Chemische Werke Ag Verfahren zur Herstellung aliphatischer, aromatischer oder gemischt aliphatisch-aromatischer Sulfone
JPS5498337A (en) * 1978-01-06 1979-08-03 Dai Ichi Seiyaku Co Ltd Anticarcinogenic and/or antimetastatic agent
DD272078A1 (de) 1986-04-15 1989-09-27 Dresden Arzneimittel Verfahren zur herstellung von 6-substituierten 2-acylamio-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridin-3-carbonsaeure-derivaten
DE4039734A1 (de) * 1990-12-13 1992-06-17 Basf Ag Substituierte 2-aminothiophene enthaltende herbizide mittel
GB9310700D0 (en) 1993-05-24 1993-07-07 Zeneca Ltd Novel composition
JP3074640B2 (ja) * 1995-12-22 2000-08-07 インターナショナル・ビジネス・マシーンズ・コーポレ−ション 液晶表示装置の駆動方法
GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
CN1300291A (zh) * 1998-03-12 2001-06-20 诺沃挪第克公司 蛋白质酪氨酸磷酸酶(ptp酶)的调节物
WO1999046267A1 (en) 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO2000014090A1 (en) 1998-09-02 2000-03-16 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine derivatives
GB0114185D0 (en) 2001-06-12 2001-08-01 Protherics Molecular Design Lt Compounds
WO2002092076A1 (en) 2001-05-16 2002-11-21 Cytovia, Inc. Substituted coumarins and quinolines as caspases activators
US20040171603A1 (en) * 2001-05-18 2004-09-02 Janos Pato Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor
US20030232994A1 (en) * 2001-10-04 2003-12-18 Shao-Po Lu Bicyclic thiophene derivatives and combinatorial libraries thereof
PL372409A1 (en) 2002-03-27 2005-07-25 Altana Pharma Ag Novel alkoxypyridine-derivatives
JP4103425B2 (ja) * 2002-03-28 2008-06-18 セイコーエプソン株式会社 電気光学装置、電子機器及び投射型表示装置
AU2003224054A1 (en) 2002-04-09 2003-10-20 Axxima Pharmaceuticals Ag 4,5,6,7-tretrahydrobenzo(b) thiophene derivatives and methods for medical intervention against mycrobacterial infections
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
WO2004024065A2 (en) 2002-09-12 2004-03-25 Merck & Co., Inc. Substituted bicyclic thiophene derivatives, compostions containing such compounds and methods of use
EP1538903A2 (en) 2002-09-12 2005-06-15 Merck & Co., Inc. Method of treating diabetes and related conditions
TW200503994A (en) 2003-01-24 2005-02-01 Novartis Ag Organic compounds
IL154306A0 (en) 2003-02-05 2003-09-17 Rimonyx Pharmaceuticals Ltd Pharmaceutical compositions comprising thieno [2,3-c] pyridine derivatives and use thereof
US7138529B2 (en) 2003-04-16 2006-11-21 Hoffmann-La Roche Inc. Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists
AU2004270394A1 (en) 2003-09-10 2005-03-17 Gpc Biotech Ag Heterobicyclic compounds as pharmaceutically active agents
WO2005030770A1 (en) 2003-10-01 2005-04-07 Altana Pharma Ag Imidazopyridine-derivatives as inducible no-synthase inhibitors
US20050085531A1 (en) 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
GB0324653D0 (en) 2003-10-22 2003-11-26 Syngenta Participations Ag Fungicides
JP2007515429A (ja) 2003-12-19 2007-06-14 エリクシアー ファーマシューティカルズ, インコーポレイテッド 障害を治療する方法
US7745630B2 (en) * 2003-12-22 2010-06-29 Justin Stephen Bryans Triazolyl piperidine arginine vasopressin receptor modulators
ATE400319T1 (de) 2004-05-28 2008-07-15 Nycomed Gmbh Tetrahydropyridothiophene
ATE397000T1 (de) 2004-06-04 2008-06-15 Nycomed Gmbh Tetrahydropyridothiophenen zur verwendung in der behandlung von krebs
AU2005251485A1 (en) 2004-06-11 2005-12-22 4Sc Ag Tetrahydropyridothiophenes for treating hyperproliferative disorders
SE0401970D0 (sv) 2004-08-02 2004-08-02 Astrazeneca Ab Novel compounds
JP2008529989A (ja) 2005-02-09 2008-08-07 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン
US7741488B2 (en) 2005-02-11 2010-06-22 4Sc Ag Tetrahydropyridothiophenes as antiproliferative agents for the treatment of cancer
AU2006251167A1 (en) 2005-05-25 2006-11-30 4Sc Ag Tetrahydropyridothiophenes for use in the treatment of cancer
EP1893618A2 (en) 2005-05-25 2008-03-05 Nycomed GmbH Tetrahydropyridothiophenes for use in the treatment of cancer
JP2010500396A (ja) 2006-08-16 2010-01-07 4エスツェー アクチェンゲゼルシャフト テトラヒドロベンゾチオフェン誘導体

Also Published As

Publication number Publication date
ES2309765T3 (es) 2008-12-16
KR20070037578A (ko) 2007-04-05
BRPI0511461A (pt) 2007-12-26
WO2005118071A2 (en) 2005-12-15
PL1753512T3 (pl) 2009-03-31
IL178727A (en) 2010-12-30
EA012280B1 (ru) 2009-08-28
MXPA06013383A (es) 2007-01-23
NO20065907L (no) 2006-12-19
DE602005008050D1 (de) 2008-08-21
AU2005249718A1 (en) 2005-12-15
ATE400319T1 (de) 2008-07-15
CN1988934A (zh) 2007-06-27
HK1106171A1 (en) 2008-03-07
AU2005249718B2 (en) 2011-01-27
EP1753512A2 (en) 2007-02-21
US7803945B2 (en) 2010-09-28
NZ550513A (en) 2009-10-30
SI1753512T1 (sl) 2008-12-31
HRP20080499T3 (en) 2008-11-30
JP2008500993A (ja) 2008-01-17
PT1753512E (pt) 2008-10-14
CY1108399T1 (el) 2014-02-12
JP4881297B2 (ja) 2012-02-22
RS50613B (sr) 2010-06-30
US7723523B2 (en) 2010-05-25
EP1753512B1 (en) 2008-07-09
US20090270378A1 (en) 2009-10-29
CA2567648A1 (en) 2005-12-15
CN1988934B (zh) 2011-01-05
IL178727A0 (en) 2007-02-11
WO2005118071A3 (en) 2006-06-01
EA200602157A1 (ru) 2007-06-29
US20070244112A1 (en) 2007-10-18

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