DE602005024572D1 - Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin - Google Patents

Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin

Info

Publication number
DE602005024572D1
DE602005024572D1 DE602005024572T DE602005024572T DE602005024572D1 DE 602005024572 D1 DE602005024572 D1 DE 602005024572D1 DE 602005024572 T DE602005024572 T DE 602005024572T DE 602005024572 T DE602005024572 T DE 602005024572T DE 602005024572 D1 DE602005024572 D1 DE 602005024572D1
Authority
DE
Germany
Prior art keywords
benzothienopyridines
kinesine
inhibitors
compounds
proliferative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005024572T
Other languages
English (en)
Inventor
Matthias Vennemann
Thomas Baer
Gudrun Groegor
Juergen Braunger
Petra Gimmnich
Thomas Maier
Heike Rothfels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
4SC AG
Original Assignee
4SC AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4SC AG filed Critical 4SC AG
Publication of DE602005024572D1 publication Critical patent/DE602005024572D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602005024572T 2004-08-18 2005-08-17 Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin Active DE602005024572D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04103958 2004-08-18
EP04104175 2004-08-31
PCT/EP2005/054054 WO2006018435A1 (en) 2004-08-18 2005-08-17 Benzothienopyridines for use as inhibitors of eg5 kinesin

Publications (1)

Publication Number Publication Date
DE602005024572D1 true DE602005024572D1 (de) 2010-12-16

Family

ID=35285513

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005024572T Active DE602005024572D1 (de) 2004-08-18 2005-08-17 Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin

Country Status (8)

Country Link
US (2) US7718665B2 (de)
EP (1) EP1781667B1 (de)
JP (1) JP2008509971A (de)
AT (1) ATE486878T1 (de)
AU (1) AU2005273867B2 (de)
CA (1) CA2576619A1 (de)
DE (1) DE602005024572D1 (de)
WO (1) WO2006018435A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005024572D1 (de) 2004-08-18 2010-12-16 4Sc Ag Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin
WO2006079645A1 (en) * 2005-01-27 2006-08-03 Nycomed Gmbh Novel indolopyridines , benzofuranopyridines and benzothienopyridines
EP1856117A1 (de) * 2005-01-28 2007-11-21 Nycomed GmbH Indolopyridine, benzofuranopyridine und benzothienopyridine
CN101389629A (zh) * 2006-02-22 2009-03-18 4Sc股份公司 作为eg5驱动蛋白调节剂的吲哚吡啶
NZ571357A (en) * 2006-02-22 2010-11-26 4Sc Ag Indolopyridines as EG5 kinesin modulators
US20100104659A1 (en) * 2006-07-13 2010-04-29 Matthias Vennemann Benzopyranopyrazoles
EP2033962A1 (de) * 2007-08-22 2009-03-11 4Sc Ag Tetrazyclische Indolopyridinderivate als EG5-Hemmer
BRPI0721950A2 (pt) * 2007-08-22 2015-09-29 4Sc Ag indolopiridinas como inibidores da proteína de fuso de cinesina
EP2582682B1 (de) 2010-06-17 2015-01-14 Cytokinetics, Inc. Mitotische kinesin-hemmer zur behandlung der pulmonalen arteriellen hypertonie
KR101390616B1 (ko) 2012-03-28 2014-04-29 주식회사 두산 신규 화합물 및 이를 포함하는 유기 전계 발광 소자
MA54543A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
CN110464722B (zh) * 2019-06-06 2023-05-23 暨南大学 一类小分子化合物或其药学上可接受的盐在制备抗肿瘤转移药物中的应用
CA3230123A1 (en) 2021-08-26 2023-03-02 Derek A. Cogan Spiro indoline inhibitors of kif18a

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0357122A3 (de) * 1988-08-29 1991-10-23 Duphar International Research B.V Verwendung von Beta-Carbolinen und deren bio-isosterischen Benzofuran- und Benzothiophenanalogen zur Herstellung eines Arzneimittels mit cytostatischer Wirkung
GB9514473D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
US6217104B1 (en) * 1999-06-16 2001-04-17 Cts Fahrzeug Dachsysteme Gmbh Retractable hard top module
US6890933B1 (en) * 2000-02-24 2005-05-10 President And Fellows Of Harvard College Kinesin inhibitors
CA2423312A1 (en) 2000-10-03 2002-04-11 Lilly Icos Llc Condensed pyridoindole derivatives
WO2002095361A2 (en) * 2001-05-22 2002-11-28 President And Fellows Of Harvard College Identification of anti-protozoal agents
ES2286275T3 (es) * 2001-09-19 2007-12-01 Pharmacia Corporation Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion.
JP2005537257A (ja) * 2002-07-08 2005-12-08 メルク　エンド　カムパニー　インコーポレーテッド 有糸分裂キネシン結合部位
US7022850B2 (en) * 2003-05-22 2006-04-04 Bristol-Myers Squibb Co. Bicyclicpyrimidones and their use to treat diseases
JP4580932B2 (ja) 2003-06-12 2010-11-17 メルク・シャープ・エンド・ドーム・コーポレイション 有糸分裂キネシン阻害剤のプロドラッグ
DE602005024572D1 (de) 2004-08-18 2010-12-16 4Sc Ag Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin
JP2008530094A (ja) 2005-02-10 2008-08-07 メルク エンド カムパニー インコーポレーテッド 有糸分裂キネシン阻害剤
CN101389629A (zh) 2006-02-22 2009-03-18 4Sc股份公司 作为eg5驱动蛋白调节剂的吲哚吡啶
NZ571357A (en) 2006-02-22 2010-11-26 4Sc Ag Indolopyridines as EG5 kinesin modulators
AU2007260040A1 (en) 2006-06-14 2007-12-21 4Sc Ag Pyrazolopyrimidones
US20100104659A1 (en) 2006-07-13 2010-04-29 Matthias Vennemann Benzopyranopyrazoles

Also Published As

Publication number Publication date
AU2005273867B2 (en) 2010-12-23
US20100183550A1 (en) 2010-07-22
AU2005273867A1 (en) 2006-02-23
US7718665B2 (en) 2010-05-18
US8044065B2 (en) 2011-10-25
WO2006018435A1 (en) 2006-02-23
ATE486878T1 (de) 2010-11-15
JP2008509971A (ja) 2008-04-03
EP1781667B1 (de) 2010-11-03
CA2576619A1 (en) 2006-02-23
US20070232596A1 (en) 2007-10-04
EP1781667A1 (de) 2007-05-09

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