EA200602157A1 - Новые производные тетрагидропиридотиофена - Google Patents

Новые производные тетрагидропиридотиофена

Info

Publication number
EA200602157A1
EA200602157A1 EA200602157A EA200602157A EA200602157A1 EA 200602157 A1 EA200602157 A1 EA 200602157A1 EA 200602157 A EA200602157 A EA 200602157A EA 200602157 A EA200602157 A EA 200602157A EA 200602157 A1 EA200602157 A1 EA 200602157A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tetrahydropyridothiophene
new derivatives
compounds
proliferative
description
Prior art date
Application number
EA200602157A
Other languages
English (en)
Other versions
EA012280B1 (ru
Inventor
Клаус Пекари
Томас Баер
Бьёрн Бартелс
Матиас Шмидт
Томас Беккерс
Original Assignee
Алтана Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алтана Фарма Аг filed Critical Алтана Фарма Аг
Publication of EA200602157A1 publication Critical patent/EA200602157A1/ru
Publication of EA012280B1 publication Critical patent/EA012280B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

В настоящей заявке описываются производные тетрагидропиридотиофена, отвечающие формуле I, в которых Ra и Rb принимают указанные в описании изобретения значения, которые являются новыми эффективными соединениями, обладающими антипролиферативной и/или стимулирующей апоптоз активностью.
EA200602157A 2004-05-28 2005-05-25 Новые производные тетрагидропиридотиофена EA012280B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04102413 2004-05-28
EP04104193 2004-09-01
PCT/EP2005/052384 WO2005118071A2 (en) 2004-05-28 2005-05-25 Tetrahydropyridothiophenes

Publications (2)

Publication Number Publication Date
EA200602157A1 true EA200602157A1 (ru) 2007-06-29
EA012280B1 EA012280B1 (ru) 2009-08-28

Family

ID=35045196

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200602157A EA012280B1 (ru) 2004-05-28 2005-05-25 Новые производные тетрагидропиридотиофена

Country Status (25)

Country Link
US (2) US7723523B2 (ru)
EP (1) EP1753512B1 (ru)
JP (1) JP4881297B2 (ru)
KR (1) KR20070037578A (ru)
CN (1) CN1988934B (ru)
AT (1) ATE400319T1 (ru)
AU (1) AU2005249718B2 (ru)
BR (1) BRPI0511461A (ru)
CA (1) CA2567648A1 (ru)
CY (1) CY1108399T1 (ru)
DE (1) DE602005008050D1 (ru)
DK (1) DK1753512T3 (ru)
EA (1) EA012280B1 (ru)
ES (1) ES2309765T3 (ru)
HK (1) HK1106171A1 (ru)
HR (1) HRP20080499T3 (ru)
IL (1) IL178727A (ru)
MX (1) MXPA06013383A (ru)
NO (1) NO20065907L (ru)
NZ (1) NZ550513A (ru)
PL (1) PL1753512T3 (ru)
PT (1) PT1753512E (ru)
RS (1) RS50613B (ru)
SI (1) SI1753512T1 (ru)
WO (1) WO2005118071A2 (ru)

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ES2308504T3 (es) 2004-06-04 2008-12-01 4Sc Ag Tetrahidropiridotiofenos para su utilizacion en el tratamiento del cancer.
CA2569623A1 (en) 2004-06-11 2005-12-22 Altana Pharma Ag Novel compounds and use of tetrahydropyridothiophenes
EP1851229A1 (en) 2005-02-09 2007-11-07 Nycomed GmbH Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
US7714136B2 (en) 2005-05-25 2010-05-11 4Sc Ag Tetrahydropyridothiophenes
US7763728B2 (en) 2005-05-25 2010-07-27 4Sc Ag Tetrahydropyridothiophenes
EP2051974A1 (en) * 2006-08-16 2009-04-29 4Sc Ag Tetrahydrobenzothiophene derivatives
AU2007285714A1 (en) * 2006-08-16 2008-02-21 4Sc Ag Ntetrahydropyridothiophene derivatives for the treatment of cancer
TWI492759B (zh) * 2008-03-05 2015-07-21 Otsuka Pharma Co Ltd 膽甾烷醇衍生物之併用用途
TW201005466A (en) * 2008-07-24 2010-02-01 Advanced Analog Technology Inc Low dropout regulator
BRPI0919898A2 (pt) * 2008-10-24 2016-02-16 Gruenenthal Gmbh 4,5,6,7-tetra-hidrotienopiridinas substituídas como moduladores de kcnq2/3
PT2404608E (pt) * 2009-03-04 2015-07-21 Otsuka Pharma Co Ltd Derivado de colestanol para utilização combinada
CN104478850A (zh) * 2014-12-08 2015-04-01 上海应用技术学院 一种2-氨基噻吩-3甲酰胺的衍生物的制备方法

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ES2308504T3 (es) * 2004-06-04 2008-12-01 4Sc Ag Tetrahidropiridotiofenos para su utilizacion en el tratamiento del cancer.
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EP2051974A1 (en) 2006-08-16 2009-04-29 4Sc Ag Tetrahydrobenzothiophene derivatives

Also Published As

Publication number Publication date
SI1753512T1 (sl) 2008-12-31
AU2005249718B2 (en) 2011-01-27
CN1988934B (zh) 2011-01-05
KR20070037578A (ko) 2007-04-05
HRP20080499T3 (en) 2008-11-30
NZ550513A (en) 2009-10-30
DK1753512T3 (da) 2008-11-17
NO20065907L (no) 2006-12-19
JP2008500993A (ja) 2008-01-17
AU2005249718A1 (en) 2005-12-15
RS50613B (sr) 2010-06-30
EP1753512B1 (en) 2008-07-09
ATE400319T1 (de) 2008-07-15
IL178727A0 (en) 2007-02-11
PT1753512E (pt) 2008-10-14
EA012280B1 (ru) 2009-08-28
US7723523B2 (en) 2010-05-25
EP1753512A2 (en) 2007-02-21
DE602005008050D1 (de) 2008-08-21
ES2309765T3 (es) 2008-12-16
HK1106171A1 (en) 2008-03-07
CY1108399T1 (el) 2014-02-12
IL178727A (en) 2010-12-30
MXPA06013383A (es) 2007-01-23
PL1753512T3 (pl) 2009-03-31
US20090270378A1 (en) 2009-10-29
BRPI0511461A (pt) 2007-12-26
WO2005118071A2 (en) 2005-12-15
US7803945B2 (en) 2010-09-28
CA2567648A1 (en) 2005-12-15
CN1988934A (zh) 2007-06-27
US20070244112A1 (en) 2007-10-18
WO2005118071A3 (en) 2006-06-01
JP4881297B2 (ja) 2012-02-22

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ RU