DK175252B1 - Implanterbart biologisk nedbrydeligt system til frigivelse af biologisk virksomme stoffer - Google Patents

Implanterbart biologisk nedbrydeligt system til frigivelse af biologisk virksomme stoffer Download PDF

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Publication number
DK175252B1
DK175252B1 DK198805615A DK561588A DK175252B1 DK 175252 B1 DK175252 B1 DK 175252B1 DK 198805615 A DK198805615 A DK 198805615A DK 561588 A DK561588 A DK 561588A DK 175252 B1 DK175252 B1 DK 175252B1
Authority
DK
Denmark
Prior art keywords
release
active
film
active substance
small
Prior art date
Application number
DK198805615A
Other languages
Danish (da)
English (en)
Other versions
DK561588A (da
DK561588D0 (da
Inventor
Bernd Zierenberg
Herbert Stricker
Otto Kern
Michel Mikhail
Guenter Entenmann
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of DK561588D0 publication Critical patent/DK561588D0/da
Publication of DK561588A publication Critical patent/DK561588A/da
Application granted granted Critical
Publication of DK175252B1 publication Critical patent/DK175252B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Prostheses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DK198805615A 1987-10-09 1988-10-07 Implanterbart biologisk nedbrydeligt system til frigivelse af biologisk virksomme stoffer DK175252B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873734223 DE3734223A1 (de) 1987-10-09 1987-10-09 Implantierbares, biologisch abbaubares wirkstofffreigabesystem
DE3734223 1987-10-09

Publications (3)

Publication Number Publication Date
DK561588D0 DK561588D0 (da) 1988-10-07
DK561588A DK561588A (da) 1989-04-10
DK175252B1 true DK175252B1 (da) 2004-07-19

Family

ID=6338006

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198805615A DK175252B1 (da) 1987-10-09 1988-10-07 Implanterbart biologisk nedbrydeligt system til frigivelse af biologisk virksomme stoffer

Country Status (17)

Country Link
EP (1) EP0311065B1 (ja)
JP (1) JP2763303B2 (ja)
KR (1) KR970006082B1 (ja)
AT (1) ATE101035T1 (ja)
AU (1) AU609194B2 (ja)
CA (1) CA1333770C (ja)
DE (2) DE3734223A1 (ja)
DK (1) DK175252B1 (ja)
ES (1) ES2061589T3 (ja)
FI (1) FI100302B (ja)
IE (1) IE62505B1 (ja)
IL (1) IL87973A (ja)
NO (1) NO176304C (ja)
NZ (1) NZ226514A (ja)
PH (1) PH30236A (ja)
PT (1) PT88703B (ja)
ZA (1) ZA887535B (ja)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5444113A (en) * 1988-08-08 1995-08-22 Ecopol, Llc End use applications of biodegradable polymers
US5180765A (en) * 1988-08-08 1993-01-19 Biopak Technology, Ltd. Biodegradable packaging thermoplastics from lactides
US5424346A (en) * 1988-08-08 1995-06-13 Ecopol, Llc Biodegradable replacement of crystal polystyrene
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5252642A (en) * 1989-03-01 1993-10-12 Biopak Technology, Ltd. Degradable impact modified polyactic acid
US5216050A (en) * 1988-08-08 1993-06-01 Biopak Technology, Ltd. Blends of polyactic acid
US5702716A (en) * 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
DE69028303T2 (de) * 1989-06-05 1997-01-30 Massachusetts Inst Technology Biodegradierbare polymere zur arzneimittelverabreichung in knochen
US5487897A (en) * 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US5439688A (en) * 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
CH679207A5 (ja) * 1989-07-28 1992-01-15 Debiopharm Sa
DK0514406T3 (da) * 1990-01-30 1994-08-15 Akzo Nobel Nv Genstand til styret afgivelse af et aktivt stof og omfattende et hulrum, der er helt omsluttet af en væg og helt eller delvis fyldt med et eller flere aktive stoffer
US5350580A (en) * 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
EP0447719B1 (en) * 1990-03-05 1993-11-03 Minnesota Mining And Manufacturing Company Device for extended delivery of pharmacologically active agents to the ear
AU2605592A (en) * 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5681873A (en) * 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
AU6491898A (en) * 1997-04-04 1998-10-30 Alcan International Limited Aluminum alloy composition and method of manufacture
AR012448A1 (es) * 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
US6261583B1 (en) 1998-07-28 2001-07-17 Atrix Laboratories, Inc. Moldable solid delivery system
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
DE19908753C2 (de) * 1999-02-20 2003-10-02 Jenapharm Gmbh Bioabbaubare, injizierbare Oligomer-Polymer-Zusammensetzung
US6306425B1 (en) * 1999-04-09 2001-10-23 Southern Research Institute Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol
US8226598B2 (en) 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
US6702849B1 (en) 1999-12-13 2004-03-09 Advanced Cardiovascular Systems, Inc. Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
WO2001070846A1 (fr) 2000-03-22 2001-09-27 Dainippon Ink And Chemicals, Inc. Antichoc et composition polyester contenant ledit antichoc
EP1637126B1 (en) * 2000-07-05 2016-12-14 Allergan, Inc. Methods for treating inflammation of the eye
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
ES2250504T3 (es) 2000-11-29 2006-04-16 Allergan Inc. Prevencion del rechazo de injerto en el ojo.
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20070224278A1 (en) 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
JP2007518804A (ja) 2004-01-20 2007-07-12 アラーガン、インコーポレイテッド トリアムシノロンアセトニドおよびヒアルロン酸を好ましく含有する眼局所治療用組成物
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
BRPI0510485A (pt) 2004-04-30 2007-11-13 Allergan Inc implantes inibidores de tirosina cinase intravìtreos biodegradáveis
US8591885B2 (en) 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8425929B2 (en) 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US20050244463A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US20050244458A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
AU2007235232B2 (en) 2006-04-06 2013-07-11 Nupathe Inc. Implants for the treatment of dopamine associated states
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US8956641B2 (en) * 2008-04-18 2015-02-17 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of inflammatory diseases
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10588855B2 (en) 2008-05-12 2020-03-17 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
MX361709B (es) 2009-11-09 2018-12-07 Allergan Inc Composiciones y metodos para estimular el crecimiento del cabello.
JP4779169B1 (ja) * 2010-10-27 2011-09-28 Ｎｅｃインフロンティア株式会社 ボタン照明構造、電子機器
WO2014127243A1 (en) 2013-02-15 2014-08-21 Allergan, Inc. Sustained drug delivery implant
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
CA3078555A1 (en) 2017-10-06 2019-04-11 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL109293C (ja) * 1955-12-22
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
DE3218150C2 (de) * 1982-05-14 1986-09-25 Akzo Gmbh, 5600 Wuppertal Wirkstoff enthaltender Körper für die Langzeitabgabe sowie Verfahren zu dessen Herstellung
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US4758435A (en) * 1986-08-11 1988-07-19 American Cyanamid Company Estradiol implant composition and method for preparation
DE3710175A1 (de) * 1987-02-12 1988-08-25 Hoechst Ag Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung

Also Published As

Publication number Publication date
DK561588A (da) 1989-04-10
EP0311065A1 (de) 1989-04-12
IE883040L (en) 1989-04-09
CA1333770C (en) 1995-01-03
ZA887535B (en) 1990-06-27
IL87973A (en) 1992-08-18
AU2352288A (en) 1989-04-13
NO176304B (no) 1994-12-05
PT88703B (pt) 1992-12-31
PT88703A (pt) 1988-11-01
NO176304C (no) 1995-03-22
NO884474L (no) 1989-04-10
DK561588D0 (da) 1988-10-07
FI100302B (fi) 1997-11-14
JPH02117A (ja) 1990-01-05
PH30236A (en) 1997-02-05
NZ226514A (en) 1990-02-26
DE3734223A1 (de) 1989-04-20
ES2061589T3 (es) 1994-12-16
FI884604A (fi) 1989-04-10
IE62505B1 (en) 1995-02-08
KR970006082B1 (ko) 1997-04-23
FI884604A0 (fi) 1988-10-07
ATE101035T1 (de) 1994-02-15
IL87973A0 (en) 1989-03-31
AU609194B2 (en) 1991-04-26
KR890006222A (ko) 1989-06-12
DE3887616D1 (de) 1994-03-17
EP0311065B1 (de) 1994-02-02
NO884474D0 (no) 1988-10-07
JP2763303B2 (ja) 1998-06-11

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