ZA887535B - Implantable,biodegradable system for releasing active substance - Google Patents
Implantable,biodegradable system for releasing active substanceInfo
- Publication number
- ZA887535B ZA887535B ZA887535A ZA887535A ZA887535B ZA 887535 B ZA887535 B ZA 887535B ZA 887535 A ZA887535 A ZA 887535A ZA 887535 A ZA887535 A ZA 887535A ZA 887535 B ZA887535 B ZA 887535B
- Authority
- ZA
- South Africa
- Prior art keywords
- implantable
- active substance
- releasing active
- biodegradable system
- carrier material
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Prostheses (AREA)
Abstract
The system consists of a carrier material based on poly-D,L-lactide and of a drug incorporated therein and, where appropriate pharmaceutical auxiliaries. The carrier material contains defined contents of additives in the form of pore formers, up to about 10% by weight of a physiologically acceptable solvent or plasticiser and/or low molecular weight polymers.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873734223 DE3734223A1 (en) | 1987-10-09 | 1987-10-09 | IMPLANTABLE, BIODEGRADABLE ACTIVE SUBSTANCE RELEASE SYSTEM |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA887535B true ZA887535B (en) | 1990-06-27 |
Family
ID=6338006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA887535A ZA887535B (en) | 1987-10-09 | 1988-10-07 | Implantable,biodegradable system for releasing active substance |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0311065B1 (en) |
JP (1) | JP2763303B2 (en) |
KR (1) | KR970006082B1 (en) |
AT (1) | ATE101035T1 (en) |
AU (1) | AU609194B2 (en) |
CA (1) | CA1333770C (en) |
DE (2) | DE3734223A1 (en) |
DK (1) | DK175252B1 (en) |
ES (1) | ES2061589T3 (en) |
FI (1) | FI100302B (en) |
IE (1) | IE62505B1 (en) |
IL (1) | IL87973A (en) |
NO (1) | NO176304C (en) |
NZ (1) | NZ226514A (en) |
PH (1) | PH30236A (en) |
PT (1) | PT88703B (en) |
ZA (1) | ZA887535B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5760118A (en) * | 1988-08-08 | 1998-06-02 | Chronopol, Inc. | End use applications of biodegradable polymers |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
US5252642A (en) * | 1989-03-01 | 1993-10-12 | Biopak Technology, Ltd. | Degradable impact modified polyactic acid |
US6323307B1 (en) | 1988-08-08 | 2001-11-27 | Cargill Dow Polymers, Llc | Degradation control of environmentally degradable disposable materials |
US5180765A (en) * | 1988-08-08 | 1993-01-19 | Biopak Technology, Ltd. | Biodegradable packaging thermoplastics from lactides |
US5424346A (en) * | 1988-08-08 | 1995-06-13 | Ecopol, Llc | Biodegradable replacement of crystal polystyrene |
US5216050A (en) * | 1988-08-08 | 1993-06-01 | Biopak Technology, Ltd. | Blends of polyactic acid |
US5702716A (en) * | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
DK0476045T3 (en) * | 1989-06-05 | 1996-09-16 | Massachusetts Inst Technology | Biodegradable polymers for drug delivery into bones |
US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
CH679207A5 (en) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
US5439688A (en) * | 1989-07-28 | 1995-08-08 | Debio Recherche Pharmaceutique S.A. | Process for preparing a pharmaceutical composition |
KR920703028A (en) * | 1990-01-30 | 1992-12-17 | 에프.지.엠.헤르만스 | Products for controlling the emission of active substances, including hollow spaces which are enclosed in walls and wholly or partially filled with one or more active substances |
DE69004415D1 (en) * | 1990-03-05 | 1993-12-09 | Minnesota Mining & Mfg | Device for delayed delivery of pharmacologically active compounds into the ear. |
US5350580A (en) * | 1990-03-05 | 1994-09-27 | Minnesota Mining And Manufacturing Company | Device and method for extended delivery of pharmacologically active agents to the ear |
AU2605592A (en) * | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
US5681873A (en) * | 1993-10-14 | 1997-10-28 | Atrix Laboratories, Inc. | Biodegradable polymeric composition |
US5605696A (en) * | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
JP4211875B2 (en) * | 1997-04-04 | 2009-01-21 | ノベリス・インコーポレイテッド | Aluminum alloy composition and production method thereof |
MY118835A (en) * | 1997-04-18 | 2005-01-31 | Ipsen Pharma Biotech | Sustained release compositions and the process for their preparation |
US6261583B1 (en) | 1998-07-28 | 2001-07-17 | Atrix Laboratories, Inc. | Moldable solid delivery system |
US6143314A (en) * | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
DE19908753C2 (en) * | 1999-02-20 | 2003-10-02 | Jenapharm Gmbh | Biodegradable, injectable oligomer-polymer composition |
US6306425B1 (en) * | 1999-04-09 | 2001-10-23 | Southern Research Institute | Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol |
US8226598B2 (en) | 1999-09-24 | 2012-07-24 | Tolmar Therapeutics, Inc. | Coupling syringe system and methods for obtaining a mixed composition |
US6702849B1 (en) | 1999-12-13 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers |
US6803443B1 (en) | 2000-03-22 | 2004-10-12 | Dainippon Ink And Chemicals, Inc. | Impact modifier and polyester composition containing the modifier |
EP3167872B1 (en) * | 2000-07-05 | 2020-10-14 | Allergan, Inc. | Methods for treating inflammation-mediated conditions of the eye |
US6726918B1 (en) | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
AU2002236495B2 (en) | 2000-11-29 | 2006-05-11 | Allergan, Inc. | Intraocular implants for preventing transplant rejection in the eye |
US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
AU2005209201B2 (en) | 2004-01-20 | 2010-06-03 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
US8512738B2 (en) | 2004-04-30 | 2013-08-20 | Allergan, Inc. | Biodegradable intravitreal tyrosine kinase implants |
US20050244458A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular neuropathies |
US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
US8591885B2 (en) | 2004-04-30 | 2013-11-26 | Allergan, Inc. | Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems |
US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
US8425929B2 (en) | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
US8147865B2 (en) | 2004-04-30 | 2012-04-03 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
US8119154B2 (en) | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
CA2648479C (en) * | 2006-04-06 | 2014-10-28 | Nupathe Inc. | Implants for the treatment of dopamine associated states |
US8802128B2 (en) | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
US8889173B2 (en) * | 2008-04-18 | 2014-11-18 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of pain and/or inflammation |
US8956641B2 (en) * | 2008-04-18 | 2015-02-17 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of inflammatory diseases |
US10588855B2 (en) | 2008-05-12 | 2020-03-17 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
MX361709B (en) | 2009-11-09 | 2018-12-07 | Allergan Inc | Compositions and methods for stimulating hair growth. |
JP4779169B1 (en) * | 2010-10-27 | 2011-09-28 | Necインフロンティア株式会社 | Button lighting structure, electronic equipment |
JP6511401B2 (en) | 2013-02-15 | 2019-05-15 | アラーガン、インコーポレイテッドAllergan,Incorporated | Sustained drug delivery implant |
GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
JP2020536955A (en) | 2017-10-06 | 2020-12-17 | ファウンドリー セラピューティクス, インコーポレイテッド | Implantable depot for controlled release of therapeutic agent |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE564759A (en) * | 1955-12-22 | |||
US3755558A (en) * | 1971-02-23 | 1973-08-28 | Du Pont | Polylactide drug mixtures for topical application atelet aggregation |
DE3218150C2 (en) * | 1982-05-14 | 1986-09-25 | Akzo Gmbh, 5600 Wuppertal | Active substance-containing body for long-term release and process for its production |
US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
US4758435A (en) * | 1986-08-11 | 1988-07-19 | American Cyanamid Company | Estradiol implant composition and method for preparation |
DE3710175A1 (en) * | 1987-02-12 | 1988-08-25 | Hoechst Ag | MULTI-PIECE IMPLANTABLE MEDICINE PREPARATION WITH LONG-TERM EFFECT |
-
1987
- 1987-10-09 DE DE19873734223 patent/DE3734223A1/en not_active Withdrawn
-
1988
- 1988-10-06 ES ES88116522T patent/ES2061589T3/en not_active Expired - Lifetime
- 1988-10-06 DE DE88116522T patent/DE3887616D1/en not_active Expired - Lifetime
- 1988-10-06 EP EP88116522A patent/EP0311065B1/en not_active Expired - Lifetime
- 1988-10-06 AT AT88116522T patent/ATE101035T1/en not_active IP Right Cessation
- 1988-10-07 IE IE304088A patent/IE62505B1/en not_active IP Right Cessation
- 1988-10-07 DK DK198805615A patent/DK175252B1/en active
- 1988-10-07 FI FI884604A patent/FI100302B/en not_active IP Right Cessation
- 1988-10-07 JP JP63253600A patent/JP2763303B2/en not_active Expired - Lifetime
- 1988-10-07 ZA ZA887535A patent/ZA887535B/en unknown
- 1988-10-07 CA CA000579561A patent/CA1333770C/en not_active Expired - Lifetime
- 1988-10-07 AU AU23522/88A patent/AU609194B2/en not_active Expired
- 1988-10-07 NO NO884474A patent/NO176304C/en not_active IP Right Cessation
- 1988-10-07 PH PH37650A patent/PH30236A/en unknown
- 1988-10-07 PT PT88703A patent/PT88703B/en not_active IP Right Cessation
- 1988-10-07 IL IL87973A patent/IL87973A/en active Protection Beyond IP Right Term
- 1988-10-08 KR KR1019880013156A patent/KR970006082B1/en not_active IP Right Cessation
- 1988-10-10 NZ NZ226514A patent/NZ226514A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5760118A (en) * | 1988-08-08 | 1998-06-02 | Chronopol, Inc. | End use applications of biodegradable polymers |
Also Published As
Publication number | Publication date |
---|---|
JPH02117A (en) | 1990-01-05 |
DK561588D0 (en) | 1988-10-07 |
FI100302B (en) | 1997-11-14 |
AU2352288A (en) | 1989-04-13 |
DK175252B1 (en) | 2004-07-19 |
FI884604A0 (en) | 1988-10-07 |
JP2763303B2 (en) | 1998-06-11 |
IE62505B1 (en) | 1995-02-08 |
ATE101035T1 (en) | 1994-02-15 |
DK561588A (en) | 1989-04-10 |
PH30236A (en) | 1997-02-05 |
NO176304C (en) | 1995-03-22 |
DE3887616D1 (en) | 1994-03-17 |
IL87973A0 (en) | 1989-03-31 |
NO884474D0 (en) | 1988-10-07 |
PT88703A (en) | 1988-11-01 |
ES2061589T3 (en) | 1994-12-16 |
CA1333770C (en) | 1995-01-03 |
FI884604A (en) | 1989-04-10 |
AU609194B2 (en) | 1991-04-26 |
PT88703B (en) | 1992-12-31 |
NZ226514A (en) | 1990-02-26 |
NO884474L (en) | 1989-04-10 |
IE883040L (en) | 1989-04-09 |
NO176304B (en) | 1994-12-05 |
EP0311065B1 (en) | 1994-02-02 |
EP0311065A1 (en) | 1989-04-12 |
KR890006222A (en) | 1989-06-12 |
IL87973A (en) | 1992-08-18 |
KR970006082B1 (en) | 1997-04-23 |
DE3734223A1 (en) | 1989-04-20 |
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