DK175218B1 - (1H-Azol-1-ylmethyl)substituerede benzotriazolderivater, fremgangsmåde til fremstilling deraf samt farmaceutisk præparat indeholdende et benzotriazolderivat ifölge opfindelsen - Google Patents

(1H-Azol-1-ylmethyl)substituerede benzotriazolderivater, fremgangsmåde til fremstilling deraf samt farmaceutisk præparat indeholdende et benzotriazolderivat ifölge opfindelsen Download PDF

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Publication number
DK175218B1
DK175218B1 DK198802952A DK295288A DK175218B1 DK 175218 B1 DK175218 B1 DK 175218B1 DK 198802952 A DK198802952 A DK 198802952A DK 295288 A DK295288 A DK 295288A DK 175218 B1 DK175218 B1 DK 175218B1
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alkyl
formula
phenyl
parts
substituted
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DK198802952A
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Danish (da)
English (en)
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DK295288A (da
DK295288D0 (da
Inventor
Alfons Herman Marg Raeymaekers
Eddy Jean Edgard Freyne
Marc Gaston Venet
Josephus Ludovicus Hube Gelder
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK295288D0 publication Critical patent/DK295288D0/da
Publication of DK295288A publication Critical patent/DK295288A/da
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Publication of DK175218B1 publication Critical patent/DK175218B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK198802952A 1987-06-01 1988-05-31 (1H-Azol-1-ylmethyl)substituerede benzotriazolderivater, fremgangsmåde til fremstilling deraf samt farmaceutisk præparat indeholdende et benzotriazolderivat ifölge opfindelsen DK175218B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5602187A 1987-06-01 1987-06-01
US5602187 1987-06-01

Publications (3)

Publication Number Publication Date
DK295288D0 DK295288D0 (da) 1988-05-31
DK295288A DK295288A (da) 1988-12-02
DK175218B1 true DK175218B1 (da) 2004-07-12

Family

ID=22001654

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198802952A DK175218B1 (da) 1987-06-01 1988-05-31 (1H-Azol-1-ylmethyl)substituerede benzotriazolderivater, fremgangsmåde til fremstilling deraf samt farmaceutisk præparat indeholdende et benzotriazolderivat ifölge opfindelsen

Country Status (24)

Country Link
EP (1) EP0293978B1 (uk)
JP (1) JPH0662612B2 (uk)
KR (1) KR970000952B1 (uk)
CN (1) CN1022184C (uk)
AU (1) AU603446B2 (uk)
BG (2) BG50278A3 (uk)
CA (1) CA1307271C (uk)
CY (1) CY1866A (uk)
DE (1) DE3884055T2 (uk)
DK (1) DK175218B1 (uk)
ES (1) ES2059490T3 (uk)
FI (1) FI90078C (uk)
HK (1) HK114795A (uk)
HU (2) HU201056B (uk)
IE (1) IE61823B1 (uk)
IL (1) IL86551A (uk)
LT (1) LT3950B (uk)
LV (1) LV10452B (uk)
NO (1) NO169900C (uk)
NZ (1) NZ224714A (uk)
PT (1) PT87623B (uk)
RU (1) RU1838308C (uk)
UA (1) UA11192A (uk)
ZA (1) ZA883861B (uk)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157046A (en) * 1988-11-29 1992-10-20 Janssen Pharmaceutica N.V. Method of treating epithelial disorders
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
CA2026792A1 (en) * 1989-11-01 1991-05-02 Michael N. Greco (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
US5066656A (en) * 1989-11-01 1991-11-19 Janssen Pharmaceutica N.V. Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
NZ236440A (en) * 1989-12-15 1993-07-27 Merck & Co Inc Reversal of sexual phenotype in poultry using an inhibitor of steroid biotransformation and/or aromatase inhibitor, poultry produced by this process
EP0445073A1 (de) * 1990-02-27 1991-09-04 Ciba-Geigy Ag Benzofurane
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
TW224461B (uk) * 1990-09-18 1994-06-01 Ciba Geigy Ag
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
TW210334B (uk) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
HU220863B1 (en) 1991-09-02 2002-06-29 Yamanouchi Pharma Co Ltd Triazolylated tertiary amines, process for producing them and pharmaceutical compositions containing them
US5635521A (en) * 1991-09-23 1997-06-03 Sandoz Ltd. Imidazolylmethyl-pyridines
JP2700595B2 (ja) * 1992-05-21 1998-01-21 呉羽化学工業株式会社 アゾール誘導体を含有する抗アロマターゼ剤
NZ257551A (en) * 1992-11-10 1995-10-26 Janssen Pharmaceutica Nv Preparation of 6-[(4-chlorophenyl)(1h-1,2,4-triazol-1-yl)methyl]-1-methyl-1h-benzotriazole in enantiomerically pure form;intermediates
EP0684235A1 (en) * 1994-05-27 1995-11-29 Mochida Pharmaceutical Co., Ltd. Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity
AU6821196A (en) * 1995-08-14 1997-03-12 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
AU742388B2 (en) * 1996-12-24 2002-01-03 Chugai Seiyaku Kabushiki Kaisha Aromatic amine derivatives having nos inhibiting action
KR20030017511A (ko) * 2000-06-28 2003-03-03 에스에스 세야쿠 가부시키 가이샤 이미다졸 유도체 또는 그의 염 및 이를 함유하는 의약
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
AU2004218463B2 (en) * 2003-03-03 2009-07-16 Array Biopharma, Inc. p38 inhibitors and methods of use thereof
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
MX2007013454A (es) * 2005-04-29 2008-01-21 Janssen Pharmaceutica Nv Derivados de benzotriazol como antagonistas del receptor de cannabinoide.
US7572807B2 (en) * 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
WO2007031833A2 (en) 2005-09-15 2007-03-22 Council Of Scientific And Industrial Research Novel series of imidazolyl substituted steroidal and indan-1-one derivatives
SG175599A1 (en) 2006-01-31 2011-11-28 Array Biopharma Inc Kinase inhibitors and methods of use thereof
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
US9394290B2 (en) * 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75101B (uk) * 1980-10-23 1984-07-13 Pfizer
US4609666A (en) * 1984-06-18 1986-09-02 Eli Lilly And Company Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4659730A (en) * 1984-06-18 1987-04-21 Eli Lilly And Company Aromatase inhibiting imidazole derivatives
EP0165781A1 (en) * 1984-06-18 1985-12-27 Eli Lilly And Company Aromatase inhibiting N-substituted imidazole derivatives
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors
DE3744589C1 (de) 1987-12-31 1988-12-29 Albrecht Josef Bohrfutter Nachspannendes Bohrfutter

Also Published As

Publication number Publication date
IE881640L (en) 1988-12-01
CN88103408A (zh) 1988-12-14
CN1022184C (zh) 1993-09-22
AU1653788A (en) 1988-12-01
FI882552A0 (fi) 1988-05-31
UA11192A (uk) 1996-12-25
FI90078C (fi) 1993-12-27
LV10452B (en) 1995-08-20
CA1307271C (en) 1992-09-08
LTIP1625A (en) 1995-07-25
HK114795A (en) 1995-07-21
EP0293978A3 (en) 1990-06-13
FI90078B (fi) 1993-09-15
CY1866A (en) 1988-05-26
NO169900B (no) 1992-05-11
IE61823B1 (en) 1994-11-30
NO169900C (no) 1992-08-19
BG60429B2 (bg) 1995-03-31
NZ224714A (en) 1990-03-27
HU201056B (en) 1990-09-28
LV10452A (lv) 1995-02-20
FI882552A (fi) 1988-12-02
JPH0662612B2 (ja) 1994-08-17
ES2059490T3 (es) 1994-11-16
DK295288A (da) 1988-12-02
NO882390D0 (no) 1988-05-31
KR890000469A (ko) 1989-03-14
RU1838308C (ru) 1993-08-30
BG50278A3 (en) 1992-06-15
KR970000952B1 (ko) 1997-01-21
HU211482A9 (en) 1995-11-28
NO882390L (no) 1988-12-02
EP0293978B1 (en) 1993-09-15
PT87623A (pt) 1988-06-01
HUT49132A (en) 1989-08-28
ZA883861B (en) 1990-01-31
IL86551A0 (en) 1988-11-15
DK295288D0 (da) 1988-05-31
DE3884055D1 (de) 1993-10-21
LT3950B (en) 1996-05-27
EP0293978A2 (en) 1988-12-07
AU603446B2 (en) 1990-11-15
JPS63316775A (ja) 1988-12-26
IL86551A (en) 1992-07-15
PT87623B (pt) 1992-09-30
DE3884055T2 (de) 1994-01-27

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