LV10452B - A process for the preparation of (1h-azolo-1-ylmethyl)-substituted derivatives of benzotriazoles - Google Patents

A process for the preparation of (1h-azolo-1-ylmethyl)-substituted derivatives of benzotriazoles Download PDF

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Publication number
LV10452B
LV10452B LVP-92-233A LV920233A LV10452B LV 10452 B LV10452 B LV 10452B LV 920233 A LV920233 A LV 920233A LV 10452 B LV10452 B LV 10452B
Authority
LV
Latvia
Prior art keywords
formula
compound
alkyl
cmecb
npn
Prior art date
Application number
LVP-92-233A
Other languages
English (en)
Latvian (lv)
Other versions
LV10452A (lv
Inventor
Alfons H M Raeymaekers
Eddy J E Freyne
Gelder Josephus L H Van
Marc G Venet
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of LV10452A publication Critical patent/LV10452A/xx
Publication of LV10452B publication Critical patent/LV10452B/lv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LVP-92-233A 1987-06-01 1992-11-27 A process for the preparation of (1h-azolo-1-ylmethyl)-substituted derivatives of benzotriazoles LV10452B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5602187A 1987-06-01 1987-06-01

Publications (2)

Publication Number Publication Date
LV10452A LV10452A (lv) 1995-02-20
LV10452B true LV10452B (en) 1995-08-20

Family

ID=22001654

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-92-233A LV10452B (en) 1987-06-01 1992-11-27 A process for the preparation of (1h-azolo-1-ylmethyl)-substituted derivatives of benzotriazoles

Country Status (24)

Country Link
EP (1) EP0293978B1 (uk)
JP (1) JPH0662612B2 (uk)
KR (1) KR970000952B1 (uk)
CN (1) CN1022184C (uk)
AU (1) AU603446B2 (uk)
BG (2) BG50278A3 (uk)
CA (1) CA1307271C (uk)
CY (1) CY1866A (uk)
DE (1) DE3884055T2 (uk)
DK (1) DK175218B1 (uk)
ES (1) ES2059490T3 (uk)
FI (1) FI90078C (uk)
HK (1) HK114795A (uk)
HU (2) HU201056B (uk)
IE (1) IE61823B1 (uk)
IL (1) IL86551A (uk)
LT (1) LT3950B (uk)
LV (1) LV10452B (uk)
NO (1) NO169900C (uk)
NZ (1) NZ224714A (uk)
PT (1) PT87623B (uk)
RU (1) RU1838308C (uk)
UA (1) UA11192A (uk)
ZA (1) ZA883861B (uk)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
US5157046A (en) * 1988-11-29 1992-10-20 Janssen Pharmaceutica N.V. Method of treating epithelial disorders
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
US5066656A (en) * 1989-11-01 1991-11-19 Janssen Pharmaceutica N.V. Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
CA2026792A1 (en) * 1989-11-01 1991-05-02 Michael N. Greco (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
NZ236440A (en) * 1989-12-15 1993-07-27 Merck & Co Inc Reversal of sexual phenotype in poultry using an inhibitor of steroid biotransformation and/or aromatase inhibitor, poultry produced by this process
EP0445073A1 (de) * 1990-02-27 1991-09-04 Ciba-Geigy Ag Benzofurane
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
TW224461B (uk) * 1990-09-18 1994-06-01 Ciba Geigy Ag
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
TW210334B (uk) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
WO1993005027A1 (en) 1991-09-02 1993-03-18 Yamanouchi Pharmaceutical Co., Ltd. Triazolylated tertiary amine compound or salt thereof
US5635521A (en) * 1991-09-23 1997-06-03 Sandoz Ltd. Imidazolylmethyl-pyridines
JP2700595B2 (ja) * 1992-05-21 1998-01-21 呉羽化学工業株式会社 アゾール誘導体を含有する抗アロマターゼ剤
US5663354A (en) * 1992-11-10 1997-09-02 Janssen Pharmaceutica, N.V. Process for preparing enantiomerically pure 6-[(4-chlorophenyl) (1H-1,2,4-triazol-1-yl) methyl]-1-methyl-1H-benzotrizole
CA2150326A1 (en) * 1994-05-27 1995-11-28 Kimihiro Murakami Azolyl methyl phenyl derivatives having aromatase inhibitory activity
WO1997006788A1 (en) * 1995-08-14 1997-02-27 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
KR100559816B1 (ko) * 1996-12-24 2006-03-10 쥬가이 세이야쿠 가부시키가이샤 Ｎｏｓ 저해작용을 가진 방향족 아민 유도체
CN1228338C (zh) 2000-06-28 2005-11-23 久光医药股份有限公司 咪唑衍生物或其盐以及含有该衍生物或其盐的药物
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US7521447B2 (en) * 2003-03-03 2009-04-21 Array Biopharma Inc. P38 inhibitors and methods of use thereof
US20090036435A1 (en) 2005-01-21 2009-02-05 Astex Therapeutics Limited Pharmaceutical Compounds
MX2007013454A (es) * 2005-04-29 2008-01-21 Janssen Pharmaceutica Nv Derivados de benzotriazol como antagonistas del receptor de cannabinoide.
US7572807B2 (en) * 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
CN101291950B (zh) 2005-09-15 2013-01-02 科学与工业研究会 咪唑基取代的类固醇和茚满-1-酮衍生物
DK1981851T3 (da) 2006-01-31 2012-03-19 Array Biopharma Inc Kinaseinhibitorer og fremgangsmåder til anvendelse deraf
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
WO2012052540A1 (en) * 2010-10-21 2012-04-26 Universitaet Des Saarlandes Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75101B (uk) * 1980-10-23 1984-07-13 Pfizer
US4609666A (en) * 1984-06-18 1986-09-02 Eli Lilly And Company Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors
US4659730A (en) * 1984-06-18 1987-04-21 Eli Lilly And Company Aromatase inhibiting imidazole derivatives
EP0165781A1 (en) * 1984-06-18 1985-12-27 Eli Lilly And Company Aromatase inhibiting N-substituted imidazole derivatives
DE3744589C1 (de) 1987-12-31 1988-12-29 Albrecht Josef Bohrfutter Nachspannendes Bohrfutter

Also Published As

Publication number Publication date
DE3884055T2 (de) 1994-01-27
LTIP1625A (en) 1995-07-25
JPS63316775A (ja) 1988-12-26
IE61823B1 (en) 1994-11-30
PT87623B (pt) 1992-09-30
NO169900B (no) 1992-05-11
EP0293978A2 (en) 1988-12-07
KR970000952B1 (ko) 1997-01-21
DE3884055D1 (de) 1993-10-21
DK295288A (da) 1988-12-02
HUT49132A (en) 1989-08-28
CA1307271C (en) 1992-09-08
CY1866A (en) 1988-05-26
UA11192A (uk) 1996-12-25
JPH0662612B2 (ja) 1994-08-17
NO882390D0 (no) 1988-05-31
IL86551A0 (en) 1988-11-15
IL86551A (en) 1992-07-15
BG50278A3 (en) 1992-06-15
AU1653788A (en) 1988-12-01
AU603446B2 (en) 1990-11-15
EP0293978B1 (en) 1993-09-15
FI90078C (fi) 1993-12-27
BG60429B2 (bg) 1995-03-31
CN1022184C (zh) 1993-09-22
FI882552A (fi) 1988-12-02
CN88103408A (zh) 1988-12-14
NO169900C (no) 1992-08-19
ZA883861B (en) 1990-01-31
ES2059490T3 (es) 1994-11-16
HU211482A9 (en) 1995-11-28
NZ224714A (en) 1990-03-27
EP0293978A3 (en) 1990-06-13
PT87623A (pt) 1988-06-01
HK114795A (en) 1995-07-21
LT3950B (en) 1996-05-27
DK175218B1 (da) 2004-07-12
IE881640L (en) 1988-12-01
LV10452A (lv) 1995-02-20
FI882552A0 (fi) 1988-05-31
NO882390L (no) 1988-12-02
DK295288D0 (da) 1988-05-31
KR890000469A (ko) 1989-03-14
FI90078B (fi) 1993-09-15
HU201056B (en) 1990-09-28
RU1838308C (ru) 1993-08-30

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