BG50278A3 - Method for the preparation of (1h- azole- 1- ilmethyl)- substituted benzotriazole derivatives - Google Patents
Method for the preparation of (1h- azole- 1- ilmethyl)- substituted benzotriazole derivativesInfo
- Publication number
- BG50278A3 BG50278A3 BG084328A BG8432888A BG50278A3 BG 50278 A3 BG50278 A3 BG 50278A3 BG 084328 A BG084328 A BG 084328A BG 8432888 A BG8432888 A BG 8432888A BG 50278 A3 BG50278 A3 BG 50278A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- azole
- preparation
- benzotriazole derivatives
- ilmethyl
- substituted benzotriazole
- Prior art date
Links
- 125000003354 benzotriazolyl group Chemical class N1N=NC2=C1C=CC=C2* 0.000 title abstract 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 abstract 1
- 239000012964 benzotriazole Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5602187A | 1987-06-01 | 1987-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG50278A3 true BG50278A3 (en) | 1992-06-15 |
Family
ID=22001654
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG084328A BG50278A3 (en) | 1987-06-01 | 1988-05-31 | Method for the preparation of (1h- azole- 1- ilmethyl)- substituted benzotriazole derivatives |
| BG098159A BG60429B2 (bg) | 1987-06-01 | 1993-10-18 | (1н-азол-1-илметил)заместени бензотриазолни производни |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG098159A BG60429B2 (bg) | 1987-06-01 | 1993-10-18 | (1н-азол-1-илметил)заместени бензотриазолни производни |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0293978B1 (uk) |
| JP (1) | JPH0662612B2 (uk) |
| KR (1) | KR970000952B1 (uk) |
| CN (1) | CN1022184C (uk) |
| AU (1) | AU603446B2 (uk) |
| BG (2) | BG50278A3 (uk) |
| CA (1) | CA1307271C (uk) |
| CY (1) | CY1866A (uk) |
| DE (1) | DE3884055T2 (uk) |
| DK (1) | DK175218B1 (uk) |
| ES (1) | ES2059490T3 (uk) |
| FI (1) | FI90078C (uk) |
| HK (1) | HK114795A (uk) |
| HU (2) | HU201056B (uk) |
| IE (1) | IE61823B1 (uk) |
| IL (1) | IL86551A (uk) |
| LT (1) | LT3950B (uk) |
| LV (1) | LV10452B (uk) |
| NO (1) | NO169900C (uk) |
| NZ (1) | NZ224714A (uk) |
| PT (1) | PT87623B (uk) |
| RU (1) | RU1838308C (uk) |
| UA (1) | UA11192A (uk) |
| ZA (1) | ZA883861B (uk) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5157046A (en) * | 1988-11-29 | 1992-10-20 | Janssen Pharmaceutica N.V. | Method of treating epithelial disorders |
| GB8827820D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
| CA2002859C (en) * | 1988-11-29 | 1998-12-29 | Jean P. F. Van Wauwe | Method of treating epithelial disorders |
| DE59010171D1 (de) * | 1989-07-14 | 1996-04-11 | Ciba Geigy Ag | Substituierte Benzonitrile |
| CA2026792A1 (en) * | 1989-11-01 | 1991-05-02 | Michael N. Greco | (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives |
| US5066656A (en) * | 1989-11-01 | 1991-11-19 | Janssen Pharmaceutica N.V. | Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives |
| NZ236440A (en) * | 1989-12-15 | 1993-07-27 | Merck & Co Inc | Reversal of sexual phenotype in poultry using an inhibitor of steroid biotransformation and/or aromatase inhibitor, poultry produced by this process |
| EP0445073A1 (de) * | 1990-02-27 | 1991-09-04 | Ciba-Geigy Ag | Benzofurane |
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| EP0457716A1 (de) * | 1990-04-20 | 1991-11-21 | Ciba-Geigy Ag | Naphthalinderivate |
| TW224461B (uk) * | 1990-09-18 | 1994-06-01 | Ciba Geigy Ag | |
| US5162337A (en) * | 1990-10-05 | 1992-11-10 | Merck & Co., Inc. | Animal growth promotion |
| TW210334B (uk) * | 1990-12-12 | 1993-08-01 | Ciba Geigy Ag | |
| CH683151A5 (de) * | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
| HU220863B1 (en) | 1991-09-02 | 2002-06-29 | Yamanouchi Pharma Co Ltd | Triazolylated tertiary amines, process for producing them and pharmaceutical compositions containing them |
| US5635521A (en) * | 1991-09-23 | 1997-06-03 | Sandoz Ltd. | Imidazolylmethyl-pyridines |
| JP2700595B2 (ja) * | 1992-05-21 | 1998-01-21 | 呉羽化学工業株式会社 | アゾール誘導体を含有する抗アロマターゼ剤 |
| NZ257551A (en) * | 1992-11-10 | 1995-10-26 | Janssen Pharmaceutica Nv | Preparation of 6-[(4-chlorophenyl)(1h-1,2,4-triazol-1-yl)methyl]-1-methyl-1h-benzotriazole in enantiomerically pure form;intermediates |
| EP0684235A1 (en) * | 1994-05-27 | 1995-11-29 | Mochida Pharmaceutical Co., Ltd. | Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity |
| AU6821196A (en) * | 1995-08-14 | 1997-03-12 | Janssen Pharmaceutica N.V. | Transdermal administration of vorozole |
| IT1286866B1 (it) * | 1996-10-28 | 1998-07-17 | Menarini Farma Ind | Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi |
| AU742388B2 (en) * | 1996-12-24 | 2002-01-03 | Chugai Seiyaku Kabushiki Kaisha | Aromatic amine derivatives having nos inhibiting action |
| KR20030017511A (ko) * | 2000-06-28 | 2003-03-03 | 에스에스 세야쿠 가부시키 가이샤 | 이미다졸 유도체 또는 그의 염 및 이를 함유하는 의약 |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| AU2004218463B2 (en) * | 2003-03-03 | 2009-07-16 | Array Biopharma, Inc. | p38 inhibitors and methods of use thereof |
| MX2007008781A (es) | 2005-01-21 | 2007-09-11 | Astex Therapeutics Ltd | Compuestos farmaceuticos. |
| MX2007013454A (es) * | 2005-04-29 | 2008-01-21 | Janssen Pharmaceutica Nv | Derivados de benzotriazol como antagonistas del receptor de cannabinoide. |
| US7572807B2 (en) * | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
| WO2007031833A2 (en) | 2005-09-15 | 2007-03-22 | Council Of Scientific And Industrial Research | Novel series of imidazolyl substituted steroidal and indan-1-one derivatives |
| SG175599A1 (en) | 2006-01-31 | 2011-11-28 | Array Biopharma Inc | Kinase inhibitors and methods of use thereof |
| EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| US9394290B2 (en) * | 2010-10-21 | 2016-07-19 | Universitaet Des Saarlandes Campus Saarbruecken | Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR75101B (uk) * | 1980-10-23 | 1984-07-13 | Pfizer | |
| US4609666A (en) * | 1984-06-18 | 1986-09-02 | Eli Lilly And Company | Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles |
| US4602025A (en) * | 1984-06-18 | 1986-07-22 | Eli Lilly And Company | Aromatase inhibitors |
| US4659730A (en) * | 1984-06-18 | 1987-04-21 | Eli Lilly And Company | Aromatase inhibiting imidazole derivatives |
| EP0165781A1 (en) * | 1984-06-18 | 1985-12-27 | Eli Lilly And Company | Aromatase inhibiting N-substituted imidazole derivatives |
| US4801594A (en) * | 1984-06-18 | 1989-01-31 | Eli Lilly And Company | Aromatase inhibitors |
| DE3744589C1 (de) | 1987-12-31 | 1988-12-29 | Albrecht Josef Bohrfutter | Nachspannendes Bohrfutter |
-
1988
- 1988-05-19 NZ NZ224714A patent/NZ224714A/xx unknown
- 1988-05-20 RU SU884355784A patent/RU1838308C/ru active
- 1988-05-20 UA UA4355784A patent/UA11192A/uk unknown
- 1988-05-23 AU AU16537/88A patent/AU603446B2/en not_active Expired
- 1988-05-25 CA CA000567618A patent/CA1307271C/en not_active Expired - Lifetime
- 1988-05-26 ES ES88201061T patent/ES2059490T3/es not_active Expired - Lifetime
- 1988-05-26 DE DE88201061T patent/DE3884055T2/de not_active Expired - Lifetime
- 1988-05-26 CY CY186688A patent/CY1866A/xx unknown
- 1988-05-26 EP EP88201061A patent/EP0293978B1/en not_active Expired - Lifetime
- 1988-05-30 IL IL86551A patent/IL86551A/xx not_active IP Right Cessation
- 1988-05-30 ZA ZA883861A patent/ZA883861B/xx unknown
- 1988-05-31 BG BG084328A patent/BG50278A3/xx unknown
- 1988-05-31 FI FI882552A patent/FI90078C/fi not_active IP Right Cessation
- 1988-05-31 IE IE164088A patent/IE61823B1/en not_active IP Right Cessation
- 1988-05-31 PT PT87623A patent/PT87623B/pt not_active IP Right Cessation
- 1988-05-31 DK DK198802952A patent/DK175218B1/da not_active IP Right Cessation
- 1988-05-31 NO NO882390A patent/NO169900C/no not_active IP Right Cessation
- 1988-06-01 HU HU882783A patent/HU201056B/hu unknown
- 1988-06-01 KR KR1019880006557A patent/KR970000952B1/ko not_active IP Right Cessation
- 1988-06-01 CN CN88103408A patent/CN1022184C/zh not_active Expired - Lifetime
- 1988-06-01 JP JP63132886A patent/JPH0662612B2/ja not_active Expired - Lifetime
-
1992
- 1992-11-27 LV LVP-92-233A patent/LV10452B/lv unknown
-
1993
- 1993-10-18 BG BG098159A patent/BG60429B2/bg unknown
- 1993-12-16 LT LTIP1625A patent/LT3950B/lt not_active IP Right Cessation
-
1995
- 1995-06-29 HU HU95P/P00533P patent/HU211482A9/hu unknown
- 1995-07-13 HK HK114795A patent/HK114795A/xx not_active IP Right Cessation
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