DK175216B1 - Dihydropyridinformulering med forlænget frigivelse og fremstilling heraf - Google Patents

Dihydropyridinformulering med forlænget frigivelse og fremstilling heraf Download PDF

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Publication number
DK175216B1
DK175216B1 DK198700477A DK47787A DK175216B1 DK 175216 B1 DK175216 B1 DK 175216B1 DK 198700477 A DK198700477 A DK 198700477A DK 47787 A DK47787 A DK 47787A DK 175216 B1 DK175216 B1 DK 175216B1
Authority
DK
Denmark
Prior art keywords
calcium channel
alkyl
acting
pharmaceutical composition
long
Prior art date
Application number
DK198700477A
Other languages
Danish (da)
English (en)
Other versions
DK47787D0 (da
DK47787A (da
Inventor
Michael John Dey
Calum Brechin Mac Farlane
Alistair Brereton Selkirk
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK47787D0 publication Critical patent/DK47787D0/da
Publication of DK47787A publication Critical patent/DK47787A/da
Application granted granted Critical
Publication of DK175216B1 publication Critical patent/DK175216B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198700477A 1986-01-30 1987-01-29 Dihydropyridinformulering med forlænget frigivelse og fremstilling heraf DK175216B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82389686A 1986-01-30 1986-01-30
US82389686 1986-01-30
US94087886A 1986-12-10 1986-12-10
US94087886 1986-12-10

Publications (3)

Publication Number Publication Date
DK47787D0 DK47787D0 (da) 1987-01-29
DK47787A DK47787A (da) 1987-07-31
DK175216B1 true DK175216B1 (da) 2004-07-12

Family

ID=27124769

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198700477A DK175216B1 (da) 1986-01-30 1987-01-29 Dihydropyridinformulering med forlænget frigivelse og fremstilling heraf

Country Status (18)

Country Link
EP (1) EP0231026B1 (ja)
JP (1) JP2524990B2 (ja)
KR (1) KR900005009B1 (ja)
AU (1) AU604672B2 (ja)
CA (1) CA1285227C (ja)
DE (1) DE3782439T2 (ja)
DK (1) DK175216B1 (ja)
ES (1) ES2052500T3 (ja)
FI (1) FI88872C (ja)
GR (1) GR3006148T3 (ja)
HU (1) HU196709B (ja)
IE (1) IE61879B1 (ja)
IL (2) IL81419A0 (ja)
IT (1) IT1206876B (ja)
NO (1) NO174325C (ja)
NZ (1) NZ219090A (ja)
PH (1) PH26366A (ja)
PT (1) PT84213B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4940556A (en) * 1986-01-30 1990-07-10 Syntex (U.S.A.) Inc. Method of preparing long acting formulation
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
IT1227336B (it) * 1987-09-11 1991-04-08 Squibb & Sons Inc Composizione farmaceutica contenente un carico elevato di medicamento e procedimento per la sua preparazione
JP2528706B2 (ja) * 1988-05-30 1996-08-28 ゼリア新薬工業株式会社 ジヒドロピリジン化合物の製剤組成物
US4925676A (en) * 1989-02-02 1990-05-15 Warner-Lambert Company Extended release gemfibrozil composition
HU203041B (en) * 1989-03-14 1991-05-28 Egyt Gyogyszervegyeszeti Gyar Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin
JPH0729926B2 (ja) * 1989-07-25 1995-04-05 大塚製薬株式会社 易吸収性製剤用組成物
ATE196733T1 (de) * 1991-12-30 2000-10-15 Fmc Corp Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen
GB2264639B (en) * 1992-02-20 1996-05-22 Euro Celtique Sa Modified Release Formulation
GB9203689D0 (en) * 1992-02-20 1992-04-08 Euro Celtique Sa Pharmaceutical composition
TW474824B (en) * 1996-09-13 2002-02-01 Basf Ag The production of solid pharmaceutical forms
US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
US6479496B1 (en) * 1998-09-10 2002-11-12 Cv Therapeutics, Inc. Methods for treating angina with ranolazine
EP1027885B1 (en) * 1999-02-09 2008-07-09 Pfizer Products Inc. Basic drug compositions with enhanced bioavailability
JP2008525313A (ja) 2004-12-27 2008-07-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗痴呆薬の安定化方法
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795766A (fr) * 1972-02-22 1973-08-22 Lilly Co Eli Particules de napsylate de propoxyphene retard et procede de fabrication de ces particules
JPS5846019A (ja) * 1981-09-14 1983-03-17 Kanebo Ltd 持続性ニフエジピン製剤
FR2581541B1 (fr) * 1985-05-09 1988-05-20 Rhone Poulenc Sante Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation

Also Published As

Publication number Publication date
AU604672B2 (en) 1991-01-03
IL81419A (en) 1991-07-18
FI88872C (fi) 1993-07-26
IT8767057A0 (it) 1987-01-29
IL81419A0 (en) 1987-08-31
JPS62252732A (ja) 1987-11-04
KR900005009B1 (ko) 1990-07-16
GR3006148T3 (ja) 1993-06-21
FI870380A (fi) 1987-07-31
HU196709B (en) 1989-01-30
EP0231026B1 (en) 1992-11-04
CA1285227C (en) 1991-06-25
NO870368L (no) 1987-07-31
IT1206876B (it) 1989-05-11
DE3782439D1 (de) 1992-12-10
NO870368D0 (no) 1987-01-29
PH26366A (en) 1992-06-01
JP2524990B2 (ja) 1996-08-14
PT84213A (en) 1987-02-01
DK47787D0 (da) 1987-01-29
DK47787A (da) 1987-07-31
PT84213B (pt) 1989-03-30
DE3782439T2 (de) 1993-05-19
FI870380A0 (fi) 1987-01-29
IE61879B1 (en) 1994-11-30
HUT42950A (en) 1987-09-28
NO174325C (no) 1994-04-20
EP0231026A1 (en) 1987-08-05
KR870007121A (ko) 1987-08-17
NZ219090A (en) 1990-04-26
ES2052500T3 (es) 1994-07-16
AU6810287A (en) 1987-08-06
FI88872B (fi) 1993-04-15
NO174325B (no) 1994-01-10
IE870229L (en) 1987-07-30

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