DK175073B1 - Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf - Google Patents

Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf Download PDF

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Publication number
DK175073B1
DK175073B1 DK199001446A DK144690A DK175073B1 DK 175073 B1 DK175073 B1 DK 175073B1 DK 199001446 A DK199001446 A DK 199001446A DK 144690 A DK144690 A DK 144690A DK 175073 B1 DK175073 B1 DK 175073B1
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Prior art keywords
formula
compound
alkyl
ester
temperature
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Application number
DK199001446A
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Danish (da)
English (en)
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DK144690D0 (da
DK144690A (da
Inventor
Kau-Ming Chen
Prasad Koteswara Kapa
George T Lee
Oljan Repic
Petr Hess
Michel Crevoisier
Original Assignee
Novartis Ag
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
DK199001446A 1988-10-13 1990-06-13 Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf DK175073B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US25747588A 1988-10-13 1988-10-13
US25747588 1988-10-13
US35553189A 1989-05-22 1989-05-22
US35553189 1989-05-22
PCT/EP1989/001201 WO1990003962A1 (fr) 1988-10-13 1989-10-11 Procede de preparation d'acides hept-6 enoiques et heptanoiques substitues en position 7 et de derives et intermediaires de ces acides
EP8901201 1989-10-11

Publications (3)

Publication Number Publication Date
DK144690D0 DK144690D0 (da) 1990-06-13
DK144690A DK144690A (da) 1990-06-13
DK175073B1 true DK175073B1 (da) 2004-05-24

Family

ID=26945992

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199001446A DK175073B1 (da) 1988-10-13 1990-06-13 Fremgangsmåde til fremstilling af beta-delta-dihydroxysubstituerede carboxylsyrer og derivater deraf

Country Status (24)

Country Link
EP (2) EP0363934B1 (fr)
JP (1) JP2853227B2 (fr)
KR (1) KR0162656B1 (fr)
AT (1) ATE99281T1 (fr)
AU (1) AU636122B2 (fr)
BG (1) BG60555B1 (fr)
CA (1) CA2000553C (fr)
CZ (1) CZ283316B6 (fr)
DE (1) DE68911834T2 (fr)
DK (1) DK175073B1 (fr)
ES (1) ES2060712T3 (fr)
FI (1) FI98063C (fr)
HK (1) HK49496A (fr)
HU (1) HU207993B (fr)
IE (2) IE63477B1 (fr)
IL (1) IL91941A (fr)
MY (1) MY105067A (fr)
NO (1) NO174623C (fr)
NZ (1) NZ230973A (fr)
RO (1) RO109732B1 (fr)
SG (1) SG139553A1 (fr)
SK (1) SK280845B6 (fr)
WO (1) WO1990003962A1 (fr)
YU (1) YU48466B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290946A (en) * 1988-10-13 1994-03-01 Sandoz Ltd. Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
US5118853A (en) * 1988-10-13 1992-06-02 Sandoz Ltd. Processes for the synthesis of 3-disubstituted aminoacroleins
IE903606A1 (en) * 1989-10-10 1991-04-24 Glaxo Group Ltd Chemical compounds
DE4424525A1 (de) * 1994-07-12 1995-01-26 Elmar Meyer Dauermagnet-Kolbenmotor
GT199800127A (es) 1997-08-29 2000-02-01 Combinaciones terapeuticas.
DE60022525T2 (de) 1999-08-30 2006-06-14 Sanofi Aventis Deutschland Ramipril zur vorbeugung von kardiovaskulären vorfällen
EP1284964A1 (fr) * 2000-05-26 2003-02-26 Ciba SC Holding AG Processus de preparation de derives indole et d'intermediaires de ce processus
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
EP1623976A4 (fr) * 2003-04-24 2008-07-30 Daicel Chem Procede pour separer des esters d'acide dihydroxy-heptenoique optiquement actifs
US7368581B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Process for the preparation of fluvastatin sodium crystal from XIV
US7368468B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
CA2613021A1 (fr) 2003-06-18 2004-12-29 Teva Pharmaceutical Industries Ltd Forme lxxx de cristaux de fluvastatine sodique, procedes pour les preparer, compositions et methodes pour les utiliser
WO2005053683A1 (fr) 2003-11-26 2005-06-16 Duke University Technique de prevention ou de traitement du glaucome
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ATE431818T1 (de) 2006-04-20 2009-06-15 Italiana Sint Spa Verfahren zur herstellung von fluvastatin-natrium
WO2010069593A1 (fr) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Utilisation de composés amphiphiles pour la cristallisation régulée de statines et d'intermédiaires de statines
EP2327682A1 (fr) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines.
JP6224624B2 (ja) 2012-02-02 2017-11-01 ザ・ユニバーシティ・オブ・シドニー 涙膜安定性における改善
EP2986599A1 (fr) 2013-04-17 2016-02-24 Pfizer Inc. Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
CA3125765A1 (fr) 2019-01-18 2020-07-23 Astrazeneca Ab Inhibiteurs de pcsk9 et leurs procedes d'utilisation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB945536A (en) * 1961-09-08 1964-01-02 Istituto Chemioterapico Method of preparing ª -amino-acroleins
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
WO1984002131A1 (fr) * 1982-11-22 1984-06-07 Sandoz Ag Produits analogues de mevalolactone et leurs derives, leurs procedes de production, compositions pharmaceutiques les contenant ainsi que leur utilisation en tant que produits pharmaceutiques
US4571428A (en) * 1983-07-08 1986-02-18 Sandoz, Inc. 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
US4650890A (en) * 1984-04-03 1987-03-17 Sandoz Corp. Preparation of olefinic compounds and intermediates thereof
JPS61502467A (ja) * 1984-06-22 1986-10-30 サンド・アクチエンゲゼルシヤフト メバロノラクトンのピラゾ−ル同族体およびその誘導体、それらの製造方法ならびに用途
EP0216785B1 (fr) * 1984-12-04 1991-01-30 Sandoz Ag Analogues indenes de mevalonolactones et leurs derives
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
EP0244364A3 (fr) * 1986-04-30 1992-04-01 Sandoz Ag Préparation de composés oléfiniques
PT85662B (pt) * 1986-09-10 1990-06-29 Sandoz Sa Processo para a preparacao de derivados de aza-indol e de indolizina e de composicoes farmaceuticas que os contem

Also Published As

Publication number Publication date
KR900701723A (ko) 1990-12-04
BG92179A (bg) 1993-12-24
EP0562643A2 (fr) 1993-09-29
DE68911834D1 (de) 1994-02-10
NO902598D0 (no) 1990-06-12
YU197389A (en) 1990-12-31
FI98063B (fi) 1996-12-31
DE68911834T2 (de) 1994-06-23
NO902598L (no) 1990-08-07
CA2000553C (fr) 2001-12-04
DK144690D0 (da) 1990-06-13
RO109732B1 (ro) 1995-05-30
KR0162656B1 (ko) 1999-01-15
FI902935A0 (fi) 1990-06-12
CA2000553A1 (fr) 1990-04-13
SK579789A3 (en) 2000-08-14
JPH03501735A (ja) 1991-04-18
WO1990003962A1 (fr) 1990-04-19
EP0363934B1 (fr) 1993-12-29
FI98063C (fi) 1997-04-10
HUT53860A (en) 1990-12-28
MY105067A (en) 1994-07-30
EP0363934A1 (fr) 1990-04-18
NO174623C (no) 1994-06-08
HU207993B (en) 1993-07-28
AU636122B2 (en) 1993-04-22
AU4344889A (en) 1990-05-01
IE893277L (en) 1990-04-13
CZ579789A3 (en) 1997-11-12
HU896048D0 (en) 1990-11-28
SG139553A1 (en) 2008-02-29
BG60555B1 (en) 1995-08-28
SK280845B6 (sk) 2000-08-14
DK144690A (da) 1990-06-13
YU48466B (sh) 1998-08-14
NZ230973A (en) 1993-03-26
IL91941A (en) 1994-10-21
EP0562643A3 (en) 1994-05-18
CZ283316B6 (cs) 1998-02-18
IE940109L (en) 1990-04-13
NO174623B (no) 1994-02-28
IE63477B1 (en) 1995-04-19
ES2060712T3 (es) 1994-12-01
JP2853227B2 (ja) 1999-02-03
ATE99281T1 (de) 1994-01-15
HK49496A (en) 1996-03-29
IL91941A0 (en) 1990-06-10

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