DK174986B1 - Anvendelse af purinderivater til fremstilling af et lægemiddel - Google Patents
Anvendelse af purinderivater til fremstilling af et lægemiddel Download PDFInfo
- Publication number
- DK174986B1 DK174986B1 DK199002649A DK264990A DK174986B1 DK 174986 B1 DK174986 B1 DK 174986B1 DK 199002649 A DK199002649 A DK 199002649A DK 264990 A DK264990 A DK 264990A DK 174986 B1 DK174986 B1 DK 174986B1
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxy
- amino
- compounds
- acid
- alkyl
- Prior art date
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- 239000003814 drug Substances 0.000 title claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 title abstract description 3
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title description 5
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 56
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 20
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 20
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- 150000002148 esters Chemical group 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 13
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
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- 125000005843 halogen group Chemical group 0.000 claims description 5
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- 238000012360 testing method Methods 0.000 description 6
- WERYXYBDKMZEQL-UHFFFAOYSA-N 1,4-butanediol Substances OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 5
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- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 description 1
- JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
- FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8801729 | 1988-05-06 | ||
SE8801729A SE8801729D0 (sv) | 1988-05-06 | 1988-05-06 | Purine derivatives for use in therapy |
SE8900255 | 1989-01-25 | ||
PCT/SE1989/000255 WO1989010923A1 (en) | 1988-05-06 | 1989-05-05 | Derivatives of purine, process for their preparation and a pharmaceutical preparation |
Publications (3)
Publication Number | Publication Date |
---|---|
DK264990A DK264990A (da) | 1990-11-05 |
DK264990D0 DK264990D0 (da) | 1990-11-05 |
DK174986B1 true DK174986B1 (da) | 2004-04-13 |
Family
ID=20372263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK199002649A DK174986B1 (da) | 1988-05-06 | 1990-11-05 | Anvendelse af purinderivater til fremstilling af et lægemiddel |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0343133B1 (ja) |
JP (1) | JP2866688B2 (ja) |
KR (1) | KR0141913B1 (ja) |
AT (1) | ATE74603T1 (ja) |
CA (1) | CA1340909C (ja) |
DE (1) | DE68901153D1 (ja) |
DK (1) | DK174986B1 (ja) |
ES (1) | ES2033548T3 (ja) |
FI (1) | FI98729C (ja) |
GR (1) | GR3004482T3 (ja) |
HU (1) | HU207082B (ja) |
IE (1) | IE62066B1 (ja) |
IL (1) | IL90166A (ja) |
MY (1) | MY108541A (ja) |
NZ (1) | NZ229002A (ja) |
PT (1) | PT90478B (ja) |
SE (1) | SE8801729D0 (ja) |
WO (1) | WO1989010923A1 (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8904855D0 (en) * | 1989-03-03 | 1989-04-12 | Beecham Group Plc | Pharmaceutical treatment |
US6346627B1 (en) * | 1990-02-01 | 2002-02-12 | Emory University | Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers |
EP0539487A1 (en) * | 1990-07-19 | 1993-05-05 | Beecham Group Plc | Antiviral phosphono-alken derivatives of purines |
GB9020932D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Heterocyclic compounds |
US5208221A (en) * | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
US5360714A (en) * | 1992-08-28 | 1994-11-01 | Fox Chase Cancer Center | Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof |
US5334525A (en) * | 1992-08-28 | 1994-08-02 | Fox Chase Cancer Center | Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof |
US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
JPH09506333A (ja) * | 1993-09-17 | 1997-06-24 | ギリアード サイエンシーズ,インコーポレイテッド | 治療化合物の投薬方法 |
US5656745A (en) * | 1993-09-17 | 1997-08-12 | Gilead Sciences, Inc. | Nucleotide analogs |
DE19540798A1 (de) * | 1995-11-02 | 1997-05-07 | Hoechst Ag | Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel |
US20030040467A1 (en) | 1998-06-15 | 2003-02-27 | Mary Ann Pelleymounter | Ig/ob fusions and uses thereof. |
US5717095A (en) * | 1995-12-29 | 1998-02-10 | Gilead Sciences, Inc. | Nucleotide analogs |
EP0874858A1 (en) * | 1995-12-29 | 1998-11-04 | Gilead Sciences, Inc. | Nucleotide analogs |
US6703394B2 (en) | 1996-02-16 | 2004-03-09 | Medivir Ab | Acyclic nucleoside derivatives |
US5869493A (en) * | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
JP2009298785A (ja) * | 1997-02-10 | 2009-12-24 | Medivir Ab | 非環状ヌクレオシド誘導体の合成 |
WO1998034917A2 (en) * | 1997-02-10 | 1998-08-13 | Medivir Ab | Synthesis of acyclic nucleoside derivatives |
US6184376B1 (en) | 1997-02-10 | 2001-02-06 | Mediver Ab | Synthesis of acyclic nucleoside derivatives |
US6753322B2 (en) | 2000-06-06 | 2004-06-22 | Pfizer Inc | 2-aminocarbonyl-9H-purine derivatives |
US7241890B2 (en) | 2001-10-30 | 2007-07-10 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
WO2005028434A2 (en) | 2003-09-18 | 2005-03-31 | Conforma Therapeutics Corporation | Novel heterocyclic compounds as hsp90-inhibitors |
MX2007011903A (es) | 2005-03-30 | 2007-12-05 | Conforma Therapeutics Corp | Alquinil pirrolopirimidinas y analogos relacionados como inhibidores de hsp90. |
US8580859B2 (en) | 2008-08-01 | 2013-11-12 | Bioxiness Pharmaceuticals, Inc. | Methionine analogs and methods of using same |
CN102250126A (zh) * | 2010-05-18 | 2011-11-23 | 北京化工大学 | 一种双嘌呤类衍生物及其合成 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK472683A (da) * | 1982-10-14 | 1984-04-15 | Wellcome Found | Fremgangsmaade til fremstilling af purinderivater |
CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
IL73682A (en) * | 1983-12-20 | 1991-08-16 | Medivir Ab | Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation |
SE8406538D0 (sv) * | 1984-12-21 | 1984-12-21 | Astra Laekemedel Ab | Novel derivatives of purine |
MY101126A (en) * | 1985-12-13 | 1991-07-31 | Beecham Group Plc | Novel compounds |
-
1988
- 1988-05-06 SE SE8801729A patent/SE8801729D0/xx unknown
-
1989
- 1989-05-03 IL IL9016689A patent/IL90166A/en active IP Right Grant
- 1989-05-04 NZ NZ229002A patent/NZ229002A/en unknown
- 1989-05-05 JP JP1505738A patent/JP2866688B2/ja not_active Expired - Fee Related
- 1989-05-05 AT AT89850146T patent/ATE74603T1/de not_active IP Right Cessation
- 1989-05-05 CA CA000598887A patent/CA1340909C/en not_active Expired - Fee Related
- 1989-05-05 DE DE8989850146T patent/DE68901153D1/de not_active Expired - Fee Related
- 1989-05-05 WO PCT/SE1989/000255 patent/WO1989010923A1/en active IP Right Grant
- 1989-05-05 MY MYPI89000618A patent/MY108541A/en unknown
- 1989-05-05 ES ES198989850146T patent/ES2033548T3/es not_active Expired - Lifetime
- 1989-05-05 HU HU893004A patent/HU207082B/hu not_active IP Right Cessation
- 1989-05-05 IE IE147289A patent/IE62066B1/en not_active IP Right Cessation
- 1989-05-05 EP EP89850146A patent/EP0343133B1/en not_active Expired - Lifetime
- 1989-05-15 PT PT90478A patent/PT90478B/pt not_active IP Right Cessation
-
1990
- 1990-01-06 KR KR90700035A patent/KR0141913B1/ko not_active IP Right Cessation
- 1990-11-05 FI FI905475A patent/FI98729C/fi active IP Right Grant
- 1990-11-05 DK DK199002649A patent/DK174986B1/da not_active IP Right Cessation
-
1992
- 1992-05-05 GR GR920400840T patent/GR3004482T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
HU893004D0 (en) | 1991-09-30 |
WO1989010923A1 (en) | 1989-11-16 |
DE68901153D1 (de) | 1992-05-14 |
CA1340909C (en) | 2000-02-22 |
IL90166A (en) | 1996-09-12 |
IL90166A0 (en) | 1989-12-15 |
PT90478A (pt) | 1989-11-30 |
AU626300B2 (en) | 1992-07-30 |
FI905475A0 (fi) | 1990-11-05 |
HU207082B (en) | 1993-03-01 |
HUT57767A (en) | 1991-12-30 |
SE8801729D0 (sv) | 1988-05-06 |
EP0343133A1 (en) | 1989-11-23 |
GR3004482T3 (ja) | 1993-03-31 |
FI98729C (fi) | 1997-08-11 |
ATE74603T1 (de) | 1992-04-15 |
NZ229002A (en) | 1997-05-26 |
DK264990A (da) | 1990-11-05 |
IE891472L (en) | 1989-11-06 |
ES2033548T3 (es) | 1993-03-16 |
MY108541A (en) | 1996-10-31 |
DK264990D0 (da) | 1990-11-05 |
KR0141913B1 (en) | 1998-06-01 |
PT90478B (pt) | 1994-08-31 |
JPH03504243A (ja) | 1991-09-19 |
EP0343133B1 (en) | 1992-04-08 |
AU3572689A (en) | 1989-11-29 |
JP2866688B2 (ja) | 1999-03-08 |
IE62066B1 (en) | 1994-12-14 |
FI98729B (fi) | 1997-04-30 |
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