SE8801729D0 - Purine derivatives for use in therapy - Google Patents
Purine derivatives for use in therapyInfo
- Publication number
- SE8801729D0 SE8801729D0 SE8801729A SE8801729A SE8801729D0 SE 8801729 D0 SE8801729 D0 SE 8801729D0 SE 8801729 A SE8801729 A SE 8801729A SE 8801729 A SE8801729 A SE 8801729A SE 8801729 D0 SE8801729 D0 SE 8801729D0
- Authority
- SE
- Sweden
- Prior art keywords
- hydroxy
- amino
- hydrogen
- compounds
- chem
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 150000003212 purines Chemical class 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- -1 hydroxy, mercapto Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8801729A SE8801729D0 (sv) | 1988-05-06 | 1988-05-06 | Purine derivatives for use in therapy |
IL9016689A IL90166A (en) | 1988-05-06 | 1989-05-03 | Antiretroviral drug preparations containing a history of 9-) 2,4-Butyl di-converted (H 9-Purine such new compounds and their preparation |
NZ229002A NZ229002A (en) | 1988-05-06 | 1989-05-04 | Purine derivatives and antiviral compositions |
JP1505738A JP2866688B2 (ja) | 1988-05-06 | 1989-05-05 | プリン誘導体を含有する抗ウィルス剤 |
DE8989850146T DE68901153D1 (de) | 1988-05-06 | 1989-05-05 | Derivate von purin, verfahren zu ihrer herstellung und pharmazeutische zubereitung. |
PCT/SE1989/000255 WO1989010923A1 (en) | 1988-05-06 | 1989-05-05 | Derivatives of purine, process for their preparation and a pharmaceutical preparation |
CA000598887A CA1340909C (en) | 1988-05-06 | 1989-05-05 | Purine derivatives and use thereof in therapy |
ES198989850146T ES2033548T3 (es) | 1988-05-06 | 1989-05-05 | Procedimiento para la preparacion de derivados de purina. |
AT89850146T ATE74603T1 (de) | 1988-05-06 | 1989-05-05 | Derivate von purin, verfahren zu ihrer herstellung und pharmazeutische zubereitung. |
MYPI89000618A MY108541A (en) | 1988-05-06 | 1989-05-05 | Purine derivatives and use thereof in therapy. |
HU893004A HU207082B (en) | 1988-05-06 | 1989-05-05 | Process for producing purine derivatives and pharmaceutical compositions comprising same |
EP89850146A EP0343133B1 (en) | 1988-05-06 | 1989-05-05 | Derivatives of purine, process for their preparation and a pharmaceutical preparation |
IE147289A IE62066B1 (en) | 1988-05-06 | 1989-05-05 | Purine derivatives and use thereof in therapy |
AU35726/89A AU626300C (en) | 1988-05-06 | 1989-05-05 | Derivatives of purine, process for their preparation and a pharmaceutical preparation |
US07/601,693 US5284837A (en) | 1988-05-06 | 1989-05-05 | Derivatives of purine, process for their preparation and a pharmaceutical preparation |
PT90478A PT90478B (pt) | 1988-05-06 | 1989-05-15 | Processo para a preparacao de derivados da purina e de composicoes farmaceuticas que os contem |
KR90700035A KR0141913B1 (en) | 1988-05-06 | 1990-01-06 | Anti-virus agents |
NO904798A NO177306C (no) | 1988-05-06 | 1990-11-05 | Analogifremgangsmåte for fremstilling av terapautisk aktive purinderivater |
DK199002649A DK174986B1 (da) | 1988-05-06 | 1990-11-05 | Anvendelse af purinderivater til fremstilling af et lægemiddel |
FI905475A FI98729C (fi) | 1988-05-06 | 1990-11-05 | Menetelmä farmaseuttisesti vaikuttavan puriinijohdannaisen valmistamiseksi |
PH43233A PH27516A (en) | 1988-05-06 | 1991-10-02 | Purine derivatives and use thereof in therapy |
GR920400840T GR3004482T3 (xx) | 1988-05-06 | 1992-05-05 | |
US08/416,539 US5565461A (en) | 1988-05-06 | 1995-04-03 | Derivatives of purine, process for their preparation and a pharmaceutical preparation |
US08/476,348 US5656617A (en) | 1988-05-06 | 1995-06-07 | Derivatives of purine, process for their preparation and a pharmaceutical preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8801729A SE8801729D0 (sv) | 1988-05-06 | 1988-05-06 | Purine derivatives for use in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
SE8801729D0 true SE8801729D0 (sv) | 1988-05-06 |
Family
ID=20372263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8801729A SE8801729D0 (sv) | 1988-05-06 | 1988-05-06 | Purine derivatives for use in therapy |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0343133B1 (xx) |
JP (1) | JP2866688B2 (xx) |
KR (1) | KR0141913B1 (xx) |
AT (1) | ATE74603T1 (xx) |
CA (1) | CA1340909C (xx) |
DE (1) | DE68901153D1 (xx) |
DK (1) | DK174986B1 (xx) |
ES (1) | ES2033548T3 (xx) |
FI (1) | FI98729C (xx) |
GR (1) | GR3004482T3 (xx) |
HU (1) | HU207082B (xx) |
IE (1) | IE62066B1 (xx) |
IL (1) | IL90166A (xx) |
MY (1) | MY108541A (xx) |
NZ (1) | NZ229002A (xx) |
PT (1) | PT90478B (xx) |
SE (1) | SE8801729D0 (xx) |
WO (1) | WO1989010923A1 (xx) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8904855D0 (en) * | 1989-03-03 | 1989-04-12 | Beecham Group Plc | Pharmaceutical treatment |
US6069252A (en) * | 1990-02-01 | 2000-05-30 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers |
WO1992001698A1 (en) * | 1990-07-19 | 1992-02-06 | Beecham Group Plc | Antiviral phosphono-alken derivatives of purines |
GB9020932D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Heterocyclic compounds |
US5208221A (en) * | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
US5334525A (en) * | 1992-08-28 | 1994-08-02 | Fox Chase Cancer Center | Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof |
US5360714A (en) * | 1992-08-28 | 1994-11-01 | Fox Chase Cancer Center | Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof |
US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
CA2171868A1 (en) * | 1993-09-17 | 1995-03-23 | Petr Alexander | Method for dosing therapeutic compounds |
US5656745A (en) * | 1993-09-17 | 1997-08-12 | Gilead Sciences, Inc. | Nucleotide analogs |
DE19540798A1 (de) * | 1995-11-02 | 1997-05-07 | Hoechst Ag | Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel |
US20030040467A1 (en) | 1998-06-15 | 2003-02-27 | Mary Ann Pelleymounter | Ig/ob fusions and uses thereof. |
US5717095A (en) * | 1995-12-29 | 1998-02-10 | Gilead Sciences, Inc. | Nucleotide analogs |
AU1427097A (en) * | 1995-12-29 | 1997-07-28 | Gilead Sciences, Inc. | Nucleotide analogs |
US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
US6703394B2 (en) | 1996-02-16 | 2004-03-09 | Medivir Ab | Acyclic nucleoside derivatives |
US6184376B1 (en) | 1997-02-10 | 2001-02-06 | Mediver Ab | Synthesis of acyclic nucleoside derivatives |
ATE227289T1 (de) * | 1997-02-10 | 2002-11-15 | Medivir Ab | Verfahren zur herstellung von azyklischen nukleosiden |
JP2009298785A (ja) * | 1997-02-10 | 2009-12-24 | Medivir Ab | 非環状ヌクレオシド誘導体の合成 |
US6753322B2 (en) | 2000-06-06 | 2004-06-22 | Pfizer Inc | 2-aminocarbonyl-9H-purine derivatives |
AU2002343604C1 (en) | 2001-10-30 | 2009-09-17 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
NZ546611A (en) | 2003-09-18 | 2010-02-26 | Conforma Therapeutics Corp | Novel heterocyclic compounds as HSP90-inhibitors |
WO2006105372A2 (en) | 2005-03-30 | 2006-10-05 | Conforma Therapeutics Corporation | Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors |
JP5650642B2 (ja) | 2008-08-01 | 2015-01-07 | バイオキシネス ファーマシューティカルズ, インコーポレイテッド | メチオニンアナログおよびそれらを使用する方法 |
CN102250126A (zh) * | 2010-05-18 | 2011-11-23 | 北京化工大学 | 一种双嘌呤类衍生物及其合成 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO161116C (no) * | 1982-10-14 | 1989-07-05 | Wellcome Found | Analogifremgangsmaate for fremstilling av antiviralt virksomme purinderivater. |
CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
IL73682A (en) * | 1983-12-20 | 1991-08-16 | Medivir Ab | Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation |
SE8406538D0 (sv) * | 1984-12-21 | 1984-12-21 | Astra Laekemedel Ab | Novel derivatives of purine |
MY101126A (en) * | 1985-12-13 | 1991-07-31 | Beecham Group Plc | Novel compounds |
-
1988
- 1988-05-06 SE SE8801729A patent/SE8801729D0/xx unknown
-
1989
- 1989-05-03 IL IL9016689A patent/IL90166A/en active IP Right Grant
- 1989-05-04 NZ NZ229002A patent/NZ229002A/en unknown
- 1989-05-05 JP JP1505738A patent/JP2866688B2/ja not_active Expired - Fee Related
- 1989-05-05 HU HU893004A patent/HU207082B/hu not_active IP Right Cessation
- 1989-05-05 IE IE147289A patent/IE62066B1/en not_active IP Right Cessation
- 1989-05-05 MY MYPI89000618A patent/MY108541A/en unknown
- 1989-05-05 WO PCT/SE1989/000255 patent/WO1989010923A1/en active IP Right Grant
- 1989-05-05 EP EP89850146A patent/EP0343133B1/en not_active Expired - Lifetime
- 1989-05-05 AT AT89850146T patent/ATE74603T1/de not_active IP Right Cessation
- 1989-05-05 DE DE8989850146T patent/DE68901153D1/de not_active Expired - Fee Related
- 1989-05-05 CA CA000598887A patent/CA1340909C/en not_active Expired - Fee Related
- 1989-05-05 ES ES198989850146T patent/ES2033548T3/es not_active Expired - Lifetime
- 1989-05-15 PT PT90478A patent/PT90478B/pt not_active IP Right Cessation
-
1990
- 1990-01-06 KR KR90700035A patent/KR0141913B1/ko not_active IP Right Cessation
- 1990-11-05 FI FI905475A patent/FI98729C/fi active IP Right Grant
- 1990-11-05 DK DK199002649A patent/DK174986B1/da not_active IP Right Cessation
-
1992
- 1992-05-05 GR GR920400840T patent/GR3004482T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL90166A (en) | 1996-09-12 |
FI905475A0 (fi) | 1990-11-05 |
DE68901153D1 (de) | 1992-05-14 |
MY108541A (en) | 1996-10-31 |
HUT57767A (en) | 1991-12-30 |
PT90478B (pt) | 1994-08-31 |
DK264990D0 (da) | 1990-11-05 |
FI98729C (fi) | 1997-08-11 |
IE891472L (en) | 1989-11-06 |
FI98729B (fi) | 1997-04-30 |
GR3004482T3 (xx) | 1993-03-31 |
JPH03504243A (ja) | 1991-09-19 |
DK174986B1 (da) | 2004-04-13 |
JP2866688B2 (ja) | 1999-03-08 |
IL90166A0 (en) | 1989-12-15 |
EP0343133A1 (en) | 1989-11-23 |
HU893004D0 (en) | 1991-09-30 |
HU207082B (en) | 1993-03-01 |
DK264990A (da) | 1990-11-05 |
IE62066B1 (en) | 1994-12-14 |
PT90478A (pt) | 1989-11-30 |
CA1340909C (en) | 2000-02-22 |
ATE74603T1 (de) | 1992-04-15 |
KR0141913B1 (en) | 1998-06-01 |
AU3572689A (en) | 1989-11-29 |
NZ229002A (en) | 1997-05-26 |
AU626300B2 (en) | 1992-07-30 |
ES2033548T3 (es) | 1993-03-16 |
EP0343133B1 (en) | 1992-04-08 |
WO1989010923A1 (en) | 1989-11-16 |
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