DK174949B1 - Formuleringer med forlænget frigivelse og deres fremstilling - Google Patents

Formuleringer med forlænget frigivelse og deres fremstilling Download PDF

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Publication number
DK174949B1
DK174949B1 DK198802463A DK246388A DK174949B1 DK 174949 B1 DK174949 B1 DK 174949B1 DK 198802463 A DK198802463 A DK 198802463A DK 246388 A DK246388 A DK 246388A DK 174949 B1 DK174949 B1 DK 174949B1
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DK
Denmark
Prior art keywords
active substance
weight
coating membrane
stearic acid
amount
Prior art date
Application number
DK198802463A
Other languages
Danish (da)
English (en)
Other versions
DK246388D0 (da
DK246388A (da
Inventor
Roberto Valducci
Original Assignee
Roberto Valducci
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roberto Valducci filed Critical Roberto Valducci
Publication of DK246388D0 publication Critical patent/DK246388D0/da
Publication of DK246388A publication Critical patent/DK246388A/da
Application granted granted Critical
Publication of DK174949B1 publication Critical patent/DK174949B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Laminated Bodies (AREA)
  • Pens And Brushes (AREA)
  • External Artificial Organs (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Silicon Polymers (AREA)
  • Color Television Systems (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Prostheses (AREA)
  • Paints Or Removers (AREA)
DK198802463A 1986-09-30 1988-05-06 Formuleringer med forlænget frigivelse og deres fremstilling DK174949B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT03530/86A IT1200217B (it) 1986-09-30 1986-09-30 Membrana per uso farmaceutico ed industriale
IT353086 1986-09-30
IT8700085 1987-09-29
PCT/IT1987/000085 WO1988002253A1 (en) 1986-09-30 1987-09-29 Coating membrane and compositions prepared therefrom

Publications (3)

Publication Number Publication Date
DK246388D0 DK246388D0 (da) 1988-05-06
DK246388A DK246388A (da) 1988-05-26
DK174949B1 true DK174949B1 (da) 2004-03-22

Family

ID=11109126

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198802463A DK174949B1 (da) 1986-09-30 1988-05-06 Formuleringer med forlænget frigivelse og deres fremstilling

Country Status (18)

Country Link
US (1) US5149542A (hu)
EP (1) EP0263083B1 (hu)
JP (1) JP2518882B2 (hu)
KR (1) KR880701542A (hu)
CN (1) CN1062444C (hu)
AT (1) ATE90871T1 (hu)
AU (1) AU602931B2 (hu)
CA (1) CA1313132C (hu)
DE (1) DE3786316T2 (hu)
DK (1) DK174949B1 (hu)
ES (1) ES2056837T3 (hu)
FI (1) FI882524A (hu)
HU (1) HU201684B (hu)
IT (1) IT1200217B (hu)
NZ (1) NZ221987A (hu)
PT (1) PT85819B (hu)
WO (1) WO1988002253A1 (hu)
ZA (1) ZA877316B (hu)

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IT1197316B (it) * 1986-10-01 1988-11-30 Proter Spa Formulazione galenica ad uso orale di derivati della reina a lento rilascio per impiego terapeutico
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DE3922167A1 (de) * 1988-04-16 1991-01-17 Sanol Arznei Schwarz Gmbh Oral zu verabreichende diltiazemhydrochlorid enthaltende pharmazeutische zubereitung zur einmal taeglichen applikation und verfahren zu deren herstellung
US5344657A (en) * 1988-04-27 1994-09-06 Elf Sanofi Microbeads of diltiazem, a process for their manufacture and a substained-release pharmaceutical composition containing them
DE3822095A1 (de) * 1988-06-30 1990-01-04 Klinge Co Chem Pharm Fab Neue arzneimittelformulierung sowie verfahren zu deren herstellung
IT1226940B (it) * 1988-09-16 1991-02-22 Recordati Chem Pharm Sistema terapeutico a rilascio controllato per formulazioni farmaceutiche liquide
US5296236A (en) * 1988-09-16 1994-03-22 Recordati S.A., Chemical And Pharmaceutical Company Controlled release therapeutic system for a liquid pharmaceutical formulations
US4956182A (en) * 1989-03-16 1990-09-11 Bristol-Myers Company Direct compression cholestyramine tablet and solvent-free coating therefor
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US4966770A (en) * 1989-07-26 1990-10-30 Himedics, Inc. Prednisone microencapsulated granules
WO1992001446A1 (en) * 1990-07-20 1992-02-06 Aps Research Limited Sustained-release formulations
DE4031881C2 (de) * 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung
US5286497A (en) * 1991-05-20 1994-02-15 Carderm Capital L.P. Diltiazem formulation
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GB2258613B (en) * 1991-08-12 1996-01-10 Euro Celtique Sa Pharmaceutical diltiazem formulation
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US5834024A (en) 1995-01-05 1998-11-10 Fh Faulding & Co. Limited Controlled absorption diltiazem pharmaceutical formulation
US5567441A (en) * 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
KR100417746B1 (ko) 1995-07-21 2004-05-31 다이이찌 세이야꾸 가부시기가이샤 입상제제의제조방법
FR2742660B1 (fr) * 1995-12-22 1998-04-03 Ethypharm Lab Prod Ethiques Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US5830503A (en) * 1996-06-21 1998-11-03 Andrx Pharmaceuticals, Inc. Enteric coated diltiazem once-a-day formulation
NZ334914A (en) * 1996-10-01 2000-09-29 Stanford Res Inst Int Taste-masked microcapsule compositions and methods of manufacture using a phase seperation-coacervation technique
KR100522248B1 (ko) * 1997-05-29 2006-02-01 동아제약주식회사 이중제어방출막구조의경구서방성제제및그제조방법
CA2261787C (en) * 1997-05-30 2006-11-14 Laboratorios Phoenix U.S.A., Inc. Multi-layered osmotic device
US6197347B1 (en) * 1998-06-29 2001-03-06 Andrx Pharmaceuticals, Inc. Oral dosage for the controlled release of analgesic
US6524620B2 (en) 1998-07-20 2003-02-25 Andrx Pharmaceuticals, Inc. Diltiazem controlled release formulation and method of manufacture
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AU6228799A (en) 1998-10-26 2000-05-15 Tanabe Seiyaku Co., Ltd. Sustained-release particles
JP2000198747A (ja) * 1998-10-26 2000-07-18 Tanabe Seiyaku Co Ltd 徐放性粒子
FR2795962B1 (fr) * 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
US20060153914A1 (en) * 1999-12-10 2006-07-13 Biovail Laboratories International S.R.L. Chronotherapeutic diltiazem formulations and the administration thereof
US7108866B1 (en) 1999-12-10 2006-09-19 Biovall Laboratories International Srl Chronotherapeutic diltiazem formulations and the administration thereof
US6635277B2 (en) 2000-04-12 2003-10-21 Wockhardt Limited Composition for pulsatile delivery of diltiazem and process of manufacture
DE60128215T2 (de) 2000-04-20 2008-01-10 Novartis Ag Beschichtungszusammensetzung zur geschmacksmaskierung
IL136899A0 (en) * 2000-06-20 2001-06-14 Caretec Ltd Microcapsules containing arginine and the different uses thereof
KR100411195B1 (ko) * 2000-09-26 2003-12-18 한국화학연구원 케토롤락 트로메타민이 함유된 서방형 펠렛
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US6592901B2 (en) * 2001-10-15 2003-07-15 Hercules Incorporated Highly compressible ethylcellulose for tableting
ATE407674T1 (de) 2002-04-09 2008-09-15 Flamel Tech Sa Orale pharmazeutische formulierung in form einer wässrigen suspension von mikrokapseln zur modifizierten freisetzung von amoxicillin
ATE419840T1 (de) 2002-04-09 2009-01-15 Flamel Tech Sa Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
JP4779970B2 (ja) 2004-06-03 2011-09-28 大正製薬株式会社 経口製剤およびその製造方法
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
AU2005299490C1 (en) 2004-10-21 2012-01-19 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
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Also Published As

Publication number Publication date
EP0263083A1 (en) 1988-04-06
CA1313132C (en) 1993-01-26
DE3786316T2 (de) 1993-10-28
CN1062444C (zh) 2001-02-28
FI882524A0 (fi) 1988-05-27
JPH01500998A (ja) 1989-04-06
PT85819A (en) 1987-10-01
PT85819B (pt) 1990-08-31
EP0263083B1 (en) 1993-06-23
JP2518882B2 (ja) 1996-07-31
DK246388D0 (da) 1988-05-06
WO1988002253A1 (en) 1988-04-07
CN87107792A (zh) 1988-06-29
ZA877316B (en) 1988-06-29
ATE90871T1 (de) 1993-07-15
HUT49815A (en) 1989-11-28
AU602931B2 (en) 1990-11-01
AU8025987A (en) 1988-04-21
IT8603530A0 (it) 1986-09-30
US5149542A (en) 1992-09-22
KR880701542A (ko) 1988-11-03
NZ221987A (en) 1990-07-26
HU201684B (en) 1990-12-28
DE3786316D1 (de) 1993-07-29
DK246388A (da) 1988-05-26
ES2056837T3 (es) 1994-10-16
IT1200217B (it) 1989-01-05
FI882524A (fi) 1988-05-27

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