DK172753B1 - N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat - Google Patents

N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat Download PDF

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Publication number
DK172753B1
DK172753B1 DK198902152A DK215289A DK172753B1 DK 172753 B1 DK172753 B1 DK 172753B1 DK 198902152 A DK198902152 A DK 198902152A DK 215289 A DK215289 A DK 215289A DK 172753 B1 DK172753 B1 DK 172753B1
Authority
DK
Denmark
Prior art keywords
pyrimidin
glutamic acid
tetrahydropyrido
hydroxy
amino
Prior art date
Application number
DK198902152A
Other languages
Danish (da)
English (en)
Other versions
DK215289A (da
DK215289D0 (da
Inventor
Chuan Shih
Edward C Taylor
Original Assignee
Lilly Co Eli
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/198,207 external-priority patent/US4882334A/en
Priority claimed from US07/198,201 external-priority patent/US4882333A/en
Application filed by Lilly Co Eli, Univ Princeton filed Critical Lilly Co Eli
Publication of DK215289D0 publication Critical patent/DK215289D0/da
Publication of DK215289A publication Critical patent/DK215289A/da
Application granted granted Critical
Publication of DK172753B1 publication Critical patent/DK172753B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK198902152A 1988-05-25 1989-05-02 N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat DK172753B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19820788 1988-05-25
US07/198,207 US4882334A (en) 1988-05-25 1988-05-25 N-(5,6,7,8-tetrahydropyrido]2,3-d]pyrimidin-6-ylethl-thineyl-and furylcarbonyl)-glutamic acid derivatives
US07/198,201 US4882333A (en) 1988-05-25 1988-05-25 N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
US19820188 1988-05-25

Publications (3)

Publication Number Publication Date
DK215289D0 DK215289D0 (da) 1989-05-02
DK215289A DK215289A (da) 1989-11-26
DK172753B1 true DK172753B1 (da) 1999-06-28

Family

ID=26893557

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198902152A DK172753B1 (da) 1988-05-25 1989-05-02 N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat

Country Status (18)

Country Link
EP (1) EP0343801B1 (zh)
JP (1) JP2818198B2 (zh)
KR (1) KR0131589B1 (zh)
CN (1) CN1025334C (zh)
AT (1) ATE109480T1 (zh)
AU (1) AU611027B2 (zh)
CA (1) CA1340631C (zh)
CY (1) CY2055B1 (zh)
DE (1) DE68917211T2 (zh)
DK (1) DK172753B1 (zh)
ES (1) ES2057116T3 (zh)
HK (1) HK1000284A1 (zh)
HU (1) HU205356B (zh)
IE (1) IE63620B1 (zh)
IL (1) IL90179A (zh)
NZ (1) NZ229242A (zh)
PT (1) PT90635B (zh)
RU (1) RU2002747C1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
CZ66893A3 (en) * 1992-04-23 1993-12-15 Lilly Co Eli Application of gar - transformylase inhibitor
US5608082A (en) * 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
ATE212632T1 (de) * 1995-09-08 2002-02-15 Univ Princeton Nicht-klassische antifolate
EP0904271A4 (en) * 1996-05-01 2002-01-23 Univ Princeton 5,6,7,8-tetrahydropyrido [2,3-d] PYRIMIDINE
HUP0100869A3 (en) 1998-02-11 2002-12-28 Lilly Co Eli Processes and intermediates useful to make antifolates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
IE60038B1 (en) * 1986-06-30 1994-05-18 Univ Princeton 4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives

Also Published As

Publication number Publication date
IE63620B1 (en) 1995-05-17
HU205356B (en) 1992-04-28
EP0343801A2 (en) 1989-11-29
HK1000284A1 (en) 1998-02-20
PT90635A (pt) 1989-11-30
DE68917211T2 (de) 1994-11-24
CA1340631C (en) 1999-07-06
PT90635B (pt) 1994-10-31
IE891767L (en) 1989-11-25
RU2002747C1 (ru) 1993-11-15
JP2818198B2 (ja) 1998-10-30
ATE109480T1 (de) 1994-08-15
DK215289A (da) 1989-11-26
KR900018100A (ko) 1990-12-20
ES2057116T3 (es) 1994-10-16
KR0131589B1 (ko) 1998-04-17
IL90179A (en) 1994-02-27
EP0343801A3 (en) 1991-05-02
CY2055B1 (en) 1998-06-12
AU611027B2 (en) 1991-05-30
JPH0267281A (ja) 1990-03-07
AU3510989A (en) 1989-11-30
IL90179A0 (en) 1989-12-15
CN1038098A (zh) 1989-12-20
DE68917211D1 (de) 1994-09-08
HUT50342A (en) 1990-01-29
DK215289D0 (da) 1989-05-02
EP0343801B1 (en) 1994-08-03
NZ229242A (en) 1990-10-26
CN1025334C (zh) 1994-07-06

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed