DK170840B1 - Tricycliske lactamer indeholdende en benzazepingruppe, lægemiddel indeholdende sådanne lactamer samt anvendelse deraf til fremstilling af et lægemiddel til behandling af hypertension - Google Patents

Tricycliske lactamer indeholdende en benzazepingruppe, lægemiddel indeholdende sådanne lactamer samt anvendelse deraf til fremstilling af et lægemiddel til behandling af hypertension Download PDF

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Publication number
DK170840B1
DK170840B1 DK300487A DK300487A DK170840B1 DK 170840 B1 DK170840 B1 DK 170840B1 DK 300487 A DK300487 A DK 300487A DK 300487 A DK300487 A DK 300487A DK 170840 B1 DK170840 B1 DK 170840B1
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Prior art keywords
acid
mmol
solution
lactams
formula
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DK300487A
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Danish (da)
English (en)
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DK300487D0 (da
DK300487A (da
Inventor
Gary A Flynn
Douglas W Beight
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Merrell Dow Pharma
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Publication of DK300487D0 publication Critical patent/DK300487D0/da
Publication of DK300487A publication Critical patent/DK300487A/da
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Publication of DK170840B1 publication Critical patent/DK170840B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
DK300487A 1986-06-13 1987-06-12 Tricycliske lactamer indeholdende en benzazepingruppe, lægemiddel indeholdende sådanne lactamer samt anvendelse deraf til fremstilling af et lægemiddel til behandling af hypertension DK170840B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87375486A 1986-06-13 1986-06-13
US87375486 1986-06-13
AT0269187A AT398425B (de) 1986-06-13 1987-10-12 Neue tricyclische lactame
AT269187 1987-10-12

Publications (3)

Publication Number Publication Date
DK300487D0 DK300487D0 (da) 1987-06-12
DK300487A DK300487A (da) 1987-12-14
DK170840B1 true DK170840B1 (da) 1996-02-05

Family

ID=25598925

Family Applications (1)

Application Number Title Priority Date Filing Date
DK300487A DK170840B1 (da) 1986-06-13 1987-06-12 Tricycliske lactamer indeholdende en benzazepingruppe, lægemiddel indeholdende sådanne lactamer samt anvendelse deraf til fremstilling af et lægemiddel til behandling af hypertension

Country Status (12)

Country Link
EP (1) EP0249223B1 (ja)
JP (1) JP2542213B2 (ja)
KR (1) KR950014572B1 (ja)
AR (1) AR247213A1 (ja)
AT (1) AT398425B (ja)
AU (1) AU601433B2 (ja)
CA (1) CA1337654C (ja)
DK (1) DK170840B1 (ja)
ES (1) ES2044870T3 (ja)
GR (1) GR3006802T3 (ja)
IE (1) IE61476B1 (ja)
ZA (1) ZA874107B (ja)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
NZ241023A (en) * 1990-12-21 1994-10-26 Merrell Dow Pharma Condensed benzazepine derivatives and pharmaceutical compositions
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
ES2106112T3 (es) * 1991-09-27 1997-11-01 Merrell Pharma Inc Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace.
ZA927211B (en) * 1991-09-27 1993-03-24 Merrell Dow Pharma Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
ES2117123T3 (es) * 1992-02-14 1998-08-01 Merrell Pharma Inc Derivados de aminocetilmercaptoacetilamida utilizados como inhibidores de la encefalinasa y del enzima de conversion de angiotensina.
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5646276A (en) * 1992-05-13 1997-07-08 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
NZ251930A (en) * 1992-05-15 1996-02-27 Merrell Dow Pharma Mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2-a]diazepine and pyrazolo[1,2-a]diazepine derivatives, pharmaceutical compositions and preparatory methods
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
DE69329701T2 (de) * 1992-10-30 2001-05-10 Merrell Pharma Inc Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace-hemmer
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
ES2112034T3 (es) * 1993-11-19 1998-03-16 Merrell Pharma Inc Nuevo procedimiento de preparacion del ester de metilo del acido (s)-1-(2(s)-(1,3-dihidro-1,3-dioxo-isoindol-2-il)-1-oxo-3-fenilpropil)-1,2,3,4-tetrahidro-2-piridino-carboxilico e intermediarios de este compuesto.
JPH09508906A (ja) * 1994-02-14 1997-09-09 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
EP0746566A1 (en) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
JP3596778B2 (ja) * 1994-02-14 2004-12-02 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
HUT75160A (en) * 1994-03-24 1997-04-28 Merrell Pharma Inc Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
CN1144482A (zh) * 1994-03-24 1997-03-05 默里尔药物公司 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物
ATE266040T1 (de) * 1994-12-21 2004-05-15 Aventis Pharma Inc Verfahren zur herstellung von zwischenprodukten von inhibitoren von enkephalinase und angiotensin konvertierendem enzym und zwischenprodukte davon
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES2044870T3 (es) 1994-01-16
IE61476B1 (en) 1994-11-02
AR247213A1 (es) 1994-11-30
AU601433B2 (en) 1990-09-13
GR3006802T3 (ja) 1993-06-30
ATA269187A (de) 1994-04-15
EP0249223A2 (en) 1987-12-16
EP0249223B1 (en) 1992-10-14
ZA874107B (ja) 1987-12-09
KR880000399A (ko) 1988-03-25
EP0249223A3 (en) 1989-01-25
AT398425B (de) 1994-12-27
CA1337654C (en) 1995-11-28
AU7402287A (en) 1987-12-17
JPS62298591A (ja) 1987-12-25
JP2542213B2 (ja) 1996-10-09
DK300487D0 (da) 1987-06-12
KR950014572B1 (ko) 1995-12-08
DK300487A (da) 1987-12-14
IE871547L (en) 1987-12-13

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired