DK300487A - Lactamer med antihypertensiv virkning samt fremgangsmaader til deres fremstilling - Google Patents
Lactamer med antihypertensiv virkning samt fremgangsmaader til deres fremstillingInfo
- Publication number
- DK300487A DK300487A DK300487A DK300487A DK300487A DK 300487 A DK300487 A DK 300487A DK 300487 A DK300487 A DK 300487A DK 300487 A DK300487 A DK 300487A DK 300487 A DK300487 A DK 300487A
- Authority
- DK
- Denmark
- Prior art keywords
- lactames
- procedures
- preparation
- hypertensive effect
- hypertensive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87375486A | 1986-06-13 | 1986-06-13 | |
US87375486 | 1986-06-13 | ||
AT269187 | 1987-10-12 | ||
AT0269187A AT398425B (de) | 1986-06-13 | 1987-10-12 | Neue tricyclische lactame |
Publications (3)
Publication Number | Publication Date |
---|---|
DK300487D0 DK300487D0 (da) | 1987-06-12 |
DK300487A true DK300487A (da) | 1987-12-14 |
DK170840B1 DK170840B1 (da) | 1996-02-05 |
Family
ID=25598925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK300487A DK170840B1 (da) | 1986-06-13 | 1987-06-12 | Tricycliske lactamer indeholdende en benzazepingruppe, lægemiddel indeholdende sådanne lactamer samt anvendelse deraf til fremstilling af et lægemiddel til behandling af hypertension |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0249223B1 (da) |
JP (1) | JP2542213B2 (da) |
KR (1) | KR950014572B1 (da) |
AR (1) | AR247213A1 (da) |
AT (1) | AT398425B (da) |
AU (1) | AU601433B2 (da) |
CA (1) | CA1337654C (da) |
DK (1) | DK170840B1 (da) |
ES (1) | ES2044870T3 (da) |
GR (1) | GR3006802T3 (da) |
IE (1) | IE61476B1 (da) |
ZA (1) | ZA874107B (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
EP0492369B1 (en) * | 1990-12-21 | 1997-09-17 | Merrell Pharmaceuticals Inc. | Novel amino and nitro containing tricyclic compounds useful as inhibitors of ace |
US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
CA2078759C (en) * | 1991-09-27 | 2003-09-16 | Alan M. Warshawsky | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace |
AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
DE69220744T2 (de) * | 1991-09-27 | 1997-11-13 | Merrell Pharma Inc | 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung |
ATE164593T1 (de) * | 1992-02-14 | 1998-04-15 | Merrell Pharma Inc | Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung |
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
AU669364B2 (en) * | 1992-05-15 | 1996-06-06 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamido pyridazo(1,2)pyridazine, pyrazolo(1,2)pyridazine, pyridazo(1,2-a)(1,2)diazepine and pyrazolo(1,2-a)(1,2)diazepine derivatives useful as inhibitors of enkephalinase and ace |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
ES2155852T3 (es) * | 1992-10-30 | 2001-06-01 | Merrell Pharma Inc | Derivados de lactama biciclica de mercaptoacetilamida utiles como inhibidores de encefalinasa y eca. |
US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
WO1995014663A2 (en) * | 1993-11-19 | 1995-06-01 | Merrell Pharmaceuticals Inc. | Novel process for preparing (s)-1-[2(s)-(1,3-dihydro-1,3-dioxo-isoindo-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester and intermediates thereof |
CN1142831A (zh) * | 1994-02-14 | 1997-02-12 | 默里尔药物公司 | 用作脑啡肽酶和ace抑制剂的新的2-取代的1,2-二氢化茚-2-巯基乙酰胺二硫化物衍生物 |
JP3596778B2 (ja) * | 1994-02-14 | 2004-12-02 | メレル ファーマスーティカルズ インコーポレーテッド | エンケファリナーゼ及びaceの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類 |
HUT74584A (en) * | 1994-02-14 | 1997-01-28 | Merrell Pharma Inc | Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them |
ATE191485T1 (de) * | 1994-02-14 | 2000-04-15 | Merrell Pharma Inc | Mercaptoacetylamid-1,3,4,5- tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren |
US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
NZ282565A (en) * | 1994-03-24 | 1999-11-29 | Merrell Pharma Inc | Condensed mercaptoacetylamidedisulphidebenzazepines used in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia |
DE69514912T2 (de) * | 1994-03-24 | 2000-10-05 | Merrell Pharmaceuticals Inc., Cincinnati | Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten |
JP3658408B2 (ja) * | 1994-12-21 | 2005-06-08 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | エンケファリナーゼおよびアンギオテンシン変換酵素の阻害剤の中間体を製造する新規な方法およびその中間体 |
US5641880A (en) * | 1994-12-21 | 1997-06-24 | Hoechst Marion Roussel, Inc. | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3373469D1 (en) * | 1982-09-30 | 1987-10-15 | Merck & Co Inc | 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents |
EP0166357A3 (en) * | 1984-06-26 | 1988-10-26 | Merck & Co. Inc. | Benzofused lactams and pharmaceutical compositions containing them |
-
1987
- 1987-06-08 ZA ZA874107A patent/ZA874107B/xx unknown
- 1987-06-08 CA CA000539111A patent/CA1337654C/en not_active Expired - Lifetime
- 1987-06-09 AU AU74022/87A patent/AU601433B2/en not_active Expired
- 1987-06-09 AR AR87307816A patent/AR247213A1/es active
- 1987-06-11 EP EP87108410A patent/EP0249223B1/en not_active Expired - Lifetime
- 1987-06-11 ES ES87108410T patent/ES2044870T3/es not_active Expired - Lifetime
- 1987-06-11 IE IE154787A patent/IE61476B1/en not_active IP Right Cessation
- 1987-06-11 KR KR1019870005908A patent/KR950014572B1/ko not_active IP Right Cessation
- 1987-06-12 DK DK300487A patent/DK170840B1/da not_active IP Right Cessation
- 1987-06-12 JP JP62145419A patent/JP2542213B2/ja not_active Expired - Lifetime
- 1987-10-12 AT AT0269187A patent/AT398425B/de not_active IP Right Cessation
-
1993
- 1993-01-14 GR GR930400057T patent/GR3006802T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AR247213A1 (es) | 1994-11-30 |
JPS62298591A (ja) | 1987-12-25 |
EP0249223A2 (en) | 1987-12-16 |
AT398425B (de) | 1994-12-27 |
JP2542213B2 (ja) | 1996-10-09 |
DK300487D0 (da) | 1987-06-12 |
GR3006802T3 (da) | 1993-06-30 |
AU601433B2 (en) | 1990-09-13 |
IE61476B1 (en) | 1994-11-02 |
KR950014572B1 (ko) | 1995-12-08 |
AU7402287A (en) | 1987-12-17 |
ATA269187A (de) | 1994-04-15 |
CA1337654C (en) | 1995-11-28 |
EP0249223A3 (en) | 1989-01-25 |
ES2044870T3 (es) | 1994-01-16 |
ZA874107B (da) | 1987-12-09 |
EP0249223B1 (en) | 1992-10-14 |
DK170840B1 (da) | 1996-02-05 |
IE871547L (en) | 1987-12-13 |
KR880000399A (ko) | 1988-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |