ATA269187A - Neue tricyclische lactame - Google Patents
Neue tricyclische lactameInfo
- Publication number
- ATA269187A ATA269187A AT0269187A AT269187A ATA269187A AT A269187 A ATA269187 A AT A269187A AT 0269187 A AT0269187 A AT 0269187A AT 269187 A AT269187 A AT 269187A AT A269187 A ATA269187 A AT A269187A
- Authority
- AT
- Austria
- Prior art keywords
- lactame
- new tricyclic
- tricyclic
- new
- tricyclic lactame
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ZA874107A ZA874107B (de) | 1986-06-13 | 1987-06-08 | |
CA000539111A CA1337654C (en) | 1986-06-13 | 1987-06-08 | Fused tricyclic lactams as antihypertensive agents |
AU74022/87A AU601433B2 (en) | 1986-06-13 | 1987-06-09 | Novel antihypertensive agent |
AR87307816A AR247213A1 (es) | 1986-06-13 | 1987-06-09 | Preparacion de acido 7-¡(1-carboxi-3-fenilpropil)amino¿-3,4,6,7,8,12b-octahidro-6-oxopirido ¡2,1-a¿ o hexahidro-6-oxo-1h(1,4-tiazino¡3,4-a¿¡2¿-benzazepin-4-carboxilico, agentes hipertensivos. |
ES87108410T ES2044870T3 (es) | 1986-06-13 | 1987-06-11 | Un procedimiento para la preparacion de nuevos agentes antihipertensivos. |
IE154787A IE61476B1 (en) | 1986-06-13 | 1987-06-11 | Novel antihypertensive agent |
EP87108410A EP0249223B1 (de) | 1986-06-13 | 1987-06-11 | Antihypertensives Mittel |
KR1019870005908A KR950014572B1 (ko) | 1986-06-13 | 1987-06-11 | 융합된 트리사이클릭 락탐 및 이의 제조방법 |
DK300487A DK170840B1 (da) | 1986-06-13 | 1987-06-12 | Tricycliske lactamer indeholdende en benzazepingruppe, lægemiddel indeholdende sådanne lactamer samt anvendelse deraf til fremstilling af et lægemiddel til behandling af hypertension |
JP62145419A JP2542213B2 (ja) | 1986-06-13 | 1987-06-12 | 抗高血圧剤として有用な新規化合物とその製法 |
AT0269187A AT398425B (de) | 1986-06-13 | 1987-10-12 | Neue tricyclische lactame |
US07/352,675 US4973585A (en) | 1986-06-13 | 1989-05-10 | Tricyclic lactams active as antihypertensive agents |
GR930400057T GR3006802T3 (de) | 1986-06-13 | 1993-01-14 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87375486A | 1986-06-13 | 1986-06-13 | |
AT0269187A AT398425B (de) | 1986-06-13 | 1987-10-12 | Neue tricyclische lactame |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA269187A true ATA269187A (de) | 1994-04-15 |
AT398425B AT398425B (de) | 1994-12-27 |
Family
ID=25598925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0269187A AT398425B (de) | 1986-06-13 | 1987-10-12 | Neue tricyclische lactame |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0249223B1 (de) |
JP (1) | JP2542213B2 (de) |
KR (1) | KR950014572B1 (de) |
AR (1) | AR247213A1 (de) |
AT (1) | AT398425B (de) |
AU (1) | AU601433B2 (de) |
CA (1) | CA1337654C (de) |
DK (1) | DK170840B1 (de) |
ES (1) | ES2044870T3 (de) |
GR (1) | GR3006802T3 (de) |
IE (1) | IE61476B1 (de) |
ZA (1) | ZA874107B (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
CA2057786C (en) * | 1990-12-21 | 2002-06-18 | Gary A. Flynn | Amino and nitro containing tricyclic compounds useful as inhibitors or ace |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
ZA927211B (en) * | 1991-09-27 | 1993-03-24 | Merrell Dow Pharma | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE. |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
ATE155143T1 (de) * | 1991-09-27 | 1997-07-15 | Merrell Pharma Inc | 2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung |
US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
CA2130116C (en) * | 1992-02-14 | 1998-04-07 | Gary A. Flynn | Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
US5646276A (en) * | 1992-05-13 | 1997-07-08 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
DK0640086T3 (da) * | 1992-05-15 | 1999-12-06 | Merrell Pharma Inc | Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
CA2146238C (en) * | 1992-10-30 | 2001-03-13 | Gary A. Flynn | Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace |
US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
AU683956B2 (en) * | 1993-11-19 | 1997-11-27 | Aventis Inc. | Novel process for preparing (S)-1-(2(S)-(1,3-dihydro-1,3-dioxo-isoindo-2-yl)-1-oxo-3- phenylpropyl)-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester and intermediates thereof |
US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
ES2168355T3 (es) * | 1994-02-14 | 2002-06-16 | Merrell Pharma Inc | Derivados de bisulfuro de indano-2-mercaptoacetilamida utiles como inhibidores de la encefalinasa. |
EP0750631B1 (de) * | 1994-02-14 | 2000-04-05 | Merrell Pharmaceuticals Inc. | Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren |
US5750521A (en) * | 1994-02-14 | 1998-05-12 | Hoechst Marion Roussel Inc. | Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE |
EP0746566A1 (de) * | 1994-02-14 | 1996-12-11 | Merrell Pharmaceuticals Inc. | 2 - substituierte Indane - 2 - Mercaptoacetylamide Disulfide Derivate zur Verwendung als Ankephalinase und ACE Hemmstoffe |
US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
CN1144482A (zh) * | 1994-03-24 | 1997-03-05 | 默里尔药物公司 | 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物 |
PT751783E (pt) * | 1994-03-24 | 2000-05-31 | Merrell Pharma Inc | Derivados aminoacetilmercapto hipocolesterolemicos antiateroscleroticos e hipotrigliceridemicos |
US5641880A (en) * | 1994-12-21 | 1997-06-24 | Hoechst Marion Roussel, Inc. | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
MX9704677A (es) * | 1994-12-21 | 1997-09-30 | Hoechst Marion Roussel Inc | Procedimientos novedosos para preparar intermediarios de inhibidores de encefalinasa y enzima de conversion a angiotensina y sus intermediarios. |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3373469D1 (en) * | 1982-09-30 | 1987-10-15 | Merck & Co Inc | 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents |
EP0166357A3 (de) * | 1984-06-26 | 1988-10-26 | Merck & Co. Inc. | Kondensierte Benzo-Laktame und deren pharmazeutische Zusammensetzungen |
-
1987
- 1987-06-08 CA CA000539111A patent/CA1337654C/en not_active Expired - Lifetime
- 1987-06-08 ZA ZA874107A patent/ZA874107B/xx unknown
- 1987-06-09 AU AU74022/87A patent/AU601433B2/en not_active Expired
- 1987-06-09 AR AR87307816A patent/AR247213A1/es active
- 1987-06-11 EP EP87108410A patent/EP0249223B1/de not_active Expired - Lifetime
- 1987-06-11 IE IE154787A patent/IE61476B1/en not_active IP Right Cessation
- 1987-06-11 KR KR1019870005908A patent/KR950014572B1/ko not_active IP Right Cessation
- 1987-06-11 ES ES87108410T patent/ES2044870T3/es not_active Expired - Lifetime
- 1987-06-12 DK DK300487A patent/DK170840B1/da not_active IP Right Cessation
- 1987-06-12 JP JP62145419A patent/JP2542213B2/ja not_active Expired - Lifetime
- 1987-10-12 AT AT0269187A patent/AT398425B/de not_active IP Right Cessation
-
1993
- 1993-01-14 GR GR930400057T patent/GR3006802T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA1337654C (en) | 1995-11-28 |
DK170840B1 (da) | 1996-02-05 |
ZA874107B (de) | 1987-12-09 |
GR3006802T3 (de) | 1993-06-30 |
ES2044870T3 (es) | 1994-01-16 |
AT398425B (de) | 1994-12-27 |
AU601433B2 (en) | 1990-09-13 |
DK300487D0 (da) | 1987-06-12 |
JPS62298591A (ja) | 1987-12-25 |
IE61476B1 (en) | 1994-11-02 |
EP0249223A2 (de) | 1987-12-16 |
JP2542213B2 (ja) | 1996-10-09 |
AU7402287A (en) | 1987-12-17 |
AR247213A1 (es) | 1994-11-30 |
KR950014572B1 (ko) | 1995-12-08 |
KR880000399A (ko) | 1988-03-25 |
EP0249223B1 (de) | 1992-10-14 |
DK300487A (da) | 1987-12-14 |
IE871547L (en) | 1987-12-13 |
EP0249223A3 (en) | 1989-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ELJ | Ceased due to non-payment of the annual fee |