ZA874107B - - Google Patents
Info
- Publication number
- ZA874107B ZA874107B ZA874107A ZA874107A ZA874107B ZA 874107 B ZA874107 B ZA 874107B ZA 874107 A ZA874107 A ZA 874107A ZA 874107 A ZA874107 A ZA 874107A ZA 874107 B ZA874107 B ZA 874107B
- Authority
- ZA
- South Africa
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87375486A | 1986-06-13 | 1986-06-13 | |
| AT0269187A AT398425B (de) | 1986-06-13 | 1987-10-12 | Neue tricyclische lactame |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA874107B true ZA874107B (de) | 1987-12-09 |
Family
ID=25598925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA874107A ZA874107B (de) | 1986-06-13 | 1987-06-08 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0249223B1 (de) |
| JP (1) | JP2542213B2 (de) |
| KR (1) | KR950014572B1 (de) |
| AR (1) | AR247213A1 (de) |
| AT (1) | AT398425B (de) |
| AU (1) | AU601433B2 (de) |
| CA (1) | CA1337654C (de) |
| DK (1) | DK170840B1 (de) |
| ES (1) | ES2044870T3 (de) |
| GR (1) | GR3006802T3 (de) |
| IE (1) | IE61476B1 (de) |
| ZA (1) | ZA874107B (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| ATE158303T1 (de) * | 1990-12-21 | 1997-10-15 | Merrell Pharma Inc | Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften |
| ZA927211B (en) * | 1991-09-27 | 1993-03-24 | Merrell Dow Pharma | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE. |
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| EP0534363B1 (de) * | 1991-09-27 | 1997-07-09 | Merrell Pharmaceuticals Inc. | 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung |
| US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| KR100276029B1 (ko) * | 1992-02-14 | 2000-12-15 | 슈테펜엘.네스비트 | 아미노아세틸 머캅토아세틸 아미드 유도체 및 이의 제조방법 |
| US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
| ES2138622T3 (es) * | 1992-05-15 | 2000-01-16 | Merrell Pharma Inc | Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca. |
| US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| NZ256589A (en) * | 1992-10-30 | 1996-05-28 | Merrell Dow Pharma | Condensed azepine analogues and medicaments (where a is c, o or s and b is o or s) |
| US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
| US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
| CA2177044C (en) * | 1993-11-19 | 1999-06-01 | Gary A. Flynn | Novel process for preparing (s)-1-[2(s)-(1,3-dihydro-1,3-dioxo-isoindo-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester and intermediates thereof |
| MX9603348A (es) * | 1994-02-14 | 1997-12-31 | Merrell Pharma Inc | Derivados de disulfuro de amida indano-2-mercaptoacetilica novedosos utiles como inhibidores de encefalinasa. |
| JPH09508906A (ja) * | 1994-02-14 | 1997-09-09 | メレル ファーマスーティカルズ インコーポレーテッド | エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類 |
| US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
| AU689192B2 (en) * | 1994-02-14 | 1998-03-26 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| DE69416873T2 (de) * | 1994-02-14 | 1999-07-29 | Merrell Pharma Inc | Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| HUP9774624A2 (en) * | 1994-03-24 | 1997-01-28 | Merrell Pharma Inc | Hypocholesterolemic, antiatheroclerotic and hypotriglyceridemic condensed benzazepine mercaptoacetylamide disulfide derivatives |
| NZ282568A (en) * | 1994-03-24 | 1997-07-27 | Merrell Pharma Inc | Use of condensed aminoacetylmercaptobenzazepines in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia |
| US5641880A (en) * | 1994-12-21 | 1997-06-24 | Hoechst Marion Roussel, Inc. | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
| CA2208569C (en) * | 1994-12-21 | 2000-07-11 | Hoechst Marion Roussel, Inc. | Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
| US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
| US5877313A (en) * | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
| US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
| US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0107095B1 (de) * | 1982-09-30 | 1987-09-09 | Merck & Co. Inc. | 1-N-Carboxyalkylbenzolaktame, brauchbar als antihypertensive Mittel |
| EP0166357A3 (de) * | 1984-06-26 | 1988-10-26 | Merck & Co. Inc. | Kondensierte Benzo-Laktame und deren pharmazeutische Zusammensetzungen |
-
1987
- 1987-06-08 CA CA000539111A patent/CA1337654C/en not_active Expired - Lifetime
- 1987-06-08 ZA ZA874107A patent/ZA874107B/xx unknown
- 1987-06-09 AU AU74022/87A patent/AU601433B2/en not_active Expired
- 1987-06-09 AR AR87307816A patent/AR247213A1/es active
- 1987-06-11 EP EP87108410A patent/EP0249223B1/de not_active Expired - Lifetime
- 1987-06-11 IE IE154787A patent/IE61476B1/en not_active IP Right Cessation
- 1987-06-11 ES ES87108410T patent/ES2044870T3/es not_active Expired - Lifetime
- 1987-06-11 KR KR1019870005908A patent/KR950014572B1/ko not_active IP Right Cessation
- 1987-06-12 DK DK300487A patent/DK170840B1/da not_active IP Right Cessation
- 1987-06-12 JP JP62145419A patent/JP2542213B2/ja not_active Expired - Lifetime
- 1987-10-12 AT AT0269187A patent/AT398425B/de not_active IP Right Cessation
-
1993
- 1993-01-14 GR GR930400057T patent/GR3006802T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK300487A (da) | 1987-12-14 |
| AT398425B (de) | 1994-12-27 |
| EP0249223A2 (de) | 1987-12-16 |
| EP0249223B1 (de) | 1992-10-14 |
| AU601433B2 (en) | 1990-09-13 |
| KR880000399A (ko) | 1988-03-25 |
| IE871547L (en) | 1987-12-13 |
| ATA269187A (de) | 1994-04-15 |
| AR247213A1 (es) | 1994-11-30 |
| EP0249223A3 (en) | 1989-01-25 |
| DK300487D0 (da) | 1987-06-12 |
| ES2044870T3 (es) | 1994-01-16 |
| KR950014572B1 (ko) | 1995-12-08 |
| GR3006802T3 (de) | 1993-06-30 |
| JPS62298591A (ja) | 1987-12-25 |
| DK170840B1 (da) | 1996-02-05 |
| AU7402287A (en) | 1987-12-17 |
| IE61476B1 (en) | 1994-11-02 |
| JP2542213B2 (ja) | 1996-10-09 |
| CA1337654C (en) | 1995-11-28 |