DK170752B1 - Cytostatisk aktive anthracyclinderivater samt anvendelse deraf - Google Patents

Cytostatisk aktive anthracyclinderivater samt anvendelse deraf Download PDF

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Publication number
DK170752B1
DK170752B1 DK640587A DK640587A DK170752B1 DK 170752 B1 DK170752 B1 DK 170752B1 DK 640587 A DK640587 A DK 640587A DK 640587 A DK640587 A DK 640587A DK 170752 B1 DK170752 B1 DK 170752B1
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Prior art keywords
alpha
beta
methyl
daunosaminyl
rhodomycinone
Prior art date
Application number
DK640587A
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Danish (da)
English (en)
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DK640587D0 (da
DK640587A (da
Inventor
Peter Hermentin
Michael Paal
Hans Peter Kraemer
Cenek Kolar
Dieter Hoffmann
Manfred Gerken
Hans Gerd Berscheid
Dirk Boettger
Original Assignee
Behringwerke Ag
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Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of DK640587D0 publication Critical patent/DK640587D0/da
Publication of DK640587A publication Critical patent/DK640587A/da
Application granted granted Critical
Publication of DK170752B1 publication Critical patent/DK170752B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Vibration Dampers (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Paper (AREA)
DK640587A 1986-12-08 1987-12-07 Cytostatisk aktive anthracyclinderivater samt anvendelse deraf DK170752B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863641833 DE3641833A1 (de) 1986-12-08 1986-12-08 Zytostatisch wirksame anthracyclinderivate
DE3641833 1986-12-08

Publications (3)

Publication Number Publication Date
DK640587D0 DK640587D0 (da) 1987-12-07
DK640587A DK640587A (da) 1988-06-09
DK170752B1 true DK170752B1 (da) 1996-01-08

Family

ID=6315675

Family Applications (1)

Application Number Title Priority Date Filing Date
DK640587A DK170752B1 (da) 1986-12-08 1987-12-07 Cytostatisk aktive anthracyclinderivater samt anvendelse deraf

Country Status (11)

Country Link
US (1) US4948880A (sv)
EP (1) EP0270992B1 (sv)
JP (1) JP2579654B2 (sv)
AT (1) ATE106890T1 (sv)
AU (1) AU613327B2 (sv)
CA (1) CA1340422C (sv)
DE (2) DE3641833A1 (sv)
DK (1) DK170752B1 (sv)
ES (1) ES2056808T3 (sv)
FI (1) FI89495C (sv)
PT (1) PT86314B (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0822869B2 (ja) * 1986-06-25 1996-03-06 ヘキストジヤパン株式会社 サイトロジンｓ誘導体およびそれを含有する抗癌剤
DE3706175A1 (de) * 1987-02-26 1988-09-08 Behringwerke Ag Verwendung von lipophilen anthracyclinen zur behandlung "sekundaer" anthracyclin-resistenter tumoren, mittel enthaltend ein lipophiles anthracyclin und verfahren zu seiner herstellung
DE3712350A1 (de) * 1987-04-11 1988-10-20 Behringwerke Ag Semisynthetische rhodomycine, verfahren zu ihrer herstellung und ihre verwendung als zytostatika
DE3733885A1 (de) * 1987-10-07 1989-04-27 Hoechst Ag Neue anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3819092A1 (de) * 1988-06-04 1989-12-14 Behringwerke Ag Zytostatisch wirksame anthracyclinderivate
DE3822220A1 (de) * 1988-07-01 1990-01-04 Behringwerke Ag Modifizierte rhodomycine, verfahren zu ihrer herstellung und ihre verwendung
DE3836122A1 (de) * 1988-10-22 1990-05-31 Behringwerke Ag Verfahren zur herstellung von 4-0-alkyl-rhodomycinen
DE3842836A1 (de) * 1988-12-20 1990-06-21 Behringwerke Ag Rhodomycine mit einer modifizierten kohlenhydrat-einheit
JP2779652B2 (ja) * 1988-12-27 1998-07-23 武田薬品工業株式会社 生理活性物質ｔａｎ―１１２０，その還元体，それらの製造法および用途ならびに微生物
DE4036155A1 (de) * 1990-11-14 1992-05-21 Behringwerke Ag Semisynthetische diastereomerenreine n-glycidyl-anthracycline, verfahren zu ihrer stereoselektiven herstellung und ihre verwendung als zytostatika
IT1262565B (it) * 1993-09-30 1996-07-04 Menarini Farma Ind Disaccaridi di antracicline, loro processi di preparazione e composizioni farmaceutiche che li contengono.
US6677309B1 (en) 1997-04-11 2004-01-13 University Technology Corporation Anti-cancer drug aldehyde conjugate drugs with enhanced cytotoxicity compounds, compositions and methods
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
SE0401066D0 (sv) * 2004-04-22 2004-04-22 Stefan Sjoeberg Chemical Derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH637160A5 (fr) * 1976-10-05 1983-07-15 Microbial Chem Res Found Procede de fabrication de glucosides anthracyclines.
JPS54141759A (en) * 1978-04-24 1979-11-05 Microbial Chem Res Found Novel anthracycline derivative
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
JPS57176995A (en) * 1981-04-23 1982-10-30 Sanraku Inc Novel anthracyclinone glycoside and its preparation
DE3325957A1 (de) * 1983-07-19 1985-02-07 Hoechst Ag, 6230 Frankfurt Anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatika
US4591637A (en) * 1985-01-17 1986-05-27 Sri International Open chain-morpholino adriamycins
JPS62207293A (ja) * 1986-03-07 1987-09-11 Sapporo Breweries Ltd 新規アンスラサイクリン抗生物質とその製造法

Also Published As

Publication number Publication date
EP0270992A3 (en) 1988-10-12
DK640587D0 (da) 1987-12-07
DE3641833A1 (de) 1988-06-09
FI89495C (sv) 1993-10-11
EP0270992B1 (de) 1994-06-08
US4948880A (en) 1990-08-14
AU613327B2 (en) 1991-08-01
ES2056808T3 (es) 1994-10-16
ATE106890T1 (de) 1994-06-15
DK640587A (da) 1988-06-09
PT86314A (de) 1988-01-01
JP2579654B2 (ja) 1997-02-05
FI875353A0 (fi) 1987-12-04
PT86314B (pt) 1990-11-07
EP0270992A2 (de) 1988-06-15
FI875353A (fi) 1988-06-09
CA1340422C (en) 1999-03-09
DE3750025D1 (de) 1994-07-14
AU8213487A (en) 1988-06-09
FI89495B (fi) 1993-06-30
JPS63145295A (ja) 1988-06-17

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired