JPS54141759A - Novel anthracycline derivative - Google Patents

Novel anthracycline derivative

Info

Publication number
JPS54141759A
JPS54141759A JP4907178A JP4907178A JPS54141759A JP S54141759 A JPS54141759 A JP S54141759A JP 4907178 A JP4907178 A JP 4907178A JP 4907178 A JP4907178 A JP 4907178A JP S54141759 A JPS54141759 A JP S54141759A
Authority
JP
Japan
Prior art keywords
formula
acid addition
addition salt
silver oxide
anthracycline glycoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4907178A
Other languages
Japanese (ja)
Other versions
JPS5638160B2 (en
Inventor
Hamao Umezawa
Tomio Takeuchi
Hiroshi Osanawa
Kuniaki Tatsuta
Shunichi Oki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP4907178A priority Critical patent/JPS54141759A/en
Publication of JPS54141759A publication Critical patent/JPS54141759A/en
Publication of JPS5638160B2 publication Critical patent/JPS5638160B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:An anthracycline glycoside derivative of formula I: (R1 is H or OH; R2 is H or CH3), and its acid addition salt.
EXAMPLE: N-Methyldaunomycin.
USE: Carcinostatics having low toxicity (side effects) and strong carcinostatic actions compared with daunomycin and adriamycin.
PROCESS: One mole of anthracycline glycoside of formula II or its acid addition salt is reacted with methyl iodide in an aprotic polar solvent in the presence of 1W2 moles of silver oxide at about room temperature for 2W10 min to give the objective substance of formula I having one or two methyl groups introduced onto the amino group of daunosamine. DMF or DMSO may be used as the solvent, and the silver oxide acts as a dehalogenating agent.
COPYRIGHT: (C)1979,JPO&Japio
JP4907178A 1978-04-24 1978-04-24 Novel anthracycline derivative Granted JPS54141759A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4907178A JPS54141759A (en) 1978-04-24 1978-04-24 Novel anthracycline derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4907178A JPS54141759A (en) 1978-04-24 1978-04-24 Novel anthracycline derivative

Publications (2)

Publication Number Publication Date
JPS54141759A true JPS54141759A (en) 1979-11-05
JPS5638160B2 JPS5638160B2 (en) 1981-09-04

Family

ID=12820839

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4907178A Granted JPS54141759A (en) 1978-04-24 1978-04-24 Novel anthracycline derivative

Country Status (1)

Country Link
JP (1) JPS54141759A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0270992A2 (en) * 1986-12-08 1988-06-15 BEHRINGWERKE Aktiengesellschaft Anthracycline derivatives with a cytostatic activity
EP0345598A2 (en) * 1988-06-04 1989-12-13 BEHRINGWERKE Aktiengesellschaft Anthracycline derivatives with a cytostatic activity
US4973674A (en) * 1987-04-14 1990-11-27 Farmitalia Carlo Erba S.R.L. Chiral synthesis of anthracyclines from substituted anthraquinones
WO1995016695A3 (en) * 1993-12-13 1995-07-13 Pharmacia Spa 3'-aziridino-anthracycline derivatives

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0270992A2 (en) * 1986-12-08 1988-06-15 BEHRINGWERKE Aktiengesellschaft Anthracycline derivatives with a cytostatic activity
JPS63145295A (en) * 1986-12-08 1988-06-17 ベーリングヴエルケ・アクチエンゲゼルシヤフト Anthracycline derivative
JP2579654B2 (en) * 1986-12-08 1997-02-05 ベーリングヴエルケ・アクチエンゲゼルシヤフト Anthracycline derivative
US4973674A (en) * 1987-04-14 1990-11-27 Farmitalia Carlo Erba S.R.L. Chiral synthesis of anthracyclines from substituted anthraquinones
EP0345598A2 (en) * 1988-06-04 1989-12-13 BEHRINGWERKE Aktiengesellschaft Anthracycline derivatives with a cytostatic activity
JPH0225497A (en) * 1988-06-04 1990-01-26 Behringwerke Ag Anthracycline derivative having cell propagation suppressing activity
JP2838145B2 (en) * 1988-06-04 1998-12-16 ヘキスト・アクチエンゲゼルシヤフト Anthracycline derivatives having cytostatic activity
WO1995016695A3 (en) * 1993-12-13 1995-07-13 Pharmacia Spa 3'-aziridino-anthracycline derivatives

Also Published As

Publication number Publication date
JPS5638160B2 (en) 1981-09-04

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