JPS54141759A - Novel anthracycline derivative - Google Patents
Novel anthracycline derivativeInfo
- Publication number
- JPS54141759A JPS54141759A JP4907178A JP4907178A JPS54141759A JP S54141759 A JPS54141759 A JP S54141759A JP 4907178 A JP4907178 A JP 4907178A JP 4907178 A JP4907178 A JP 4907178A JP S54141759 A JPS54141759 A JP S54141759A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- acid addition
- addition salt
- silver oxide
- anthracycline glycoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:An anthracycline glycoside derivative of formula I: (R1 is H or OH; R2 is H or CH3), and its acid addition salt.
EXAMPLE: N-Methyldaunomycin.
USE: Carcinostatics having low toxicity (side effects) and strong carcinostatic actions compared with daunomycin and adriamycin.
PROCESS: One mole of anthracycline glycoside of formula II or its acid addition salt is reacted with methyl iodide in an aprotic polar solvent in the presence of 1W2 moles of silver oxide at about room temperature for 2W10 min to give the objective substance of formula I having one or two methyl groups introduced onto the amino group of daunosamine. DMF or DMSO may be used as the solvent, and the silver oxide acts as a dehalogenating agent.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4907178A JPS54141759A (en) | 1978-04-24 | 1978-04-24 | Novel anthracycline derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4907178A JPS54141759A (en) | 1978-04-24 | 1978-04-24 | Novel anthracycline derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54141759A true JPS54141759A (en) | 1979-11-05 |
JPS5638160B2 JPS5638160B2 (en) | 1981-09-04 |
Family
ID=12820839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4907178A Granted JPS54141759A (en) | 1978-04-24 | 1978-04-24 | Novel anthracycline derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54141759A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0270992A2 (en) * | 1986-12-08 | 1988-06-15 | BEHRINGWERKE Aktiengesellschaft | Anthracycline derivatives with a cytostatic activity |
EP0345598A2 (en) * | 1988-06-04 | 1989-12-13 | BEHRINGWERKE Aktiengesellschaft | Anthracycline derivatives with a cytostatic activity |
US4973674A (en) * | 1987-04-14 | 1990-11-27 | Farmitalia Carlo Erba S.R.L. | Chiral synthesis of anthracyclines from substituted anthraquinones |
WO1995016695A3 (en) * | 1993-12-13 | 1995-07-13 | Pharmacia Spa | 3'-aziridino-anthracycline derivatives |
-
1978
- 1978-04-24 JP JP4907178A patent/JPS54141759A/en active Granted
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0270992A2 (en) * | 1986-12-08 | 1988-06-15 | BEHRINGWERKE Aktiengesellschaft | Anthracycline derivatives with a cytostatic activity |
JPS63145295A (en) * | 1986-12-08 | 1988-06-17 | ベーリングヴエルケ・アクチエンゲゼルシヤフト | Anthracycline derivative |
JP2579654B2 (en) * | 1986-12-08 | 1997-02-05 | ベーリングヴエルケ・アクチエンゲゼルシヤフト | Anthracycline derivative |
US4973674A (en) * | 1987-04-14 | 1990-11-27 | Farmitalia Carlo Erba S.R.L. | Chiral synthesis of anthracyclines from substituted anthraquinones |
EP0345598A2 (en) * | 1988-06-04 | 1989-12-13 | BEHRINGWERKE Aktiengesellschaft | Anthracycline derivatives with a cytostatic activity |
JPH0225497A (en) * | 1988-06-04 | 1990-01-26 | Behringwerke Ag | Anthracycline derivative having cell propagation suppressing activity |
JP2838145B2 (en) * | 1988-06-04 | 1998-12-16 | ヘキスト・アクチエンゲゼルシヤフト | Anthracycline derivatives having cytostatic activity |
WO1995016695A3 (en) * | 1993-12-13 | 1995-07-13 | Pharmacia Spa | 3'-aziridino-anthracycline derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS5638160B2 (en) | 1981-09-04 |
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