DK169546B1 - 1,2,4-triazolonderivater, en fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne - Google Patents

1,2,4-triazolonderivater, en fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne Download PDF

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Publication number
DK169546B1
DK169546B1 DK468284A DK468284A DK169546B1 DK 169546 B1 DK169546 B1 DK 169546B1 DK 468284 A DK468284 A DK 468284A DK 468284 A DK468284 A DK 468284A DK 169546 B1 DK169546 B1 DK 169546B1
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DK
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Prior art keywords
formula
compound
pharmaceutically acceptable
pharmaceutical composition
acid
Prior art date
Application number
DK468284A
Other languages
Danish (da)
English (en)
Other versions
DK468284A (da
DK468284D0 (da
Inventor
Richard E Gammans
David W Smith
Joseph P Yevich
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24145128&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK169546(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of DK468284D0 publication Critical patent/DK468284D0/da
Publication of DK468284A publication Critical patent/DK468284A/da
Application granted granted Critical
Publication of DK169546B1 publication Critical patent/DK169546B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK468284A 1983-09-30 1984-09-28 1,2,4-triazolonderivater, en fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne DK169546B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/538,027 US4613600A (en) 1983-09-30 1983-09-30 Antidepressant 1,2,4-triazolone compounds
US53802783 1983-09-30

Publications (3)

Publication Number Publication Date
DK468284D0 DK468284D0 (da) 1984-09-28
DK468284A DK468284A (da) 1985-03-31
DK169546B1 true DK169546B1 (da) 1994-11-28

Family

ID=24145128

Family Applications (1)

Application Number Title Priority Date Filing Date
DK468284A DK169546B1 (da) 1983-09-30 1984-09-28 1,2,4-triazolonderivater, en fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne

Country Status (25)

Country Link
US (1) US4613600A (enExample)
JP (1) JPS60100560A (enExample)
KR (1) KR880002624B1 (enExample)
AT (1) AT387963B (enExample)
AU (1) AU561460B2 (enExample)
BE (1) BE900714A (enExample)
CA (1) CA1237723A (enExample)
CH (1) CH661924A5 (enExample)
CY (1) CY1541A (enExample)
DE (1) DE3435745C2 (enExample)
DK (1) DK169546B1 (enExample)
ES (1) ES8601966A1 (enExample)
FI (1) FI83310C (enExample)
FR (1) FR2552759B1 (enExample)
GB (1) GB2147297B (enExample)
GR (1) GR80475B (enExample)
HK (1) HK37391A (enExample)
IE (1) IE58084B1 (enExample)
IT (1) IT1178522B (enExample)
LU (1) LU85561A1 (enExample)
MY (1) MY102123A (enExample)
NL (1) NL8402946A (enExample)
SE (1) SE465928B (enExample)
YU (1) YU45667B (enExample)
ZA (1) ZA847589B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
YU44721B (en) * 1983-11-30 1990-12-31 Bristol Myers Co Process for obtaining 4-(2-phenoxyethyl)-1,2,4-triazolone
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
US5504086A (en) * 1989-10-17 1996-04-02 Ellinwood, Jr.; Everett H. Intraoral dosing method of administering trifluorobenzodiazepines, propoxyphene, and nefazodone
US5256664A (en) * 1992-04-28 1993-10-26 Bristol-Myers Squibb Company Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones
DE4425144A1 (de) * 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
US6403593B1 (en) 1995-07-14 2002-06-11 Abbott Laboratories Triazole compounds and the use thereof
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
EP1189616A2 (en) 1999-04-09 2002-03-27 Sepracor Inc. S-hydroxynefazodone
US6469008B2 (en) 1999-04-09 2002-10-22 Sepracor Inc. (R)-hydroxynefazodone antipsychotic therapy
DE60028955T2 (de) 1999-04-09 2007-07-05 Sepracor Inc., Marlborough R-hydroxynefazodon
US6586437B2 (en) 1999-04-09 2003-07-01 Sepracor Inc. (S)-hydroxynefazodone antipsychotic therapy
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1737473A4 (en) * 2004-04-19 2009-08-26 Noven Therapeutics Llc COMBINATIONS OF LITHIUM AND USES THEREOF
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
WO2009111031A2 (en) * 2008-03-04 2009-09-11 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2012072665A1 (en) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
US9072660B2 (en) 2011-09-09 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Topical itraconazole formulations and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
IT1052119B (it) * 1972-10-16 1981-06-20 Sigma Tau Ind Farmaceuti Derivati del triazolinone e procedimento per la loro preparazione
US4338317A (en) * 1981-03-16 1982-07-06 Mead Johnson & Company Phenoxyethyl-1,2,4,-triazol-3-one antidepressants

Also Published As

Publication number Publication date
SE8404869D0 (sv) 1984-09-28
AU3364884A (en) 1985-04-04
ES536286A0 (es) 1985-11-16
DK468284A (da) 1985-03-31
NL8402946A (nl) 1985-04-16
CA1237723A (en) 1988-06-07
ES8601966A1 (es) 1985-11-16
DK468284D0 (da) 1984-09-28
DE3435745C2 (de) 1994-11-03
YU172184A (en) 1986-10-31
JPS60100560A (ja) 1985-06-04
DE3435745A1 (de) 1985-04-11
AU561460B2 (en) 1987-05-07
KR880002624B1 (ko) 1988-12-07
YU45667B (sh) 1992-07-20
GB2147297A (en) 1985-05-09
FI83310C (fi) 1991-06-25
IT1178522B (it) 1987-09-09
SE465928B (sv) 1991-11-18
JPH0542435B2 (enExample) 1993-06-28
FI83310B (fi) 1991-03-15
GR80475B (en) 1985-01-31
KR850002270A (ko) 1985-05-10
ATA310884A (de) 1988-09-15
CH661924A5 (de) 1987-08-31
LU85561A1 (fr) 1985-06-04
HK37391A (en) 1991-05-24
IE842476L (en) 1985-03-30
SE8404869L (sv) 1985-03-31
IE58084B1 (en) 1993-06-30
FR2552759B1 (fr) 1988-10-07
MY102123A (en) 1992-03-31
US4613600A (en) 1986-09-23
FI843779A0 (fi) 1984-09-26
GB2147297B (en) 1987-04-15
ZA847589B (en) 1985-05-29
BE900714A (fr) 1985-03-28
IT8422922A0 (it) 1984-09-28
FR2552759A1 (fr) 1985-04-05
FI843779L (fi) 1985-03-31
AT387963B (de) 1989-04-10
GB8424535D0 (en) 1984-11-07
CY1541A (en) 1991-03-22

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired