DK168991B1 - Substituerede thiazoler og oxazoler, lægemiddel indeholdende en sådan forbindelse, anvendelse af en sådan forbindelse til fremstilling af et lægemiddel, fremgangsmåde til fremstilling af lægemidlet og fremgangsmåde til fremstilling af forbindelserne, samt substituerede thiazoler og oxazoler med mellemproduktanvendelse - Google Patents

Substituerede thiazoler og oxazoler, lægemiddel indeholdende en sådan forbindelse, anvendelse af en sådan forbindelse til fremstilling af et lægemiddel, fremgangsmåde til fremstilling af lægemidlet og fremgangsmåde til fremstilling af forbindelserne, samt substituerede thiazoler og oxazoler med mellemproduktanvendelse Download PDF

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Publication number
DK168991B1
DK168991B1 DK127487A DK127487A DK168991B1 DK 168991 B1 DK168991 B1 DK 168991B1 DK 127487 A DK127487 A DK 127487A DK 127487 A DK127487 A DK 127487A DK 168991 B1 DK168991 B1 DK 168991B1
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DK
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Prior art keywords
group
general formula
hydroxy
thiazol
compound
Prior art date
Application number
DK127487A
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Danish (da)
English (en)
Other versions
DK127487D0 (da
DK127487A (da
Inventor
Manfred Reiffen
Rudolf Hurnaus
Robert Sauter
Wolfgang Grell
Eckhard Rupprecht
Original Assignee
Thomae Gmbh Dr K
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Filing date
Publication date
Priority claimed from DE19863608290 external-priority patent/DE3608290A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK127487D0 publication Critical patent/DK127487D0/da
Publication of DK127487A publication Critical patent/DK127487A/da
Application granted granted Critical
Publication of DK168991B1 publication Critical patent/DK168991B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
DK127487A 1986-03-13 1987-03-12 Substituerede thiazoler og oxazoler, lægemiddel indeholdende en sådan forbindelse, anvendelse af en sådan forbindelse til fremstilling af et lægemiddel, fremgangsmåde til fremstilling af lægemidlet og fremgangsmåde til fremstilling af forbindelserne, samt substituerede thiazoler og oxazoler med mellemproduktanvendelse DK168991B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3608290 1986-03-13
DE19863608290 DE3608290A1 (de) 1986-03-13 1986-03-13 Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE19863621775 DE3621775A1 (de) 1986-03-13 1986-06-28 Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3621775 1986-06-28

Publications (3)

Publication Number Publication Date
DK127487D0 DK127487D0 (da) 1987-03-12
DK127487A DK127487A (da) 1987-09-14
DK168991B1 true DK168991B1 (da) 1994-07-25

Family

ID=25841907

Family Applications (1)

Application Number Title Priority Date Filing Date
DK127487A DK168991B1 (da) 1986-03-13 1987-03-12 Substituerede thiazoler og oxazoler, lægemiddel indeholdende en sådan forbindelse, anvendelse af en sådan forbindelse til fremstilling af et lægemiddel, fremgangsmåde til fremstilling af lægemidlet og fremgangsmåde til fremstilling af forbindelserne, samt substituerede thiazoler og oxazoler med mellemproduktanvendelse

Country Status (19)

Country Link
US (2) US5457205A (ja)
EP (1) EP0239815B1 (ja)
JP (1) JPH0784446B2 (ja)
KR (1) KR870008876A (ja)
CA (1) CA1296002C (ja)
DE (2) DE3621775A1 (ja)
DK (1) DK168991B1 (ja)
ES (1) ES2040215T3 (ja)
FI (1) FI87777C (ja)
GR (1) GR3002839T3 (ja)
HK (1) HK106494A (ja)
HU (1) HU196974B (ja)
IE (1) IE59800B1 (ja)
IL (1) IL81874A (ja)
MX (1) MX9202818A (ja)
NO (1) NO172849C (ja)
PH (1) PH23996A (ja)
PL (1) PL154772B1 (ja)
PT (1) PT84462B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3805382A1 (de) * 1988-02-20 1989-08-31 Boehringer Ingelheim Vetmed Verwendung von thiazolen zur leistungssteigerung bei tieren
JP3003148B2 (ja) * 1989-01-05 2000-01-24 藤沢薬品工業株式会社 チアゾール化合物、その製造法およびそれを含有する医薬組成物
US5576442A (en) * 1991-07-22 1996-11-19 Pfizer Inc. Process and chiral intermediates for thiazole antidiabetics
AU7084294A (en) * 1993-07-14 1995-02-13 Taisho Pharmaceutical Co., Ltd. 5-acetylthiazoline oxime derivative
US6472387B1 (en) 1996-10-07 2002-10-29 Eli Lilly And Company Methods of using compounds as neuro-protective agents
PT971709E (pt) 1996-10-07 2003-09-30 Lilly Co Eli Novos compostos uteis como agentes neuro-protectores
US6121288A (en) * 1996-11-08 2000-09-19 Nippon Chemiphar Co., Ltd. Visceral fat lowering agent
IL135433A0 (en) 1997-10-06 2001-05-20 Lilly Co Eli Novel compounds useful as neuro-protective agents
US5972099A (en) * 1997-12-17 1999-10-26 Bayer Corporation Process for preparing organic pigment compositions
US6121300A (en) * 1998-11-10 2000-09-19 Wagle; Dilip R. Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
ES2234929T3 (es) * 2000-11-28 2005-07-01 Smithkline Beecham Plc Derivados de morfolina como antagonistas de los receptores de orexina.
CN101912380A (zh) * 2003-04-15 2010-12-15 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
JP4697973B2 (ja) 2003-04-22 2011-06-08 ウェルスタット セラピューティクス コーポレイション 代謝障害の処置のための化合物
GB0324654D0 (en) * 2003-10-22 2003-11-26 Glaxo Group Ltd Medicinal compounds
TW200526588A (en) * 2003-11-17 2005-08-16 Smithkline Beecham Corp Chemical compounds
JP6063948B2 (ja) * 2011-10-27 2017-01-18 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ベータ３アゴニストおよび中間体を製造するプロセス
US10791890B2 (en) 2018-03-27 2020-10-06 Omachron Intellectual Property Inc. Surface cleaning apparatus

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3225042A (en) * 1962-07-31 1965-12-21 Lilly Co Eli Hydroxymorpholines
US3514465A (en) * 1966-12-30 1970-05-26 Degussa Certain thiazolyl- and pyridinylaminoketones
LU69079A1 (ja) * 1973-12-27 1975-08-20
DD144050A5 (de) * 1978-06-05 1980-09-24 Ciba Geigy Ag Verfahren zur herstellung von n-alkylierten aminoalkoholen
IE50355B1 (en) * 1979-10-20 1986-04-02 Wyeth John & Brother Ltd Morpholine derivatives
GB8418657D0 (en) * 1984-07-21 1984-08-22 Beecham Group Plc Compounds
US4826990A (en) * 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents

Also Published As

Publication number Publication date
JPS62226971A (ja) 1987-10-05
IL81874A (en) 1991-01-31
NO172849C (no) 1993-09-15
ES2040215T3 (es) 1993-10-16
DE3771541D1 (de) 1991-08-29
PT84462A (de) 1987-04-01
NO871028L (no) 1987-09-14
GR3002839T3 (en) 1993-01-25
PL154772B1 (en) 1991-09-30
NO871028D0 (no) 1987-03-12
PT84462B (pt) 1989-10-04
MX9202818A (es) 1992-06-30
DE3621775A1 (de) 1988-01-07
FI87777C (fi) 1993-02-25
KR870008876A (ko) 1987-10-21
NO172849B (no) 1993-06-07
FI871052A (fi) 1987-09-14
HU196974B (en) 1989-02-28
CA1296002C (en) 1992-02-18
EP0239815B1 (de) 1991-07-24
IL81874A0 (en) 1987-10-20
PL264545A1 (en) 1988-07-21
IE870644L (en) 1987-09-13
HK106494A (en) 1994-10-14
DK127487D0 (da) 1987-03-12
FI87777B (fi) 1992-11-13
PH23996A (en) 1990-02-09
US5604225A (en) 1997-02-18
FI871052A0 (fi) 1987-03-11
DK127487A (da) 1987-09-14
HUT44246A (en) 1988-02-29
EP0239815A1 (de) 1987-10-07
JPH0784446B2 (ja) 1995-09-13
US5457205A (en) 1995-10-10
IE59800B1 (en) 1994-04-06

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