DK161327C - Substituerede 2-piperazinopteridiner, fremgangsmaade til fremstilling deraf samt laegemidler indeholdende forbindelserne - Google Patents

Substituerede 2-piperazinopteridiner, fremgangsmaade til fremstilling deraf samt laegemidler indeholdende forbindelserne

Info

Publication number
DK161327C
DK161327C DK572685A DK572685A DK161327C DK 161327 C DK161327 C DK 161327C DK 572685 A DK572685 A DK 572685A DK 572685 A DK572685 A DK 572685A DK 161327 C DK161327 C DK 161327C
Authority
DK
Denmark
Prior art keywords
piperazinopteridines
procedures
substituted
preparing
compounds
Prior art date
Application number
DK572685A
Other languages
Danish (da)
English (en)
Other versions
DK572685D0 (da
DK572685A (da
DK161327B (da
Inventor
Josef Roch
Armin Heckel
Josef Nickl
Erich Mueller
Berthold Narr
Rainer Zimmermann
Hans Weisenberger
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK572685D0 publication Critical patent/DK572685D0/da
Publication of DK572685A publication Critical patent/DK572685A/da
Publication of DK161327B publication Critical patent/DK161327B/da
Application granted granted Critical
Publication of DK161327C publication Critical patent/DK161327C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK572685A 1984-12-12 1985-12-11 Substituerede 2-piperazinopteridiner, fremgangsmaade til fremstilling deraf samt laegemidler indeholdende forbindelserne DK161327C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843445298 DE3445298A1 (de) 1984-12-12 1984-12-12 Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
DE3445298 1984-12-12

Publications (4)

Publication Number Publication Date
DK572685D0 DK572685D0 (da) 1985-12-11
DK572685A DK572685A (da) 1986-06-13
DK161327B DK161327B (da) 1991-06-24
DK161327C true DK161327C (da) 1991-12-09

Family

ID=6252576

Family Applications (1)

Application Number Title Priority Date Filing Date
DK572685A DK161327C (da) 1984-12-12 1985-12-11 Substituerede 2-piperazinopteridiner, fremgangsmaade til fremstilling deraf samt laegemidler indeholdende forbindelserne

Country Status (15)

Country Link
EP (1) EP0185259A3 (cs)
JP (1) JPS61140585A (cs)
AU (1) AU576924B2 (cs)
CA (1) CA1252783A (cs)
DE (1) DE3445298A1 (cs)
DK (1) DK161327C (cs)
ES (1) ES8707238A1 (cs)
FI (1) FI82696C (cs)
GR (1) GR852996B (cs)
IL (1) IL77294A (cs)
NO (1) NO161373C (cs)
NZ (1) NZ214522A (cs)
PH (1) PH24451A (cs)
PT (1) PT81650B (cs)
ZA (1) ZA859462B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
CN1547472A (zh) 2001-06-28 2004-11-17 ��������ҽѧ���޹�˾ 作为d-丙氨酰-d-丙氨酸连接酶抑制剂的稠合嘧啶
DE10202468A1 (de) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
EP1658081B1 (en) * 2003-08-29 2007-10-24 4 Aza Ip Nv Immunosuppressive effects of pteridine derivatives
ATE369862T1 (de) * 2003-10-17 2007-09-15 4 Aza Ip Nv Heterocyclus-substituierte pteridin-derivate und ihre verwendung in der therapie
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
WO2005087227A1 (en) * 2004-03-04 2005-09-22 Neurogen Corporation Arylalkylamino-substituted quinazoline analogues
DE102004057618A1 (de) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057645A1 (de) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057595A1 (de) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057594A1 (de) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen
RU2445315C2 (ru) * 2005-11-22 2012-03-20 Кудос Фармасьютиклз Лимитед ПРОИЗВОДНЫЕ ПИРИДО-, ПИРАЗО- И ПИРИМИДО-ПИРИМИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR
CA2628920C (en) * 2005-11-22 2015-12-29 Kudos Pharmaceuticals Limited Pyrido-,pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors
JP5440934B2 (ja) 2006-05-24 2014-03-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換プテリジン
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2008009079A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
PL2057156T3 (pl) 2006-08-23 2017-08-31 Kudos Pharmaceuticals Limited Pochodne 2-metylomorfolinowe pirydo-, pirazo- i pirymido-pirymidyny jako inhibitory mTOR
BRPI0914912A2 (pt) 2008-06-20 2017-06-20 Astrazeneca Ab processo para a preparação de um composto, e de um inibidor de mtor quinase, sal de fumarato, composição farmacêutica, uso de um sal de fumarato, e, métodos para produzir um efeito inibitório mtor, e para produzir um efeito anti-câncer em um animal de sangue quente
RS56787B1 (sr) 2015-03-04 2018-04-30 Gilead Sciences Inc Toll-like receptor koji modulira jedinjenja 4,6-diamino-pirido[3,2-d]pirimidina
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
CA3035346A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. Toll like receptor modulator compounds
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3159628A (en) * 1962-05-28 1964-12-01 Smith Kline French Lab Pteridine-5-oxide derivatives
DE3323932A1 (de) * 1983-07-02 1985-01-10 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-piperazino-pteridine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel

Also Published As

Publication number Publication date
IL77294A (en) 1989-02-28
DK572685D0 (da) 1985-12-11
FI82696B (fi) 1990-12-31
EP0185259A2 (de) 1986-06-25
AU576924B2 (en) 1988-09-08
PT81650A (de) 1986-01-01
JPS61140585A (ja) 1986-06-27
DE3445298A1 (de) 1986-06-12
FI854862A7 (fi) 1986-06-13
DK572685A (da) 1986-06-13
NZ214522A (en) 1988-07-28
ZA859462B (en) 1987-07-29
CA1252783A (en) 1989-04-18
NO854965L (no) 1986-06-13
NO161373B (no) 1989-05-02
DK161327B (da) 1991-06-24
NO161373C (no) 1989-08-09
GR852996B (cs) 1986-04-16
FI854862A0 (fi) 1985-12-10
AU5123285A (en) 1986-06-19
ES549806A0 (es) 1987-07-16
EP0185259A3 (de) 1989-03-01
ES8707238A1 (es) 1987-07-16
FI82696C (fi) 1991-04-10
PH24451A (en) 1990-06-25
PT81650B (pt) 1988-04-21

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