DK431185A - Substituerede quinazolindioner samt fremgangsmaade til fremstilling deraf - Google Patents

Substituerede quinazolindioner samt fremgangsmaade til fremstilling deraf Download PDF

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Publication number
DK431185A
DK431185A DK431185A DK431185A DK431185A DK 431185 A DK431185 A DK 431185A DK 431185 A DK431185 A DK 431185A DK 431185 A DK431185 A DK 431185A DK 431185 A DK431185 A DK 431185A
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DK
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Prior art keywords
indones
quinazol
procedures
substituted
preparing
Prior art date
Application number
DK431185A
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English (en)
Other versions
DK431185D0 (da
Inventor
Stanley C Bell
Donald W Combs
Robert Falotico
Alfonso J Tobia
Victor T Bandurco
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of DK431185D0 publication Critical patent/DK431185D0/da
Publication of DK431185A publication Critical patent/DK431185A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C205/60Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/95Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK431185A 1984-09-24 1985-09-23 Substituerede quinazolindioner samt fremgangsmaade til fremstilling deraf DK431185A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/653,620 US4639518A (en) 1984-09-24 1984-09-24 Substituted quinazolinediones

Publications (2)

Publication Number Publication Date
DK431185D0 DK431185D0 (da) 1985-09-23
DK431185A true DK431185A (da) 1986-03-25

Family

ID=24621636

Family Applications (1)

Application Number Title Priority Date Filing Date
DK431185A DK431185A (da) 1984-09-24 1985-09-23 Substituerede quinazolindioner samt fremgangsmaade til fremstilling deraf

Country Status (17)

Country Link
US (1) US4639518A (da)
EP (1) EP0176333A3 (da)
KR (1) KR900001181B1 (da)
AU (1) AU578491B2 (da)
DK (1) DK431185A (da)
ES (2) ES8701737A1 (da)
FI (1) FI853639L (da)
GR (1) GR852324B (da)
HU (1) HU196188B (da)
IL (1) IL76467A0 (da)
NO (1) NO853730L (da)
NZ (1) NZ213474A (da)
PL (1) PL255499A1 (da)
PT (1) PT81182B (da)
SU (1) SU1409129A3 (da)
ZA (1) ZA857302B (da)
ZW (1) ZW16785A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711883A (en) * 1985-09-30 1987-12-08 Ortho Pharmaceutical Corporation Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use
US4703120A (en) * 1986-04-28 1987-10-27 Ortho Pharmaceutical Corporation Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof
DE3929589A1 (de) * 1989-09-06 1991-03-07 Basf Ag Verfahren zur herstellung von 3,7-dialkylxanthinen
JPH06509115A (ja) * 1991-07-15 1994-10-13 メルク エンド カンパニー インコーポレーテッド 新規な芳香族臭素化方法
DE4339209A1 (de) * 1993-11-17 1995-05-18 Hoechst Ag Verfahren zur Herstellung von substituierten Chinazolin-2,4-dionen
DE4429978A1 (de) * 1994-08-24 1996-02-29 Bayer Ag Verfahren zur Herstellung von Chinazolin-2,4-dionen
EP0742213A1 (de) * 1995-05-10 1996-11-13 Hoechst Aktiengesellschaft Verfahren zur Herstellung von substituierten 3-Arylchinazolin-2,4-dionen
DE19532052C2 (de) * 1995-08-31 1998-11-19 Clariant Gmbh Verfahren zur Herstellung von Chinazolinderivaten
AU1618697A (en) * 1996-02-06 1997-08-28 Japan Tobacco Inc. Novel compounds and pharmaceutical use thereof
JP6667091B2 (ja) * 2014-08-11 2020-03-18 ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーHydra Biosciences, LLC Trpc5調節因子としての、精神神経障害の処置のためのキナゾリン−2,4(1h,3h)−ジオン誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202895A (en) * 1971-06-04 1980-05-13 Sumitomo Chemical Company, Limited 1-Polyhaloalkyl-2(1H)-quinazolinone derivatives
US4146717A (en) * 1972-04-07 1979-03-27 Sumitomo Chemical Company, Limited Nitroquinazolinone compounds having antiviral properties
US3879393A (en) * 1973-06-18 1975-04-22 Miles Lab Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
US3983120A (en) * 1974-11-06 1976-09-28 Bristol-Myers Company Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US3988340A (en) * 1975-01-23 1976-10-26 Bristol-Myers Company 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
ATE8626T1 (de) * 1980-03-10 1984-08-15 Berri-Balzac Societe Dite: 3-amino-(1h,3h)-2,4-chinazolindionderivate.
US4634769A (en) * 1984-09-25 1987-01-06 Ortho Pharmaceutical Corporation Process for the preparation of 8-halo-5,6-dialkoxyquinazoline-2,4-diones and their salts

Also Published As

Publication number Publication date
NO853730L (no) 1986-03-25
IL76467A0 (en) 1986-01-31
DK431185D0 (da) 1985-09-23
ZW16785A1 (en) 1987-04-15
EP0176333A2 (en) 1986-04-02
KR860002478A (ko) 1986-04-26
ES547205A0 (es) 1986-12-01
PL255499A1 (en) 1987-06-15
FI853639A0 (fi) 1985-09-23
SU1409129A3 (ru) 1988-07-07
HUT40087A (en) 1986-11-28
ZA857302B (en) 1987-05-27
GR852324B (da) 1986-01-24
NZ213474A (en) 1988-10-28
ES553602A0 (es) 1987-12-01
ES8701737A1 (es) 1986-12-01
EP0176333A3 (en) 1987-03-18
HU196188B (en) 1988-10-28
AU4769885A (en) 1986-04-10
KR900001181B1 (ko) 1990-02-27
PT81182B (en) 1987-03-30
FI853639L (fi) 1986-03-25
PT81182A (en) 1985-10-01
US4639518A (en) 1987-01-27
ES8800910A1 (es) 1987-12-01
AU578491B2 (en) 1988-10-27

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