DK1610784T3 - Former af 5-azacytidin - Google Patents

Former af 5-azacytidin Download PDF

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Publication number
DK1610784T3
DK1610784T3 DK04721074.5T DK04721074T DK1610784T3 DK 1610784 T3 DK1610784 T3 DK 1610784T3 DK 04721074 T DK04721074 T DK 04721074T DK 1610784 T3 DK1610784 T3 DK 1610784T3
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DK
Denmark
Prior art keywords
azacytidine
xrpd
pharmaceutical composition
angles
radiation
Prior art date
Application number
DK04721074.5T
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English (en)
Inventor
Dumitru Ionescu
Peter Blumbergs
Lee Alani Selvey
Original Assignee
Celgene Int Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32987557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1610784(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Int Sarl filed Critical Celgene Int Sarl
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Publication of DK1610784T3 publication Critical patent/DK1610784T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (5)

1. Farmaceutisk sammensætning omfattende en krystallinsk form af 5-azacytidin til anvendelse i en fremgangsmåde til behandling af myelodysplastisk syndrom, hvor den krystallinske form af 5-azacytidin er kendetegnet ved toppe observeret under anvendelse af røntgenpulverdiffraktion (Cu Ka stråling) med følgende 2Θ vinkler:
, og hvor fremgangsmåden omfatter oral indgivelse af den farmaceutiske sammensætning.
2. Farmaceutisk sammensætning til anvendelse ifølge krav 1, hvor den krystallinske form af 5-azacytidin er kendetegnet ved røntgenpulverdiffraktions-(XRPD (Cu Ka stråling)) mønstret i det væsentlige i overensstemmelse med Figur 1; og hvor fremgangsmåden omfatter oral indgivelse af den farmaceutiske sammensætning.
3. Farmaceutisk sammensætning til anvendelse ifølge krav 1 eller 2, hvor den krystallinske form af 5-azacytidin er kendetegnet ved toppe observeret under anvendelse af røntgenpulverdiffraktion (Cu Ka stråling) med følgende 2Θ vinkler, d-spacing og relative intensiteter:
og hvor fremgangsmåden omfatter oral indgivelse af den farmaceutiske sammensætning.
4. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor den farmaceutiske sammensætning fremstilles i enhedsdosisform.
5. Farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor hver dosisenhed indeholder fra 5 mg til 200 mg, fortrinsvis 100 mg af den krystallinske form af 5-azacytidin.
DK04721074.5T 2003-03-17 2004-03-16 Former af 5-azacytidin DK1610784T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/390,578 US6887855B2 (en) 2003-03-17 2003-03-17 Forms of 5-azacytidine
PCT/US2004/007895 WO2004082619A2 (en) 2003-03-17 2004-03-16 Forms of 5-azacytidine

Publications (1)

Publication Number Publication Date
DK1610784T3 true DK1610784T3 (da) 2016-09-12

Family

ID=32987557

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10179540.9T DK2258711T3 (da) 2003-03-17 2004-03-16 Nye former af 5-azacytidin
DK04721074.5T DK1610784T3 (da) 2003-03-17 2004-03-16 Former af 5-azacytidin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10179540.9T DK2258711T3 (da) 2003-03-17 2004-03-16 Nye former af 5-azacytidin

Country Status (11)

Country Link
US (7) US6887855B2 (da)
EP (5) EP2258711B9 (da)
CY (2) CY1117990T1 (da)
DK (2) DK2258711T3 (da)
ES (2) ES2621531T3 (da)
HU (2) HUE033508T2 (da)
LT (1) LT1610784T (da)
PL (2) PL2258711T3 (da)
PT (2) PT2258711T (da)
SI (2) SI2258711T1 (da)
WO (1) WO2004082619A2 (da)

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Also Published As

Publication number Publication date
EP2270023A1 (en) 2011-01-05
US8513406B2 (en) 2013-08-20
LT1610784T (lt) 2016-10-25
US20130059810A1 (en) 2013-03-07
PL1610784T3 (pl) 2017-02-28
EP2258711A2 (en) 2010-12-08
US20100298253A1 (en) 2010-11-25
EP1610784B1 (en) 2016-07-06
EP2258710A1 (en) 2010-12-08
ES2621531T3 (es) 2017-07-04
US20140107058A1 (en) 2014-04-17
US8779117B2 (en) 2014-07-15
WO2004082619A2 (en) 2004-09-30
US20130059809A1 (en) 2013-03-07
US20040186065A1 (en) 2004-09-23
EP1610784A2 (en) 2006-01-04
EP2270022A1 (en) 2011-01-05
US8614313B2 (en) 2013-12-24
US20060247189A1 (en) 2006-11-02
PT2258711T (pt) 2017-03-30
WO2004082619A3 (en) 2005-05-26
EP2270023B1 (en) 2016-06-15
EP2258711A3 (en) 2011-03-30
PL2258711T3 (pl) 2017-08-31
DK2258711T3 (da) 2017-04-24
HUE030717T2 (en) 2017-05-29
EP2258711B9 (en) 2017-12-27
EP1610784A4 (en) 2007-11-07
ES2592287T3 (es) 2016-11-29
US7772199B2 (en) 2010-08-10
US6887855B2 (en) 2005-05-03
EP2270022B1 (en) 2016-06-29
US7078518B2 (en) 2006-07-18
HUE033508T2 (en) 2017-12-28
SI2258711T1 (sl) 2017-08-31
CY1118805T1 (el) 2018-01-10
EP2258711B1 (en) 2017-01-18
CY1117990T1 (el) 2017-05-17
EP2258710B1 (en) 2016-10-19
SI1610784T1 (sl) 2017-01-31
US9192620B2 (en) 2015-11-24
US20050137150A1 (en) 2005-06-23
PT1610784T (pt) 2016-09-23

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