CY1117990T1 - Μορφες 5-αζακιτιδινης - Google Patents
Μορφες 5-αζακιτιδινηςInfo
- Publication number
- CY1117990T1 CY1117990T1 CY20161100901T CY161100901T CY1117990T1 CY 1117990 T1 CY1117990 T1 CY 1117990T1 CY 20161100901 T CY20161100901 T CY 20161100901T CY 161100901 T CY161100901 T CY 161100901T CY 1117990 T1 CY1117990 T1 CY 1117990T1
- Authority
- CY
- Cyprus
- Prior art keywords
- forms
- azakitidine
- azacytidine
- preparing
- represented
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Abstract
Η εφεύρεση παρέχει καινοτομικές πολυμορφικές και ψευδοπολυμορφικές κρυσταλλικές μορφές 5-αζακιτιδίνης, μαζί με μεθόδους παρασκευής αυτών των μορφών, όπου η 5-αζακιτιδίνη αντιπροσωπεύεται από τον τύπο (I). Η εφεύρεση περιλαμβάνει επίσης φαρμακευτικές συνθέσεις που περιέχουν τις εν λόγω μορφές.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/390,578 US6887855B2 (en) | 2003-03-17 | 2003-03-17 | Forms of 5-azacytidine |
PCT/US2004/007895 WO2004082619A2 (en) | 2003-03-17 | 2004-03-16 | Forms of 5-azacytidine |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1117990T1 true CY1117990T1 (el) | 2017-05-17 |
Family
ID=32987557
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100901T CY1117990T1 (el) | 2003-03-17 | 2016-09-13 | Μορφες 5-αζακιτιδινης |
CY20171100369T CY1118805T1 (el) | 2003-03-17 | 2017-03-24 | Νεες μορφες 5-αζακιτιδινης |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100369T CY1118805T1 (el) | 2003-03-17 | 2017-03-24 | Νεες μορφες 5-αζακιτιδινης |
Country Status (11)
Country | Link |
---|---|
US (7) | US6887855B2 (el) |
EP (5) | EP2270023B1 (el) |
CY (2) | CY1117990T1 (el) |
DK (2) | DK2258711T3 (el) |
ES (2) | ES2592287T3 (el) |
HU (2) | HUE030717T2 (el) |
LT (1) | LT1610784T (el) |
PL (2) | PL2258711T3 (el) |
PT (2) | PT1610784T (el) |
SI (2) | SI2258711T1 (el) |
WO (1) | WO2004082619A2 (el) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8404716B2 (en) * | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
US8404717B2 (en) * | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes using lenalidomide |
US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
US6887855B2 (en) | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
US6943249B2 (en) | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
US7038038B2 (en) * | 2003-03-17 | 2006-05-02 | Pharmion Corporation | Synthesis of 5-azacytidine |
EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
EP2118117A2 (en) * | 2007-01-11 | 2009-11-18 | IVAX Pharmaceuticals s.r.o. | Solid state forms of 5-azacytidine and processes for preparation thereof |
WO2009016617A2 (en) * | 2007-08-02 | 2009-02-05 | Chemagis Ltd. | Stable highly pure azacitidine and preparation methods therefor |
KR20100072230A (ko) * | 2007-09-26 | 2010-06-30 | 마운트 시나이 스쿨 오브 메디신 오브 뉴욕 유니버시티 | 아자시티딘 유사체 및 이의 용도 |
WO2009058394A1 (en) * | 2007-11-01 | 2009-05-07 | Celgene Corporation | Cytidine analogs for treatment of myelodysplastic syndromes |
AU2009246926B2 (en) | 2008-05-15 | 2014-06-26 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
WO2010014883A2 (en) | 2008-08-01 | 2010-02-04 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
AR073003A1 (es) * | 2008-08-08 | 2010-10-06 | Scinopharm Taiwan Ltd | Proceso para preparar 5-azacitosina nucleosidos y sus derivados |
CA2755976C (en) | 2009-03-23 | 2020-04-07 | Ambit Biosciences Corporation | Methods of treatment using combination therapy |
AR076418A1 (es) * | 2009-04-27 | 2011-06-08 | Reddys Lab Inc Dr | Preparacion de decitabina |
US20110042247A1 (en) * | 2009-06-25 | 2011-02-24 | Chandrasekhar Kocherlakota | Formulations of azacitidine and its derivatives |
ES2378018T3 (es) * | 2009-09-14 | 2012-04-04 | The Procter & Gamble Company | Composición detergente |
SG10201500124VA (en) * | 2010-01-08 | 2015-03-30 | Agency Science Tech & Res | Methods and Compositions for Treating Cancer |
WO2012106299A1 (en) * | 2011-01-31 | 2012-08-09 | Celgene Corporation | Pharmaceutical compositions of cytidine analogs and methods of use thereof |
US9951098B2 (en) * | 2011-03-31 | 2018-04-24 | Pharmion Llc | Synthesis of 5-azacytidine |
WO2013022872A1 (en) | 2011-08-10 | 2013-02-14 | Celgene Corporation | Gene methylation biomarkers and methods of use thereof |
JP2014526558A (ja) | 2011-09-23 | 2014-10-06 | セルジーン コーポレイション | リンパ腫の治療に使用するためのロミデプシン及び5−アザシチジン |
US20130244950A1 (en) | 2011-09-26 | 2013-09-19 | Celgene Corporation | Combination therapy for chemoresistant cancers |
BR112014010699B1 (pt) | 2011-11-03 | 2020-12-15 | Millennium Pharmaceuticals, Inc | Uso de um inibidor nae com um agente de hipometilação para tratar malignidade hematológica e kit |
US9765108B2 (en) | 2012-11-19 | 2017-09-19 | Shilpa Medicare Limited | Formulation of 5-azacytidine |
WO2014076616A2 (en) * | 2012-11-19 | 2014-05-22 | Shilpa Medicare Limited | Formulations of 5-azacytidine |
WO2014160698A1 (en) | 2013-03-26 | 2014-10-02 | Celgene Corporation | SOLID FORMS COMPRISING 4-AMINO-I-β-D-RIBOFURANOSYL-1,3,5-TRIAZIN-2(1H)-ONE AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
CN103450303A (zh) * | 2013-09-04 | 2013-12-18 | 重庆泰濠制药有限公司 | 阿扎胞苷晶型a、阿扎胞苷晶型b及其制备方法 |
PL3182996T3 (pl) | 2014-08-22 | 2023-04-17 | Celgene Corporation | Sposoby leczenia szpiczaka mnogiego związkami immunomodulującymi w kombinacji z przeciwciałami |
US20160095925A1 (en) * | 2014-10-01 | 2016-04-07 | Cadila Healthcare Limited | Stable formulation of azacitidine or salts thereof and their process for preparation |
GB2542881B (en) * | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
WO2017066611A1 (en) | 2015-10-15 | 2017-04-20 | Celgene Corporation | Combination therapy for treating malignancies |
DK3362066T3 (da) | 2015-10-15 | 2021-11-22 | Les Laboratoires Servier Sas | Kombinationsterapi til behandling af maligniteter |
WO2019025256A1 (en) | 2017-08-01 | 2019-02-07 | Bayer Aktiengesellschaft | COMBINATION OF MIDH1 INHIBITORS AND DNA HYPOMETHYLATION (AHM) AGENTS |
CN107827944B (zh) * | 2017-11-02 | 2020-11-24 | 北京满格医药科技有限公司 | 一种阿扎胞苷单晶的制备方法 |
CN109988207B (zh) * | 2017-12-29 | 2022-01-04 | 江苏豪森药业集团有限公司 | 阿扎胞苷晶型的制备方法 |
CN110642901A (zh) * | 2019-11-11 | 2020-01-03 | 扬子江药业集团有限公司 | 阿扎胞苷甲醇化物及其制备方法和药物组合物、用途 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1050899A (el) | 1963-12-22 | |||
CH527207A (de) | 1968-05-08 | 1972-08-31 | Ceskoslovenska Akademie Ved | Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen |
CH507969A (de) | 1968-11-12 | 1971-05-31 | Ceskoslovenska Akademie Ved | Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen |
DE2012888C3 (de) | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
FR2123632A6 (en) | 1971-01-26 | 1972-09-15 | Ceskoslovenska Akademie Ved | Prepn of 5-azacytosines and 5-azacytidines - from bis trimethylsilyl-5-azacytosine |
DE2122991C2 (de) | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
DE2508312A1 (de) | 1975-02-24 | 1976-09-02 | Schering Ag | Neues verfahren zur herstellung von nucleosiden |
DE2757365A1 (de) | 1977-12-20 | 1979-06-21 | Schering Ag | Neues verfahren zur herstellung von nucleosiden |
US5700640A (en) * | 1994-09-16 | 1997-12-23 | Basf Aktiengesellschaft | Inducers of gamma globin gene expression and screening assays therefor |
US5872104A (en) * | 1994-12-27 | 1999-02-16 | Oridigm Corporation | Combinations and methods for reducing antimicrobial resistance |
TW513409B (en) | 1996-06-07 | 2002-12-11 | Eisai Co Ltd | Polymorphs of donepezil hydrochloride |
PT1132393E (pt) | 1996-10-16 | 2003-08-29 | Ribapharm Inc | L-ribavirina e usos da mesma |
AU5105100A (en) | 1999-06-03 | 2000-12-28 | Eisai Co. Ltd. | Crystals of carbapenem derivatives and pharmaceutical preparations for injection |
ES2253233T3 (es) | 1999-07-09 | 2006-06-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Procedimiento para sintesis de compuestos de urea heteroaril sustituidos. |
DE60139264D1 (de) | 2000-09-07 | 2009-08-27 | Kaneka Corp | Verfahren zur kristallisation von hydroxycarbonsäuren |
EP1903041B1 (en) * | 2001-03-01 | 2015-02-18 | AbbVie Inc. | Polymorphic and other crystalline forms of cis-FTC |
US7772197B2 (en) * | 2002-09-24 | 2010-08-10 | 1,3,5-Triazines for Treatment of Viral Diseases | 1,3,5-triazines for treatment of viral diseases |
US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
WO2004041195A2 (en) | 2002-10-31 | 2004-05-21 | Supergen, Inc. | Pharmaceutical formulations targeting specific regions of the gastrointestinal tract |
WO2004069796A2 (en) | 2003-02-03 | 2004-08-19 | Teva Pharmaceutical Industries Ltd. | Process for producing levetiracetam |
US6943249B2 (en) | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
US7038038B2 (en) | 2003-03-17 | 2006-05-02 | Pharmion Corporation | Synthesis of 5-azacytidine |
US6887855B2 (en) | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
CN102349927A (zh) | 2003-08-29 | 2012-02-15 | Hdac默克研究有限责任公司 | 联合治疗癌症的方法 |
US7192781B2 (en) | 2004-04-13 | 2007-03-20 | Pharmion Corporation | Methods for stabilizing 5-azacytidine in plasma |
US20060063735A1 (en) | 2004-09-17 | 2006-03-23 | Supergen, Inc. | Salts of 5-azacytidine |
US20060069060A1 (en) | 2004-09-27 | 2006-03-30 | Sanjeev Redkar | Salts of decitabine |
US20060128654A1 (en) | 2004-12-10 | 2006-06-15 | Chunlin Tang | Pharmaceutical formulation of cytidine analogs and derivatives |
WO2008028193A2 (en) | 2006-09-01 | 2008-03-06 | Pharmion Corporation | Colon-targeted oral formulations of cytidine analogs |
EP2118117A2 (en) | 2007-01-11 | 2009-11-18 | IVAX Pharmaceuticals s.r.o. | Solid state forms of 5-azacytidine and processes for preparation thereof |
WO2008092127A1 (en) | 2007-01-25 | 2008-07-31 | Nevada Cancer Institute | Use of acetylated or esterificated azacytidine, decitabine, or other nucleoside analogs as oral agents for the treatment of tumors or other dysplastic syndromes sensitive to hypomethylating agents |
WO2009016617A2 (en) | 2007-08-02 | 2009-02-05 | Chemagis Ltd. | Stable highly pure azacitidine and preparation methods therefor |
EP2048151A1 (en) | 2007-10-10 | 2009-04-15 | Cilag AG | Method for producing nucleosides by direct glycosylation of the nucleoside base |
WO2009058394A1 (en) | 2007-11-01 | 2009-05-07 | Celgene Corporation | Cytidine analogs for treatment of myelodysplastic syndromes |
AU2009246926B2 (en) | 2008-05-15 | 2014-06-26 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
WO2010014883A2 (en) | 2008-08-01 | 2010-02-04 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
WO2010017374A1 (en) | 2008-08-06 | 2010-02-11 | Sicor Inc. | Process for preparing azacytidine intermediate |
AR073003A1 (es) | 2008-08-08 | 2010-10-06 | Scinopharm Taiwan Ltd | Proceso para preparar 5-azacitosina nucleosidos y sus derivados |
US20110042247A1 (en) | 2009-06-25 | 2011-02-24 | Chandrasekhar Kocherlakota | Formulations of azacitidine and its derivatives |
WO2011014541A1 (en) | 2009-07-30 | 2011-02-03 | Eagle Pharmaceuticals, Inc. | Stable formulations of azacitidine |
IT1399195B1 (it) | 2010-03-30 | 2013-04-11 | Chemi Spa | Processo per la sintesi di azacitidina e decitabina |
-
2003
- 2003-03-17 US US10/390,578 patent/US6887855B2/en not_active Expired - Lifetime
-
2004
- 2004-03-16 HU HUE04721074A patent/HUE030717T2/en unknown
- 2004-03-16 SI SI200432388T patent/SI2258711T1/sl unknown
- 2004-03-16 PT PT47210745T patent/PT1610784T/pt unknown
- 2004-03-16 ES ES04721074.5T patent/ES2592287T3/es not_active Expired - Lifetime
- 2004-03-16 HU HUE10179540A patent/HUE033508T2/en unknown
- 2004-03-16 EP EP10178303.3A patent/EP2270023B1/en not_active Expired - Lifetime
- 2004-03-16 EP EP10178261.3A patent/EP2258710B1/en not_active Expired - Lifetime
- 2004-03-16 DK DK10179540.9T patent/DK2258711T3/en active
- 2004-03-16 PL PL10179540T patent/PL2258711T3/pl unknown
- 2004-03-16 EP EP04721074.5A patent/EP1610784B1/en not_active Revoked
- 2004-03-16 ES ES10179540.9T patent/ES2621531T3/es not_active Expired - Lifetime
- 2004-03-16 PL PL04721074T patent/PL1610784T3/pl unknown
- 2004-03-16 PT PT101795409T patent/PT2258711T/pt unknown
- 2004-03-16 SI SI200432342A patent/SI1610784T1/sl unknown
- 2004-03-16 WO PCT/US2004/007895 patent/WO2004082619A2/en active Application Filing
- 2004-03-16 EP EP10179540.9A patent/EP2258711B9/en not_active Revoked
- 2004-03-16 EP EP10178245.6A patent/EP2270022B1/en not_active Expired - Lifetime
- 2004-03-16 DK DK04721074.5T patent/DK1610784T3/en active
- 2004-03-16 LT LTEP04721074.5T patent/LT1610784T/lt unknown
-
2005
- 2005-02-07 US US11/052,615 patent/US7078518B2/en not_active Expired - Lifetime
-
2006
- 2006-07-18 US US11/458,365 patent/US7772199B2/en not_active Expired - Lifetime
-
2010
- 2010-05-25 US US12/787,214 patent/US8779117B2/en not_active Expired - Lifetime
-
2012
- 2012-08-16 US US13/587,770 patent/US8513406B2/en not_active Expired - Lifetime
- 2012-08-16 US US13/587,768 patent/US8614313B2/en not_active Expired - Lifetime
-
2013
- 2013-12-20 US US14/137,907 patent/US9192620B2/en not_active Expired - Lifetime
-
2016
- 2016-09-13 CY CY20161100901T patent/CY1117990T1/el unknown
-
2017
- 2017-03-24 CY CY20171100369T patent/CY1118805T1/el unknown
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