PL1610784T3 - Postacie 5-azacytydyny - Google Patents

Postacie 5-azacytydyny

Info

Publication number
PL1610784T3
PL1610784T3 PL04721074T PL04721074T PL1610784T3 PL 1610784 T3 PL1610784 T3 PL 1610784T3 PL 04721074 T PL04721074 T PL 04721074T PL 04721074 T PL04721074 T PL 04721074T PL 1610784 T3 PL1610784 T3 PL 1610784T3
Authority
PL
Poland
Prior art keywords
azacytidine
forms
Prior art date
Application number
PL04721074T
Other languages
English (en)
Inventor
Dumitru Ionescu
Peter Blumbergs
Lee Alani Selvey
Original Assignee
Celgene International Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32987557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1610784(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene International Sarl filed Critical Celgene International Sarl
Publication of PL1610784T3 publication Critical patent/PL1610784T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL04721074T 2003-03-17 2004-03-16 Postacie 5-azacytydyny PL1610784T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/390,578 US6887855B2 (en) 2003-03-17 2003-03-17 Forms of 5-azacytidine

Publications (1)

Publication Number Publication Date
PL1610784T3 true PL1610784T3 (pl) 2017-02-28

Family

ID=32987557

Family Applications (2)

Application Number Title Priority Date Filing Date
PL10179540T PL2258711T3 (pl) 2003-03-17 2004-03-16 Nowe postacie 5-azacytydyny
PL04721074T PL1610784T3 (pl) 2003-03-17 2004-03-16 Postacie 5-azacytydyny

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL10179540T PL2258711T3 (pl) 2003-03-17 2004-03-16 Nowe postacie 5-azacytydyny

Country Status (11)

Country Link
US (7) US6887855B2 (pl)
EP (5) EP2270022B1 (pl)
CY (2) CY1117990T1 (pl)
DK (2) DK1610784T3 (pl)
ES (2) ES2621531T3 (pl)
HU (2) HUE030717T2 (pl)
LT (1) LT1610784T (pl)
PL (2) PL2258711T3 (pl)
PT (2) PT1610784T (pl)
SI (2) SI2258711T1 (pl)
WO (1) WO2004082619A2 (pl)

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US11116782B2 (en) 2002-10-15 2021-09-14 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US8404716B2 (en) * 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
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US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
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WO2009016617A2 (en) * 2007-08-02 2009-02-05 Chemagis Ltd. Stable highly pure azacitidine and preparation methods therefor
BRPI0817269A2 (pt) * 2007-09-26 2014-10-07 Sinai School Medicine Análogos de azacitidina e usos dos mesmos
CA2742252A1 (en) * 2007-11-01 2009-05-07 Celgene Corporation Cytidine analogs for treatment of myelodysplastic syndromes
MX363023B (es) * 2008-05-15 2019-03-05 Celgene Corp Formulaciones orales de analogos de citidina y metodos para usar los mismos.
EP2321302B1 (en) 2008-08-01 2014-10-29 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
ES2487525T3 (es) * 2008-08-08 2014-08-21 Scinopharm Taiwan Ltd. Procedimiento para preparar nucleósidos de 5-azacitosina y sus derivados
CA2755976C (en) * 2009-03-23 2020-04-07 Ambit Biosciences Corporation Methods of treatment using combination therapy
WO2010129211A2 (en) * 2009-04-27 2010-11-11 Dr. Reddy's Laboratories Ltd. Preparation of decitabine
US20110042247A1 (en) * 2009-06-25 2011-02-24 Chandrasekhar Kocherlakota Formulations of azacitidine and its derivatives
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WO2011084108A1 (en) * 2010-01-08 2011-07-14 Agency For Science, Technology And Research Methods and compositions for treating cancer
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RU2013148580A (ru) * 2011-03-31 2015-05-10 Селджин Интернешнл Сарл Синтез 5-азацитидина
WO2013022872A1 (en) 2011-08-10 2013-02-14 Celgene Corporation Gene methylation biomarkers and methods of use thereof
AU2012312308B2 (en) 2011-09-23 2015-11-19 Celgene Corporation Romidepsin and 5-azacitidine for use in treating lymphoma
MX2014003591A (es) 2011-09-26 2014-09-08 Celgene Corp Terapia de combinacion para canceres quimiorresistentes.
EP2773360B1 (en) 2011-11-03 2018-02-28 Millennium Pharmaceuticals, Inc. Administration of nedd8-activating enzyme inhibitor and hypomethylating agent
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WO2014076616A2 (en) * 2012-11-19 2014-05-22 Shilpa Medicare Limited Formulations of 5-azacytidine
US9968627B2 (en) 2013-03-26 2018-05-15 Celgene Corporation Solid forms comprising 4-amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one and a coformer, compositions and methods of use thereof
CN103450303A (zh) * 2013-09-04 2013-12-18 重庆泰濠制药有限公司 阿扎胞苷晶型a、阿扎胞苷晶型b及其制备方法
ES2940302T3 (es) 2014-08-22 2023-05-05 Celgene Corp Métodos para tratar el mieloma múltiple con compuestos inmunomoduladores en combinación con anticuerpos
US20160095925A1 (en) * 2014-10-01 2016-04-07 Cadila Healthcare Limited Stable formulation of azacitidine or salts thereof and their process for preparation
GB2542881B (en) * 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
MX2018004586A (es) 2015-10-15 2018-08-16 Agios Pharmaceuticals Inc Terapia de combinacion para tratar tumores malignos.
EP3362070B1 (en) 2015-10-15 2021-01-27 Celgene Corporation Combination of a mutant isocitrate dehydrogenase 2 inhibitor with azacitidine and its use for treating acute myelogenous leukemia
WO2019025256A1 (en) 2017-08-01 2019-02-07 Bayer Aktiengesellschaft COMBINATION OF MIDH1 INHIBITORS AND DNA HYPOMETHYLATION (AHM) AGENTS
CN107827944B (zh) * 2017-11-02 2020-11-24 北京满格医药科技有限公司 一种阿扎胞苷单晶的制备方法
CN109988207B (zh) * 2017-12-29 2022-01-04 江苏豪森药业集团有限公司 阿扎胞苷晶型的制备方法
US10632211B2 (en) 2018-06-11 2020-04-28 The Regents Of The University Of California Demethylation to treat eye disease
CN110642901A (zh) * 2019-11-11 2020-01-03 扬子江药业集团有限公司 阿扎胞苷甲醇化物及其制备方法和药物组合物、用途

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Also Published As

Publication number Publication date
EP2258711A3 (en) 2011-03-30
US20130059810A1 (en) 2013-03-07
HUE033508T2 (en) 2017-12-28
PT1610784T (pt) 2016-09-23
EP2270022B1 (en) 2016-06-29
US20040186065A1 (en) 2004-09-23
DK1610784T3 (en) 2016-09-12
HUE030717T2 (en) 2017-05-29
US9192620B2 (en) 2015-11-24
ES2621531T3 (es) 2017-07-04
US8779117B2 (en) 2014-07-15
EP2258711A2 (en) 2010-12-08
EP2258711B9 (en) 2017-12-27
US6887855B2 (en) 2005-05-03
US20100298253A1 (en) 2010-11-25
SI2258711T1 (sl) 2017-08-31
LT1610784T (lt) 2016-10-25
US7078518B2 (en) 2006-07-18
US8614313B2 (en) 2013-12-24
US7772199B2 (en) 2010-08-10
ES2592287T3 (es) 2016-11-29
WO2004082619A2 (en) 2004-09-30
SI1610784T1 (sl) 2017-01-31
EP2258710B1 (en) 2016-10-19
EP2270022A1 (en) 2011-01-05
EP2258710A1 (en) 2010-12-08
EP1610784A4 (en) 2007-11-07
EP1610784A2 (en) 2006-01-04
US20140107058A1 (en) 2014-04-17
CY1118805T1 (el) 2018-01-10
US20130059809A1 (en) 2013-03-07
WO2004082619A3 (en) 2005-05-26
US20050137150A1 (en) 2005-06-23
EP2270023B1 (en) 2016-06-15
US20060247189A1 (en) 2006-11-02
EP1610784B1 (en) 2016-07-06
EP2270023A1 (en) 2011-01-05
PT2258711T (pt) 2017-03-30
CY1117990T1 (el) 2017-05-17
PL2258711T3 (pl) 2017-08-31
DK2258711T3 (en) 2017-04-24
EP2258711B1 (en) 2017-01-18
US8513406B2 (en) 2013-08-20

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