SI1610784T1 - Oblike 5-azacitidina - Google Patents

Oblike 5-azacitidina

Info

Publication number
SI1610784T1
SI1610784T1 SI200432342A SI200432342A SI1610784T1 SI 1610784 T1 SI1610784 T1 SI 1610784T1 SI 200432342 A SI200432342 A SI 200432342A SI 200432342 A SI200432342 A SI 200432342A SI 1610784 T1 SI1610784 T1 SI 1610784T1
Authority
SI
Slovenia
Prior art keywords
azacytidine
forms
Prior art date
Application number
SI200432342A
Other languages
English (en)
Inventor
Dumitru Ionescu
Peter Blumbergs
Lee Alani Selvey
Original Assignee
Celgene International Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32987557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1610784(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene International Sarl filed Critical Celgene International Sarl
Publication of SI1610784T1 publication Critical patent/SI1610784T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
SI200432342A 2003-03-17 2004-03-16 Oblike 5-azacitidina SI1610784T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/390,578 US6887855B2 (en) 2003-03-17 2003-03-17 Forms of 5-azacytidine
EP04721074.5A EP1610784B1 (en) 2003-03-17 2004-03-16 Forms of 5-azacytidine
PCT/US2004/007895 WO2004082619A2 (en) 2003-03-17 2004-03-16 Forms of 5-azacytidine

Publications (1)

Publication Number Publication Date
SI1610784T1 true SI1610784T1 (sl) 2017-01-31

Family

ID=32987557

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200432388T SI2258711T1 (sl) 2003-03-17 2004-03-16 Nove oblike 5-azacitidina
SI200432342A SI1610784T1 (sl) 2003-03-17 2004-03-16 Oblike 5-azacitidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200432388T SI2258711T1 (sl) 2003-03-17 2004-03-16 Nove oblike 5-azacitidina

Country Status (11)

Country Link
US (7) US6887855B2 (sl)
EP (5) EP2258711B9 (sl)
CY (2) CY1117990T1 (sl)
DK (2) DK2258711T3 (sl)
ES (2) ES2621531T3 (sl)
HU (2) HUE033508T2 (sl)
LT (1) LT1610784T (sl)
PL (2) PL2258711T3 (sl)
PT (2) PT2258711T (sl)
SI (2) SI2258711T1 (sl)
WO (1) WO2004082619A2 (sl)

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US11116782B2 (en) 2002-10-15 2021-09-14 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6887855B2 (en) * 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) * 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
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AU2008304380A1 (en) * 2007-09-26 2009-04-02 Mount Sinai School Of Medicine Azacytidine analogues and uses thereof
EP2211870A1 (en) * 2007-11-01 2010-08-04 Celgene Corporation Cytidine analogs for treatment of myelodysplastic syndromes
BRPI0912717A2 (pt) * 2008-05-15 2014-12-23 Celgene Corp Composição farmacêutica, e, uso de 5-azacitidina
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AR073003A1 (es) * 2008-08-08 2010-10-06 Scinopharm Taiwan Ltd Proceso para preparar 5-azacitosina nucleosidos y sus derivados
JP6033678B2 (ja) 2009-03-23 2016-11-30 アムビト ビオスシエンセス コルポラチオン 併用療法を用いた治療方法
EP2424845A4 (en) * 2009-04-27 2014-03-05 Reddys Lab Ltd Dr PREPARATION OF DECITABIN
US20110042247A1 (en) * 2009-06-25 2011-02-24 Chandrasekhar Kocherlakota Formulations of azacitidine and its derivatives
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EP2670396A1 (en) * 2011-01-31 2013-12-11 Celgene Corporation Pharmaceutical compositions of cytidine analogs and methods of use thereof
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CA2849708A1 (en) 2011-09-23 2013-03-28 Celgene Corporation Romidepsin and 5 - azacitidine for use in treating lymphoma
AU2012316266B2 (en) 2011-09-26 2015-07-30 Celgene Corporation Combination therapy for chemoresistant cancers
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CN103450303A (zh) * 2013-09-04 2013-12-18 重庆泰濠制药有限公司 阿扎胞苷晶型a、阿扎胞苷晶型b及其制备方法
RS64038B1 (sr) 2014-08-22 2023-04-28 Celgene Corp Postupci za lečenje multiplog mijeloma imunomodulatornim jedinjenjima u kombinaciji sa antitelima
US20160095925A1 (en) * 2014-10-01 2016-04-07 Cadila Healthcare Limited Stable formulation of azacitidine or salts thereof and their process for preparation
GB2542881B (en) * 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
JP6895956B2 (ja) 2015-10-15 2021-06-30 セルジーン コーポレイション 悪性腫瘍を治療するための併用療法
US10653710B2 (en) 2015-10-15 2020-05-19 Agios Pharmaceuticals, Inc. Combination therapy for treating malignancies
CN111278465A (zh) 2017-08-01 2020-06-12 德国癌症研究中心 mIDH1抑制剂和DNA低甲基化剂（HMA）的组合
CN107827944B (zh) * 2017-11-02 2020-11-24 北京满格医药科技有限公司 一种阿扎胞苷单晶的制备方法
CN109988207B (zh) * 2017-12-29 2022-01-04 江苏豪森药业集团有限公司 阿扎胞苷晶型的制备方法
CA3103436A1 (en) 2018-06-11 2019-12-19 The Regents Of The University Of California Demethylation to treat eye disease
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Also Published As

Publication number Publication date
EP2270023A1 (en) 2011-01-05
US8513406B2 (en) 2013-08-20
LT1610784T (lt) 2016-10-25
US20130059810A1 (en) 2013-03-07
PL1610784T3 (pl) 2017-02-28
EP2258711A2 (en) 2010-12-08
US20100298253A1 (en) 2010-11-25
EP1610784B1 (en) 2016-07-06
EP2258710A1 (en) 2010-12-08
ES2621531T3 (es) 2017-07-04
US20140107058A1 (en) 2014-04-17
US8779117B2 (en) 2014-07-15
WO2004082619A2 (en) 2004-09-30
US20130059809A1 (en) 2013-03-07
US20040186065A1 (en) 2004-09-23
EP1610784A2 (en) 2006-01-04
EP2270022A1 (en) 2011-01-05
US8614313B2 (en) 2013-12-24
US20060247189A1 (en) 2006-11-02
PT2258711T (pt) 2017-03-30
WO2004082619A3 (en) 2005-05-26
EP2270023B1 (en) 2016-06-15
EP2258711A3 (en) 2011-03-30
PL2258711T3 (pl) 2017-08-31
DK2258711T3 (en) 2017-04-24
HUE030717T2 (en) 2017-05-29
EP2258711B9 (en) 2017-12-27
EP1610784A4 (en) 2007-11-07
ES2592287T3 (es) 2016-11-29
US7772199B2 (en) 2010-08-10
US6887855B2 (en) 2005-05-03
EP2270022B1 (en) 2016-06-29
DK1610784T3 (en) 2016-09-12
US7078518B2 (en) 2006-07-18
HUE033508T2 (en) 2017-12-28
SI2258711T1 (sl) 2017-08-31
CY1118805T1 (el) 2018-01-10
EP2258711B1 (en) 2017-01-18
CY1117990T1 (el) 2017-05-17
EP2258710B1 (en) 2016-10-19
US9192620B2 (en) 2015-11-24
US20050137150A1 (en) 2005-06-23
PT1610784T (pt) 2016-09-23

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