DK160279C - Analogifremgangsmaade til fremstilling af 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-on-derivater - Google Patents
Analogifremgangsmaade til fremstilling af 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-on-derivaterInfo
- Publication number
- DK160279C DK160279C DK228878A DK228878A DK160279C DK 160279 C DK160279 C DK 160279C DK 228878 A DK228878 A DK 228878A DK 228878 A DK228878 A DK 228878A DK 160279 C DK160279 C DK 160279C
- Authority
- DK
- Denmark
- Prior art keywords
- tetrazol
- pyrido
- pyrimidin
- derivatives
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80026477 | 1977-05-25 | ||
| US05/800,264 US4122274A (en) | 1977-05-25 | 1977-05-25 | 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK228878A DK228878A (da) | 1978-11-26 |
| DK160279B DK160279B (da) | 1991-02-18 |
| DK160279C true DK160279C (da) | 1991-07-22 |
Family
ID=25177928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK228878A DK160279C (da) | 1977-05-25 | 1978-05-23 | Analogifremgangsmaade til fremstilling af 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-on-derivater |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4122274A (ru) |
| JP (1) | JPS6050197B2 (ru) |
| AT (1) | AT365187B (ru) |
| AU (1) | AU521211B2 (ru) |
| BE (1) | BE867295A (ru) |
| CA (1) | CA1098520A (ru) |
| CH (1) | CH642656A5 (ru) |
| CY (1) | CY1218A (ru) |
| DE (1) | DE2822544A1 (ru) |
| DK (1) | DK160279C (ru) |
| FI (1) | FI64594C (ru) |
| FR (1) | FR2401159A1 (ru) |
| GB (1) | GB1596476A (ru) |
| GR (1) | GR71887B (ru) |
| HK (1) | HK25884A (ru) |
| IE (1) | IE46849B1 (ru) |
| IT (1) | IT1105040B (ru) |
| KE (1) | KE3357A (ru) |
| LU (1) | LU79694A1 (ru) |
| MY (1) | MY8500305A (ru) |
| NL (1) | NL190702C (ru) |
| NO (1) | NO150361C (ru) |
| SE (1) | SE437830B (ru) |
| SG (1) | SG73383G (ru) |
| YU (2) | YU42163B (ru) |
| ZA (1) | ZA782816B (ru) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU173438B (hu) * | 1975-11-27 | 1979-05-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom |
| US4495189A (en) * | 1975-11-27 | 1985-01-22 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | Condensed pyrimidines |
| HU180439B (en) * | 1977-12-29 | 1983-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 9-amino-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives |
| US4192944A (en) * | 1978-04-03 | 1980-03-11 | Bristol-Myers Company | Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents |
| US4491587A (en) * | 1978-05-05 | 1985-01-01 | Mead Johnson & Company | Tetrazole derivatives |
| US4223031A (en) * | 1978-05-05 | 1980-09-16 | Mead Johnson & Company | Azolopyrimidinones |
| US4282360A (en) * | 1979-10-12 | 1981-08-04 | Hoffmann-La Roche Inc. | 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid |
| US4419357A (en) * | 1982-01-18 | 1983-12-06 | The Dow Chemical Company | 3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinones |
| US4476130A (en) * | 1982-09-09 | 1984-10-09 | Riker Laboratories, Inc. | 3-(1H-Tetrazol-5-yl)-4H-pyrimido[2,1-b]benzoxazol-4-one compounds exhibiting anti-allergic activity |
| US4507477A (en) * | 1982-09-09 | 1985-03-26 | Riker Laboratories, Inc. | Process for tetrazolyl-pyrimidinone derivatives |
| US4474953A (en) * | 1982-09-09 | 1984-10-02 | Riker Laboratories, Inc. | Process and intermediates for the preparation of 3(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-ones |
| US4457932A (en) * | 1983-07-22 | 1984-07-03 | Bristol-Myers Company | Anti-ulcer agents |
| AU588917B2 (en) * | 1985-09-25 | 1989-09-28 | Shionogi & Co., Ltd. | 9-(substituted thio)-4h-pryido(1,2-a) pyrimidin-4-one derivatives |
| JPS63183581A (ja) * | 1985-10-03 | 1988-07-28 | Tokyo Tanabe Co Ltd | ピリド〔１，２−ａ〕ピリミジン誘導体、その製造法及びそれを有効成分とするアレルギ−疾患治療薬 |
| JPS62242682A (ja) * | 1986-04-16 | 1987-10-23 | Tokyo Tanabe Co Ltd | 新規なピリド［１，２―ａ］ピリミジン誘導体及びその製造法 |
| JP2504788B2 (ja) * | 1987-11-10 | 1996-06-05 | 東京田辺製薬株式会社 | ９−メチル−３−（１Ｈ−テトラゾ―ル−５−イル）−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンカリウム塩の水性製剤 |
| KR920002329B1 (ko) * | 1987-12-25 | 1992-03-21 | 산뗑 세이야꾸 가부시끼가이샤 | 항-알레르기성 점안제 |
| CA2010336C (en) * | 1989-02-27 | 1996-11-19 | Atsunori Sano | Process for producing pyrido[1,2-a]pyrimidine derivative |
| HU209793B (en) * | 1990-09-25 | 1994-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for the production of pyrido[1,2-a]pyrimidine-derivatives and pharmaceutical compositions containing the same |
| EP0653209A4 (en) | 1992-07-30 | 1997-03-19 | Tokyo Tanabe Co | MEDICINAL PRODUCTS FOR INFLAMMATORY COLON DISEASES. |
| US5527802A (en) * | 1992-10-01 | 1996-06-18 | Bristol-Myers Squibb Company | New uses of 3-tetrazolo -5,6,7,8- substituted-pyrido (1,2-a) pyrimidin-4-ones |
| JPH0892093A (ja) * | 1994-11-10 | 1996-04-09 | Tokyo Tanabe Co Ltd | ９−メチル−３−（１Ｈ−テトラゾール−５−イル）−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンの水性製剤 |
| WO2002072580A1 (fr) * | 2001-02-26 | 2002-09-19 | Mitsubishi Pharma Corporation | Preventifs et/ou remedes contres des maladies renales et l'insuffisance renale |
| ITMI20011764A1 (it) | 2001-08-10 | 2003-02-10 | Dinamite Dipharma Spa | Metodo per l'ottenimento del pemirolast ad elevata purezza |
| GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
| NZ577467A (en) * | 2006-12-18 | 2012-04-27 | Cardoz Ab | Combination of pemirolast and a statin for use in the treatment of inflammatory disorders |
| AU2007336077A1 (en) * | 2006-12-20 | 2008-06-26 | Cardoz Ab | New combination for use in the treatment of inflammatory disorders |
| WO2009007679A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and a thromboxane a2 antagonist |
| US20100184783A1 (en) * | 2007-07-11 | 2010-07-22 | Johan Raud | Combination for use in the treatment of inflammatory atherosclerosis comprising a mast cell inhibitor and a ppar gamma agonist |
| WO2009007675A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and a p2 gamma 12 antagonist |
| ES2395002T3 (es) * | 2008-04-07 | 2013-02-07 | Cardoz Ab | Nueva combinación para uso en el tratamiento de trastornos inflamatorios |
| UY32711A (es) | 2009-06-16 | 2011-01-31 | Cardoz Ab | Nueva forma cristalina de pemirolast |
| USD661900S1 (en) | 2010-02-22 | 2012-06-19 | Bajer Design & Marketing, Inc. | Collapsible structure |
| WO2013119916A2 (en) * | 2012-02-10 | 2013-08-15 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| MX352962B (es) | 2012-03-01 | 2017-12-15 | Ptc Therapeutics Inc | Compuestos para tratar atrofia muscular espinal. |
| EP2828247B1 (en) | 2012-03-23 | 2019-01-16 | PTC Therapeutics, Inc. | 4h-chromen-4-one derivatives for treating spinal muscular atrophy |
| WO2015105657A1 (en) | 2013-12-19 | 2015-07-16 | Ptc Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| US20160243122A1 (en) | 2014-10-23 | 2016-08-25 | Rspr Pharma Ab | Use of pemirolast in the treatment of acute asthma |
| WO2016102941A1 (en) | 2014-12-22 | 2016-06-30 | Rspr Pharma Ab | New combination of pemirolast and montelukast |
| CN107635999B (zh) * | 2015-05-20 | 2020-09-25 | 豪夫迈·罗氏有限公司 | 用于治疗脊髓性肌萎缩的化合物 |
| EP4249472A3 (en) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| GB201518831D0 (en) | 2015-10-23 | 2015-12-09 | Rspr Pharma Ab | New use |
| ES2879995T3 (es) | 2015-12-10 | 2021-11-23 | Ptc Therapeutics Inc | Métodos para el tratamiento de la enfermedad de Huntington |
| GB201601138D0 (en) * | 2016-01-21 | 2016-03-09 | Rspr Pharma Ab | New use |
| CN110352007A (zh) | 2016-11-28 | 2019-10-18 | Ptc医疗公司 | 用于调节rna剪接的方法 |
| WO2018226622A1 (en) | 2017-06-05 | 2018-12-13 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| BR112019026508A2 (pt) | 2017-06-14 | 2020-07-14 | Ptc Therapeutics, Inc. | métodos para modificar o splicing do rna |
| CA3067592A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
| EP3644996B1 (en) | 2017-06-28 | 2023-07-26 | PTC Therapeutics, Inc. | Methods for treating huntington's disease |
| JP7399870B2 (ja) | 2018-03-27 | 2023-12-18 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
| WO2020005873A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heterocyclic and heteroaryl compounds for treating huntington's disease |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3072485A (en) * | 1960-08-24 | 1963-01-08 | Eastman Kodak Co | Optically sensitized azido polymers for photomechanical resist compositions |
| AT286990B (de) * | 1966-11-02 | 1971-01-11 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von neuen Homopyrimidazol-Derivaten sowie von deren Salzen |
| US3960847A (en) * | 1972-04-17 | 1976-06-01 | E. R. Squibb & Sons, Inc. | 9-Substituted-4-oxopyrido(1,2-α)pyrimidine-3-carboxylic acids and derivatives thereof |
| US3929787A (en) * | 1974-04-22 | 1975-12-30 | Squibb & Sons Inc | 6,7,8,9-Tetrahydro-pyrido(1,2-a)pyrimidin-4-ones |
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| US4017625A (en) * | 1975-08-01 | 1977-04-12 | Pfizer Inc. | Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor |
| US4012387A (en) * | 1975-09-18 | 1977-03-15 | Warner-Lambert Company | Benzo-[g]pyrido[2,1-b]quinazolinones |
-
1977
- 1977-05-25 US US05/800,264 patent/US4122274A/en not_active Expired - Lifetime
-
1978
- 1978-05-15 GR GR56238A patent/GR71887B/el unknown
- 1978-05-17 ZA ZA00782816A patent/ZA782816B/xx unknown
- 1978-05-19 CA CA303,794A patent/CA1098520A/en not_active Expired
- 1978-05-19 BE BE187888A patent/BE867295A/xx not_active IP Right Cessation
- 1978-05-22 NL NL7805534A patent/NL190702C/xx not_active IP Right Cessation
- 1978-05-22 FI FI781614A patent/FI64594C/fi not_active IP Right Cessation
- 1978-05-22 AU AU36319/78A patent/AU521211B2/en not_active Expired
- 1978-05-23 AT AT0373278A patent/AT365187B/de not_active IP Right Cessation
- 1978-05-23 NO NO781786A patent/NO150361C/no unknown
- 1978-05-23 DK DK228878A patent/DK160279C/da active
- 1978-05-23 LU LU79694A patent/LU79694A1/xx unknown
- 1978-05-23 DE DE19782822544 patent/DE2822544A1/de active Granted
- 1978-05-24 IT IT49523/78A patent/IT1105040B/it active
- 1978-05-24 CY CY1218A patent/CY1218A/xx unknown
- 1978-05-24 SE SE7805954A patent/SE437830B/sv not_active IP Right Cessation
- 1978-05-24 YU YU1236/78A patent/YU42163B/xx unknown
- 1978-05-24 FR FR7815398A patent/FR2401159A1/fr active Granted
- 1978-05-24 IE IE1036/78A patent/IE46849B1/en not_active IP Right Cessation
- 1978-05-24 GB GB22090/78A patent/GB1596476A/en not_active Expired
- 1978-05-25 JP JP53061768A patent/JPS6050197B2/ja not_active Expired
- 1978-05-25 CH CH572378A patent/CH642656A5/de not_active IP Right Cessation
-
1982
- 1982-10-15 YU YU2330/82A patent/YU44212B/xx unknown
-
1983
- 1983-11-25 SG SG733/83A patent/SG73383G/en unknown
- 1983-12-15 KE KE3357A patent/KE3357A/xx unknown
-
1984
- 1984-03-22 HK HK258/84A patent/HK25884A/xx not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY305/85A patent/MY8500305A/xx unknown
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