DK138281A - Fremgangsmaade til fremstilling af 3-(1-piperidinylalkyl)-4h-pyrido (1,2-a) pyrimidin-4-on-derivater - Google Patents
Fremgangsmaade til fremstilling af 3-(1-piperidinylalkyl)-4h-pyrido (1,2-a) pyrimidin-4-on-derivaterInfo
- Publication number
- DK138281A DK138281A DK138281A DK138281A DK138281A DK 138281 A DK138281 A DK 138281A DK 138281 A DK138281 A DK 138281A DK 138281 A DK138281 A DK 138281A DK 138281 A DK138281 A DK 138281A
- Authority
- DK
- Denmark
- Prior art keywords
- piperidinylalkyl
- pyrido
- pyrimidin
- derivatives
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13484580A | 1980-03-28 | 1980-03-28 | |
| US13484580 | 1980-03-28 | ||
| US19163280 | 1980-09-29 | ||
| US06/191,632 US4342870A (en) | 1980-03-28 | 1980-09-29 | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK138281A true DK138281A (da) | 1981-09-29 |
| DK159390B DK159390B (da) | 1990-10-08 |
| DK159390C DK159390C (da) | 1991-03-04 |
Family
ID=26832744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK138281A DK159390C (da) | 1980-03-28 | 1981-03-26 | Analogifremgangsmaade til fremstilling af 3-(1-piperidinylalkyl)-4h-pyridooe1,2-aaapyrimidin-4-on-derivater |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4342870A (da) |
| EP (1) | EP0037265B1 (da) |
| AU (1) | AU537700B2 (da) |
| BG (1) | BG36199A3 (da) |
| CA (1) | CA1163994A (da) |
| CS (1) | CS256366B2 (da) |
| DE (1) | DE3168433D1 (da) |
| DK (1) | DK159390C (da) |
| ES (1) | ES500814A0 (da) |
| FI (1) | FI71737C (da) |
| GR (1) | GR72488B (da) |
| HU (1) | HU187329B (da) |
| IE (1) | IE51319B1 (da) |
| IL (1) | IL62494A (da) |
| MA (1) | MA19107A1 (da) |
| NO (1) | NO156752C (da) |
| NZ (1) | NZ196522A (da) |
| PH (1) | PH16530A (da) |
| PT (1) | PT72740B (da) |
| RO (1) | RO82508A (da) |
| SU (1) | SU1068037A3 (da) |
| YU (1) | YU43010B (da) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443451A (en) | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
| US4548938A (en) * | 1981-07-15 | 1985-10-22 | Janssen Pharmaceutica N.V. | 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds |
| US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
| US4485107A (en) * | 1982-11-01 | 1984-11-27 | Janssen Pharmaceutica N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
| US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4695569A (en) * | 1983-11-30 | 1987-09-22 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines |
| US4888426A (en) * | 1983-11-30 | 1989-12-19 | Janssen Pharmaceutica N.V. | 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| EP0268309B1 (en) * | 1986-09-22 | 1996-12-11 | Janssen Pharmaceutica N.V. | Serotonin antagonists for treating wounds |
| IL90879A0 (en) * | 1988-09-02 | 1990-02-09 | Janssen Pharmaceutica Nv | 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them |
| CA2000786C (en) * | 1988-11-07 | 1999-01-26 | Cornelus G. M. Janssen | 3-piperidinyl-1,2-benzisoxazoles |
| US5153206A (en) * | 1988-12-02 | 1992-10-06 | Pfizer Inc. | Arylpiperidine derivatives |
| WO1990011093A1 (en) * | 1989-03-23 | 1990-10-04 | Mallinckrodt, Inc. | Radioactive iodine- or bromine labelled piperidine compound as well as method of preparing same and composition comprising said compound |
| DE4138756A1 (de) * | 1991-11-26 | 1993-05-27 | Troponwerke Gmbh & Co Kg | Kombination mit neuroprotektiver wirkung |
| US5266571A (en) * | 1992-01-09 | 1993-11-30 | Amer Moh Samir | Treatment of hemorrhoids with 5-HT2 antagonists |
| AU669156B2 (en) * | 1992-02-13 | 1996-05-30 | Merrell Dow Pharmaceuticals Inc. | Piperidinyl thiacyclic derivatives |
| JPH07508741A (ja) * | 1992-07-13 | 1995-09-28 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 新規４−（３−ベンゾフラニル）ピペリジニル及び４−（３−ベンゾチエニル）ピペリジニル誘導体，ならびにそれらを含む製薬学的組成物 |
| ES2236700T3 (es) * | 1993-11-19 | 2005-07-16 | Janssen Pharmaceutica N.V. | 1,2-benzazoles microencapsulados. |
| ES2085234B1 (es) * | 1994-02-24 | 1997-01-16 | Vita Invest Sa | Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
| TW421649B (en) * | 1995-01-31 | 2001-02-11 | Janssen Pharmaceutica Nv | 4-(1H-indol-1yl)-1-piperidinyl derivatives |
| US5753664A (en) * | 1995-03-16 | 1998-05-19 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
| EP1560814A1 (en) * | 2002-11-13 | 2005-08-10 | Synthon B.V. | Process for making risperidone and intermediates therefor |
| WO2004094415A1 (en) * | 2003-04-22 | 2004-11-04 | Synthon B.V. | Risperidone monohydrochloride |
| DK3106166T3 (da) | 2008-02-29 | 2021-01-11 | Vm Therapeutics Llc | Forbindelser til behandling af smertesyndrom og andre lidelser |
| PE20142364A1 (es) | 2012-02-10 | 2015-01-10 | Hoffmann La Roche | Compuestos para tratar atrofia muscular espinal |
| KR102099997B1 (ko) | 2012-03-01 | 2020-04-13 | 피티씨 테라퓨틱스, 인크. | 척수성 근위축증을 치료하기 위한 화합물 |
| EA028382B1 (ru) | 2012-03-23 | 2017-11-30 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Соединения для лечения спинальной мышечной атрофии |
| WO2014143915A1 (en) * | 2013-03-15 | 2014-09-18 | Vm Therapeutics Llc | Novel crystalline forms |
| EP3082820B1 (en) | 2013-12-19 | 2022-07-20 | PTC Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| EP4249472A3 (en) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| IL281633B (en) | 2015-12-10 | 2022-07-01 | Ptc Therapeutics Inc | Methods for treating Huntington's disease |
| EP3544435A4 (en) | 2016-11-28 | 2020-11-04 | PTC Therapeutics, Inc. | RNA SPLICE MODULATION PROCESSES |
| EP3634953B1 (en) | 2017-06-05 | 2024-01-03 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
| CN111372611A (zh) | 2017-06-14 | 2020-07-03 | Ptc医疗公司 | 修饰rna剪接的方法 |
| US11395822B2 (en) | 2017-06-28 | 2022-07-26 | Ptc Therapeutics, Inc. | Methods for treating Huntington's disease |
| CA3067591A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
| CA3094703A1 (en) | 2018-03-27 | 2019-10-03 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| WO2020005873A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heterocyclic and heteroaryl compounds for treating huntington's disease |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3412094A (en) * | 1967-06-21 | 1968-11-19 | Searle & Co | 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners |
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| JPS5146497A (en) * | 1974-10-19 | 1976-04-20 | Masato Aiura | Hobuban |
| JPS525795A (en) * | 1975-06-28 | 1977-01-17 | Sankyo Co Ltd | Preparation of tetrahydro pyridopyrimidinone derivatives |
| HU173438B (hu) * | 1975-11-27 | 1979-05-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom |
-
1980
- 1980-09-29 US US06/191,632 patent/US4342870A/en not_active Expired - Lifetime
-
1981
- 1981-03-03 GR GR64291A patent/GR72488B/el unknown
- 1981-03-04 CA CA000372258A patent/CA1163994A/en not_active Expired
- 1981-03-17 NZ NZ196522A patent/NZ196522A/en unknown
- 1981-03-17 AU AU68429/81A patent/AU537700B2/en not_active Ceased
- 1981-03-21 MA MA19313A patent/MA19107A1/fr unknown
- 1981-03-24 CS CS812134A patent/CS256366B2/cs unknown
- 1981-03-24 SU SU813261927A patent/SU1068037A3/ru active
- 1981-03-26 PH PH25429A patent/PH16530A/en unknown
- 1981-03-26 PT PT72740A patent/PT72740B/pt not_active IP Right Cessation
- 1981-03-26 IL IL62494A patent/IL62494A/xx unknown
- 1981-03-26 DK DK138281A patent/DK159390C/da not_active IP Right Cessation
- 1981-03-27 DE DE8181301335T patent/DE3168433D1/de not_active Expired
- 1981-03-27 YU YU810/81A patent/YU43010B/xx unknown
- 1981-03-27 HU HU81783A patent/HU187329B/hu not_active IP Right Cessation
- 1981-03-27 ES ES500814A patent/ES500814A0/es active Granted
- 1981-03-27 BG BG051433A patent/BG36199A3/xx unknown
- 1981-03-27 IE IE706/81A patent/IE51319B1/en not_active IP Right Cessation
- 1981-03-27 NO NO811058A patent/NO156752C/no unknown
- 1981-03-27 FI FI810956A patent/FI71737C/fi not_active IP Right Cessation
- 1981-03-27 EP EP81301335A patent/EP0037265B1/en not_active Expired
- 1981-03-28 RO RO81103848A patent/RO82508A/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU81081A (en) | 1983-12-31 |
| EP0037265B1 (en) | 1985-01-23 |
| IL62494A0 (en) | 1981-05-20 |
| GR72488B (da) | 1983-11-14 |
| BG36199A3 (en) | 1984-09-14 |
| NZ196522A (en) | 1985-10-11 |
| IL62494A (en) | 1984-08-31 |
| CS256366B2 (en) | 1988-04-15 |
| FI71737C (fi) | 1987-02-09 |
| AU537700B2 (en) | 1984-07-05 |
| MA19107A1 (fr) | 1981-10-01 |
| AU6842981A (en) | 1981-10-01 |
| FI810956L (fi) | 1981-09-29 |
| IE810706L (en) | 1981-09-28 |
| NO156752C (no) | 1987-11-18 |
| DK159390C (da) | 1991-03-04 |
| IE51319B1 (en) | 1986-12-10 |
| NO811058L (no) | 1981-09-29 |
| EP0037265A1 (en) | 1981-10-07 |
| FI71737B (fi) | 1986-10-31 |
| DE3168433D1 (de) | 1985-03-07 |
| ES8300763A1 (es) | 1982-11-01 |
| SU1068037A3 (ru) | 1984-01-15 |
| HU187329B (en) | 1985-12-28 |
| US4342870A (en) | 1982-08-03 |
| PT72740A (en) | 1981-04-01 |
| ES500814A0 (es) | 1982-11-01 |
| YU43010B (en) | 1989-02-28 |
| NO156752B (no) | 1987-08-10 |
| PT72740B (en) | 1982-11-16 |
| DK159390B (da) | 1990-10-08 |
| RO82508A (ro) | 1983-09-26 |
| RO82508B (ro) | 1983-08-30 |
| CA1163994A (en) | 1984-03-20 |
| PH16530A (en) | 1983-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |