NO811058L - 3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidin-4-on-derivater - Google Patents

3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidin-4-on-derivater

Info

Publication number
NO811058L
NO811058L NO811058A NO811058A NO811058L NO 811058 L NO811058 L NO 811058L NO 811058 A NO811058 A NO 811058A NO 811058 A NO811058 A NO 811058A NO 811058 L NO811058 L NO 811058L
Authority
NO
Norway
Prior art keywords
piperidinylalkyl
pyrido
pyrimidine
derivative
Prior art date
Application number
NO811058A
Other languages
English (en)
Other versions
NO156752C (no
NO156752B (no
Inventor
Ludo Edmond Josephine Kennis
Josephus Carolus Mertens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO811058L publication Critical patent/NO811058L/no
Publication of NO156752B publication Critical patent/NO156752B/no
Publication of NO156752C publication Critical patent/NO156752C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO811058A 1980-03-28 1981-03-27 Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-(1-piperidinylalkyl)-4hpyrido(1,2-a)pyrimidin-4-0n derivater NO156752C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13484580A 1980-03-28 1980-03-28
US06/191,632 US4342870A (en) 1980-03-28 1980-09-29 Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Publications (3)

Publication Number Publication Date
NO811058L true NO811058L (no) 1981-09-29
NO156752B NO156752B (no) 1987-08-10
NO156752C NO156752C (no) 1987-11-18

Family

ID=26832744

Family Applications (1)

Application Number Title Priority Date Filing Date
NO811058A NO156752C (no) 1980-03-28 1981-03-27 Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-(1-piperidinylalkyl)-4hpyrido(1,2-a)pyrimidin-4-0n derivater

Country Status (22)

Country Link
US (1) US4342870A (no)
EP (1) EP0037265B1 (no)
AU (1) AU537700B2 (no)
BG (1) BG36199A3 (no)
CA (1) CA1163994A (no)
CS (1) CS256366B2 (no)
DE (1) DE3168433D1 (no)
DK (1) DK159390C (no)
ES (1) ES8300763A1 (no)
FI (1) FI71737C (no)
GR (1) GR72488B (no)
HU (1) HU187329B (no)
IE (1) IE51319B1 (no)
IL (1) IL62494A (no)
MA (1) MA19107A1 (no)
NO (1) NO156752C (no)
NZ (1) NZ196522A (no)
PH (1) PH16530A (no)
PT (1) PT72740B (no)
RO (1) RO82508A (no)
SU (1) SU1068037A3 (no)
YU (1) YU43010B (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443451A (en) 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4888426A (en) * 1983-11-30 1989-12-19 Janssen Pharmaceutica N.V. 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
ATE146077T1 (de) * 1986-09-22 1996-12-15 Janssen Pharmaceutica Nv Serotonin-antagonisten zur behandlung von wunden
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
WO1990006303A1 (en) * 1988-12-02 1990-06-14 Pfizer Inc. Arylpiperidine derivatives
EP0460118A1 (en) * 1989-03-23 1991-12-11 Mallinckrodt International Corporation Radioactive iodine- or bromine labelled piperidine compound as well as method of preparing same and composition comprising said compound
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
NZ249286A (en) * 1992-02-13 1996-02-27 Merrell Dow Pharma Piperidine-4-ylmethyl thiophene and thiazole derivatives and pharmaceutical compositions
NZ254113A (en) * 1992-07-13 1995-08-28 Janssen Pharmaceutica Nv Fused piperidine derivatives and medicaments
JP3645906B2 (ja) * 1993-11-19 2005-05-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイクロカプセル封入された３−ピペリジニル−置換１，２−ベンズイソオキサゾール類及び１，２−ベンズイソチアゾール類
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
AU2003288017A1 (en) * 2002-11-13 2004-06-03 Synthon B.V. Process for making risperidone and intermediates therefor
EP1615924A1 (en) * 2003-04-22 2006-01-18 Synthon B.V. Water soluble salts of risperidone
EP2252608A4 (en) 2008-02-29 2012-10-03 Vm Discovery Inc METHOD FOR TREATING PAIN SYNDROME AND OTHER SUFFERING
WO2013119916A2 (en) 2012-02-10 2013-08-15 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
CN104302181B (zh) 2012-03-01 2017-09-15 Ptc医疗公司 用于治疗脊髓性肌萎缩的化合物
CN104470909B (zh) 2012-03-23 2018-04-24 Ptc医疗公司 用于治疗脊髓性肌萎缩的化合物
US9724348B2 (en) 2013-03-15 2017-08-08 Vm Therapeutics Llc Crystalline forms
WO2015105657A1 (en) 2013-12-19 2015-07-16 Ptc Therapeutics, Inc. Methods for modulating the amount of rna transcripts
WO2016196386A1 (en) 2015-05-30 2016-12-08 Ptc Therapeutics, Inc. Methods for modulating rna splicing
CN113717154A (zh) 2015-12-10 2021-11-30 Ptc医疗公司 用于治疗亨廷顿病的方法
US11702646B2 (en) 2016-11-28 2023-07-18 Ptc Therapeutics, Inc. Methods for modulating RNA splicing
WO2018226622A1 (en) 2017-06-05 2018-12-13 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
CN111372611A (zh) 2017-06-14 2020-07-03 Ptc医疗公司 修饰rna剪接的方法
EP3645121A4 (en) 2017-06-28 2021-03-17 PTC Therapeutics, Inc. HUNTINGTON'S DISEASE TREATMENT METHODS
BR112019027717A2 (pt) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
KR20210005559A (ko) 2018-03-27 2021-01-14 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 화합물
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
CA3103976A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating huntington's disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
JPS5146497A (en) * 1974-10-19 1976-04-20 Masato Aiura Hobuban
JPS525795A (en) * 1975-06-28 1977-01-17 Sankyo Co Ltd Preparation of tetrahydro pyridopyrimidinone derivatives
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Also Published As

Publication number Publication date
HU187329B (en) 1985-12-28
IE51319B1 (en) 1986-12-10
CS256366B2 (en) 1988-04-15
RO82508B (ro) 1983-08-30
BG36199A3 (en) 1984-09-14
ES500814A0 (es) 1982-11-01
MA19107A1 (fr) 1981-10-01
AU537700B2 (en) 1984-07-05
EP0037265A1 (en) 1981-10-07
DK159390C (da) 1991-03-04
CA1163994A (en) 1984-03-20
GR72488B (no) 1983-11-14
PT72740A (en) 1981-04-01
PT72740B (en) 1982-11-16
RO82508A (ro) 1983-09-26
IL62494A (en) 1984-08-31
NZ196522A (en) 1985-10-11
DK138281A (da) 1981-09-29
ES8300763A1 (es) 1982-11-01
SU1068037A3 (ru) 1984-01-15
YU43010B (en) 1989-02-28
FI71737B (fi) 1986-10-31
AU6842981A (en) 1981-10-01
NO156752C (no) 1987-11-18
FI71737C (fi) 1987-02-09
IL62494A0 (en) 1981-05-20
DK159390B (da) 1990-10-08
YU81081A (en) 1983-12-31
DE3168433D1 (de) 1985-03-07
US4342870A (en) 1982-08-03
FI810956L (fi) 1981-09-29
NO156752B (no) 1987-08-10
IE810706L (en) 1981-09-28
PH16530A (en) 1983-11-10
EP0037265B1 (en) 1985-01-23

Similar Documents

Publication Publication Date Title
NO811058L (no) 3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidin-4-on-derivater
BE867295A (fr) 3-(1h-tetrazol-5-yl)-4h-pyrido (1,2-a) pyrimidine-4-ones
AU540840B2 (en) Imidazo(1,2-a)pyridines
FI822266L (fi) Nya imidazo/1,2-a/pyridiner och pyraziner
DK495287D0 (da) 2-eller 3-arylsubstituerede imidazo(1,2-a)pyridi ner
IT8120784A0 (it) Imidazopiridine.
JPS56150091A (en) 3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidine- 4-one derivative and its manufacture
ATE33651T1 (de) Imidazo(1,5-a)pyridin-derivate.
AU516695B2 (en) Heterocyclic substituted imidazo (1, 2-a)pyridines
AR229519A1 (es) Procedimiento de preparacion de derivados de 2,3-dihidro-9-fenil-1h-pirazolo(1,2-a)-indazolio
FI864891A (fi) Foerfarande foer framstaellning av 6,7,8,9-tetrahydro-10-metylpyrido/1,2-a/indol-9-aminer och deras derivat.
IT8021821A0 (it) Pirido [1,2-a] pirimidine sostituite
FI833055A0 (fi) Framstaellningsfoerfarande foer nya imidazo/1,2-a/pyrimidiner
DE3682244D1 (de) Substituierte dihydroimidazo(1,2-a)chinoxalinderivate.
FI853027L (fi) Imidazo/1,2-a/kinoliner, deras framstaellning och deras terapeutiska tillaempning.
DE3267918D1 (de) Pyrazolo(3,4-b)pyridine derivatives
FI813757L (fi) Nytt foerfarande foer framstaellning av imidazo/4,5-b/pyridiner och -pyrimidiner
DK33684D0 (da) Pyrazino (2',3'-3,4)pyrido(1,2-a)-indol-derivater
GB2080794B (en) 1,6-naphthyridine derivatives
ATE11415T1 (de) 3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidi - 4-on-derivate.
DE3578177D1 (de) 4,7-dihydropyrazolo(3,4-b)pyridin-derivate.
FI821308L (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-ubstituerade imidazo/1,2-a/kinoxaliner
FI853274L (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara piperazinylpyridol/2,3-b/- och -/3,4-b/ pyrazinderivat.