MA19107A1 - Nouveaux derives de 3-(i,piperidinylalkyl)4h-pyrido [i,2-a]-pyridine-4-one . - Google Patents

Nouveaux derives de 3-(i,piperidinylalkyl)4h-pyrido [i,2-a]-pyridine-4-one .

Info

Publication number
MA19107A1
MA19107A1 MA19313A MA19313A MA19107A1 MA 19107 A1 MA19107 A1 MA 19107A1 MA 19313 A MA19313 A MA 19313A MA 19313 A MA19313 A MA 19313A MA 19107 A1 MA19107 A1 MA 19107A1
Authority
MA
Morocco
Prior art keywords
piperidinylalkyl
pyrido
pyridine
derivatives
new
Prior art date
Application number
MA19313A
Other languages
English (en)
Inventor
E J Kennis L
C Mertens J
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA19107A1 publication Critical patent/MA19107A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA19313A 1980-03-28 1981-03-21 Nouveaux derives de 3-(i,piperidinylalkyl)4h-pyrido [i,2-a]-pyridine-4-one . MA19107A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13484580A 1980-03-28 1980-03-28
US06/191,632 US4342870A (en) 1980-03-28 1980-09-29 Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Publications (1)

Publication Number Publication Date
MA19107A1 true MA19107A1 (fr) 1981-10-01

Family

ID=26832744

Family Applications (1)

Application Number Title Priority Date Filing Date
MA19313A MA19107A1 (fr) 1980-03-28 1981-03-21 Nouveaux derives de 3-(i,piperidinylalkyl)4h-pyrido [i,2-a]-pyridine-4-one .

Country Status (22)

Country Link
US (1) US4342870A (fr)
EP (1) EP0037265B1 (fr)
AU (1) AU537700B2 (fr)
BG (1) BG36199A3 (fr)
CA (1) CA1163994A (fr)
CS (1) CS256366B2 (fr)
DE (1) DE3168433D1 (fr)
DK (1) DK159390C (fr)
ES (1) ES500814A0 (fr)
FI (1) FI71737C (fr)
GR (1) GR72488B (fr)
HU (1) HU187329B (fr)
IE (1) IE51319B1 (fr)
IL (1) IL62494A (fr)
MA (1) MA19107A1 (fr)
NO (1) NO156752C (fr)
NZ (1) NZ196522A (fr)
PH (1) PH16530A (fr)
PT (1) PT72740B (fr)
RO (1) RO82508A (fr)
SU (1) SU1068037A3 (fr)
YU (1) YU43010B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443451A (en) 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4888426A (en) * 1983-11-30 1989-12-19 Janssen Pharmaceutica N.V. 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
EP0268309B1 (fr) * 1986-09-22 1996-12-11 Janssen Pharmaceutica N.V. Antagonistes de la sérotonine pour le traitement des plaies
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
CA2000786C (fr) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
WO1990006303A1 (fr) * 1988-12-02 1990-06-14 Pfizer Inc. Derives arylpiperidine
EP0460118A1 (fr) * 1989-03-23 1991-12-11 Mallinckrodt International Corporation Compose de piperidine marque a l'iode ou au brome radioactif, son procede de preparation et composition comprenant ledit compose
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
CA2129995C (fr) * 1992-02-13 2000-04-11 Albert A. Carr Derives thiacycliques de piperidinyle
EP0672043B1 (fr) * 1992-07-13 2001-05-30 Janssen Pharmaceutica N.V. Nouveaux derives de 4-(3-benzofuranyl) piperidinyle et 4-(3-benzothienyle) piperidinyle et compositions pharmaceutiques les contenant
ES2236700T3 (es) * 1993-11-19 2005-07-16 Janssen Pharmaceutica N.V. 1,2-benzazoles microencapsulados.
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
AU2003288017A1 (en) * 2002-11-13 2004-06-03 Synthon B.V. Process for making risperidone and intermediates therefor
WO2004094414A1 (fr) * 2003-04-22 2004-11-04 Synthon B.V. Sels hydrosolubles de risperidone
ES2842289T3 (es) * 2008-02-29 2021-07-13 Vm Therapeutics Llc Compuestos para tratar el síndrome del dolor y otros trastornos
EA037123B1 (ru) 2012-02-10 2021-02-09 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Соединения для лечения спинальной мышечной атрофии
JP6092264B2 (ja) 2012-03-01 2017-03-08 ピーティーシー セラピューティクス, インコーポレイテッド 脊髄性筋委縮症を処置するための化合物
BR112014023483B1 (pt) 2012-03-23 2022-05-10 Ptc Therapeutics, Inc Composto e seu uso, composição farmacêutica e seu uso
WO2014143915A1 (fr) * 2013-03-15 2014-09-18 Vm Therapeutics Llc Nouvelles formes cristallines
WO2015105657A1 (fr) 2013-12-19 2015-07-16 Ptc Therapeutics, Inc. Procédés pour moduler la quantité de transcrits d'arn
EP4249472A3 (fr) 2015-05-30 2023-12-13 PTC Therapeutics, Inc. Procédés de modulation de l'épissage de l'arn
AU2016366694C1 (en) 2015-12-10 2021-03-25 Ptc Therapeutics, Inc. Methods for treating huntington's disease
AU2017363369A1 (en) 2016-11-28 2019-05-30 Ptc Therapeutics, Inc Methods for modulating RNA splicing
KR20200033249A (ko) 2017-06-05 2020-03-27 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 화합물
US11608501B2 (en) 2017-06-14 2023-03-21 Ptc Therapeutics, Inc. Methods for modifying RNA splicing
MX2019015578A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
MX2019015580A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
JP7399870B2 (ja) 2018-03-27 2023-12-18 ピーティーシー セラピューティクス, インコーポレイテッド ハンチントン病を処置するための化合物
DK3814357T3 (da) 2018-06-27 2024-07-22 Ptc Therapeutics Inc Heterocykliske og heteroarylforbindelser til behandling af huntingtons sygdom
EP3814360A1 (fr) 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Composés hétéroaryles pour le traitement de la maladie de huntington

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
JPS5146497A (en) * 1974-10-19 1976-04-20 Masato Aiura Hobuban
JPS525795A (en) * 1975-06-28 1977-01-17 Sankyo Co Ltd Preparation of tetrahydro pyridopyrimidinone derivatives
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Also Published As

Publication number Publication date
PH16530A (en) 1983-11-10
IE810706L (en) 1981-09-28
AU537700B2 (en) 1984-07-05
IL62494A0 (en) 1981-05-20
AU6842981A (en) 1981-10-01
ES8300763A1 (es) 1982-11-01
PT72740B (en) 1982-11-16
EP0037265A1 (fr) 1981-10-07
SU1068037A3 (ru) 1984-01-15
YU81081A (en) 1983-12-31
NO156752C (no) 1987-11-18
IE51319B1 (en) 1986-12-10
CA1163994A (fr) 1984-03-20
ES500814A0 (es) 1982-11-01
US4342870A (en) 1982-08-03
HU187329B (en) 1985-12-28
YU43010B (en) 1989-02-28
FI810956L (fi) 1981-09-29
FI71737B (fi) 1986-10-31
RO82508A (fr) 1983-09-26
DK159390C (da) 1991-03-04
FI71737C (fi) 1987-02-09
DE3168433D1 (de) 1985-03-07
CS256366B2 (en) 1988-04-15
DK159390B (da) 1990-10-08
BG36199A3 (en) 1984-09-14
RO82508B (ro) 1983-08-30
NO156752B (no) 1987-08-10
IL62494A (en) 1984-08-31
NZ196522A (en) 1985-10-11
EP0037265B1 (fr) 1985-01-23
GR72488B (fr) 1983-11-14
PT72740A (en) 1981-04-01
NO811058L (no) 1981-09-29
DK138281A (da) 1981-09-29

Similar Documents

Publication Publication Date Title
MA19107A1 (fr) Nouveaux derives de 3-(i,piperidinylalkyl)4h-pyrido [i,2-a]-pyridine-4-one .
MX9203592A (es) Derivados de sulfamoil-fenetilamina substituida.
ATE7657T1 (de) 3-aryl-5-isothiazolderivate.
IT8120784A0 (it) Imidazopiridine.
ES506783A0 (es) Derivados de encefalina.
ATE33651T1 (de) Imidazo(1,5-a)pyridin-derivate.
DE3682244D1 (de) Substituierte dihydroimidazo(1,2-a)chinoxalinderivate.
DE3267918D1 (de) Pyrazolo(3,4-b)pyridine derivatives
IT7924171A0 (it) Imidazoliletossi-derivati di pirazol-aperta parentesi quadra 3,4-b chiusa parentesi quadra-piridin-5-metanoli.
FI811577L (fi) Nya kinoxalin-1,4-dioxidderivat
FI874400A (fi) Foerfarande foer framstaellning av imidazo-4,5-b pyridin-2-on-derivat.
FI813757L (fi) Nytt foerfarande foer framstaellning av imidazo/4,5-b/pyridiner och -pyrimidiner
NO884788L (no) Nye rifamycin-derivater.
FI872073A (fi) Derivat av propargyloxybenzener, deras framstaellning och fungicida sammansaettningar i vilka de ingaor.
BE886395A (fr) Derives de rifamycine
DE3578177D1 (de) 4,7-dihydropyrazolo(3,4-b)pyridin-derivate.
ATE11415T1 (de) 3-(1-piperidinylalkyl)-4h-pyrido(1,2-a)pyrimidi - 4-on-derivate.
AR229879A1 (es) Procedimiento de preparacion de derivados de metil-quinoxalinil-1,4-dioxido
FI882389A0 (fi) 5-substituerat-10-cyanmetylentieno/ 3,4-b/benzoazepin.
ES513538A0 (es) Derivados de 24-ciclopropilcoleno-3 b,22-dioles.
FI810878L (fi) Imidazo /4,5-b/ pyridinderivat anvaendbara som hjaertmedicin och dess framstaellning
FI854026A0 (fi) 2-fenylpyrano/2,3-b/pyridiner.
MA19336A1 (fr) Nouveaux derives organophosphonothioniques .
BE890893A (fr) Derives de rifamycine
AR226749A1 (es) Procedimiento de preparacion de derivados de 1,4-dioxido de 2-metilen-quinoxalina