IL62494A - 2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL62494A
IL62494A IL62494A IL6249481A IL62494A IL 62494 A IL62494 A IL 62494A IL 62494 A IL62494 A IL 62494A IL 6249481 A IL6249481 A IL 6249481A IL 62494 A IL62494 A IL 62494A
Authority
IL
Israel
Prior art keywords
alkyl
aroyl
pyrido
indol
pyrimidin
Prior art date
Application number
IL62494A
Other languages
English (en)
Other versions
IL62494A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL62494A0 publication Critical patent/IL62494A0/xx
Publication of IL62494A publication Critical patent/IL62494A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL62494A 1980-03-28 1981-03-26 2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing them IL62494A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13484580A 1980-03-28 1980-03-28
US06/191,632 US4342870A (en) 1980-03-28 1980-09-29 Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Publications (2)

Publication Number Publication Date
IL62494A0 IL62494A0 (en) 1981-05-20
IL62494A true IL62494A (en) 1984-08-31

Family

ID=26832744

Family Applications (1)

Application Number Title Priority Date Filing Date
IL62494A IL62494A (en) 1980-03-28 1981-03-26 2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (1) US4342870A (fr)
EP (1) EP0037265B1 (fr)
AU (1) AU537700B2 (fr)
BG (1) BG36199A3 (fr)
CA (1) CA1163994A (fr)
CS (1) CS256366B2 (fr)
DE (1) DE3168433D1 (fr)
DK (1) DK159390C (fr)
ES (1) ES500814A0 (fr)
FI (1) FI71737C (fr)
GR (1) GR72488B (fr)
HU (1) HU187329B (fr)
IE (1) IE51319B1 (fr)
IL (1) IL62494A (fr)
MA (1) MA19107A1 (fr)
NO (1) NO156752C (fr)
NZ (1) NZ196522A (fr)
PH (1) PH16530A (fr)
PT (1) PT72740B (fr)
RO (1) RO82508A (fr)
SU (1) SU1068037A3 (fr)
YU (1) YU43010B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443451A (en) 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4888426A (en) * 1983-11-30 1989-12-19 Janssen Pharmaceutica N.V. 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
DE3751974T2 (de) * 1986-09-22 1997-04-10 Janssen Pharmaceutica Nv Serotonin-Antagonisten zur Behandlung von Wunden
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
CA2000786C (fr) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
HU207310B (en) * 1988-12-02 1993-03-29 Pfizer Process for producing aryl-piperidine derivatives
WO1990011093A1 (fr) * 1989-03-23 1990-10-04 Mallinckrodt, Inc. Compose de piperidine marque a l'iode ou au brome radioactif, son procede de preparation et composition comprenant ledit compose
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
ES2163407T3 (es) * 1992-02-13 2002-02-01 Merrell Pharma Inc Derivados piperidinilos tiaciclicos.
WO1994001437A1 (fr) 1992-07-13 1994-01-20 Janssen Pharmaceutica N.V. Nouveaux derives de 4-(3-benzofuranyl) piperidinyle et 4-(3-benzothienyle) piperidinyle et compositions pharmaceutiques les contenant
RO119224B1 (ro) 1993-11-19 2004-06-30 Janssenápharmaceuticaán.V. Compoziţie farmaceutică pentru tratamentul unor afecţiuni psihotice şi utilizarea acesteia
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
EP1560814A1 (fr) * 2002-11-13 2005-08-10 Synthon B.V. Procede de fabrication de la risperidone et des intermediaires associes
WO2004094414A1 (fr) * 2003-04-22 2004-11-04 Synthon B.V. Sels hydrosolubles de risperidone
EP3106166B1 (fr) * 2008-02-29 2020-12-02 VM Therapeutics LLC Composes pour le traitement du syndrome de la douleur et autres troubles
SG10201609188WA (en) 2012-02-10 2016-12-29 Ptc Therapeutics Inc Compounds for treating spinal muscular atrophy
JP6092264B2 (ja) 2012-03-01 2017-03-08 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋委縮症を処置するための化合物
MX358514B (es) 2012-03-23 2018-08-24 Ptc Therapeutics Inc Compuestos para tratar la atrofia muscular espinal.
EP2970188A4 (fr) * 2013-03-15 2016-10-19 Vm Therapeutics Llc Nouvelles formes cristallines
WO2015105657A1 (fr) 2013-12-19 2015-07-16 Ptc Therapeutics, Inc. Procédés pour moduler la quantité de transcrits d'arn
US10668171B2 (en) 2015-05-30 2020-06-02 Ptc Therapeutics, Inc. Methods for modulating RNA splicing
IL281633B (en) 2015-12-10 2022-07-01 Ptc Therapeutics Inc Methods for treating Huntington's disease
US11702646B2 (en) 2016-11-28 2023-07-18 Ptc Therapeutics, Inc. Methods for modulating RNA splicing
SG11201911615WA (en) 2017-06-05 2020-01-30 Ptc Therapeutics Inc Compounds for treating huntington's disease
US11608501B2 (en) 2017-06-14 2023-03-21 Ptc Therapeutics, Inc. Methods for modifying RNA splicing
US11395822B2 (en) 2017-06-28 2022-07-26 Ptc Therapeutics, Inc. Methods for treating Huntington's disease
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
BR112020019373A2 (pt) 2018-03-27 2020-12-29 Ptc Therapeutics, Inc. Compostos para o tratamento da doença de hutington
EA202092896A1 (ru) 2018-06-27 2021-04-13 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Гетероциклические и гетероарильные соединения для лечения болезни гентингтона
WO2020005882A1 (fr) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Composés hétéroaryles pour le traitement de la maladie de huntington

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
JPS5146497A (en) * 1974-10-19 1976-04-20 Masato Aiura Hobuban
JPS525795A (en) * 1975-06-28 1977-01-17 Sankyo Co Ltd Preparation of tetrahydro pyridopyrimidinone derivatives
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Also Published As

Publication number Publication date
HU187329B (en) 1985-12-28
NZ196522A (en) 1985-10-11
DE3168433D1 (de) 1985-03-07
PT72740B (en) 1982-11-16
DK159390C (da) 1991-03-04
CS256366B2 (en) 1988-04-15
IE51319B1 (en) 1986-12-10
DK159390B (da) 1990-10-08
YU43010B (en) 1989-02-28
AU537700B2 (en) 1984-07-05
PT72740A (en) 1981-04-01
FI71737C (fi) 1987-02-09
FI810956L (fi) 1981-09-29
YU81081A (en) 1983-12-31
BG36199A3 (en) 1984-09-14
IE810706L (en) 1981-09-28
IL62494A0 (en) 1981-05-20
EP0037265A1 (fr) 1981-10-07
GR72488B (fr) 1983-11-14
CA1163994A (fr) 1984-03-20
ES8300763A1 (es) 1982-11-01
FI71737B (fi) 1986-10-31
AU6842981A (en) 1981-10-01
NO156752B (no) 1987-08-10
NO811058L (no) 1981-09-29
ES500814A0 (es) 1982-11-01
SU1068037A3 (ru) 1984-01-15
NO156752C (no) 1987-11-18
RO82508A (fr) 1983-09-26
DK138281A (da) 1981-09-29
US4342870A (en) 1982-08-03
PH16530A (en) 1983-11-10
EP0037265B1 (fr) 1985-01-23
MA19107A1 (fr) 1981-10-01
RO82508B (ro) 1983-08-30

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