DK1583830T3 - Fremgangsmåde til fremstilling af rekombinante polyklonale proteiner - Google Patents
Fremgangsmåde til fremstilling af rekombinante polyklonale proteinerInfo
- Publication number
- DK1583830T3 DK1583830T3 DK04700438T DK04700438T DK1583830T3 DK 1583830 T3 DK1583830 T3 DK 1583830T3 DK 04700438 T DK04700438 T DK 04700438T DK 04700438 T DK04700438 T DK 04700438T DK 1583830 T3 DK1583830 T3 DK 1583830T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- collection
- library
- nucleic acid
- recombinant polyclonal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43840303P | 2003-01-07 | 2003-01-07 | |
DKPA200300008 | 2003-01-07 | ||
US47601803P | 2003-06-05 | 2003-06-05 | |
PCT/DK2004/000001 WO2004061104A2 (fr) | 2003-01-07 | 2004-01-07 | Methode de production de proteines polyclonales de recombinaison |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1583830T3 true DK1583830T3 (da) | 2007-01-15 |
Family
ID=32718469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04700438T DK1583830T3 (da) | 2003-01-07 | 2004-01-07 | Fremgangsmåde til fremstilling af rekombinante polyklonale proteiner |
Country Status (19)
Country | Link |
---|---|
US (1) | US9163232B2 (fr) |
EP (2) | EP1762617A1 (fr) |
JP (2) | JP4589914B2 (fr) |
KR (1) | KR101024443B1 (fr) |
AT (1) | ATE338816T1 (fr) |
AU (1) | AU2004203727C1 (fr) |
BR (1) | BRPI0406678A (fr) |
CA (1) | CA2512647C (fr) |
DE (1) | DE602004002275T2 (fr) |
DK (1) | DK1583830T3 (fr) |
EA (1) | EA013225B1 (fr) |
ES (1) | ES2273202T3 (fr) |
HK (1) | HK1078896A1 (fr) |
IL (1) | IL169101A (fr) |
MX (1) | MXPA05006724A (fr) |
NZ (1) | NZ541458A (fr) |
PT (1) | PT1583830E (fr) |
SI (1) | SI1583830T1 (fr) |
WO (1) | WO2004061104A2 (fr) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2965865C (fr) | 2002-07-18 | 2021-10-19 | Merus N.V. | Production par recombinaison de melanges d'anticorps |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
EA013225B1 (ru) | 2003-01-07 | 2010-04-30 | Симфоген А/С | Способ получения линии клеток, продуцирующей рекомбинантный поликлональный белок, способ получения поликлонального белка, линия клеток, продуцирующая рекомбинантный поликлональный белок, библиотека векторов, популяция клеток |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
BRPI0513714A (pt) * | 2004-07-20 | 2008-05-13 | Symphogen As | procedimento para caracterização estrutural de uma proteìna policlonal recombinante ou uma linhagem de célula policlonal |
MX2007000644A (es) * | 2004-07-20 | 2007-03-28 | Symphogen As | Anticuerpo policlonal recombinante anti-rhesus d y metodos de fabricacion. |
JP4856177B2 (ja) | 2005-06-24 | 2012-01-18 | ユニジーン・ラボラトリーズ・インコーポレーテッド | アミド化生成物の調製に有用な酵素を発現させるための細胞株 |
JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
KR20080113223A (ko) * | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
US7504106B2 (en) | 2006-03-14 | 2009-03-17 | Boris Skurkovich | Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis |
FR2910490B1 (fr) * | 2006-12-20 | 2012-10-26 | Lab Francais Du Fractionnement | Lignee cellulaire a forte activite transcriptionnelle pour la production de proteines, notamment therapeutiques |
US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
US8859229B2 (en) * | 2007-02-02 | 2014-10-14 | Yale University | Transient transfection with RNA |
TW200846362A (en) * | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
EP2121920B1 (fr) | 2007-03-01 | 2011-08-24 | Symphogen A/S | Procede de clonage d'anticorps apparentes |
EP2132229B1 (fr) | 2007-03-01 | 2016-05-11 | Symphogen A/S | Compositions d'anticorps recombinants dirigés contre le récepteur du facteur de croissance épidermique |
MX2009009226A (es) * | 2007-03-06 | 2009-10-28 | Symphogen As | Anticuerpos recombinantes para el tratamiento de infecciones con el virus respiratorio sincitial. |
DE602008002593D1 (de) * | 2007-05-25 | 2010-10-28 | Symphogen As | Verfahren zur herstellung eines rekombinanten polyklonalen proteins |
TWI443109B (zh) | 2007-08-30 | 2014-07-01 | Daiichi Sankyo Co Ltd | 抗epha2抗體 |
EP2244735A4 (fr) | 2007-10-02 | 2011-02-23 | Avaxia Biologics Inc | Thérapie aux anticorps pour une utilisation dans le tube digestif |
ES2540733T3 (es) | 2007-10-11 | 2015-07-13 | Daiichi Sankyo Company, Limited | Anticuerpo que se dirige a la proteína Siglec-15 relacionada con osteoclastos |
RU2010147652A (ru) * | 2008-04-23 | 2012-05-27 | Симфоген А/С (Dk) | Способы производства поликлонального белка |
BRPI0918768B1 (pt) | 2008-08-29 | 2022-08-30 | Symphogen A/S | Composições de anticorpo recombinante de antireceptor do fator de crescimento epidérmico |
AU2009287165A1 (en) * | 2008-08-29 | 2010-03-04 | Symphogen A/S | Method for cloning avian-derived antibodies |
BRPI1006134A2 (pt) | 2009-04-09 | 2016-02-23 | Daiichi Sankyo Co Ltd | anticorpo ou um fragmento funcional do anticorpo, composição farmacêutica, uso de um anticorpo ou um fragmento funcional do mesmo, polinucleotídeo, vetor, e, célula hospedeira transformada. |
EP2488202B1 (fr) | 2009-10-15 | 2015-07-08 | Avaxia Biologics, Inc. | Agents thérapeutiques à base d'anticorps d'activité locale dans le tractus digestif |
NZ623347A (en) | 2010-10-29 | 2014-07-25 | Daiichi Sankyo Co Ltd | Novel anti-dr5 antibody |
JP6033783B2 (ja) | 2010-11-01 | 2016-11-30 | シムフォゲン・アクティーゼルスカブSymphogen A/S | Pan−her抗体組成物 |
DK2640743T3 (en) | 2010-11-16 | 2017-01-23 | Excelimmune Inc | PROCEDURES FOR THE PREPARATION OF RECOMBINANT PROTEINS |
AU2012248470B2 (en) | 2011-04-25 | 2016-10-27 | Daiichi Sankyo Company, Limited | Anti-B7-H3 antibody |
JP2015502165A (ja) | 2011-12-22 | 2015-01-22 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 発現ベクター構成、新規の産生細胞生成法、およびポリペプチドの組換え産生のためのそれらの使用 |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
US9464133B2 (en) | 2012-03-30 | 2016-10-11 | Daiichi Sankyo Company, Limited | CDR-modified anti-Siglec-15 antibody |
TW201345925A (zh) | 2012-03-30 | 2013-11-16 | Daiichi Sankyo Co Ltd | 新穎抗siglec-15抗體 |
AU2013247645B2 (en) | 2012-04-09 | 2019-02-14 | Daiichi Sankyo Company, Limited | Anti-FGFR2 antibody |
SG10201607369QA (en) | 2012-04-20 | 2016-10-28 | Merus Nv | Methods and means for the production of ig-like molecules |
DK2841457T3 (da) | 2012-04-27 | 2019-07-22 | Daiichi Sankyo Co Ltd | Antistof imod ROBO4 |
AU2013255537B2 (en) | 2012-05-02 | 2018-02-15 | Symphogen A/S | Humanized pan-her antibody compositions |
JP2015163047A (ja) * | 2012-06-20 | 2015-09-10 | 国立大学法人 東京大学 | タンパク質の迅速改良法 |
JP6514103B2 (ja) | 2012-07-06 | 2019-05-15 | ゲンマブ ビー.ブイ. | 三重変異を有する二量体タンパク質 |
HUE042040T2 (hu) | 2012-09-27 | 2019-06-28 | Merus Nv | Bispecifikus IGG antitestek mint T-sejt kapcsolók |
US9790269B2 (en) | 2013-02-08 | 2017-10-17 | Misfolding Diagnostics, Inc. | Transthyretin antibodies and uses thereof |
WO2015046505A1 (fr) | 2013-09-30 | 2015-04-02 | 第一三共株式会社 | Anticorps anti-lps 011 |
ES2768618T3 (es) | 2013-10-08 | 2020-06-23 | Daiichi Sankyo Co Ltd | Combinación de anticuerpo anti-FGFR2 y otro agente |
WO2015093925A1 (fr) * | 2013-12-19 | 2015-06-25 | CASTRO ALDRETE, Jorge Isaac | Méthode de production d'anticorps spécifiques |
ES2826774T3 (es) | 2014-02-28 | 2021-05-19 | Merus Nv | Anticuerpo que se une a ERBB-2 y ERBB-3 |
NZ724013A (en) | 2014-02-28 | 2019-11-29 | Merus Nv | Antibodies that bind egfr and erbb3 |
ES2748295T3 (es) | 2014-09-16 | 2020-03-16 | Symphogen As | Anticuerpos anti-MET y composiciones |
WO2016160618A2 (fr) | 2015-03-27 | 2016-10-06 | University Of Southern California | Thérapie à base de lymphocytes t car dirigés contre le récepteur lhr pour le traitement des tumeurs solides |
JP7010473B2 (ja) | 2015-06-04 | 2022-02-10 | ユニバーシティ オブ サザン カリフォルニア | Lym-1およびlym-2標的化car細胞免疫療法 |
WO2017010874A1 (fr) | 2015-07-10 | 2017-01-19 | Merus N.V. | Anticorps se liant à un cd3 humain |
WO2017053889A2 (fr) | 2015-09-23 | 2017-03-30 | Precision Immunotherapy, Inc. | Cellules car dirigée contre flt3 pour l'immunothérapie |
PT3354729T (pt) | 2015-09-24 | 2024-04-11 | Daiichi Sankyo Co Ltd | Anticorpo anti-garp |
WO2017069628A2 (fr) | 2015-10-23 | 2017-04-27 | Merus N.V. | Molécules de liaison inhibant la croissance de cancer |
JP7301540B2 (ja) | 2016-05-26 | 2023-07-03 | チールー ピュージェット サウンド バイオセラピューティクス コーポレイション | 抗体の混合物 |
CN118126180A (zh) | 2016-12-22 | 2024-06-04 | 第一三共株式会社 | 抗cd3抗体和包含所述抗体的分子 |
CN110462038A (zh) | 2017-02-07 | 2019-11-15 | 第一三共株式会社 | 抗gprc5d抗体和包含所述抗体的分子 |
TWI782000B (zh) | 2017-03-30 | 2022-11-01 | 日商第一三共股份有限公司 | 抗gpr20抗體、其製造方法及其應用 |
US11780925B2 (en) | 2017-03-31 | 2023-10-10 | Merus N.V. | ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment of cells that have an NRG1 fusion gene |
CN110621698B (zh) | 2017-04-05 | 2024-04-12 | 法国施维雅药厂 | 靶向pd-1、tim-3及lag-3的组合疗法 |
WO2019004487A1 (fr) | 2017-06-30 | 2019-01-03 | 国立大学法人北海道大学 | Médicament contre l'ostéoporose pédiatrique ne causant pas de troubles de la croissance |
AU2018307292A1 (en) | 2017-07-27 | 2020-02-20 | Daiichi Sankyo Company, Limited | Anti-CD147 antibody |
BR112020002695A2 (pt) | 2017-08-09 | 2020-08-25 | Merus N.V. | anticorpos que se ligam à egfr e cmet |
US20200262917A1 (en) | 2017-10-05 | 2020-08-20 | Daiichi Sankyo Company, Limited | Composition for cytotoxic t cell depletion |
CA3084315A1 (fr) | 2017-12-11 | 2019-06-20 | Abalone Bio, Inc. | Presentation de proteines sur levure dans l'espace periplasmique |
CA3093205A1 (fr) | 2018-03-05 | 2019-09-12 | Saitama Medical University | Composition pharmaceutique pour le traitement ou la prevention de l'ossification heterotopique |
MX2020011814A (es) | 2018-05-31 | 2020-12-07 | Daiichi Sankyo Co Ltd | Anticuerpo anti-tlr7 humano. |
CA3104390A1 (fr) | 2018-06-22 | 2019-12-26 | Genmab A/S | Procede de production d'un melange controle d'au moins deux anticorps differents |
CN117024593A (zh) | 2018-07-10 | 2023-11-10 | 国立大学法人神户大学 | 抗SIRPα抗体 |
CA3107732A1 (fr) | 2018-07-27 | 2020-01-30 | Daiichi Sankyo Company, Limited | Proteine reconnaissant la fraction medicamenteuse d'un conjugue anticorps-medicament |
JPWO2021020282A1 (fr) | 2019-07-26 | 2021-02-04 | ||
WO2021079958A1 (fr) | 2019-10-25 | 2021-04-29 | 第一三共株式会社 | Combinaison d'anticorps anti-garp et d'immunorégulateur |
EP4084824A1 (fr) | 2019-12-31 | 2022-11-09 | Antagonis | Compositions et procédés pour la prévention d'une infection à s. aureus |
CA3177152A1 (fr) | 2020-06-12 | 2021-12-16 | David Scott Johnson | Proteines polyclonales recombinees ciblant la covid-19 et leurs methodes d'utilisation |
WO2022031834A1 (fr) * | 2020-08-05 | 2022-02-10 | Gigagen, Inc. | Protéines polyclonales recombinées ciblant le virus zika et leurs méthodes d'utilisation |
EP4204005A1 (fr) | 2020-08-31 | 2023-07-05 | Sab, Llc | Immunoglobuline polyclonale dérivée d'ongulés spécifique à la protéine de coronavirus et ses utilisations |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US155114A (en) * | 1874-09-15 | Improvement in methods of laying and forming cast-iron pipes | ||
CA1293460C (fr) * | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Recombinaison a des sites specifiques de l'adn dans les levures |
EP0530216A4 (en) | 1990-04-19 | 1993-06-30 | Medimmune, Inc. | Administration of monoclonal antibodies against respiratory viruses |
GB9022543D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
WO1992015694A1 (fr) | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Modification de genes induite par recombinase dans des cellules de mammifere, compositions et cellules utiles a cet effet |
DE69531148T2 (de) * | 1994-01-31 | 2004-04-29 | Trustees Of Boston University, Boston | Bibliotheken aus polyklonalen antikörpern |
US6111166A (en) | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
IL131746A0 (en) * | 1997-03-14 | 2001-03-19 | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same | |
US6368821B1 (en) | 1997-04-14 | 2002-04-09 | Stratagene | Process for infecting eukaryotic cells with a bacterial virus |
US6632672B2 (en) * | 1998-08-19 | 2003-10-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for genomic modification |
US20020155114A1 (en) | 1998-08-31 | 2002-10-24 | James D. Marks | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
CA2373690A1 (fr) | 1999-07-14 | 2001-01-25 | Clontech Laboratories, Inc. | Procedes faisant intervenir la recombinase pour la production de vecteurs d'expression et compositions permettant d'atteindre ce resultat |
AU6364800A (en) | 1999-07-23 | 2001-02-13 | Regents Of The University Of California, The | Dna recombination in eukaryotic cells by the bacteriophage phic31 recombination system |
CA2410586C (fr) * | 2000-05-26 | 2010-07-20 | Symphogen A/S | Anticorps polyclonaux recombines ou purifies, destines au traitement des allergies |
EP1293564A4 (fr) | 2000-06-08 | 2005-08-17 | Mitsubishi Pharma Corp | Vecteur d'expression permettant le criblage de cellules a haute expression de proteine de recombinaison, transformant a haute expression de proteine de recombinaison, et leur utilisation |
US6849259B2 (en) | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
US6610472B1 (en) | 2000-10-31 | 2003-08-26 | Genetastix Corporation | Assembly and screening of highly complex and fully human antibody repertoire in yeast |
JP2004514444A (ja) * | 2000-11-28 | 2004-05-20 | アプライド モレキュラー エボリューション, インコーポレイテッド | 二重lox組換えに基づく真核生物発現ライブラリーおよび使用方法 |
US20030044398A1 (en) | 2001-03-20 | 2003-03-06 | Robl James M. | Methods for producing antibodies in mammals |
CA2965865C (fr) | 2002-07-18 | 2021-10-19 | Merus N.V. | Production par recombinaison de melanges d'anticorps |
WO2004029284A2 (fr) | 2002-09-30 | 2004-04-08 | Protein Design Labs, Inc. | Generation efficace de lignees cellulaires d'expression stable par utilisation de genes rapporteurs homeostatiques pouvant etre soumis a notation |
EA013225B1 (ru) | 2003-01-07 | 2010-04-30 | Симфоген А/С | Способ получения линии клеток, продуцирующей рекомбинантный поликлональный белок, способ получения поликлонального белка, линия клеток, продуцирующая рекомбинантный поликлональный белок, библиотека векторов, популяция клеток |
US20060275766A1 (en) | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
CA2553731A1 (fr) | 2004-01-21 | 2005-08-04 | Novozymes A/S | Production d'un anticorps monoclonal dans un champignon heterocaryon ou dans une cellule hote fongique |
MX2007000644A (es) | 2004-07-20 | 2007-03-28 | Symphogen As | Anticuerpo policlonal recombinante anti-rhesus d y metodos de fabricacion. |
BRPI0513714A (pt) | 2004-07-20 | 2008-05-13 | Symphogen As | procedimento para caracterização estrutural de uma proteìna policlonal recombinante ou uma linhagem de célula policlonal |
JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
KR20080113223A (ko) | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
TW200846362A (en) | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
DE602008002593D1 (de) | 2007-05-25 | 2010-10-28 | Symphogen As | Verfahren zur herstellung eines rekombinanten polyklonalen proteins |
-
2004
- 2004-01-07 EA EA200501101A patent/EA013225B1/ru not_active IP Right Cessation
- 2004-01-07 ES ES04700438T patent/ES2273202T3/es not_active Expired - Lifetime
- 2004-01-07 DK DK04700438T patent/DK1583830T3/da active
- 2004-01-07 BR BR0406678-2A patent/BRPI0406678A/pt not_active Application Discontinuation
- 2004-01-07 AU AU2004203727A patent/AU2004203727C1/en not_active Ceased
- 2004-01-07 JP JP2006500508A patent/JP4589914B2/ja not_active Expired - Fee Related
- 2004-01-07 SI SI200430074T patent/SI1583830T1/sl unknown
- 2004-01-07 CA CA2512647A patent/CA2512647C/fr not_active Expired - Fee Related
- 2004-01-07 WO PCT/DK2004/000001 patent/WO2004061104A2/fr active IP Right Grant
- 2004-01-07 AT AT04700438T patent/ATE338816T1/de active
- 2004-01-07 PT PT04700438T patent/PT1583830E/pt unknown
- 2004-01-07 DE DE602004002275T patent/DE602004002275T2/de not_active Expired - Lifetime
- 2004-01-07 EP EP06018504A patent/EP1762617A1/fr not_active Withdrawn
- 2004-01-07 EP EP04700438A patent/EP1583830B1/fr not_active Expired - Lifetime
- 2004-01-07 KR KR1020057012745A patent/KR101024443B1/ko not_active IP Right Cessation
- 2004-01-07 NZ NZ541458A patent/NZ541458A/en not_active IP Right Cessation
- 2004-01-07 MX MXPA05006724A patent/MXPA05006724A/es active IP Right Grant
-
2005
- 2005-06-09 IL IL169101A patent/IL169101A/en not_active IP Right Cessation
- 2005-11-25 HK HK05110692A patent/HK1078896A1/xx not_active IP Right Cessation
-
2008
- 2008-12-19 US US12/339,490 patent/US9163232B2/en not_active Expired - Fee Related
-
2010
- 2010-07-08 JP JP2010155716A patent/JP2010268806A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20090136498A1 (en) | 2009-05-28 |
KR20050101538A (ko) | 2005-10-24 |
WO2004061104A3 (fr) | 2004-11-04 |
PT1583830E (pt) | 2006-11-30 |
DE602004002275D1 (de) | 2006-10-19 |
EP1583830B1 (fr) | 2006-09-06 |
JP2006515520A (ja) | 2006-06-01 |
ATE338816T1 (de) | 2006-09-15 |
JP4589914B2 (ja) | 2010-12-01 |
CA2512647A1 (fr) | 2004-07-22 |
SI1583830T1 (sl) | 2006-12-31 |
MXPA05006724A (es) | 2005-09-08 |
KR101024443B1 (ko) | 2011-03-23 |
ES2273202T3 (es) | 2007-05-01 |
DE602004002275T2 (de) | 2007-09-06 |
EP1583830A2 (fr) | 2005-10-12 |
CA2512647C (fr) | 2013-10-08 |
NZ541458A (en) | 2006-04-28 |
EA200501101A1 (ru) | 2006-02-24 |
WO2004061104A2 (fr) | 2004-07-22 |
AU2004203727C1 (en) | 2008-08-21 |
BRPI0406678A (pt) | 2005-12-20 |
EA013225B1 (ru) | 2010-04-30 |
US9163232B2 (en) | 2015-10-20 |
HK1078896A1 (en) | 2006-03-24 |
EP1762617A1 (fr) | 2007-03-14 |
JP2010268806A (ja) | 2010-12-02 |
AU2004203727B2 (en) | 2008-01-31 |
IL169101A (en) | 2009-02-11 |
AU2004203727A1 (en) | 2004-07-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1583830T3 (da) | Fremgangsmåde til fremstilling af rekombinante polyklonale proteiner | |
EA200700249A1 (ru) | Рекомбинантное поликлональное антитело против резус-фактора d и способы его получения | |
CN104854133B (zh) | 用于制备重组抗体治疗剂的最佳重链和轻链信号肽 | |
JP6573331B2 (ja) | 同起源の抗体可変領域遺伝子セグメントをクローニングおよび発現させるための迅速な方法 | |
DK2152872T3 (da) | Fremgangsmåde til fremstilling af et rekombinant polyklonalt protein | |
CN104011080B (zh) | 用于真核细胞的全长抗体展示系统及其用途 | |
Kurosawa et al. | Rapid production of antigen-specific monoclonal antibodies from a variety of animals | |
CN105602960A (zh) | 抗体的快速人源化 | |
DE60039596D1 (de) | Verfahren zur herstellung von monoklonalen antikörpern | |
Price et al. | Engineered cell surface expression of membrane immunoglobulin as a means to identify monoclonal antibody-secreting hybridomas | |
CN106478773A (zh) | 一种人工合成的新型信号肽 | |
ES2700442T3 (es) | Método para producir anticuerpos | |
CN102083984A (zh) | 食蟹猴Toll样受体3 | |
US12024548B2 (en) | Rapid method for cloning and expression of cognate antibody variable gene segments | |
CN104558180B (zh) | 靶向t淋巴细胞的人源单链抗体 |