DK158269C - Analogifremgangsmaade til fremstilling af morpholinyldaunorubicin- eller morpholinyldoxorubicinderivater - Google Patents
Analogifremgangsmaade til fremstilling af morpholinyldaunorubicin- eller morpholinyldoxorubicinderivaterInfo
- Publication number
- DK158269C DK158269C DK332983A DK332983A DK158269C DK 158269 C DK158269 C DK 158269C DK 332983 A DK332983 A DK 332983A DK 332983 A DK332983 A DK 332983A DK 158269 C DK158269 C DK 158269C
- Authority
- DK
- Denmark
- Prior art keywords
- morpholinyldoxorubicin
- morpholinyldaunorubicin
- analogue
- derivatives
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40012082A | 1982-07-20 | 1982-07-20 | |
US40012082 | 1982-07-20 | ||
US06/496,122 US4464529A (en) | 1982-07-20 | 1983-05-24 | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
US49612283 | 1983-05-24 |
Publications (4)
Publication Number | Publication Date |
---|---|
DK332983D0 DK332983D0 (da) | 1983-07-19 |
DK332983A DK332983A (da) | 1984-01-21 |
DK158269B DK158269B (da) | 1990-04-23 |
DK158269C true DK158269C (da) | 1990-10-08 |
Family
ID=27016900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK332983A DK158269C (da) | 1982-07-20 | 1983-07-19 | Analogifremgangsmaade til fremstilling af morpholinyldaunorubicin- eller morpholinyldoxorubicinderivater |
Country Status (24)
Country | Link |
---|---|
US (1) | US4464529A (de) |
KR (1) | KR880002461B1 (de) |
AT (1) | AT381319B (de) |
AU (1) | AU555902B2 (de) |
BE (1) | BE897312A (de) |
CA (1) | CA1239396A (de) |
CH (1) | CH655729A5 (de) |
DE (1) | DE3325816A1 (de) |
DK (1) | DK158269C (de) |
ES (2) | ES8501415A1 (de) |
FI (1) | FI75174C (de) |
FR (1) | FR2530640B1 (de) |
GB (1) | GB2124224B (de) |
GR (1) | GR78885B (de) |
IE (1) | IE55795B1 (de) |
IL (1) | IL69260A (de) |
IT (1) | IT1163818B (de) |
NL (1) | NL188905C (de) |
NO (1) | NO157146C (de) |
NZ (1) | NZ204911A (de) |
PH (1) | PH21860A (de) |
PT (1) | PT77060B (de) |
SE (1) | SE459921B (de) |
YU (2) | YU155083A (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826964A (en) * | 1982-07-20 | 1989-05-02 | Sri International | Bridged oxygen analogs of daunorubcin and doxorubicin |
JPS59212499A (ja) * | 1983-05-13 | 1984-12-01 | アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド | 抗腫瘍性抗生物質アントラサイクリンの4−デメトキシ−3′−デアミノ−3′(4−モリホリニル)誘導体 |
GB2140006A (en) * | 1983-05-17 | 1984-11-21 | Erba Farmitalia | Anthracycline derivatives |
US4585859A (en) * | 1983-05-24 | 1986-04-29 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
FR2560876B1 (fr) * | 1984-03-09 | 1987-01-16 | Hoechst Lab | Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments |
FR2565982B1 (fr) * | 1984-06-15 | 1988-01-15 | Hoechst Lab | Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals |
GB8426672D0 (en) * | 1984-10-22 | 1984-11-28 | Erba Farmitalia | Pharmaceutical compositions |
US4705850A (en) * | 1984-10-25 | 1987-11-10 | Sri International | C-glycosidic adriamycin analogs |
US4591637A (en) * | 1985-01-17 | 1986-05-27 | Sri International | Open chain-morpholino adriamycins |
US4710564A (en) * | 1985-01-18 | 1987-12-01 | Microbial Chemistry Research Foundation | Anthracycline compounds |
GB2172594B (en) * | 1985-03-22 | 1988-06-08 | Erba Farmitalia | New morpholino derivatives of daunorubicin and doxorubicin |
GB8519452D0 (en) * | 1985-08-02 | 1985-09-11 | Erba Farmitalia | Injectable solutions |
US5124317A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
US5137877B1 (en) * | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
GB9019933D0 (en) * | 1990-09-12 | 1990-10-24 | Erba Carlo Spa | 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines |
US5196522A (en) * | 1990-11-01 | 1993-03-23 | Board Of Regents, The University Of Texas System | Anthracycline analogues bearing latent alkylating substituents |
US5843903A (en) * | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
ATE344801T1 (de) * | 1999-12-29 | 2006-11-15 | Immunogen Inc | Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung |
WO2005086951A2 (en) * | 2004-03-10 | 2005-09-22 | Threshold Pharmaceuticals, Inc. | Hypoxia-activated anti-cancer agents |
US20070060534A1 (en) * | 2005-06-30 | 2007-03-15 | Threshold Pharmaceuticals, Inc. | Anthracycline analogs |
US9115165B2 (en) * | 2008-04-11 | 2015-08-25 | Tianjin Hemay Bio-Tech Co., Ltd. | Tetracyclic anthraquinone antibiotic derivatives with high activity, process for preparing the same and use thereof |
EP2588490B1 (de) | 2010-07-02 | 2017-02-22 | Angiochem Inc. | Kurze und d-aminosäure-haltige polypeptide für therapeutische konjugate und ihre verwendungen |
WO2016040825A1 (en) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
EP4180061A1 (de) | 2021-11-10 | 2023-05-17 | Nerviano Medical Sciences S.r.l. | Linker-reagenzien für anthracyclinderivate, antikörper-arznemittelkonjugate und verfahren |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4109076A (en) * | 1977-09-08 | 1978-08-22 | Sri International | 5-iminodaunomycin |
US4202967A (en) * | 1978-10-02 | 1980-05-13 | Sri International | N,N-pentamethylene derivatives of daunomycin and adriamycin |
US4301277A (en) * | 1980-10-20 | 1981-11-17 | Sri International | 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin |
US4314054A (en) * | 1981-03-23 | 1982-02-02 | Sri International | 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin |
-
1983
- 1983-05-24 US US06/496,122 patent/US4464529A/en not_active Expired - Lifetime
- 1983-07-15 AT AT0260883A patent/AT381319B/de not_active IP Right Cessation
- 1983-07-15 NZ NZ204911A patent/NZ204911A/en unknown
- 1983-07-15 GB GB08319165A patent/GB2124224B/en not_active Expired
- 1983-07-18 PH PH29236A patent/PH21860A/en unknown
- 1983-07-18 AU AU16946/83A patent/AU555902B2/en not_active Ceased
- 1983-07-18 IL IL69260A patent/IL69260A/xx unknown
- 1983-07-18 FR FR8311803A patent/FR2530640B1/fr not_active Expired
- 1983-07-18 DE DE19833325816 patent/DE3325816A1/de active Granted
- 1983-07-18 YU YU01550/83A patent/YU155083A/xx unknown
- 1983-07-18 BE BE0/211190A patent/BE897312A/fr not_active IP Right Cessation
- 1983-07-18 NO NO832610A patent/NO157146C/no unknown
- 1983-07-19 FI FI832637A patent/FI75174C/fi not_active IP Right Cessation
- 1983-07-19 DK DK332983A patent/DK158269C/da not_active IP Right Cessation
- 1983-07-19 ES ES524271A patent/ES8501415A1/es not_active Expired
- 1983-07-19 SE SE8304045A patent/SE459921B/sv not_active IP Right Cessation
- 1983-07-19 KR KR1019830003323A patent/KR880002461B1/ko not_active IP Right Cessation
- 1983-07-19 NL NLAANVRAGE8302586,A patent/NL188905C/xx not_active IP Right Cessation
- 1983-07-19 IE IE1680/83A patent/IE55795B1/en not_active IP Right Cessation
- 1983-07-19 CH CH3949/83A patent/CH655729A5/de not_active IP Right Cessation
- 1983-07-19 CA CA000432737A patent/CA1239396A/en not_active Expired
- 1983-07-19 GR GR71976A patent/GR78885B/el unknown
- 1983-07-19 PT PT77060A patent/PT77060B/pt not_active IP Right Cessation
- 1983-07-20 IT IT22143/83A patent/IT1163818B/it active
-
1984
- 1984-03-14 ES ES530593A patent/ES8602032A1/es not_active Expired
-
1985
- 1985-09-09 YU YU01405/85A patent/YU140585A/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |