DK157881C - Analogifremgangsmaade til fremstilling af 3-amino-(1)benzazepin-2-on-1-alkansyrer eller derivater deraf eller stereoisomerer eller salte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 3-amino-(1)benzazepin-2-on-1-alkansyrer eller derivater deraf eller stereoisomerer eller salte deraf

Info

Publication number
DK157881C
DK157881C DK358682A DK358682A DK157881C DK 157881 C DK157881 C DK 157881C DK 358682 A DK358682 A DK 358682A DK 358682 A DK358682 A DK 358682A DK 157881 C DK157881 C DK 157881C
Authority
DK
Denmark
Prior art keywords
benzazepin
stereoisomers
analogue
derivatives
salts
Prior art date
Application number
DK358682A
Other languages
Danish (da)
English (en)
Other versions
DK358682A (da
DK157881B (da
Inventor
Jeffrey W H Watthey
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK358682A publication Critical patent/DK358682A/da
Publication of DK157881B publication Critical patent/DK157881B/da
Application granted granted Critical
Publication of DK157881C publication Critical patent/DK157881C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK358682A 1981-08-11 1982-08-10 Analogifremgangsmaade til fremstilling af 3-amino-(1)benzazepin-2-on-1-alkansyrer eller derivater deraf eller stereoisomerer eller salte deraf DK157881C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29190781A 1981-08-11 1981-08-11
US29190781 1981-08-11
US31986381A 1981-11-09 1981-11-09
US31986381 1981-11-09

Publications (3)

Publication Number Publication Date
DK358682A DK358682A (da) 1983-02-12
DK157881B DK157881B (da) 1990-02-26
DK157881C true DK157881C (da) 1990-07-23

Family

ID=26967047

Family Applications (1)

Application Number Title Priority Date Filing Date
DK358682A DK157881C (da) 1981-08-11 1982-08-10 Analogifremgangsmaade til fremstilling af 3-amino-(1)benzazepin-2-on-1-alkansyrer eller derivater deraf eller stereoisomerer eller salte deraf

Country Status (22)

Country Link
EP (1) EP0072352B1 (es)
KR (3) KR890003425B1 (es)
AR (3) AR240806A1 (es)
AT (1) ATE18397T1 (es)
AU (1) AU561395B2 (es)
CA (1) CA1196636A (es)
CY (1) CY1403A (es)
DD (1) DD202546A5 (es)
DE (1) DE3269625D1 (es)
DK (1) DK157881C (es)
ES (6) ES514856A0 (es)
FI (1) FI76074C (es)
GB (1) GB2103614B (es)
GR (1) GR77256B (es)
HK (1) HK93387A (es)
HU (1) HU189628B (es)
IE (1) IE53668B1 (es)
IL (1) IL66501A (es)
NL (1) NL930112I2 (es)
NO (1) NO161558C (es)
NZ (1) NZ201555A (es)
PT (1) PT75395B (es)

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DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
JPS608284A (ja) * 1983-06-29 1985-01-17 Mitsui Toatsu Chem Inc ベンゾチアゼピン誘導体およびその製造法
US4539150A (en) * 1983-06-29 1985-09-03 Mitsui Toatsu Chemicals, Inc. Benzothiazepine derivatives and their methods of preparation
AU570710B2 (en) * 1983-08-12 1988-03-24 Takeda Chemical Industries Ltd. 4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
US4638000A (en) * 1983-08-12 1987-01-20 Takeda Chemical Industries, Ltd. Condensed seven-membered ring compounds, their production and use
IL72523A (en) * 1983-08-12 1988-06-30 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
EP0166354B1 (en) * 1984-06-26 1992-08-05 Merck & Co. Inc. Benzofused lactam compounds and pharmaceutical compositions containing them
CA1266647A (en) * 1984-06-26 1990-03-13 William H. Parsons Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3704661A1 (de) * 1987-02-14 1988-08-25 Hoechst Ag Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof
TW197945B (es) * 1990-11-27 1993-01-11 Hoechst Ag
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
US5610153A (en) * 1992-12-11 1997-03-11 Ciba-Geigy Corporation Benzazepinone derivatives
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
MXPA02005070A (es) * 1999-11-18 2003-09-25 Antexpharma Inc 1-benzazepinas sustituidas y derivados de las mismas.
EP2256104A1 (en) 2000-12-27 2010-12-01 Merck Patent GmbH Process for the preparation of alpha-aminosubstituted carboxylic acid amides
CN1585744A (zh) 2001-03-27 2005-02-23 兰贝克赛实验室有限公司 贝那普利的制备方法
EP1443919A4 (en) 2001-11-16 2006-03-22 Bristol Myers Squibb Co DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES
EP1525189A1 (en) * 2002-07-26 2005-04-27 Ciba Specialty Chemicals Holding Inc. Crystalline polymorphic and amorphous forms of benazepril hydrochloride
KR100710548B1 (ko) * 2002-12-26 2007-04-24 에스케이 주식회사 (ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8080579B2 (en) 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP2089355A2 (en) 2006-11-01 2009-08-19 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
JP2010508358A (ja) 2006-11-01 2010-03-18 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の調節剤、並びにその使用
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US7828840B2 (en) 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
WO2009158380A1 (en) 2008-06-24 2009-12-30 Bristol-Myers Squibb Company Cyclopentathiophene modulators of the glucocorticoid receptor, ap-1, and/or nf-kappa b activity and use thereof
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
US9593113B2 (en) 2013-08-22 2017-03-14 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN113292495B (zh) * 2021-06-18 2022-09-13 迪嘉药业集团有限公司 一种 (s)-氨基化合物的合成方法

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US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1305278A (es) * 1970-03-12 1973-01-31

Also Published As

Publication number Publication date
ES530658A0 (es) 1985-12-01
ES526886A0 (es) 1985-11-01
NL930112I1 (nl) 1993-10-18
FI822770A0 (fi) 1982-08-09
NZ201555A (en) 1986-06-11
PT75395B (en) 1985-11-15
HU189628B (en) 1986-07-28
ES526889A0 (es) 1986-02-01
DE3269625D1 (en) 1986-04-10
ES526888A0 (es) 1985-04-16
EP0072352A1 (de) 1983-02-16
AR241222A1 (es) 1992-02-28
GR77256B (es) 1984-09-11
IL66501A0 (en) 1982-12-31
IE821929L (en) 1983-02-11
ES526887A0 (es) 1986-04-16
AU8701482A (en) 1983-05-12
FI76074B (fi) 1988-05-31
PT75395A (en) 1982-09-01
ES8502974A1 (es) 1985-02-01
FI76074C (fi) 1988-09-09
ES8504728A1 (es) 1985-04-16
ES514856A0 (es) 1985-02-01
KR900001191B1 (ko) 1990-02-28
AR240806A1 (es) 1991-02-28
NL930112I2 (nl) 1996-11-01
NO822722L (no) 1983-02-14
ES8606285A1 (es) 1986-04-16
GB2103614B (en) 1984-11-21
ES8601142A1 (es) 1985-11-01
NO161558B (no) 1989-05-22
AU561395B2 (en) 1987-05-07
KR840001139A (ko) 1984-03-28
DK358682A (da) 1983-02-12
CA1196636A (en) 1985-11-12
AR240807A1 (es) 1991-02-28
IE53668B1 (en) 1989-01-04
KR900001190B1 (ko) 1990-02-28
ES8604523A1 (es) 1986-02-01
CY1403A (en) 1987-12-18
DD202546A5 (de) 1983-09-21
ES8602682A1 (es) 1985-12-01
AR240807A2 (es) 1991-02-28
GB2103614A (en) 1983-02-23
AR240806A2 (es) 1991-02-28
HK93387A (en) 1987-12-18
KR890003425B1 (ko) 1989-09-20
ATE18397T1 (de) 1986-03-15
NO161558C (no) 1989-08-30
IL66501A (en) 1987-10-20
EP0072352B1 (de) 1986-03-05
DK157881B (da) 1990-02-26
FI822770L (fi) 1983-02-12

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