ES8606285A1 - Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanoicos - Google Patents

Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanoicos

Info

Publication number
ES8606285A1
ES8606285A1 ES526887A ES526887A ES8606285A1 ES 8606285 A1 ES8606285 A1 ES 8606285A1 ES 526887 A ES526887 A ES 526887A ES 526887 A ES526887 A ES 526887A ES 8606285 A1 ES8606285 A1 ES 8606285A1
Authority
ES
Spain
Prior art keywords
alkyl
compounds
hydrogen
formula
benzazepin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526887A
Other languages
English (en)
Other versions
ES526887A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8606285A1 publication Critical patent/ES8606285A1/es
Publication of ES526887A0 publication Critical patent/ES526887A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NUEVOS ACIDOS 3-AMINO-(1)BENZAZEPIN-2-ONA-1-ALCANICOS. CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA (III), EN PRESENCIA DE UN ALCANO INFERIOR CLORADO O UNA AMIDA TERCIARIA DE BAJO PESO MOLECULAR COMO DISOLVENTE, Y UN HIDROXIDO ALCALINO, UN BICARBONATO U OTRO AGENTE REDUCTOR, ENTRE 0 Y 100JC, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: RA Y RB, RESTOS DE FORMULA (IV) O (V); RO, CARBOXI; R1, H, ALQUILO INFERIOR, AMINO-ALQUILO INFERIOR Y OTROS; R2, H O ALQUILO INFERIOR; R3 Y R4, INDEPENDIENTES ENTRE SI, H, ALCOXI INFERIOR Y OTROS; R3 Y R4, JUNTOS, ALQUILENDIOXI INFERIOR; R5, COMO R2; X, OXO, DOS ATOMOS DE HIDROGENO, O JUNTO CON UN ATOMO DE H, UN GRUPO HIDROXI; E Y, OXO O GRUPO HIDROXILO ESTERIFICADO. SE UTILIZA COMO INHIBIDOR DE LA ENZIMA TRANSFORMADORA DE LA ANGIOTENSINA EN EL TRATAMIENTO DE LA ALTA PRESION SANGUINEA Y LA INSUFICIENCIA CARDIACA CONGESTIVA.
ES526887A 1981-08-11 1983-10-28 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanoicos Expired ES8606285A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29190781A 1981-08-11 1981-08-11
US31986381A 1981-11-09 1981-11-09

Publications (2)

Publication Number Publication Date
ES8606285A1 true ES8606285A1 (es) 1986-04-16
ES526887A0 ES526887A0 (es) 1986-04-16

Family

ID=26967047

Family Applications (6)

Application Number Title Priority Date Filing Date
ES514856A Expired ES8502974A1 (es) 1981-08-11 1982-08-09 Procedimiento para la obtencion de nuevos acidos 3-amino 1 benza-zepin-2-on-1-alcanicos.
ES526889A Expired ES8604523A1 (es) 1981-08-11 1983-10-28 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos
ES526887A Expired ES8606285A1 (es) 1981-08-11 1983-10-28 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanoicos
ES526888A Expired ES8504728A1 (es) 1981-08-11 1983-10-28 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos
ES526886A Granted ES526886A0 (es) 1981-08-11 1983-10-28 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos
ES530658A Granted ES530658A0 (es) 1981-08-11 1984-03-15 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)-benzazepin-2-on-1-alcanicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES514856A Expired ES8502974A1 (es) 1981-08-11 1982-08-09 Procedimiento para la obtencion de nuevos acidos 3-amino 1 benza-zepin-2-on-1-alcanicos.
ES526889A Expired ES8604523A1 (es) 1981-08-11 1983-10-28 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES526888A Expired ES8504728A1 (es) 1981-08-11 1983-10-28 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos
ES526886A Granted ES526886A0 (es) 1981-08-11 1983-10-28 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)benzazepin-2-on-1-alcanicos
ES530658A Granted ES530658A0 (es) 1981-08-11 1984-03-15 Procedimiento para la obtencion de nuevos acidos 3-amino-(1)-benzazepin-2-on-1-alcanicos

Country Status (22)

Country Link
EP (1) EP0072352B1 (es)
KR (3) KR890003425B1 (es)
AR (3) AR240806A1 (es)
AT (1) ATE18397T1 (es)
AU (1) AU561395B2 (es)
CA (1) CA1196636A (es)
CY (1) CY1403A (es)
DD (1) DD202546A5 (es)
DE (1) DE3269625D1 (es)
DK (1) DK157881C (es)
ES (6) ES8502974A1 (es)
FI (1) FI76074C (es)
GB (1) GB2103614B (es)
GR (1) GR77256B (es)
HK (1) HK93387A (es)
HU (1) HU189628B (es)
IE (1) IE53668B1 (es)
IL (1) IL66501A (es)
NL (1) NL930112I2 (es)
NO (1) NO161558C (es)
NZ (1) NZ201555A (es)
PT (1) PT75395B (es)

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DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
JPS608284A (ja) * 1983-06-29 1985-01-17 Mitsui Toatsu Chem Inc ベンゾチアゼピン誘導体およびその製造法
US4539150A (en) * 1983-06-29 1985-09-03 Mitsui Toatsu Chemicals, Inc. Benzothiazepine derivatives and their methods of preparation
IL72523A (en) * 1983-08-12 1988-06-30 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
AU570710B2 (en) * 1983-08-12 1988-03-24 Takeda Chemical Industries Ltd. 4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
US4638000A (en) * 1983-08-12 1987-01-20 Takeda Chemical Industries, Ltd. Condensed seven-membered ring compounds, their production and use
CA1266647A (en) * 1984-06-26 1990-03-13 William H. Parsons Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
EP0166354B1 (en) * 1984-06-26 1992-08-05 Merck & Co. Inc. Benzofused lactam compounds and pharmaceutical compositions containing them
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3704661A1 (de) * 1987-02-14 1988-08-25 Hoechst Ag Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof
TW197945B (es) * 1990-11-27 1993-01-11 Hoechst Ag
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
US5610153A (en) * 1992-12-11 1997-03-11 Ciba-Geigy Corporation Benzazepinone derivatives
GB9310075D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
EP1229913A4 (en) * 1999-11-18 2005-01-19 Antexpharma Inc SUBSTITUTED 1-BENZAZEPINE AND THEIR DERIVATIVES
JP4508528B2 (ja) 2000-12-27 2010-07-21 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング α−アミノ置換カルボン酸アミドの製造方法
RU2003131337A (ru) 2001-03-27 2005-05-10 Рэнбакси Лабораториз Лимитед (IN) Рэнбакси Лабораториз Лимитед (IN) Способ получения беназеприла
AU2002348276A1 (en) 2001-11-16 2003-06-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US20050107359A1 (en) * 2002-07-26 2005-05-19 Van Der Schaaf Paul A. Crystalline polymorphic and amorphous forms of benazepril hydrochloride
KR100710548B1 (ko) * 2002-12-26 2007-04-24 에스케이 주식회사 (ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8080579B2 (en) 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2008057862A2 (en) 2006-11-01 2008-05-15 Bristol-Myers Squibb Company MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
EP2099767A1 (en) 2006-11-01 2009-09-16 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof
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MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US7828840B2 (en) 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
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JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
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Also Published As

Publication number Publication date
ES526888A0 (es) 1985-04-16
IE821929L (en) 1983-02-11
ES8601142A1 (es) 1985-11-01
IL66501A0 (en) 1982-12-31
HU189628B (en) 1986-07-28
GB2103614B (en) 1984-11-21
AU561395B2 (en) 1987-05-07
GR77256B (es) 1984-09-11
EP0072352B1 (de) 1986-03-05
PT75395B (en) 1985-11-15
GB2103614A (en) 1983-02-23
ES526889A0 (es) 1986-02-01
NL930112I2 (nl) 1996-11-01
KR900001190B1 (ko) 1990-02-28
AU8701482A (en) 1983-05-12
AR240807A2 (es) 1991-02-28
KR890003425B1 (ko) 1989-09-20
AR241222A1 (es) 1992-02-28
KR840001139A (ko) 1984-03-28
AR240806A1 (es) 1991-02-28
ES514856A0 (es) 1985-02-01
AR240806A2 (es) 1991-02-28
FI822770L (fi) 1983-02-12
NO822722L (no) 1983-02-14
IE53668B1 (en) 1989-01-04
ES8604523A1 (es) 1986-02-01
PT75395A (en) 1982-09-01
FI76074C (fi) 1988-09-09
AR240807A1 (es) 1991-02-28
ATE18397T1 (de) 1986-03-15
KR900001191B1 (ko) 1990-02-28
ES8602682A1 (es) 1985-12-01
DD202546A5 (de) 1983-09-21
CY1403A (en) 1987-12-18
DE3269625D1 (en) 1986-04-10
FI822770A0 (fi) 1982-08-09
NZ201555A (en) 1986-06-11
NO161558B (no) 1989-05-22
EP0072352A1 (de) 1983-02-16
IL66501A (en) 1987-10-20
ES530658A0 (es) 1985-12-01
NL930112I1 (nl) 1993-10-18
DK157881C (da) 1990-07-23
NO161558C (no) 1989-08-30
ES526886A0 (es) 1985-11-01
ES526887A0 (es) 1986-04-16
HK93387A (en) 1987-12-18
ES8504728A1 (es) 1985-04-16
FI76074B (fi) 1988-05-31
ES8502974A1 (es) 1985-02-01
DK358682A (da) 1983-02-12
CA1196636A (en) 1985-11-12
DK157881B (da) 1990-02-26

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FD1A Patent lapsed

Effective date: 20060116