AR240806A2 - Procedimiento para la elaboracion de acidos 3-amino-(1)benzazepin- 2-ona-1-alcanoicos y sus sales. - Google Patents
Procedimiento para la elaboracion de acidos 3-amino-(1)benzazepin- 2-ona-1-alcanoicos y sus sales.Info
- Publication number
- AR240806A2 AR240806A2 AR29029582A AR29029582A AR240806A2 AR 240806 A2 AR240806 A2 AR 240806A2 AR 29029582 A AR29029582 A AR 29029582A AR 29029582 A AR29029582 A AR 29029582A AR 240806 A2 AR240806 A2 AR 240806A2
- Authority
- AR
- Argentina
- Prior art keywords
- alcoxi
- cor7
- become
- alkyl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA ELABORAR NUEVOS ACIDOS 3-AMINO-(1)BENZAZEPIN-2-ONA-1-ALCANOICOS DE LA FORMULA GENERAL (I), DONDE RA ES UN RADICAL CHR1R0 Y RB ES UN RADICAL CHR2R0 EN QUE R0 EN RA ES COR7, Y DONDE UNO O AMBOS SIMBOLOS R6 Y R7 SON OH- ALCOXI O FENIL-ALCOXI; DONDE R1 ES H, ALQUILO O FENIL-ALQUILO; R2 ES H, O ALQUILO, R3 ES H, ALCOXI EN POSICION 8 O HALOGENO EN POSICION 7; Y X SIGNIFICA ATOMOS DE H O, SIMULTANEAMENTE H Y OH; SUS ESTEREOISOMEROS, RACEMATOS Y SALES. SE HACE REACCIONAR UN COMPUESTO DE LA FORMULA (II) EN QUE X, RB Y R3 SON LOS VALORES YA DADOS CON UN COMPUESTO DE LA FORMULA RA-Z, EN QUE Z SIGNIFICA UN RADICAL DE ACIDO SULFONICO O HALOGENO Y RA TIENE LOS VALORES YA DADOS, O CON UN COMPUESTO DE LA FORMULA R1-CO-R0, EN QUE R1 Y R0 TIENEN LOS VALORES YA INDICADOS, CON EL AGREGADO DE UN BORHIDRURO COMO AGENTE DE REDUCCION Y, SI ES NECESARIO, A) LOS GRUPOS COR6 Y/O COR7, EN LOS CUALES R6 Y/O R7 SIGNIFICAN FENIL-ALCOXI SE CONVIERTEN EN LOS GRUPOS COOH CON H, B) LOS GRUPOS COR6 Y/O COR7, EN LOS CUALES R6 Y/O R7 SIGNIFICAN ALCOXI, MEDIANTE HIDROLISIS, SE CONVIERTEN EN EL GRUPO COOH, C) LOS GRUPOS COOH, POR ESTERIFICACION CON UN ALQUILHALOGENURO SE CONVIERTEN EN UN GRUPO COR6 Y/O COR7, EN QUE R6 O R7 REPRESENTAN ALCOXI, D)LOS COMPUESTOS OBTENIDOS EN LOS CUALES EL CICLO AROMATICO SE HALLA INSUBSTITUIDO, SE HALOGENAN, OBTENIENDO HALOGENADOS EN POSICION 7, E) AQUELLOS COMPUESTOS QUE EXHIBEN PROPIEDADES SALIFICANTES, SE CONVIERTEN EN SU SAL, F) SE ENRIQUECEN MEZCLAS DE ESTEREOISOMEROS OPTICOS, EN UNO EN PARTICULAR.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29190781A | 1981-08-11 | 1981-08-11 | |
| US31986381A | 1981-11-09 | 1981-11-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AR240806A1 AR240806A1 (es) | 1991-02-28 |
| AR240806A2 true AR240806A2 (es) | 1991-02-28 |
Family
ID=26967047
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR290295A AR240806A1 (es) | 1981-08-11 | 1982-08-11 | Procedimiento para la elaboracion de acidos 3-amino-(1)benzazepin- 2-ona-1-alcanoicos y sus sales. |
| AR295866A AR240807A1 (es) | 1981-08-11 | 1984-02-28 | Procedimiento para obtener derivados de benzazepin-2-ona y sus sales |
| AR84295865A AR241222A1 (es) | 1981-08-11 | 1984-02-28 | Procedimiento para elaborar nuevos acidos 3-amino- (1) benzazepin-2-alcanoicos y sus sales. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR295866A AR240807A1 (es) | 1981-08-11 | 1984-02-28 | Procedimiento para obtener derivados de benzazepin-2-ona y sus sales |
| AR84295865A AR241222A1 (es) | 1981-08-11 | 1984-02-28 | Procedimiento para elaborar nuevos acidos 3-amino- (1) benzazepin-2-alcanoicos y sus sales. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0072352B1 (es) |
| KR (3) | KR890003425B1 (es) |
| AR (3) | AR240806A1 (es) |
| AT (1) | ATE18397T1 (es) |
| AU (1) | AU561395B2 (es) |
| CA (1) | CA1196636A (es) |
| CY (1) | CY1403A (es) |
| DD (1) | DD202546A5 (es) |
| DE (1) | DE3269625D1 (es) |
| DK (1) | DK157881C (es) |
| ES (6) | ES8502974A1 (es) |
| FI (1) | FI76074C (es) |
| GB (1) | GB2103614B (es) |
| GR (1) | GR77256B (es) |
| HK (1) | HK93387A (es) |
| HU (1) | HU189628B (es) |
| IE (1) | IE53668B1 (es) |
| IL (1) | IL66501A (es) |
| NL (1) | NL930112I2 (es) |
| NO (1) | NO161558C (es) |
| NZ (1) | NZ201555A (es) |
| PT (1) | PT75395B (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3242599A1 (de) * | 1982-11-18 | 1984-05-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel |
| US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
| DE3373469D1 (en) * | 1982-09-30 | 1987-10-15 | Merck & Co Inc | 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents |
| US4575503A (en) * | 1983-02-10 | 1986-03-11 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4564612A (en) * | 1983-04-22 | 1986-01-14 | Takeda Chemical Industries, Ltd. | Condensed, seven-membered ring compounds and their use |
| JPS608284A (ja) * | 1983-06-29 | 1985-01-17 | Mitsui Toatsu Chem Inc | ベンゾチアゼピン誘導体およびその製造法 |
| US4539150A (en) * | 1983-06-29 | 1985-09-03 | Mitsui Toatsu Chemicals, Inc. | Benzothiazepine derivatives and their methods of preparation |
| IL72523A (en) * | 1983-08-12 | 1988-06-30 | Takeda Chemical Industries Ltd | 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them |
| AU570710B2 (en) * | 1983-08-12 | 1988-03-24 | Takeda Chemical Industries Ltd. | 4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives |
| US4638000A (en) * | 1983-08-12 | 1987-01-20 | Takeda Chemical Industries, Ltd. | Condensed seven-membered ring compounds, their production and use |
| CA1266647A (en) * | 1984-06-26 | 1990-03-13 | William H. Parsons | Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists |
| EP0166354B1 (en) * | 1984-06-26 | 1992-08-05 | Merck & Co. Inc. | Benzofused lactam compounds and pharmaceutical compositions containing them |
| EP0166357A3 (en) * | 1984-06-26 | 1988-10-26 | Merck & Co. Inc. | Benzofused lactams and pharmaceutical compositions containing them |
| US4785089A (en) * | 1985-06-13 | 1988-11-15 | Ciba-Geigy Corporation | Novel sulfonic acid esters and their preparation |
| DE3704661A1 (de) * | 1987-02-14 | 1988-08-25 | Hoechst Ag | Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung |
| EP0322779A3 (en) * | 1987-12-29 | 1991-05-08 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzolactam compounds and pharmaceutical uses thereof |
| TW197945B (es) * | 1990-11-27 | 1993-01-11 | Hoechst Ag | |
| GB9100028D0 (en) * | 1991-01-02 | 1991-02-20 | Ici Plc | Compounds |
| GB9212308D0 (en) * | 1992-06-10 | 1992-07-22 | Ici Plc | Therapeutic compositions |
| US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
| US5610153A (en) * | 1992-12-11 | 1997-03-11 | Ciba-Geigy Corporation | Benzazepinone derivatives |
| GB9310075D0 (en) * | 1993-05-17 | 1993-06-30 | Fujisawa Pharmaceutical Co | New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
| US5801168A (en) * | 1994-06-09 | 1998-09-01 | Zeneca Limited | Substituted nitrogen heterocycles |
| US5597922A (en) * | 1994-07-29 | 1997-01-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Glycine receptor antagonist pharmacophore |
| EP1229913A4 (en) * | 1999-11-18 | 2005-01-19 | Antexpharma Inc | SUBSTITUTED 1-BENZAZEPINE AND THEIR DERIVATIVES |
| JP4508528B2 (ja) | 2000-12-27 | 2010-07-21 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | α−アミノ置換カルボン酸アミドの製造方法 |
| RU2003131337A (ru) | 2001-03-27 | 2005-05-10 | Рэнбакси Лабораториз Лимитед (IN) Рэнбакси Лабораториз Лимитед (IN) | Способ получения беназеприла |
| AU2002348276A1 (en) | 2001-11-16 | 2003-06-10 | Bristol-Myers Squibb Company | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein |
| US20050107359A1 (en) * | 2002-07-26 | 2005-05-19 | Van Der Schaaf Paul A. | Crystalline polymorphic and amorphous forms of benazepril hydrochloride |
| KR100710548B1 (ko) * | 2002-12-26 | 2007-04-24 | 에스케이 주식회사 | (ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법 |
| US7459474B2 (en) | 2003-06-11 | 2008-12-02 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| US8080579B2 (en) | 2005-10-03 | 2011-12-20 | The Regents Of The University Of Michigan | Compositions and methods for treatment of inflammatory bowel disease |
| US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| WO2008057862A2 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF |
| EP2099767A1 (en) | 2006-11-01 | 2009-09-16 | Brystol-Myers Squibb Company | Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US7828840B2 (en) | 2007-11-15 | 2010-11-09 | Med Institute, Inc. | Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| CN102149710A (zh) | 2008-06-24 | 2011-08-10 | 百时美施贵宝公司 | 糖皮质激素受体、AP-1和/或NF-κB 活性的环戊噻吩调节剂及其用途 |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法 |
| WO2015027021A1 (en) | 2013-08-22 | 2015-02-26 | Bristol-Myers Squibb Company | Imide and acylurea derivatives as modulators of the glucocorticoid receptor |
| CN113292495B (zh) * | 2021-06-18 | 2022-09-13 | 迪嘉药业集团有限公司 | 一种 (s)-氨基化合物的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3395150A (en) * | 1965-02-26 | 1968-07-30 | Squibb & Sons Inc | Benzothiazepine carboxamides and derivatives thereof |
| GB1305278A (es) * | 1970-03-12 | 1973-01-31 |
-
1982
- 1982-08-05 DE DE8282810329T patent/DE3269625D1/de not_active Expired
- 1982-08-05 EP EP82810329A patent/EP0072352B1/de not_active Expired
- 1982-08-05 AT AT82810329T patent/ATE18397T1/de active
- 1982-08-05 GB GB08222564A patent/GB2103614B/en not_active Expired
- 1982-08-05 CY CY140382A patent/CY1403A/xx unknown
- 1982-08-09 PT PT75395A patent/PT75395B/pt unknown
- 1982-08-09 IL IL66501A patent/IL66501A/xx not_active IP Right Cessation
- 1982-08-09 FI FI822770A patent/FI76074C/fi not_active IP Right Cessation
- 1982-08-09 CA CA000409019A patent/CA1196636A/en not_active Expired
- 1982-08-09 ES ES514856A patent/ES8502974A1/es not_active Expired
- 1982-08-09 GR GR68996A patent/GR77256B/el unknown
- 1982-08-10 KR KR8203588A patent/KR890003425B1/ko not_active IP Right Cessation
- 1982-08-10 DK DK358682A patent/DK157881C/da active
- 1982-08-10 HU HU822585A patent/HU189628B/hu unknown
- 1982-08-10 NO NO822722A patent/NO161558C/no not_active IP Right Cessation
- 1982-08-10 DD DD82242400A patent/DD202546A5/de not_active IP Right Cessation
- 1982-08-10 IE IE1929/82A patent/IE53668B1/en not_active IP Right Cessation
- 1982-08-10 NZ NZ201555A patent/NZ201555A/en unknown
- 1982-08-10 AU AU87014/82A patent/AU561395B2/en not_active Expired
- 1982-08-11 AR AR290295A patent/AR240806A1/es active
-
1983
- 1983-10-28 ES ES526889A patent/ES8604523A1/es not_active Expired
- 1983-10-28 ES ES526887A patent/ES8606285A1/es not_active Expired
- 1983-10-28 ES ES526888A patent/ES8504728A1/es not_active Expired
- 1983-10-28 ES ES526886A patent/ES526886A0/es active Granted
-
1984
- 1984-02-28 AR AR295866A patent/AR240807A1/es active
- 1984-02-28 AR AR84295865A patent/AR241222A1/es active
- 1984-03-15 ES ES530658A patent/ES530658A0/es active Granted
-
1987
- 1987-12-10 HK HK933/87A patent/HK93387A/xx not_active IP Right Cessation
-
1989
- 1989-05-13 KR KR8906486A patent/KR900001190B1/ko not_active IP Right Cessation
- 1989-05-13 KR KR1019890006487A patent/KR900001191B1/ko not_active IP Right Cessation
-
1993
- 1993-06-29 NL NL930112C patent/NL930112I2/nl unknown
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