DK157008C - Analogifremgangsmaade til fremstilling af n-pyrrolidinyl- eller n-pyrrolidinylmethylsubstituerede benzamider samt mellemprodukter til brug ved fremstillingen - Google Patents

Analogifremgangsmaade til fremstilling af n-pyrrolidinyl- eller n-pyrrolidinylmethylsubstituerede benzamider samt mellemprodukter til brug ved fremstillingen

Info

Publication number
DK157008C
DK157008C DK021079A DK21079A DK157008C DK 157008 C DK157008 C DK 157008C DK 021079 A DK021079 A DK 021079A DK 21079 A DK21079 A DK 21079A DK 157008 C DK157008 C DK 157008C
Authority
DK
Denmark
Prior art keywords
preparation
pyrrolidinylmethyl
pyrrolidinyl
intermediates
substituted benzamides
Prior art date
Application number
DK021079A
Other languages
Danish (da)
English (en)
Other versions
DK157008B (da
DK21079A (da
Inventor
Michel Thominet
Jacques Acher
Jean-Claude Monier
Original Assignee
Ile De France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7801633A external-priority patent/FR2424909A1/fr
Application filed by Ile De France filed Critical Ile De France
Publication of DK21079A publication Critical patent/DK21079A/da
Publication of DK157008B publication Critical patent/DK157008B/da
Application granted granted Critical
Publication of DK157008C publication Critical patent/DK157008C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK021079A 1978-01-20 1979-01-18 Analogifremgangsmaade til fremstilling af n-pyrrolidinyl- eller n-pyrrolidinylmethylsubstituerede benzamider samt mellemprodukter til brug ved fremstillingen DK157008C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR7801633 1978-01-20
FR7801633A FR2424909A1 (fr) 1978-01-20 1978-01-20 Nouveaux derives d'ortho-anisamides utiles comme medicaments modificateurs du comportement, et leurs procedes de preparation
FR7831458A FR2440946A2 (fr) 1978-01-20 1978-11-07 Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement
FR7831458 1978-11-07

Publications (3)

Publication Number Publication Date
DK21079A DK21079A (da) 1979-07-21
DK157008B DK157008B (da) 1989-10-30
DK157008C true DK157008C (da) 1990-03-26

Family

ID=26220412

Family Applications (1)

Application Number Title Priority Date Filing Date
DK021079A DK157008C (da) 1978-01-20 1979-01-18 Analogifremgangsmaade til fremstilling af n-pyrrolidinyl- eller n-pyrrolidinylmethylsubstituerede benzamider samt mellemprodukter til brug ved fremstillingen

Country Status (39)

Country Link
US (2) US4673686A (hu)
JP (1) JPS54138553A (hu)
AR (2) AR221355A1 (hu)
AT (2) AT377254B (hu)
AU (1) AU520746B2 (hu)
BE (1) BE873522A (hu)
BG (2) BG48335A3 (hu)
CA (1) CA1133477A (hu)
CH (2) CH639369A5 (hu)
CS (2) CS241016B2 (hu)
CY (1) CY1202A (hu)
DD (1) DD141521A5 (hu)
DE (1) DE2901170A1 (hu)
DK (1) DK157008C (hu)
EG (1) EG13764A (hu)
ES (2) ES476757A1 (hu)
FI (1) FI69833C (hu)
FR (1) FR2440946A2 (hu)
GB (2) GB2013662B (hu)
GR (1) GR64398B (hu)
HK (1) HK12284A (hu)
HU (1) HU177902B (hu)
IE (2) IE48209B1 (hu)
IL (2) IL56413A (hu)
IN (1) IN150618B (hu)
IT (1) IT1164821B (hu)
LU (1) LU80793A1 (hu)
MC (1) MC1231A1 (hu)
MX (2) MX6192E (hu)
NL (1) NL7900455A (hu)
NO (1) NO153530C (hu)
NZ (2) NZ189381A (hu)
OA (1) OA06153A (hu)
PL (1) PL117195B1 (hu)
PT (1) PT69069A (hu)
RO (2) RO76554A (hu)
SE (2) SE449862B (hu)
SU (1) SU1158040A3 (hu)
YU (2) YU41608B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8101536L (sv) * 1981-03-11 1982-09-12 Astra Laekemedel Ab Bensamid-derivat
SE8205135D0 (sv) * 1982-09-09 1982-09-09 Astra Laekemedel Ab Benzamido-derivatives
CH656126A5 (de) * 1983-08-18 1986-06-13 Ciba Geigy Ag Durch 2-propynyloxygruppen substituierte phthalsaeureanhydride.
SE8400478D0 (sv) * 1984-01-31 1984-01-31 Astra Laekemedel Ab Oxysalicylamido derivatives
US5240957A (en) * 1984-01-31 1993-08-31 Astra Lakemedel Akteibolag Oxysalicylamido derivatives
FR2574795B1 (fr) * 1984-12-18 1987-11-20 Ile De France Nouveau procede industriel de synthese du n-((1'-allyl 2'-pyrrolidinyl) methyl) 2-methoxy 4,5-azimido benzamide
FR2586018B1 (fr) * 1985-08-12 1988-03-25 Ile De France Nouveau benzodioxepanne, son procede de synthese et ses applications en therapeutique
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US5154913A (en) * 1987-11-19 1992-10-13 Vanderbilt University Radioiodinated benzamines method of their use as radioimaging agents
EP0320630A1 (en) * 1987-11-19 1989-06-21 The Vanderbilt University Enantiometric iodobenzamides
CA2036516A1 (en) * 1990-02-19 1991-08-20 Yoshikazu Asahina Optically active 8-methoxyouinolonecarboxylic acid derivatives, their preparative processes and their intermediates
FR2678266A1 (fr) * 1991-06-28 1992-12-31 Delagrange Laboratoires Nouveaux derives de 2-hydroxy 4-amino 5-ethylsulfonyl benzamide utiles comme anxiolytiques.
US5993777A (en) * 1993-05-06 1999-11-30 Research Corporation Technologies, Inc. Benzamide compounds for cancer imaging and therapy
US5911970A (en) * 1993-05-06 1999-06-15 Research Corporation Technologies, Inc. Methods for cancer imaging and therapy using benzamine compounds
US6517811B2 (en) 1993-05-06 2003-02-11 Research Corporation Technologies, Inc. Compounds for cancer imaging and therapy
WO1994026314A1 (en) * 1993-05-06 1994-11-24 John Christy S Compounds for cancer imaging and therapy
CN103450058B (zh) * 2013-09-18 2015-10-14 广安凯特医药化工有限公司 一种氨磺必利酸的制备方法
CN105503666A (zh) * 2015-12-30 2016-04-20 苏州诚和医药化学有限公司 一种便捷合成2-甲氧基-5-氨磺酰基苯甲酸甲酯的方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
FR6787M (hu) * 1967-08-17 1969-03-17
US3891671A (en) * 1968-08-01 1975-06-24 Ile De France N-(2-pyrrolidyl or piperidyl alkyl)-4-hydroxy benzamides
US3959477A (en) * 1968-08-01 1976-05-25 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Methods of protection against emesis in mammals by administration of a heterocyclic benzamide
GB1364231A (en) * 1968-12-23 1974-08-21 Robins Co Inc A H N-/1-substituted-3-pyrrolidinyl/benzamides and thiobenzamides
US3577440A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-amido-pyrrolidines
FR2097031A1 (en) * 1970-07-29 1972-03-03 Berri Balzac 2-aminoethoxyethyl-6,6-dimethyl nor pinane derivs - local anaesthetics spasmolytics and anticholinergics
GB1392194A (en) * 1971-09-23 1975-04-30 Wyeth John & Brother Ltd Pyrrolidine derivatives
US4279822A (en) * 1972-04-03 1981-07-21 A. H. Robins Company, Inc. N-(1-Substituted-3-pyrrolidinyl)benzamides
US3966957A (en) * 1972-04-03 1976-06-29 A. H. Robins Company, Incorporated Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
US3862139A (en) * 1972-06-23 1975-01-21 Delmar Chem Heterocyclic benzamide compounds
US4048321A (en) * 1973-12-14 1977-09-13 Science Union Et Cie Disubstituted azabicycloalkanes
CH605793A5 (hu) * 1974-03-05 1978-10-13 Ile De France
CA1039731A (en) * 1974-12-18 1978-10-03 Synthelabo Process for preparing new 2-methoxy-benzamide derivatives
US4158060A (en) * 1974-12-18 1979-06-12 Synthelabo 2-Methoxy-benzamide derivatives
US4172143A (en) * 1974-12-18 1979-10-23 Synthelabo 2-Methoxy-benzamide derivatives
US4039672A (en) * 1975-01-11 1977-08-02 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France N-(1'-allypyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimido benzamide and its pharmaceutically acceptable salts
GB1520584A (en) * 1975-04-02 1978-08-09 Yamanouchi Pharma Co Ltd 2 - alkoxy - 5 substituted benzamide derivatives and their use in pharmaceutical compositions
US4197243A (en) * 1975-04-02 1980-04-08 Yamanouchi Pharmaceutical Co., Ltd. N-1-Benzyl-3-pyrrolidinyl-4-dimethylamino benzamide derivatives
CH614709A5 (hu) * 1975-09-25 1979-12-14 Ciba Geigy Ag
JPS5248661A (en) * 1975-10-14 1977-04-18 Synthelabo 22methoxyybenzamide derivatives
NZ186175A (en) * 1977-01-27 1980-03-05 Shionogi & Co Meta-sulphonamidobenzamide derivatives
FR2415099A1 (fr) * 1978-01-20 1979-08-17 Ile De France Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes
IL61642A0 (en) * 1979-12-20 1981-01-30 Beecham Group Ltd Aniline derivatives,their preparation and pharmalceutical compositions containing them
IL61972A0 (en) * 1980-01-30 1981-02-27 Beecham Group Ltd Azabicyclic compounds,their preparation and pharmaceutical compositions containing them
US4352802A (en) * 1980-06-10 1982-10-05 Beecham Group Limited Bicyclo[3.3.1]nonyl-benzamide
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
IE790091L (en) 1979-07-20
AR221428A1 (es) 1981-01-30
CS241016B2 (en) 1986-03-13
GB2083459A (en) 1982-03-24
US4816471A (en) 1989-03-28
PT69069A (fr) 1979-02-01
BG48335A3 (en) 1991-01-15
IL56413A (en) 1982-11-30
JPS54138553A (en) 1979-10-27
ATA301483A (de) 1984-10-15
AU4337479A (en) 1979-07-26
EG13764A (en) 1982-06-30
IT1164821B (it) 1987-04-15
PL117195B1 (en) 1981-07-31
SU1158040A3 (ru) 1985-05-23
AT377979B (de) 1985-05-28
CY1202A (en) 1983-12-31
ES477783A1 (es) 1979-10-16
FI69833C (fi) 1986-05-26
GB2083459B (en) 1982-12-15
YU43809B (en) 1989-12-31
FI69833B (fi) 1985-12-31
IN150618B (hu) 1982-11-13
IT7947707A0 (it) 1979-01-18
DD141521A5 (de) 1980-05-07
NZ196409A (en) 1982-03-09
MX6192E (es) 1984-12-13
GB2013662A (en) 1979-08-15
RO80716A (ro) 1982-12-06
NL7900455A (nl) 1979-07-24
AT377254B (de) 1985-02-25
ATA39779A (de) 1983-10-15
AR221355A1 (es) 1981-01-30
US4673686A (en) 1987-06-16
DE2901170C2 (hu) 1992-09-17
FI790181A (fi) 1979-07-21
OA06153A (fr) 1981-06-30
YU41608B (en) 1987-12-31
FR2440946A2 (fr) 1980-06-06
CH639369A5 (fr) 1983-11-15
DE2901170A1 (de) 1979-07-26
NZ189381A (en) 1982-03-09
YU10579A (en) 1983-02-28
IL64928A0 (en) 1982-04-30
FR2440946B2 (hu) 1981-07-17
HU177902B (en) 1982-01-28
NO790179L (no) 1979-07-23
SE8604394D0 (sv) 1986-10-16
DK157008B (da) 1989-10-30
CS241039B2 (en) 1986-03-13
HK12284A (en) 1984-02-24
SE449862B (sv) 1987-05-25
PL212898A1 (hu) 1980-03-24
ES476757A1 (es) 1979-05-16
AU520746B2 (en) 1982-02-25
MX7622E (es) 1990-03-27
IE48208B1 (en) 1984-10-31
NO153530C (no) 1986-04-09
GB2013662B (en) 1982-10-06
BE873522A (fr) 1979-07-17
IE48209B1 (en) 1984-10-31
CS44479A2 (en) 1985-06-13
MC1231A1 (fr) 1979-10-26
RO76554A (ro) 1981-04-30
NO153530B (no) 1985-12-30
SE7900419L (sv) 1979-07-21
JPS6343386B2 (hu) 1988-08-30
DK21079A (da) 1979-07-21
GR64398B (en) 1980-03-21
LU80793A1 (fr) 1979-09-07
CA1133477A (en) 1982-10-12
YU268582A (en) 1987-10-31
CH641154A5 (fr) 1984-02-15
SE8604394L (sv) 1986-10-16
IL56413A0 (en) 1979-03-12
BG48336A3 (en) 1991-01-15
CS8083A2 (en) 1985-06-13
SE463972B (sv) 1991-02-18

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