DK1560812T3 - Aminocyclohexyletherforbindelser og anvendelser deraf - Google Patents
Aminocyclohexyletherforbindelser og anvendelser derafInfo
- Publication number
- DK1560812T3 DK1560812T3 DK03781611T DK03781611T DK1560812T3 DK 1560812 T3 DK1560812 T3 DK 1560812T3 DK 03781611 T DK03781611 T DK 03781611T DK 03781611 T DK03781611 T DK 03781611T DK 1560812 T3 DK1560812 T3 DK 1560812T3
- Authority
- DK
- Denmark
- Prior art keywords
- ether compounds
- aminocyclohexyl ether
- compounds
- compositions
- present
- Prior art date
Links
- MHWUUEBDNXLKJI-UHFFFAOYSA-N 1-(1-aminocyclohexyl)oxycyclohexan-1-amine Chemical class C1CCCCC1(N)OC1(N)CCCCC1 MHWUUEBDNXLKJI-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46715903P | 2003-05-02 | 2003-05-02 | |
US47608303P | 2003-06-04 | 2003-06-04 | |
US47644703P | 2003-06-05 | 2003-06-05 | |
US47588403P | 2003-06-05 | 2003-06-05 | |
US47591203P | 2003-06-05 | 2003-06-05 | |
US48965903P | 2003-07-23 | 2003-07-23 | |
US49339203P | 2003-08-07 | 2003-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1560812T3 true DK1560812T3 (da) | 2006-09-04 |
Family
ID=33437310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03781611T DK1560812T3 (da) | 2003-05-02 | 2003-10-31 | Aminocyclohexyletherforbindelser og anvendelser deraf |
Country Status (22)
Country | Link |
---|---|
US (3) | US20070099983A1 (pl) |
EP (3) | EP1560812B1 (pl) |
JP (2) | JP4919661B2 (pl) |
KR (1) | KR101059379B1 (pl) |
AT (2) | ATE325789T1 (pl) |
AU (2) | AU2003287378B2 (pl) |
BR (2) | BRPI0318278B8 (pl) |
CA (1) | CA2524323C (pl) |
CY (1) | CY1105137T1 (pl) |
DE (1) | DE60305200T2 (pl) |
DK (1) | DK1560812T3 (pl) |
ES (2) | ES2375820T3 (pl) |
HK (1) | HK1091814A1 (pl) |
IL (2) | IL171653A (pl) |
NO (1) | NO334094B1 (pl) |
NZ (1) | NZ543921A (pl) |
PL (1) | PL227937B1 (pl) |
PT (1) | PT1560812E (pl) |
RU (1) | RU2478617C2 (pl) |
SG (2) | SG2010079697A (pl) |
SI (1) | SI1560812T1 (pl) |
WO (1) | WO2004099137A1 (pl) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100631299B1 (ko) * | 1998-04-01 | 2006-10-09 | 카디오메 파마 코포레이션 | 아미노사이클로헥실 에테르 화합물 및 이를 포함하는 약제학적 조성물 |
US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
JP4919661B2 (ja) | 2003-05-02 | 2012-04-18 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物およびそれらの用途 |
US20080063707A1 (en) * | 2003-05-02 | 2008-03-13 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
US7345086B2 (en) | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
WO2005018635A2 (en) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
US7977373B2 (en) | 2004-04-01 | 2011-07-12 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
US7786119B2 (en) | 2004-04-01 | 2010-08-31 | Cardiome Pharma Corp. | Drug conjugates of ion channel modulating compounds |
WO2005097087A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
EP1868598B1 (en) | 2004-11-08 | 2014-04-23 | Cardiome Pharma Corp. | A new dosing regimen for ion channel modulating compounds for treating acute atrial fibrillation in a human |
JP5159314B2 (ja) * | 2004-11-18 | 2013-03-06 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物の合成方法 |
US20090005576A1 (en) * | 2005-01-12 | 2009-01-01 | Astellas Pharma Inc. | Production Method of Optically Active Cyclohexane Ether Compounds |
EP1915340B1 (en) | 2005-06-15 | 2013-08-07 | Cardiome Pharma Corp. | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
WO2007023824A1 (ja) | 2005-08-23 | 2007-03-01 | Kaneka Corporation | 3-アラルキルオキシピロリジン誘導体の製造法 |
JP5004073B2 (ja) * | 2006-06-13 | 2012-08-22 | 東レ・ファインケミカル株式会社 | 光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体及びその製造法 |
JP5004067B2 (ja) * | 2005-10-31 | 2012-08-22 | 東レ・ファインケミカル株式会社 | ベンジルオキシ含窒素環状化合物の製造法 |
CA2627502C (en) * | 2005-10-31 | 2014-04-01 | Toray Fine Chemicals Co., Ltd. | Process for production of benzyloxypyrrolidine derivative, and process for production of hydrochloride salt powder of optically active benzyloxypyrrolidine derivative |
JP2007131597A (ja) * | 2005-11-11 | 2007-05-31 | Toray Fine Chemicals Co Ltd | ベンジルオキシピロリジン誘導体の製造方法 |
WO2008137778A2 (en) * | 2007-05-04 | 2008-11-13 | Cardiome Pharma Corp. | Controlled release oral formulations of ion channel modulating compounds and related methods for preventing arrhythmia |
US9006460B2 (en) | 2010-08-16 | 2015-04-14 | Cardiome International Ag | Process for preparing aminocyclohexyl ether compounds |
EP2606139B1 (en) | 2010-08-16 | 2015-07-15 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
CN106536630B (zh) * | 2014-08-01 | 2019-07-19 | 科思创德国股份有限公司 | 具有环状和线性低聚物以及改进的光学性质的共聚碳酸酯组合物 |
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JP4919661B2 (ja) * | 2003-05-02 | 2012-04-18 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物およびそれらの用途 |
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US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
-
2003
- 2003-10-31 JP JP2005510835A patent/JP4919661B2/ja not_active Expired - Lifetime
- 2003-10-31 SI SI200330358T patent/SI1560812T1/sl unknown
- 2003-10-31 DE DE60305200T patent/DE60305200T2/de not_active Expired - Lifetime
- 2003-10-31 NZ NZ543921A patent/NZ543921A/en not_active IP Right Cessation
- 2003-10-31 EP EP03781611A patent/EP1560812B1/en not_active Expired - Lifetime
- 2003-10-31 WO PCT/US2003/034655 patent/WO2004099137A1/en active Application Filing
- 2003-10-31 BR BRPI0318278A patent/BRPI0318278B8/pt not_active IP Right Cessation
- 2003-10-31 PL PL378918A patent/PL227937B1/pl unknown
- 2003-10-31 ES ES06000750T patent/ES2375820T3/es not_active Expired - Lifetime
- 2003-10-31 SG SG2010079697A patent/SG2010079697A/en unknown
- 2003-10-31 EP EP10014986A patent/EP2298735A1/en not_active Withdrawn
- 2003-10-31 AT AT03781611T patent/ATE325789T1/de active
- 2003-10-31 BR BR122018009866A patent/BR122018009866B8/pt active IP Right Grant
- 2003-10-31 US US10/555,364 patent/US20070099983A1/en not_active Abandoned
- 2003-10-31 PT PT03781611T patent/PT1560812E/pt unknown
- 2003-10-31 SG SG200716599-6A patent/SG167670A1/en unknown
- 2003-10-31 AT AT06000750T patent/ATE529401T1/de not_active IP Right Cessation
- 2003-10-31 ES ES03781611T patent/ES2264776T3/es not_active Expired - Lifetime
- 2003-10-31 DK DK03781611T patent/DK1560812T3/da active
- 2003-10-31 KR KR1020057020862A patent/KR101059379B1/ko active IP Right Grant
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2005
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2006
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2007
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2008
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2010
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2011
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