DK1486511T3 - Genfoldning af polypeptider - Google Patents

Genfoldning af polypeptider

Info

Publication number
DK1486511T3
DK1486511T3 DK04006513T DK04006513T DK1486511T3 DK 1486511 T3 DK1486511 T3 DK 1486511T3 DK 04006513 T DK04006513 T DK 04006513T DK 04006513 T DK04006513 T DK 04006513T DK 1486511 T3 DK1486511 T3 DK 1486511T3
Authority
DK
Denmark
Prior art keywords
buffer
polypeptides
repfolding
refolding
alcoholic
Prior art date
Application number
DK04006513T
Other languages
English (en)
Inventor
Roger Hart
David Reifsnyder
Stuart Builder
Phillip Lester
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK1486511T3 publication Critical patent/DK1486511T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04006513T 1993-08-20 1994-08-15 Genfoldning af polypeptider DK1486511T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/110,664 US5663304A (en) 1993-08-20 1993-08-20 Refolding of misfolded insulin-like growth factor-I
PCT/US1994/009120 WO1995006064A1 (en) 1993-08-20 1994-08-15 Refolding of polypeptides like recombinant insulin-like growth factor igf-i

Publications (1)

Publication Number Publication Date
DK1486511T3 true DK1486511T3 (da) 2007-05-29

Family

ID=22334224

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04006513T DK1486511T3 (da) 1993-08-20 1994-08-15 Genfoldning af polypeptider
DK94927917T DK0714406T3 (da) 1993-08-20 1994-08-15 Genfoldning af polypeptider som rekombinant insulinlignende vækstfaktor IGF-I

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK94927917T DK0714406T3 (da) 1993-08-20 1994-08-15 Genfoldning af polypeptider som rekombinant insulinlignende vækstfaktor IGF-I

Country Status (10)

Country Link
US (3) US5663304A (da)
EP (2) EP1486511B1 (da)
JP (1) JP3648242B2 (da)
AT (2) ATE264872T1 (da)
CA (1) CA2168552C (da)
DE (2) DE69434919T2 (da)
DK (2) DK1486511T3 (da)
ES (2) ES2219649T3 (da)
PT (2) PT1486511E (da)
WO (1) WO1995006064A1 (da)

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MY143274A (en) 2005-12-22 2011-04-15 Genentech Inc Recombinant production of heparin binding proteins
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HUE037633T2 (hu) 2007-07-09 2018-09-28 Genentech Inc Diszulfidkötés redukciójának megelõzése polipeptidek rekombináns elõállítása során
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US9052323B2 (en) * 2009-08-27 2015-06-09 The University Of Kansas Osmolyte mixture for protein stabilization
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Also Published As

Publication number Publication date
ATE264872T1 (de) 2004-05-15
CA2168552C (en) 2000-02-15
US5663304A (en) 1997-09-02
US5756672A (en) 1998-05-26
EP0714406B1 (en) 2004-04-21
WO1995006064A1 (en) 1995-03-02
DE69433724D1 (de) 2004-05-27
ES2280857T3 (es) 2007-09-16
DE69434919D1 (de) 2007-03-15
DE69433724T2 (de) 2005-04-28
ES2219649T3 (es) 2004-12-01
PT714406E (pt) 2004-09-30
EP0714406A1 (en) 1996-06-05
EP1486511B1 (en) 2007-01-24
ATE352568T1 (de) 2007-02-15
EP1486511A1 (en) 2004-12-15
PT1486511E (pt) 2007-04-30
JP3648242B2 (ja) 2005-05-18
US5808006A (en) 1998-09-15
DE69434919T2 (de) 2007-11-29
JPH09501693A (ja) 1997-02-18
CA2168552A1 (en) 1995-03-02
DK0714406T3 (da) 2004-07-26

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