PT714406E - Re-enrolamento de polipeptidos tais como o factor de crescimento semelhante a insulina igf-i recombinante - Google Patents

Re-enrolamento de polipeptidos tais como o factor de crescimento semelhante a insulina igf-i recombinante

Info

Publication number
PT714406E
PT714406E PT94927917T PT94927917T PT714406E PT 714406 E PT714406 E PT 714406E PT 94927917 T PT94927917 T PT 94927917T PT 94927917 T PT94927917 T PT 94927917T PT 714406 E PT714406 E PT 714406E
Authority
PT
Portugal
Prior art keywords
polypeptides
insulin
development
growth factor
factor similar
Prior art date
Application number
PT94927917T
Other languages
English (en)
Inventor
Stuart Builder
Roger Hart
Philip Lester
David Reifsnyder
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT714406E publication Critical patent/PT714406E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/65Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT94927917T 1993-08-20 1994-08-15 Re-enrolamento de polipeptidos tais como o factor de crescimento semelhante a insulina igf-i recombinante PT714406E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/110,664 US5663304A (en) 1993-08-20 1993-08-20 Refolding of misfolded insulin-like growth factor-I

Publications (1)

Publication Number Publication Date
PT714406E true PT714406E (pt) 2004-09-30

Family

ID=22334224

Family Applications (2)

Application Number Title Priority Date Filing Date
PT04006513T PT1486511E (pt) 1993-08-20 1994-08-15 Re-enrolamento de polipéptidos
PT94927917T PT714406E (pt) 1993-08-20 1994-08-15 Re-enrolamento de polipeptidos tais como o factor de crescimento semelhante a insulina igf-i recombinante

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT04006513T PT1486511E (pt) 1993-08-20 1994-08-15 Re-enrolamento de polipéptidos

Country Status (10)

Country Link
US (3) US5663304A (pt)
EP (2) EP1486511B1 (pt)
JP (1) JP3648242B2 (pt)
AT (2) ATE264872T1 (pt)
CA (1) CA2168552C (pt)
DE (2) DE69434919T2 (pt)
DK (2) DK1486511T3 (pt)
ES (2) ES2219649T3 (pt)
PT (2) PT1486511E (pt)
WO (1) WO1995006064A1 (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996007744A1 (en) * 1994-09-08 1996-03-14 Chiron Corporation A method of improved production of insulin-like growth factor
US5650496A (en) 1995-04-14 1997-07-22 Cephalon, Inc. IGF-I purification process
US6756484B1 (en) 1995-04-14 2004-06-29 Cephalon, Inc. IGF-I purification process
US7071313B1 (en) * 1995-06-07 2006-07-04 Cephalon, Inc. Methods of purifying authentic IGF from yeast hosts
AU6167596A (en) * 1995-06-07 1996-12-30 Chiron Corporation Methods for purifying authentic igf from yeast hosts
US7193042B1 (en) 1995-06-07 2007-03-20 Chiron Corporation Methods for purifying authentic IGF from yeast hosts
SE9504019D0 (sv) * 1995-11-13 1995-11-13 Pharmacia Ab Method for production of proteins
US20020052026A1 (en) * 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6265542B1 (en) 1997-10-24 2001-07-24 Genentech, Inc. Purification of molecules
US6417330B1 (en) 1998-06-01 2002-07-09 Celtrix Pharmaceuticals, Inc. Insulin-like growth factor binding protein variants
SE9802454D0 (sv) * 1998-07-08 1998-07-08 Pharmacia & Upjohn Ab Production of peptides
PT1115863E (pt) 1998-09-22 2008-03-07 Genentech Inc Ucp4
US7399751B2 (en) 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
US7342102B2 (en) 1998-11-30 2008-03-11 Genentech, Inc. Uncoupling protein 5 (UCP5)
EP1135496B1 (en) * 1998-11-30 2010-12-22 Genentech, Inc. Ucp5
EP1142908A4 (en) * 1999-01-07 2002-05-22 Takeda Chemical Industries Ltd PROCESS FOR PRODUCING ACTIVATED PROTEINS
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
JP2003504638A (ja) * 1999-07-16 2003-02-04 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド 赤外分光法に応じたリアルタイムのインサイチュバイオマニュファクチャリングプロセスのモニタリングおよび制御
PL365671A1 (en) * 2000-09-08 2005-01-10 Gryphon Therapeutics, Inc. Synthetic erythropoiesis stimulating proteins
US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
NZ523679A (en) * 2000-11-27 2005-10-28 Rmf Dictagene S Process for folding chemically synthesized polypeptides containing derivatised cysteine
US20060252917A1 (en) * 2001-02-08 2006-11-09 University Of Utah Methods for refolding conformationally constrained peptides
US20030077682A1 (en) * 2001-09-07 2003-04-24 Hung Paul Porwen Human tissue urokinase type plasminogen activator formulation
EP1314739A1 (en) * 2001-11-22 2003-05-28 Bayer Ag Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines
DK1572127T4 (da) * 2002-02-14 2014-11-24 Univ Leland Stanford Junior Enzymbehandling af fødevarer til cøliaki
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
US20030224476A1 (en) * 2002-03-01 2003-12-04 Szu-Yi Chou Method of producing transglutaminase reactive compound
WO2004045392A2 (en) 2002-11-20 2004-06-03 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic method for celiac sprue
US7189811B2 (en) * 2002-09-06 2007-03-13 National Institute Of Immunology Process for solubilization of recombinant proteins expressed as inclusion body
US20050272117A1 (en) * 2003-06-23 2005-12-08 Astrazeneca Ab Method
CA2531022C (en) * 2003-07-03 2014-09-09 Jannette Dufour Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants
US7579313B2 (en) * 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
EP4155385A1 (en) 2005-12-08 2023-03-29 Amgen Inc. Improved production of glycoproteins using manganese
MY143274A (en) 2005-12-22 2011-04-15 Genentech Inc Recombinant production of heparin binding proteins
US20090081145A1 (en) * 2005-12-23 2009-03-26 Aplagen Gmbh Process for forming disulphide bridges
TWI476207B (zh) * 2006-07-14 2015-03-11 Genentech Inc 重組蛋白之再摺疊
NZ580425A (en) * 2007-03-16 2011-12-22 Univ Leland Stanford Junior Combination enzyme therapy for digestion of dietary gluten
US8148105B2 (en) * 2007-03-16 2012-04-03 The Board Of Trustees Of The Leland Stanford Junior University Scaleable manufacturing process for cysteine endoprotease B, isoform 2
HUE037633T2 (hu) 2007-07-09 2018-09-28 Genentech Inc Diszulfidkötés redukciójának megelõzése polipeptidek rekombináns elõállítása során
US20100203001A1 (en) * 2007-07-11 2010-08-12 Aplagen Gmbh Process for forming disulfide bridges
AU2010228926B2 (en) * 2009-03-26 2015-12-10 Warsaw Orthopedic, Inc. Methods of identifying potential components for targeted drug delivery compositions
EP3366692A1 (en) 2009-06-22 2018-08-29 Amgen, Inc Refolding proteins using a chemically controlled redox state
EP2445924B2 (en) 2009-06-25 2023-12-13 Amgen Inc. Capture purification processes for proteins expressed in a non-mammalian system
US9052323B2 (en) * 2009-08-27 2015-06-09 The University Of Kansas Osmolyte mixture for protein stabilization
US8758802B2 (en) 2009-12-14 2014-06-24 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
WO2012177847A2 (en) * 2011-06-21 2012-12-27 Synthetech Pharmaceuticals, Llc Methods of dissolving blood clots and the like
EP2968239B1 (en) 2013-03-14 2019-04-24 The University of Massachusetts Methods of inhibiting cataracts and presbyopia
CN108348494A (zh) 2015-11-13 2018-07-31 马萨诸塞大学 用于抑制白内障和老花眼的含peg的双官能分子
US20220396787A1 (en) * 2021-06-11 2022-12-15 Acutis Diagnostics, Inc. Method for enhanced direct detection of microbial antigens from biological fluids
CN117603332B (zh) * 2023-11-23 2024-09-10 基因科技(上海)股份有限公司 重组人ny-eso-1蛋白的制备方法及其应用

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518256A (en) * 1977-05-23 1985-05-21 Sanders Associates, Inc. Enhanced accuracy optical radar
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
US4673641A (en) * 1982-12-16 1987-06-16 Molecular Genetics Research And Development Limited Partnership Co-aggregate purification of proteins
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
SE8303626D0 (sv) * 1983-06-23 1983-06-23 Kabigen Ab A recombinant plasmid a transformant microorganism, a polydoxyrebonucleotide segment, a process for producing a biologically active protein, and the protein thus produced
US4710473A (en) * 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
WO1985000831A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of insulin-like growth factor
DK108685A (da) * 1984-03-19 1985-09-20 Fujisawa Pharmaceutical Co Vaekstfaktor i
US5028531A (en) * 1984-03-19 1991-07-02 Fujisawa Pharmaceutical Company, Ltd. IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof
US4738921A (en) * 1984-09-27 1988-04-19 Eli Lilly And Company Derivative of the tryptophan operon for expression of fused gene products
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US4795706A (en) * 1985-01-31 1989-01-03 Eli Lilly And Company Novel expression control sequences
US4652630A (en) * 1985-02-22 1987-03-24 Monsanto Company Method of somatotropin naturation
ATE63757T1 (de) * 1985-03-28 1991-06-15 Chiron Corp Expression durch verwendung von fusionsgenen fuer proteinproduktion.
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
EP0219814B1 (en) * 1985-10-21 1991-09-11 Fujisawa Pharmaceutical Co., Ltd. Process for production of isulin-like growth factor i and plasmid for production thereof
JPH0759598B2 (ja) * 1986-02-14 1995-06-28 藤沢薬品工業株式会社 ヒトインスリン様成長因子▲i▼の製造法
US4705848A (en) * 1986-06-02 1987-11-10 International Minerals & Chemical Corp. Isolation of bioactive, monomeric growth hormone
ES2044887T3 (es) * 1986-10-09 1994-01-16 Fujisawa Pharmaceutical Co Metodo para la preparacion de factor de crecimiento de tipo insulina i.
JP2502563B2 (ja) * 1987-02-20 1996-05-29 松下電器産業株式会社 フロントパネルの外観仕上げ方法
US5104796A (en) * 1987-04-06 1992-04-14 International Minerals & Chemical Corp. High titer production of human somatomedin c
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
AU607209B2 (en) * 1987-04-23 1991-02-28 Monsanto Technology Llc Secretion of insulin-like growth factor-i in e. coli
EP0368857B1 (en) * 1987-05-11 1997-08-06 Chiron Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
JPS63294796A (ja) * 1987-05-27 1988-12-01 Sagami Chem Res Center タンパク質の再賦活化方法
IL86455A0 (en) * 1987-06-01 1988-11-15 Takeda Chemical Industries Ltd Polypeptide and production thereof
US4985544A (en) * 1987-08-04 1991-01-15 Kyowa Hakko Kogyo Co., Ltd. Process for renaturing fish growth hormone
JPH01132598A (ja) * 1987-10-14 1989-05-25 Pitman Moore Inc 変性剤溶液中に含まれる組換え蛋白質における分子内ジスルフィド結合の生成を促進する方法
CA1340586C (en) * 1988-09-23 1999-06-08 Cetus Corporation Process for recovering microbially produced interferon-beta
US4923967A (en) * 1988-09-26 1990-05-08 Eli Lilly And Company Purification and refolding of recombinant proteins
US5191063A (en) * 1989-05-02 1993-03-02 University Of Medicine And Dentistry Of New Jersey Production of biologically active polypeptides by treatment with an exogenous peptide sequence
GB8915130D0 (en) * 1989-06-30 1989-08-23 Univ Dundee Enzyme production
EP0647713B1 (en) * 1989-07-19 1998-05-13 Tonen Corporation Peptidyl prolyl-cis.trans-isomerase
US5124444A (en) * 1989-07-24 1992-06-23 Microprobe Corporation Lactam-containing compositions and methods useful for the extraction of nucleic acids
US5158875A (en) * 1989-08-25 1992-10-27 Amgen Inc. Production of biologically active insulin-like growth factor i from high expression host cell systems
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
EP0545999B1 (en) * 1990-08-20 1997-06-04 Novo Nordisk A/S Process for the preparation of biologically active IGF-1 using IGF-1 having an amino-terminal extension
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
AU3812993A (en) * 1992-03-24 1993-10-21 Synergen, Inc. Refolding and purification of insulin-like growth factor I

Also Published As

Publication number Publication date
ATE264872T1 (de) 2004-05-15
CA2168552C (en) 2000-02-15
US5663304A (en) 1997-09-02
US5756672A (en) 1998-05-26
EP0714406B1 (en) 2004-04-21
WO1995006064A1 (en) 1995-03-02
DE69433724D1 (de) 2004-05-27
ES2280857T3 (es) 2007-09-16
DE69434919D1 (de) 2007-03-15
DE69433724T2 (de) 2005-04-28
ES2219649T3 (es) 2004-12-01
EP0714406A1 (en) 1996-06-05
EP1486511B1 (en) 2007-01-24
ATE352568T1 (de) 2007-02-15
DK1486511T3 (da) 2007-05-29
EP1486511A1 (en) 2004-12-15
PT1486511E (pt) 2007-04-30
JP3648242B2 (ja) 2005-05-18
US5808006A (en) 1998-09-15
DE69434919T2 (de) 2007-11-29
JPH09501693A (ja) 1997-02-18
CA2168552A1 (en) 1995-03-02
DK0714406T3 (da) 2004-07-26

Similar Documents

Publication Publication Date Title
PT714406E (pt) Re-enrolamento de polipeptidos tais como o factor de crescimento semelhante a insulina igf-i recombinante
PL323858A1 (en) Compounds and peptides capable to bond to a receptor of erythropoetin
EP1686172A3 (en) Myocardial grafts and cellular compositions useful for same
EE04223B1 (et) Interferooni stabiilne vedelkompositsioon, mis sisaldab aminohappeid
IL142350A0 (en) Interferon-beta fusion proteins and pharmaceutical compositions containing the same
AU2223401A (en) Branched polyalkylene glycols
DE69027666D1 (de) Herstellung von biologischaktivem insulinähnlichem wachstumsfaktor i aus hochexpressions-wirtszellsystemen
EP0722461A4 (en) EXPRESSION OF FUSION POLYPEPTIDES TRANSPORTED OUT OF CYTOPLASM WITHOUT HEAD SEQUENCE
EP0714665A3 (en) Osteogenic devices
IE842881L (en) Atrial peptides
FI844230L (fi) Enzyminhibition.
EP0293158A3 (en) Parathyroid hormone antagonists
ES8501364A1 (es) Un metodo para la preparacion de nuevos polipeptidos.
GB8727045D0 (en) Immunoglobulin e competitor
CA2236751A1 (en) Method for producing a correctly folded, biological active recombinant protein
EP0293130A3 (en) Dimers of parathyroid hormone antagonists
EP1739090A3 (en) Interferon-beta fusion proteins and uses
ATE202363T1 (de) Antibiotische peptide aus der kuhmilch