DE69433724D1 - Mit rekombinantem insulin-ähnlichen wachstumsfaktor igf-i vergleichbare rückfaltung von polypeptiden - Google Patents
Mit rekombinantem insulin-ähnlichen wachstumsfaktor igf-i vergleichbare rückfaltung von polypeptidenInfo
- Publication number
- DE69433724D1 DE69433724D1 DE69433724T DE69433724T DE69433724D1 DE 69433724 D1 DE69433724 D1 DE 69433724D1 DE 69433724 T DE69433724 T DE 69433724T DE 69433724 T DE69433724 T DE 69433724T DE 69433724 D1 DE69433724 D1 DE 69433724D1
- Authority
- DE
- Germany
- Prior art keywords
- refolding
- comparative
- growth factor
- recombinant insulin
- factor igf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 title 1
- 230000000052 comparative effect Effects 0.000 title 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 230000003196 chaotropic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 150000002696 manganese Chemical class 0.000 abstract 1
- 239000003880 polar aprotic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/110,664 US5663304A (en) | 1993-08-20 | 1993-08-20 | Refolding of misfolded insulin-like growth factor-I |
US110664 | 1993-08-20 | ||
PCT/US1994/009120 WO1995006064A1 (en) | 1993-08-20 | 1994-08-15 | Refolding of polypeptides like recombinant insulin-like growth factor igf-i |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433724D1 true DE69433724D1 (de) | 2004-05-27 |
DE69433724T2 DE69433724T2 (de) | 2005-04-28 |
Family
ID=22334224
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69434919T Expired - Lifetime DE69434919T2 (de) | 1993-08-20 | 1994-08-15 | Faltung von Polypeptiden |
DE69433724T Expired - Lifetime DE69433724T2 (de) | 1993-08-20 | 1994-08-15 | Mit rekombinantem Insulin-ahnlichen Wachstumsfaktor IGF-I vergleichbare Rückhaltung von Polypeptiden |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69434919T Expired - Lifetime DE69434919T2 (de) | 1993-08-20 | 1994-08-15 | Faltung von Polypeptiden |
Country Status (10)
Country | Link |
---|---|
US (3) | US5663304A (de) |
EP (2) | EP0714406B1 (de) |
JP (1) | JP3648242B2 (de) |
AT (2) | ATE352568T1 (de) |
CA (1) | CA2168552C (de) |
DE (2) | DE69434919T2 (de) |
DK (2) | DK1486511T3 (de) |
ES (2) | ES2280857T3 (de) |
PT (2) | PT1486511E (de) |
WO (1) | WO1995006064A1 (de) |
Families Citing this family (51)
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AU3545795A (en) * | 1994-09-08 | 1996-03-27 | Chiron Corporation | A method of improved production of insulin-like growth factor |
US6756484B1 (en) | 1995-04-14 | 2004-06-29 | Cephalon, Inc. | IGF-I purification process |
US5650496A (en) * | 1995-04-14 | 1997-07-22 | Cephalon, Inc. | IGF-I purification process |
US7193042B1 (en) | 1995-06-07 | 2007-03-20 | Chiron Corporation | Methods for purifying authentic IGF from yeast hosts |
US7071313B1 (en) * | 1995-06-07 | 2006-07-04 | Cephalon, Inc. | Methods of purifying authentic IGF from yeast hosts |
ATE253079T1 (de) * | 1995-06-07 | 2003-11-15 | Chiron Corp | Methoden zur aufreinigung von authentischem igf aus hefewirtszellen |
SE9504019D0 (sv) * | 1995-11-13 | 1995-11-13 | Pharmacia Ab | Method for production of proteins |
US20020052026A1 (en) * | 1997-10-08 | 2002-05-02 | Steven M. Vicik | Methods of refolding proteins |
US6265542B1 (en) | 1997-10-24 | 2001-07-24 | Genentech, Inc. | Purification of molecules |
US6417330B1 (en) | 1998-06-01 | 2002-07-09 | Celtrix Pharmaceuticals, Inc. | Insulin-like growth factor binding protein variants |
SE9802454D0 (sv) * | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
DK1115863T3 (da) | 1998-09-22 | 2008-03-31 | Genentech Inc | Ucp4 |
US7399751B2 (en) * | 1999-11-04 | 2008-07-15 | Sertoli Technologies, Inc. | Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells |
US7342102B2 (en) | 1998-11-30 | 2008-03-11 | Genentech, Inc. | Uncoupling protein 5 (UCP5) |
EP1135496B1 (de) * | 1998-11-30 | 2010-12-22 | Genentech, Inc. | Loslösendes protein 5 - ucp5 |
EP1142908A4 (de) * | 1999-01-07 | 2002-05-22 | Takeda Chemical Industries Ltd | Methode zum herstellen von aktivierten proteinen |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
DE19930676B4 (de) * | 1999-07-02 | 2006-01-19 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln |
CA2379823A1 (en) * | 1999-07-16 | 2001-01-25 | Human Genome Sciences, Inc. | Real-time, in situ biomanufacturing process monitoring and control in response to ir spectroscopy |
CN1454097A (zh) * | 2000-09-08 | 2003-11-05 | 格莱风治疗公司 | 聚合物修饰的合成的蛋白质类 |
US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
EP1337549B1 (de) * | 2000-11-27 | 2006-04-05 | Rmf Dictagene S.A. | Verfahren zur rückfaltung von chemisch hergestellten polypeptiden |
US20060252917A1 (en) * | 2001-02-08 | 2006-11-09 | University Of Utah | Methods for refolding conformationally constrained peptides |
KR20040062535A (ko) * | 2001-09-07 | 2004-07-07 | 글로벌 바이오텍 인코포레이티드 | 인간 조직 유로키나아제형 플라스미노겐 활성화제 배합물 |
EP1314739A1 (de) * | 2001-11-22 | 2003-05-28 | Bayer Ag | Verfahren zur Renaturierung rekombinanter, Disulfid-enthaltender Proteine bei hohen Proteinkonzentrationen in Gegenwart von Aminen |
US7303871B2 (en) | 2002-02-14 | 2007-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
US20030224476A1 (en) * | 2002-03-01 | 2003-12-04 | Szu-Yi Chou | Method of producing transglutaminase reactive compound |
US7189811B2 (en) * | 2002-09-06 | 2007-03-13 | National Institute Of Immunology | Process for solubilization of recombinant proteins expressed as inclusion body |
ES2383595T3 (es) | 2002-11-20 | 2012-06-22 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimiento de diagnóstico de la celiaquía |
US20050272117A1 (en) * | 2003-06-23 | 2005-12-08 | Astrazeneca Ab | Method |
WO2005018540A2 (en) * | 2003-07-03 | 2005-03-03 | Jannette Dufour | Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants |
US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
AU2006324163B2 (en) * | 2005-12-08 | 2013-05-02 | Amgen Inc. | Improved production of glycoproteins using manganese |
US20080032343A1 (en) | 2005-12-22 | 2008-02-07 | Genentech, Inc. | Recombinant Production of Heparin Binding Proteins |
US20090081145A1 (en) * | 2005-12-23 | 2009-03-26 | Aplagen Gmbh | Process for forming disulphide bridges |
RU2439076C2 (ru) * | 2006-07-14 | 2012-01-10 | Дженентек, Инк. | Способ выделения повторно свернутого рекомбинантного белка из культуры прокариотических клеток (варианты) |
EP2125863A1 (de) * | 2006-12-23 | 2009-12-02 | AplaGen GmbH | Verfahren zur ausbildung von disulfidbrücken |
US8148105B2 (en) * | 2007-03-16 | 2012-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Scaleable manufacturing process for cysteine endoprotease B, isoform 2 |
CA2680590C (en) * | 2007-03-16 | 2017-10-17 | Jonathan David Gass | Combination enzyme therapy for digestion of dietary gluten |
LT3597659T (lt) | 2007-07-09 | 2023-05-10 | Genentech, Inc. | Disulfidinės jungties redukcijos prevencijos būdas gaminant polipeptidą rekombinantiniu būdu |
WO2010111212A1 (en) * | 2009-03-26 | 2010-09-30 | Warsaw Orthopedic, Inc. | Methods of identifying potential components for targeted drug delivery compositions |
SG176963A1 (en) | 2009-06-22 | 2012-02-28 | Amgen Inc | Refolding proteins using a chemically controlled redox state |
MX2011013417A (es) | 2009-06-25 | 2012-03-29 | Amgen Inc | Procesos de purificacion por captura para proteinas expresadas en un sistema no mamifero. |
US9052323B2 (en) * | 2009-08-27 | 2015-06-09 | The University Of Kansas | Osmolyte mixture for protein stabilization |
EP2512492A1 (de) | 2009-12-14 | 2012-10-24 | University of Massachusetts | Verfahren zur hemmung von grauem star und altersweitsichtigkeit |
US8906421B2 (en) * | 2011-06-21 | 2014-12-09 | Med-Genesis, Llc | Methods of dissolving blood clots and the like |
EA029070B1 (ru) | 2013-03-14 | 2018-02-28 | Дзе Юниверсити Оф Массачусетс | Способ задержки развития катаракты и пресбиопии |
US10736863B2 (en) | 2015-11-13 | 2020-08-11 | University Of Massachusetts | Methods of inhibiting cataracts and presbyopia |
WO2022261443A1 (en) * | 2021-06-11 | 2022-12-15 | Acutis Diagnostics, Inc. | Method for enhanced direct detection of microbial antigens from biological fluids |
CN117603332A (zh) * | 2023-11-23 | 2024-02-27 | 基因科技(上海)股份有限公司 | 重组人ny-eso-1蛋白的制备方法及其应用 |
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US4518256A (en) * | 1977-05-23 | 1985-05-21 | Sanders Associates, Inc. | Enhanced accuracy optical radar |
US4565785A (en) * | 1978-06-08 | 1986-01-21 | The President And Fellows Of Harvard College | Recombinant DNA molecule |
US4673641A (en) * | 1982-12-16 | 1987-06-16 | Molecular Genetics Research And Development Limited Partnership | Co-aggregate purification of proteins |
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US5191063A (en) * | 1989-05-02 | 1993-03-02 | University Of Medicine And Dentistry Of New Jersey | Production of biologically active polypeptides by treatment with an exogenous peptide sequence |
GB8915130D0 (en) * | 1989-06-30 | 1989-08-23 | Univ Dundee | Enzyme production |
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ATE154073T1 (de) * | 1990-08-20 | 1997-06-15 | Novo Nordisk As | Prozess für die herstellung von biologisch aktivem igf-1 durch verwendung von amino-terminal verlängertem igf-1 |
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-
1993
- 1993-08-20 US US08/110,664 patent/US5663304A/en not_active Expired - Lifetime
-
1994
- 1994-08-15 JP JP50762695A patent/JP3648242B2/ja not_active Expired - Lifetime
- 1994-08-15 ES ES04006513T patent/ES2280857T3/es not_active Expired - Lifetime
- 1994-08-15 EP EP94927917A patent/EP0714406B1/de not_active Expired - Lifetime
- 1994-08-15 AT AT04006513T patent/ATE352568T1/de active
- 1994-08-15 DK DK04006513T patent/DK1486511T3/da active
- 1994-08-15 DK DK94927917T patent/DK0714406T3/da active
- 1994-08-15 PT PT04006513T patent/PT1486511E/pt unknown
- 1994-08-15 EP EP04006513A patent/EP1486511B1/de not_active Expired - Lifetime
- 1994-08-15 DE DE69434919T patent/DE69434919T2/de not_active Expired - Lifetime
- 1994-08-15 PT PT94927917T patent/PT714406E/pt unknown
- 1994-08-15 AT AT94927917T patent/ATE264872T1/de active
- 1994-08-15 ES ES94927917T patent/ES2219649T3/es not_active Expired - Lifetime
- 1994-08-15 CA CA002168552A patent/CA2168552C/en not_active Expired - Lifetime
- 1994-08-15 DE DE69433724T patent/DE69433724T2/de not_active Expired - Lifetime
- 1994-08-15 WO PCT/US1994/009120 patent/WO1995006064A1/en active IP Right Grant
- 1994-08-15 US US08/318,628 patent/US5808006A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/470,108 patent/US5756672A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH09501693A (ja) | 1997-02-18 |
ATE264872T1 (de) | 2004-05-15 |
ES2280857T3 (es) | 2007-09-16 |
ES2219649T3 (es) | 2004-12-01 |
DE69434919T2 (de) | 2007-11-29 |
CA2168552A1 (en) | 1995-03-02 |
US5756672A (en) | 1998-05-26 |
PT1486511E (pt) | 2007-04-30 |
DE69434919D1 (de) | 2007-03-15 |
CA2168552C (en) | 2000-02-15 |
US5808006A (en) | 1998-09-15 |
DE69433724T2 (de) | 2005-04-28 |
DK0714406T3 (da) | 2004-07-26 |
EP1486511A1 (de) | 2004-12-15 |
EP0714406A1 (de) | 1996-06-05 |
US5663304A (en) | 1997-09-02 |
PT714406E (pt) | 2004-09-30 |
ATE352568T1 (de) | 2007-02-15 |
EP1486511B1 (de) | 2007-01-24 |
JP3648242B2 (ja) | 2005-05-18 |
WO1995006064A1 (en) | 1995-03-02 |
EP0714406B1 (de) | 2004-04-21 |
DK1486511T3 (da) | 2007-05-29 |
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