ATE352568T1 - Faltung von polypeptiden - Google Patents
Faltung von polypeptidenInfo
- Publication number
- ATE352568T1 ATE352568T1 AT04006513T AT04006513T ATE352568T1 AT E352568 T1 ATE352568 T1 AT E352568T1 AT 04006513 T AT04006513 T AT 04006513T AT 04006513 T AT04006513 T AT 04006513T AT E352568 T1 ATE352568 T1 AT E352568T1
- Authority
- AT
- Austria
- Prior art keywords
- buffer
- polypeptides
- folding
- refolding
- alcoholic
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 230000003196 chaotropic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 150000002696 manganese Chemical class 0.000 abstract 1
- 239000003880 polar aprotic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/110,664 US5663304A (en) | 1993-08-20 | 1993-08-20 | Refolding of misfolded insulin-like growth factor-I |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE352568T1 true ATE352568T1 (de) | 2007-02-15 |
Family
ID=22334224
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04006513T ATE352568T1 (de) | 1993-08-20 | 1994-08-15 | Faltung von polypeptiden |
AT94927917T ATE264872T1 (de) | 1993-08-20 | 1994-08-15 | Mit rekombinantem insulin-ähnlichen wachstumsfaktor igf-i vergleichbare rückfaltung von polypeptiden |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94927917T ATE264872T1 (de) | 1993-08-20 | 1994-08-15 | Mit rekombinantem insulin-ähnlichen wachstumsfaktor igf-i vergleichbare rückfaltung von polypeptiden |
Country Status (10)
Country | Link |
---|---|
US (3) | US5663304A (de) |
EP (2) | EP0714406B1 (de) |
JP (1) | JP3648242B2 (de) |
AT (2) | ATE352568T1 (de) |
CA (1) | CA2168552C (de) |
DE (2) | DE69433724T2 (de) |
DK (2) | DK0714406T3 (de) |
ES (2) | ES2280857T3 (de) |
PT (2) | PT714406E (de) |
WO (1) | WO1995006064A1 (de) |
Families Citing this family (51)
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---|---|---|---|---|
EP0779927A1 (de) * | 1994-09-08 | 1997-06-25 | Chiron Corporation | Methode zur gesteigerten herstellung von insulin-ähnlichem wachstumsfaktor |
US5650496A (en) * | 1995-04-14 | 1997-07-22 | Cephalon, Inc. | IGF-I purification process |
US6756484B1 (en) | 1995-04-14 | 2004-06-29 | Cephalon, Inc. | IGF-I purification process |
US7193042B1 (en) | 1995-06-07 | 2007-03-20 | Chiron Corporation | Methods for purifying authentic IGF from yeast hosts |
US7071313B1 (en) * | 1995-06-07 | 2006-07-04 | Cephalon, Inc. | Methods of purifying authentic IGF from yeast hosts |
AU6167596A (en) * | 1995-06-07 | 1996-12-30 | Chiron Corporation | Methods for purifying authentic igf from yeast hosts |
SE9504019D0 (sv) * | 1995-11-13 | 1995-11-13 | Pharmacia Ab | Method for production of proteins |
US20020052026A1 (en) * | 1997-10-08 | 2002-05-02 | Steven M. Vicik | Methods of refolding proteins |
US6265542B1 (en) | 1997-10-24 | 2001-07-24 | Genentech, Inc. | Purification of molecules |
US6417330B1 (en) | 1998-06-01 | 2002-07-09 | Celtrix Pharmaceuticals, Inc. | Insulin-like growth factor binding protein variants |
SE9802454D0 (sv) * | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
CA2344467C (en) | 1998-09-22 | 2011-01-25 | Genentech, Inc. | Ucp4 |
US7399751B2 (en) * | 1999-11-04 | 2008-07-15 | Sertoli Technologies, Inc. | Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells |
US7342102B2 (en) | 1998-11-30 | 2008-03-11 | Genentech, Inc. | Uncoupling protein 5 (UCP5) |
WO2000032624A2 (en) * | 1998-11-30 | 2000-06-08 | Genentech, Inc. | Uncoupling protein 5 - ucp5 |
EP1142908A4 (de) * | 1999-01-07 | 2002-05-22 | Takeda Chemical Industries Ltd | Methode zum herstellen von aktivierten proteinen |
US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
DE19930676B4 (de) * | 1999-07-02 | 2006-01-19 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln |
US6395538B1 (en) | 1999-07-16 | 2002-05-28 | Human Genome Sciences, Inc. | Method and system for providing real-time, in situ biomanufacturing process monitoring and control in response to IR spectroscopy |
AU2001273388B2 (en) * | 2000-09-08 | 2005-01-13 | Gryphon Therapeutics, Inc. | "Pseudo"-native chemical ligation |
US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
AU2002229603B2 (en) * | 2000-11-27 | 2007-11-08 | Rmf Dictagene S.A. | Process for folding chemically synthesized polypeptides |
US20060252917A1 (en) * | 2001-02-08 | 2006-11-09 | University Of Utah | Methods for refolding conformationally constrained peptides |
WO2003022997A2 (en) * | 2001-09-07 | 2003-03-20 | Global Biotech Inc. | Human tissue urokinase type plasminogen activator formulation |
EP1314739A1 (de) * | 2001-11-22 | 2003-05-28 | Bayer Ag | Verfahren zur Renaturierung rekombinanter, Disulfid-enthaltender Proteine bei hohen Proteinkonzentrationen in Gegenwart von Aminen |
US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
ATE505201T1 (de) | 2002-02-14 | 2011-04-15 | Univ Leland Stanford Junior | Enzymbehandlung von nahrungsmitteln für zöliakie- sprue |
US20030224476A1 (en) * | 2002-03-01 | 2003-12-04 | Szu-Yi Chou | Method of producing transglutaminase reactive compound |
US7189811B2 (en) * | 2002-09-06 | 2007-03-13 | National Institute Of Immunology | Process for solubilization of recombinant proteins expressed as inclusion body |
EP1563300B1 (de) | 2002-11-20 | 2012-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnoseverfahren für sprue/zöliakie |
US20050272117A1 (en) * | 2003-06-23 | 2005-12-08 | Astrazeneca Ab | Method |
EP1648380B1 (de) * | 2003-07-03 | 2015-04-08 | Sertoli Technologies, LLC | Zusammensetzungen mit sertoli-zellen und myoid-zellen und ihre verwendung in zellulären transplanten |
US7579313B2 (en) * | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
EP3026109B1 (de) * | 2005-12-08 | 2022-03-09 | Amgen Inc. | Verbesserte herstellung von glykoproteinen unter verwendung von mangan |
BRPI0621124A2 (pt) | 2005-12-22 | 2011-11-29 | Genentech Inc | métodos para recuperação de uma proteìna de ligação à heparina |
US20090081145A1 (en) * | 2005-12-23 | 2009-03-26 | Aplagen Gmbh | Process for forming disulphide bridges |
WO2008008975A2 (en) * | 2006-07-14 | 2008-01-17 | Genentech, Inc. | Refolding of recombinant proteins |
EP2125863A1 (de) * | 2006-12-23 | 2009-12-02 | AplaGen GmbH | Verfahren zur ausbildung von disulfidbrücken |
WO2008115411A1 (en) * | 2007-03-16 | 2008-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Combination enzyme therapy for digestion of dietary gluten |
WO2008115428A2 (en) * | 2007-03-16 | 2008-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | A scaleable manufacturing process for cysteine endoprotease b, isoform 2 |
KR101643514B1 (ko) | 2007-07-09 | 2016-07-27 | 제넨테크, 인크. | 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지 |
JP5763617B2 (ja) * | 2009-03-26 | 2015-08-12 | ウォーソー・オーソペディック・インコーポレーテッド | 標的化薬物送達用組成物のための潜在的成分を特定する方法 |
JP5808323B2 (ja) | 2009-06-22 | 2015-11-10 | アムジエン・インコーポレーテツド | 化学的に制御されたレドックス状態を用いたタンパク質のリフォールディング |
EP2445924B2 (de) | 2009-06-25 | 2023-12-13 | Amgen Inc. | Vefahren zur aufreinigung von proteinen aus prokaryotischen zellen |
US9052323B2 (en) * | 2009-08-27 | 2015-06-09 | The University Of Kansas | Osmolyte mixture for protein stabilization |
EP2512492A1 (de) | 2009-12-14 | 2012-10-24 | University of Massachusetts | Verfahren zur hemmung von grauem star und altersweitsichtigkeit |
WO2012177847A2 (en) * | 2011-06-21 | 2012-12-27 | Synthetech Pharmaceuticals, Llc | Methods of dissolving blood clots and the like |
EP2968239B1 (de) | 2013-03-14 | 2019-04-24 | The University of Massachusetts | Verfahren zur hemmung von grauem star und altersweitsichtigkeit |
EA035402B1 (ru) | 2015-11-13 | 2020-06-08 | Зе Юниверсити Оф Массачусеттс | Бифункциональные молекулы, содержащие полиэтиленгликоль, для подавления катаракт и пресбиопии |
WO2022261443A1 (en) * | 2021-06-11 | 2022-12-15 | Acutis Diagnostics, Inc. | Method for enhanced direct detection of microbial antigens from biological fluids |
CN117603332A (zh) * | 2023-11-23 | 2024-02-27 | 基因科技(上海)股份有限公司 | 重组人ny-eso-1蛋白的制备方法及其应用 |
Family Cites Families (44)
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US4518256A (en) * | 1977-05-23 | 1985-05-21 | Sanders Associates, Inc. | Enhanced accuracy optical radar |
US4565785A (en) * | 1978-06-08 | 1986-01-21 | The President And Fellows Of Harvard College | Recombinant DNA molecule |
US4673641A (en) * | 1982-12-16 | 1987-06-16 | Molecular Genetics Research And Development Limited Partnership | Co-aggregate purification of proteins |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
SE8303626D0 (sv) * | 1983-06-23 | 1983-06-23 | Kabigen Ab | A recombinant plasmid a transformant microorganism, a polydoxyrebonucleotide segment, a process for producing a biologically active protein, and the protein thus produced |
WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
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US5028531A (en) * | 1984-03-19 | 1991-07-02 | Fujisawa Pharmaceutical Company, Ltd. | IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof |
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ATE63757T1 (de) * | 1985-03-28 | 1991-06-15 | Chiron Corp | Expression durch verwendung von fusionsgenen fuer proteinproduktion. |
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EP0219814B1 (de) * | 1985-10-21 | 1991-09-11 | Fujisawa Pharmaceutical Co., Ltd. | Verfahren zur Herstellung von insulinähnlichem Wachstumsfaktor I (IGF-I) und Plasmid zu dessen Herstellung |
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ES2044887T3 (es) * | 1986-10-09 | 1994-01-16 | Fujisawa Pharmaceutical Co | Metodo para la preparacion de factor de crecimiento de tipo insulina i. |
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US5104796A (en) * | 1987-04-06 | 1992-04-14 | International Minerals & Chemical Corp. | High titer production of human somatomedin c |
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DE3855986T2 (de) * | 1987-05-11 | 1998-02-05 | Chiron Corp | Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen |
JPS63294796A (ja) * | 1987-05-27 | 1988-12-01 | Sagami Chem Res Center | タンパク質の再賦活化方法 |
IL86455A0 (en) * | 1987-06-01 | 1988-11-15 | Takeda Chemical Industries Ltd | Polypeptide and production thereof |
US4985544A (en) * | 1987-08-04 | 1991-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for renaturing fish growth hormone |
JPH01132598A (ja) * | 1987-10-14 | 1989-05-25 | Pitman Moore Inc | 変性剤溶液中に含まれる組換え蛋白質における分子内ジスルフィド結合の生成を促進する方法 |
CA1340586C (en) * | 1988-09-23 | 1999-06-08 | Cetus Corporation | Process for recovering microbially produced interferon-beta |
US4923967A (en) * | 1988-09-26 | 1990-05-08 | Eli Lilly And Company | Purification and refolding of recombinant proteins |
US5191063A (en) * | 1989-05-02 | 1993-03-02 | University Of Medicine And Dentistry Of New Jersey | Production of biologically active polypeptides by treatment with an exogenous peptide sequence |
GB8915130D0 (en) * | 1989-06-30 | 1989-08-23 | Univ Dundee | Enzyme production |
EP0647713B1 (de) * | 1989-07-19 | 1998-05-13 | Tonen Corporation | Peptidyl prolyl-cis.trans-isomersae |
US5124444A (en) * | 1989-07-24 | 1992-06-23 | Microprobe Corporation | Lactam-containing compositions and methods useful for the extraction of nucleic acids |
US5158875A (en) * | 1989-08-25 | 1992-10-27 | Amgen Inc. | Production of biologically active insulin-like growth factor i from high expression host cell systems |
GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
DE69126434D1 (de) * | 1990-08-20 | 1997-07-10 | Novo Nordisk As | Prozess für die Herstellung von biologisch aktivem IGF-1 durch Verwendung von amino-terminal verlängertem IGF-1 |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
WO1993019084A1 (en) * | 1992-03-24 | 1993-09-30 | Synergen, Inc. | Refolding and purification of insulin-like growth factor i |
-
1993
- 1993-08-20 US US08/110,664 patent/US5663304A/en not_active Expired - Lifetime
-
1994
- 1994-08-15 WO PCT/US1994/009120 patent/WO1995006064A1/en active IP Right Grant
- 1994-08-15 DE DE69433724T patent/DE69433724T2/de not_active Expired - Lifetime
- 1994-08-15 JP JP50762695A patent/JP3648242B2/ja not_active Expired - Lifetime
- 1994-08-15 PT PT94927917T patent/PT714406E/pt unknown
- 1994-08-15 PT PT04006513T patent/PT1486511E/pt unknown
- 1994-08-15 ES ES04006513T patent/ES2280857T3/es not_active Expired - Lifetime
- 1994-08-15 DK DK94927917T patent/DK0714406T3/da active
- 1994-08-15 DK DK04006513T patent/DK1486511T3/da active
- 1994-08-15 US US08/318,628 patent/US5808006A/en not_active Expired - Lifetime
- 1994-08-15 CA CA002168552A patent/CA2168552C/en not_active Expired - Lifetime
- 1994-08-15 ES ES94927917T patent/ES2219649T3/es not_active Expired - Lifetime
- 1994-08-15 AT AT04006513T patent/ATE352568T1/de active
- 1994-08-15 AT AT94927917T patent/ATE264872T1/de active
- 1994-08-15 DE DE69434919T patent/DE69434919T2/de not_active Expired - Lifetime
- 1994-08-15 EP EP94927917A patent/EP0714406B1/de not_active Expired - Lifetime
- 1994-08-15 EP EP04006513A patent/EP1486511B1/de not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/470,108 patent/US5756672A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE264872T1 (de) | 2004-05-15 |
DE69434919T2 (de) | 2007-11-29 |
US5808006A (en) | 1998-09-15 |
CA2168552A1 (en) | 1995-03-02 |
DE69433724T2 (de) | 2005-04-28 |
JPH09501693A (ja) | 1997-02-18 |
ES2280857T3 (es) | 2007-09-16 |
EP0714406A1 (de) | 1996-06-05 |
DE69434919D1 (de) | 2007-03-15 |
EP1486511A1 (de) | 2004-12-15 |
EP0714406B1 (de) | 2004-04-21 |
US5756672A (en) | 1998-05-26 |
PT714406E (pt) | 2004-09-30 |
US5663304A (en) | 1997-09-02 |
DE69433724D1 (de) | 2004-05-27 |
JP3648242B2 (ja) | 2005-05-18 |
CA2168552C (en) | 2000-02-15 |
ES2219649T3 (es) | 2004-12-01 |
WO1995006064A1 (en) | 1995-03-02 |
DK0714406T3 (da) | 2004-07-26 |
EP1486511B1 (de) | 2007-01-24 |
PT1486511E (pt) | 2007-04-30 |
DK1486511T3 (da) | 2007-05-29 |
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