ATE294189T1 - Kristallisation von proteinen - Google Patents
Kristallisation von proteinenInfo
- Publication number
- ATE294189T1 ATE294189T1 AT98901323T AT98901323T ATE294189T1 AT E294189 T1 ATE294189 T1 AT E294189T1 AT 98901323 T AT98901323 T AT 98901323T AT 98901323 T AT98901323 T AT 98901323T AT E294189 T1 ATE294189 T1 AT E294189T1
- Authority
- AT
- Austria
- Prior art keywords
- solution
- value
- providing
- crystalization
- proteins
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 239000013078 crystal Substances 0.000 abstract 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 150000003751 zinc Chemical class 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK14697 | 1997-02-07 | ||
| PCT/DK1998/000042 WO1998034953A1 (en) | 1997-02-07 | 1998-02-03 | Crystallisation of proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE294189T1 true ATE294189T1 (de) | 2005-05-15 |
Family
ID=8090294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98901323T ATE294189T1 (de) | 1997-02-07 | 1998-02-03 | Kristallisation von proteinen |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0966482B1 (de) |
| JP (1) | JP3343129B2 (de) |
| AT (1) | ATE294189T1 (de) |
| AU (1) | AU5749198A (de) |
| DE (1) | DE69829953T2 (de) |
| ES (1) | ES2242270T3 (de) |
| WO (1) | WO1998034953A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001521004A (ja) | 1997-10-24 | 2001-11-06 | イーライ・リリー・アンド・カンパニー | 脂肪酸−アシル化インスリン類似体 |
| CO4970787A1 (es) | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| PT1146896E (pt) * | 1999-01-26 | 2002-10-31 | Lilly Co Eli | Formulacoes monodispersas de analogo acilado e hexamerico insulina |
| WO2008102469A1 (ja) * | 2007-02-23 | 2008-08-28 | Kwansei Gakuin Educational Foundation | 蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法 |
| PL2464655T3 (pl) * | 2009-08-11 | 2017-08-31 | Biocon Limited | Procesy chromatograficzne |
| WO2012104339A1 (en) | 2011-02-01 | 2012-08-09 | Novo Nordisk A/S | Purification of insulin |
| WO2016032869A1 (en) * | 2014-08-26 | 2016-03-03 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin or insulin analog compositions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856771A (en) * | 1973-07-16 | 1974-12-24 | Lilly Co Eli | Process for manufacturing alkali metal or ammonium insulin |
| DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
| US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
-
1998
- 1998-02-03 AU AU57491/98A patent/AU5749198A/en not_active Abandoned
- 1998-02-03 AT AT98901323T patent/ATE294189T1/de not_active IP Right Cessation
- 1998-02-03 JP JP53358198A patent/JP3343129B2/ja not_active Expired - Fee Related
- 1998-02-03 WO PCT/DK1998/000042 patent/WO1998034953A1/en not_active Ceased
- 1998-02-03 ES ES98901323T patent/ES2242270T3/es not_active Expired - Lifetime
- 1998-02-03 DE DE69829953T patent/DE69829953T2/de not_active Expired - Lifetime
- 1998-02-03 EP EP98901323A patent/EP0966482B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU5749198A (en) | 1998-08-26 |
| DE69829953D1 (de) | 2005-06-02 |
| DE69829953T2 (de) | 2006-03-02 |
| JP2000510161A (ja) | 2000-08-08 |
| EP0966482B1 (de) | 2005-04-27 |
| WO1998034953A1 (en) | 1998-08-13 |
| ES2242270T3 (es) | 2005-11-01 |
| EP0966482A1 (de) | 1999-12-29 |
| JP3343129B2 (ja) | 2002-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |