ES2186886T3 - Proteinas solubles. - Google Patents
Proteinas solubles.Info
- Publication number
- ES2186886T3 ES2186886T3 ES97918634T ES97918634T ES2186886T3 ES 2186886 T3 ES2186886 T3 ES 2186886T3 ES 97918634 T ES97918634 T ES 97918634T ES 97918634 T ES97918634 T ES 97918634T ES 2186886 T3 ES2186886 T3 ES 2186886T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- native protein
- proteins
- soluble
- native
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Peptides Or Proteins (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Bipolar Transistors (AREA)
- General Preparation And Processing Of Foods (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Detergent Compositions (AREA)
Abstract
Proteína PrPsc modificada que se caracteriza por: a) comprender menos aminoácidos que una proteína PrPs° nativa; b) causar una enfermedad priónica cuando se inocula un animal con la proteína soluble; y c) ser por lo menos dos veces más soluble que la proteína PrPs° nativa en una solución acuosa, ausencia de un detergente desnaturalizante.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/740,947 US5834593A (en) | 1996-11-05 | 1996-11-05 | Soluble form of PrPSC which is insoluble in native form |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2186886T3 true ES2186886T3 (es) | 2003-05-16 |
Family
ID=24978724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97918634T Expired - Lifetime ES2186886T3 (es) | 1996-11-05 | 1997-04-15 | Proteinas solubles. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5834593A (es) |
EP (1) | EP1012162B1 (es) |
JP (1) | JP2001506979A (es) |
AT (1) | ATE227736T1 (es) |
AU (1) | AU720533B2 (es) |
BR (1) | BR9712874A (es) |
CA (1) | CA2268354A1 (es) |
DE (1) | DE69717167T2 (es) |
DK (1) | DK1012162T3 (es) |
ES (1) | ES2186886T3 (es) |
NZ (1) | NZ335103A (es) |
PT (1) | PT1012162E (es) |
WO (1) | WO1998020022A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2758337B1 (fr) * | 1997-01-14 | 1999-03-05 | Commissariat Energie Atomique | Methode de criblage de substances a action therapeutique dans le traitement des esst comprenant une etape d'isolement de la prpres, a partir de la rate, procede d'isolement de le prpres et ses applications |
GB2348203B (en) | 1998-11-04 | 2002-06-19 | Imp College Innovations Ltd | Solube beta-forms of prion proteins, methods of preparation and use |
US6166187A (en) * | 1999-03-05 | 2000-12-26 | The Regents Of The University Of California | Method of concentrating prion proteins in blood samples |
DE19918141A1 (de) * | 1999-04-21 | 2000-10-26 | Boehringer Ingelheim Vetmed | Verfahren zur Diagnose von übertragbaren Spongiformen Enzephalopathien |
US6437102B1 (en) | 1999-11-24 | 2002-08-20 | Bayer Corporation | Method of separating prions from biological materials |
AU2002258646A1 (en) * | 2001-03-30 | 2002-10-15 | Texas A And M University System | Transgenic animals resistant to transmissible spongiform encephalopathies |
GB0419628D0 (en) * | 2004-09-03 | 2004-10-06 | European Molecular Biology Lab Embl | Method for determining protein solubility |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5013720A (en) * | 1986-05-06 | 1991-05-07 | Abbott Laboratories | SAP-6-Val proteins and methods |
US5266684A (en) * | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
EP0483247A4 (en) * | 1989-07-21 | 1992-12-09 | Washington University | Recombinantly produced human membrane cofactor protein (mcp) |
US5182366A (en) * | 1990-05-15 | 1993-01-26 | Huebner Verena D | Controlled synthesis of peptide mixtures using mixed resins |
ES2237747T3 (es) * | 1991-11-14 | 2005-08-01 | Prionics Ag | Animales transgenicos no humanos que carecen de proteinas prionicas. |
AU4376093A (en) * | 1992-05-15 | 1993-12-13 | Instituto Nazionale Neurologico C. Besta | Soluble prion polypeptides, and methods for detecting and purifying thereof |
US5605691A (en) * | 1992-09-17 | 1997-02-25 | Ophidian Pharmaceuticals, Inc. | Immunologically active proteins from inclusion bodies |
US5565186A (en) * | 1994-05-13 | 1996-10-15 | The Regents Of The University Of California | Method of detecting prions in a sample and transgenic animal used for same |
-
1996
- 1996-11-05 US US08/740,947 patent/US5834593A/en not_active Expired - Fee Related
-
1997
- 1997-04-15 DK DK97918634T patent/DK1012162T3/da active
- 1997-04-15 BR BR9712874-0A patent/BR9712874A/pt not_active IP Right Cessation
- 1997-04-15 JP JP52134698A patent/JP2001506979A/ja active Pending
- 1997-04-15 AU AU26694/97A patent/AU720533B2/en not_active Ceased
- 1997-04-15 AT AT97918634T patent/ATE227736T1/de not_active IP Right Cessation
- 1997-04-15 WO PCT/US1997/006227 patent/WO1998020022A1/en active IP Right Grant
- 1997-04-15 CA CA002268354A patent/CA2268354A1/en not_active Abandoned
- 1997-04-15 PT PT97918634T patent/PT1012162E/pt unknown
- 1997-04-15 ES ES97918634T patent/ES2186886T3/es not_active Expired - Lifetime
- 1997-04-15 NZ NZ335103A patent/NZ335103A/xx unknown
- 1997-04-15 DE DE69717167T patent/DE69717167T2/de not_active Expired - Fee Related
- 1997-04-15 EP EP97918634A patent/EP1012162B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1012162B1 (en) | 2002-11-13 |
BR9712874A (pt) | 2000-02-01 |
EP1012162A1 (en) | 2000-06-28 |
AU2669497A (en) | 1998-05-29 |
DE69717167T2 (de) | 2003-07-24 |
PT1012162E (pt) | 2003-04-30 |
WO1998020022A1 (en) | 1998-05-14 |
US5834593A (en) | 1998-11-10 |
ATE227736T1 (de) | 2002-11-15 |
NZ335103A (en) | 2000-10-27 |
EP1012162A4 (en) | 2000-06-28 |
DE69717167D1 (de) | 2002-12-19 |
CA2268354A1 (en) | 1998-05-14 |
AU720533B2 (en) | 2000-06-01 |
JP2001506979A (ja) | 2001-05-29 |
DK1012162T3 (da) | 2003-03-10 |
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