BR9712874A - Proteìnas solúveis - Google Patents
Proteìnas solúveisInfo
- Publication number
- BR9712874A BR9712874A BR9712874-0A BR9712874A BR9712874A BR 9712874 A BR9712874 A BR 9712874A BR 9712874 A BR9712874 A BR 9712874A BR 9712874 A BR9712874 A BR 9712874A
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- native protein
- proteins
- soluble
- native
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Bipolar Transistors (AREA)
- General Preparation And Processing Of Foods (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<B>PROTEìNAS SOLúVEIS<D>. A invenção inclui deletar segmentos de códon a partir de DNA exprimindo uma proteína nativa com a finalidade de obter uma proteína solúvel, mais curta a qual imita as características de uma proteína nativa insolúvel. Proteínas solúveis da invenção são caracterizadas por: (1) ter menos amino ácidos do que a proteína nativa de comprimento total; (2) ter um grau superior de solubilidade do que a proteína nativa; (3) reter as características biológicas básicas da proteína nativa tal como (a) não estar sujeita à digestão enzimática e (b) causar doença. Proteínas solúveis da invenção são obtidas mediante provisão de uma seq³ência de DNA a qual codifica uma proteína nativa e removendo sistematicamente códons, fazendo cópias das versões reduzidas de DNA as quais são então exprimidas para proporcionar as proteínas reduzidas. As proteínas reduzidas são então testadas em termos de solubilidade. Proteínas solúveis são então testadas adicionalmente para confirmar que as mesmas retêm as características biológicas da proteína nativa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/740,947 US5834593A (en) | 1996-11-05 | 1996-11-05 | Soluble form of PrPSC which is insoluble in native form |
PCT/US1997/006227 WO1998020022A1 (en) | 1996-11-05 | 1997-04-15 | Soluble proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712874A true BR9712874A (pt) | 2000-02-01 |
Family
ID=24978724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712874-0A BR9712874A (pt) | 1996-11-05 | 1997-04-15 | Proteìnas solúveis |
Country Status (13)
Country | Link |
---|---|
US (1) | US5834593A (pt) |
EP (1) | EP1012162B1 (pt) |
JP (1) | JP2001506979A (pt) |
AT (1) | ATE227736T1 (pt) |
AU (1) | AU720533B2 (pt) |
BR (1) | BR9712874A (pt) |
CA (1) | CA2268354A1 (pt) |
DE (1) | DE69717167T2 (pt) |
DK (1) | DK1012162T3 (pt) |
ES (1) | ES2186886T3 (pt) |
NZ (1) | NZ335103A (pt) |
PT (1) | PT1012162E (pt) |
WO (1) | WO1998020022A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2758337B1 (fr) * | 1997-01-14 | 1999-03-05 | Commissariat Energie Atomique | Methode de criblage de substances a action therapeutique dans le traitement des esst comprenant une etape d'isolement de la prpres, a partir de la rate, procede d'isolement de le prpres et ses applications |
GB2348203B (en) | 1998-11-04 | 2002-06-19 | Imp College Innovations Ltd | Solube beta-forms of prion proteins, methods of preparation and use |
US6166187A (en) * | 1999-03-05 | 2000-12-26 | The Regents Of The University Of California | Method of concentrating prion proteins in blood samples |
DE19918141A1 (de) * | 1999-04-21 | 2000-10-26 | Boehringer Ingelheim Vetmed | Verfahren zur Diagnose von übertragbaren Spongiformen Enzephalopathien |
US6437102B1 (en) | 1999-11-24 | 2002-08-20 | Bayer Corporation | Method of separating prions from biological materials |
WO2002079416A2 (en) * | 2001-03-30 | 2002-10-10 | Texas A & M University System | Transgenic animals resistant to transmissible spongiform encephalopathies |
GB0419628D0 (en) * | 2004-09-03 | 2004-10-06 | European Molecular Biology Lab Embl | Method for determining protein solubility |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5013720A (en) * | 1986-05-06 | 1991-05-07 | Abbott Laboratories | SAP-6-Val proteins and methods |
US5266684A (en) * | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
AU651068B2 (en) * | 1989-07-21 | 1994-07-14 | Washington University | Recombinantly produced human membrane cofactor protein (MCP) |
US5182366A (en) * | 1990-05-15 | 1993-01-26 | Huebner Verena D | Controlled synthesis of peptide mixtures using mixed resins |
SG47979A1 (en) * | 1991-11-14 | 1998-04-17 | Charles Weissman | Transgenic animals lacking prion proteins |
WO1993023432A1 (en) * | 1992-05-15 | 1993-11-25 | New York University | Soluble prion polypeptides, and methods for detecting and purifying thereof |
US5605691A (en) * | 1992-09-17 | 1997-02-25 | Ophidian Pharmaceuticals, Inc. | Immunologically active proteins from inclusion bodies |
US5565186A (en) * | 1994-05-13 | 1996-10-15 | The Regents Of The University Of California | Method of detecting prions in a sample and transgenic animal used for same |
-
1996
- 1996-11-05 US US08/740,947 patent/US5834593A/en not_active Expired - Fee Related
-
1997
- 1997-04-15 DK DK97918634T patent/DK1012162T3/da active
- 1997-04-15 AU AU26694/97A patent/AU720533B2/en not_active Ceased
- 1997-04-15 EP EP97918634A patent/EP1012162B1/en not_active Expired - Lifetime
- 1997-04-15 AT AT97918634T patent/ATE227736T1/de not_active IP Right Cessation
- 1997-04-15 ES ES97918634T patent/ES2186886T3/es not_active Expired - Lifetime
- 1997-04-15 CA CA002268354A patent/CA2268354A1/en not_active Abandoned
- 1997-04-15 PT PT97918634T patent/PT1012162E/pt unknown
- 1997-04-15 DE DE69717167T patent/DE69717167T2/de not_active Expired - Fee Related
- 1997-04-15 BR BR9712874-0A patent/BR9712874A/pt not_active IP Right Cessation
- 1997-04-15 WO PCT/US1997/006227 patent/WO1998020022A1/en active IP Right Grant
- 1997-04-15 NZ NZ335103A patent/NZ335103A/xx unknown
- 1997-04-15 JP JP52134698A patent/JP2001506979A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69717167D1 (de) | 2002-12-19 |
JP2001506979A (ja) | 2001-05-29 |
NZ335103A (en) | 2000-10-27 |
EP1012162B1 (en) | 2002-11-13 |
EP1012162A4 (en) | 2000-06-28 |
ES2186886T3 (es) | 2003-05-16 |
AU2669497A (en) | 1998-05-29 |
WO1998020022A1 (en) | 1998-05-14 |
EP1012162A1 (en) | 2000-06-28 |
US5834593A (en) | 1998-11-10 |
AU720533B2 (en) | 2000-06-01 |
PT1012162E (pt) | 2003-04-30 |
DK1012162T3 (da) | 2003-03-10 |
CA2268354A1 (en) | 1998-05-14 |
ATE227736T1 (de) | 2002-11-15 |
DE69717167T2 (de) | 2003-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A,8A, 9A E 10A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1908 DE 31/07/2007. |