ME00184B - Osteoprotegerin vezujući proteini i receptori - Google Patents
Osteoprotegerin vezujući proteini i receptoriInfo
- Publication number
- ME00184B ME00184B MEP-2008-328A MEP2008328A ME00184B ME 00184 B ME00184 B ME 00184B ME P2008328 A MEP2008328 A ME P2008328A ME 00184 B ME00184 B ME 00184B
- Authority
- ME
- Montenegro
- Prior art keywords
- receptors
- osteoprotegerin
- binding proteins
- methods
- osteoprotegerin binding
- Prior art date
Links
- 102000008108 Osteoprotegerin Human genes 0.000 title abstract 4
- 108010035042 Osteoprotegerin Proteins 0.000 title abstract 4
- 108091008324 binding proteins Proteins 0.000 title abstract 4
- XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 title abstract 4
- 102000005962 receptors Human genes 0.000 title abstract 3
- 108020003175 receptors Proteins 0.000 title abstract 3
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 102000023732 binding proteins Human genes 0.000 abstract 3
- 208000020084 Bone disease Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 230000001599 osteoclastic effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
Abstract
Novi polipeptid, osteoprotegerinski vezujući protein, koji učestvuje u osteoklastnom sazrijevanju jeidentifikovan bazirano na njegovom afinitetu za osteoprotegerin. Opisane su nukleinske kisjelinske sekvence koje kodiraju polipeptid, ili njegov fragment, analog ili derivat, vektori i ćelije domaćina za proizvodnju, postupci dobijanja osteoprotegerinskog vezujućeg proteina i ispitivanja vezivanja. Preparati i postupci za tretiranje koštanih oboljenja takvih kao što su osteoporozis, koštani gubitak usljed artritisa ili metastazis, hiperkalcemija i Paget’ovo oboljenje su takođe obezbijeđeni. Receptori za osteoprotegernske vezujuće proteine su takođe opisani. Receptori i njihovi agonisti i antagonisti mogu da budu korišćeni za treti ranje koštanih oboljenja.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/842,842 US5843678A (en) | 1997-04-16 | 1997-04-16 | Osteoprotegerin binding proteins |
US88085597A | 1997-06-23 | 1997-06-23 | |
US09/052,521 US6316408B1 (en) | 1997-04-16 | 1998-03-30 | Methods of use for osetoprotegerin binding protein receptors |
PCT/US1998/007584 WO1998046751A1 (en) | 1997-04-16 | 1998-04-15 | Osteoprotegerin binding proteins and receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
ME00184B true ME00184B (me) | 2010-10-10 |
Family
ID=27126366
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-328/08A MEP32808A (en) | 1997-04-16 | 1998-04-15 | Osteoprotegerin binding proteins and receptors |
MEP-2008-328A ME00184B (me) | 1997-04-16 | 1998-04-15 | Osteoprotegerin vezujući proteini i receptori |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-328/08A MEP32808A (en) | 1997-04-16 | 1998-04-15 | Osteoprotegerin binding proteins and receptors |
Country Status (15)
Country | Link |
---|---|
US (4) | US6316408B1 (me) |
EP (1) | EP2311955A3 (me) |
JP (2) | JP2009001566A (me) |
KR (2) | KR101328809B1 (me) |
CN (1) | CN103990122B (me) |
CA (1) | CA2706609A1 (me) |
CY (1) | CY1108998T1 (me) |
GE (1) | GEP20033002B (me) |
IL (1) | IL132304A (me) |
LT (1) | LTC0975754I2 (me) |
ME (2) | MEP32808A (me) |
NO (1) | NO2010022I2 (me) |
PT (1) | PT975754E (me) |
RO (1) | RO122495B1 (me) |
RS (1) | RS50358B (me) |
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-
1998
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- 1998-04-15 RS YUP-506/99A patent/RS50358B/sr unknown
- 1998-04-15 ME MEP-328/08A patent/MEP32808A/xx unknown
- 1998-04-15 EP EP10184791A patent/EP2311955A3/en not_active Withdrawn
- 1998-04-15 ME MEP-2008-328A patent/ME00184B/me unknown
- 1998-04-15 CN CN201310463795.5A patent/CN103990122B/zh not_active Expired - Lifetime
- 1998-04-15 KR KR1020127021477A patent/KR101328809B1/ko not_active IP Right Cessation
- 1998-04-15 RO RO99-01101A patent/RO122495B1/ro unknown
- 1998-04-15 GE GEAP19985034A patent/GEP20033002B/en unknown
- 1998-04-15 KR KR1019997009492A patent/KR101314478B1/ko not_active IP Right Cessation
- 1998-04-15 PT PT98918244T patent/PT975754E/pt unknown
- 1998-04-15 CA CA2706609A patent/CA2706609A1/en not_active Abandoned
- 1998-12-14 US US09/211,315 patent/US7097834B1/en not_active Expired - Lifetime
- 1998-12-14 US US09/211,297 patent/US7807795B2/en not_active Expired - Fee Related
-
1999
- 1999-10-08 IL IL132304A patent/IL132304A/en active Protection Beyond IP Right Term
-
2004
- 2004-04-15 US US10/825,898 patent/US20050003400A1/en not_active Abandoned
-
2007
- 2007-06-21 CY CY20071100833T patent/CY1108998T1/el unknown
-
2008
- 2008-06-11 JP JP2008153218A patent/JP2009001566A/ja not_active Withdrawn
-
2010
- 2010-11-24 LT LTPA2010013C patent/LTC0975754I2/lt unknown
- 2010-11-25 NO NO2010022C patent/NO2010022I2/no unknown
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2012
- 2012-09-13 JP JP2012201172A patent/JP2013028622A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR101314478B1 (ko) | 2014-01-17 |
IL132304A (en) | 2015-07-30 |
GEP20033002B (en) | 2003-06-25 |
MEP32808A (en) | 2010-10-10 |
US7807795B2 (en) | 2010-10-05 |
YU50699A (sh) | 2000-10-30 |
US20030100488A1 (en) | 2003-05-29 |
RS50358B (sr) | 2009-11-10 |
RO122495B1 (ro) | 2009-07-30 |
KR101328809B1 (ko) | 2014-01-17 |
LTPA2010013I1 (lt) | 2021-05-25 |
CA2706609A1 (en) | 1998-10-22 |
CN103990122B (zh) | 2017-01-04 |
LTC0975754I2 (lt) | 2022-03-25 |
PT975754E (pt) | 2007-08-20 |
KR20010006405A (ko) | 2001-01-26 |
NO2010022I2 (no) | 2015-03-30 |
US20050003400A1 (en) | 2005-01-06 |
CY1108998T1 (el) | 2014-07-02 |
NO2010022I1 (no) | 2011-01-10 |
CN103990122A (zh) | 2014-08-20 |
US6316408B1 (en) | 2001-11-13 |
US7097834B1 (en) | 2006-08-29 |
JP2009001566A (ja) | 2009-01-08 |
EP2311955A3 (en) | 2012-12-12 |
EP2311955A2 (en) | 2011-04-20 |
KR20120108046A (ko) | 2012-10-04 |
JP2013028622A (ja) | 2013-02-07 |
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